LOCUS       NM_012530               1438 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Rattus norvegicus creatine kinase, M-type (Ckm), mRNA.
ACCESSION   NM_012530
VERSION     NM_012530.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1438)
  AUTHORS   Fowler,E.D., Benoist,D., Drinkhill,M.J., Stones,R., Helmes,M.,
            Wust,R.C., Stienen,G.J., Steele,D.S. and White,E.
  TITLE     Decreased creatine kinase is linked to diastolic dysfunction in
            rats with right heart failure induced by pulmonary artery
            hypertension
  JOURNAL   J Mol Cell Cardiol 86, 1-8 (2015)
   PUBMED   26116865
  REMARK    GeneRIF: Creatine kinase inhibition also mimics a definitive
            characteristic of heart failure, the inability to respond to
            increased demand. Novel therapies for pulmonary artery hypertension
            are needed.
REFERENCE   2  (bases 1 to 1438)
  AUTHORS   Demonbreun,A.R., Rossi,A.E., Alvarez,M.G., Swanson,K.E.,
            Deveaux,H.K., Earley,J.U., Hadhazy,M., Vohra,R., Walter,G.A.,
            Pytel,P. and McNally,E.M.
  TITLE     Dysferlin and myoferlin regulate transverse tubule formation and
            glycerol sensitivity
  JOURNAL   Am J Pathol 184 (1), 248-259 (2014)
   PUBMED   24177035
REFERENCE   3  (bases 1 to 1438)
  AUTHORS   Diguet,N., Mallat,Y., Ladouce,R., Clodic,G., Prola,A., Tritsch,E.,
            Blanc,J., Larcher,J.C., Delcayre,C., Samuel,J.L., Friguet,B.,
            Bolbach,G., Li,Z. and Mericskay,M.
  TITLE     Muscle creatine kinase deficiency triggers both actin
            depolymerization and desmin disorganization by advanced glycation
            end products in dilated cardiomyopathy
  JOURNAL   J Biol Chem 286 (40), 35007-35019 (2011)
   PUBMED   21768101
  REMARK    GeneRIF: strong down-regulation of MCK activity contributes to
            F-actin instability and induces post-translational modification of
            alphaB-crystallin and desmin
REFERENCE   4  (bases 1 to 1438)
  AUTHORS   Callahan,L.A. and Supinski,G.S.
  TITLE     Diaphragm and cardiac mitochondrial creatine kinases are impaired
            in sepsis
  JOURNAL   J Appl Physiol (1985) 102 (1), 44-53 (2007)
   PUBMED   16916915
  REMARK    GeneRIF: Endotoxin-induced sepsis markedly reduced diaphragm and
            cardiac mitochondrial creatine kinase activity
REFERENCE   5  (bases 1 to 1438)
  AUTHORS   Oriyanhan,W., Miyamoto,T.A., Yamazaki,K., Miwa,S., Takaba,K.,
            Ikeda,T. and Komeda,M.
  TITLE     Regionally perfused taurine. Part I. Minimizes lactic acidosis and
            preserves CKMB and myocardial contractility after
            ischemia/reperfusion
  JOURNAL   Adv Exp Med Biol 583, 271-288 (2006)
   PUBMED   17153612
  REMARK    GeneRIF: Data show that taurine minimizes lactic acidosis and
            preserves creatine kinase activity and myocardial contractility
            after ischemia/reperfusion.
REFERENCE   6  (bases 1 to 1438)
  AUTHORS   Park,S.J., Zhang,J., Ye,Y., Ormaza,S., Liang,P., Bank,A.J.,
            Miller,L.W. and Bache,R.J.
  TITLE     Myocardial creatine kinase expression after left ventricular assist
            device support
  JOURNAL   J Am Coll Cardiol 39 (11), 1773-1779 (2002)
   PUBMED   12039490
REFERENCE   7  (bases 1 to 1438)
  AUTHORS   Zhao,J., Schmieg,F.I., Simmons,D.T. and Molloy,G.R.
  TITLE     Mouse p53 represses the rat brain creatine kinase gene but
            activates the rat muscle creatine kinase gene
  JOURNAL   Mol Cell Biol 14 (12), 8483-8492 (1994)
   PUBMED   7969181
REFERENCE   8  (bases 1 to 1438)
  AUTHORS   Diaz-Nido,J., Mizuno,K., Nawa,H. and Marshak,D.R.
  TITLE     Regulation of protein kinase CK2 isoform expression during rat
            brain development
  JOURNAL   Cell Mol Biol Res 40 (5-6), 581-585 (1994)
   PUBMED   7735332
REFERENCE   9  (bases 1 to 1438)
  AUTHORS   Benfield,P.A., Zivin,R.A., Miller,L.S., Sowder,R., Smythers,G.W.,
            Henderson,L., Oroszlan,S. and Pearson,M.L.
  TITLE     Isolation and sequence analysis of cDNA clones coding for rat
            skeletal muscle creatine kinase
  JOURNAL   J Biol Chem 259 (23), 14979-14984 (1984)
   PUBMED   6209281
REFERENCE   10 (bases 1 to 1438)
  AUTHORS   Bulfield,G., Siller,W.G., Wight,P.A. and Moore,K.J.
  TITLE     X chromosome-linked muscular dystrophy (mdx) in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 81 (4), 1189-1192 (1984)
   PUBMED   6583703
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM056549.1, DN931989.1, FM053193.1 and CR458343.1.
            
            On Nov 28, 2013 this sequence version replaced NM_012530.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216665.1, M10140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                FM056549.1         1-47
            48-788              DN931989.1         47-787
            789-1174            FM053193.1         105-490
            1175-1438           CR458343.1         3-266               c
FEATURES             Location/Qualifiers
     source          1..1438
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1438
                     /gene="Ckm"
                     /gene_synonym="Ckmm; CPK-M"
                     /note="creatine kinase, M-type"
                     /db_xref="GeneID:24265"
                     /db_xref="RGD:2358"
     exon            1..77
                     /gene="Ckm"
                     /gene_synonym="Ckmm; CPK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            78..289
                     /gene="Ckm"
                     /gene_synonym="Ckmm; CPK-M"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1242
                     /gene="Ckm"
                     /gene_synonym="Ckmm; CPK-M"
                     /EC_number="2.7.3.2"
                     /note="M-CK; creatine kinase M chain; creatine kinase,
                     muscle; creatine phosphokinase M-type"
                     /codon_start=1
                     /product="creatine kinase M-type"
                     /protein_id="NP_036662.1"
                     /db_xref="GeneID:24265"
                     /db_xref="RGD:2358"
                     /translation="MPFGNTHNKFKLNYKSQEEYPDLSKHNNHMAKVLTPDLYNKLRD
                     KETPSGFTLDDVIQTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGFKP
                     TDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVE
                     ALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIW
                     HNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNEH
                     LGYVLTCPSNLGTGLRGGVHVKLANLSKHPKFEEILTRLRLQKRGTGGVDTAAVGAVF
                     DISNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK"
     exon            290..444
                     /gene="Ckm"
                     /gene_synonym="Ckmm; CPK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            445..577
                     /gene="Ckm"
                     /gene_synonym="Ckmm; CPK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            578..749
                     /gene="Ckm"
                     /gene_synonym="Ckmm; CPK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            750..873
                     /gene="Ckm"
                     /gene_synonym="Ckmm; CPK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1063
                     /gene="Ckm"
                     /gene_synonym="Ckmm; CPK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1438
                     /gene="Ckm"
                     /gene_synonym="Ckmm; CPK-M"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaggggctg caggggctgc ccccgggtca ccaccacctc cacagcaaag acagacactc
       61 aggagccagc cagccagggt cccaaaggcc gtcaccatgc cgttcggcaa cacccacaac
      121 aagttcaagc tgaactacaa gtcgcaggag gagtacccag acctcagcaa acacaacaac
      181 cacatggcca aggtgctgac tcctgacctc tacaataagc ttcgagacaa ggagacccca
      241 tccggcttca ctctggacga tgtcatccag actggggtgg acaacccggg tcaccctttc
      301 atcatgacgg tcggctgtgt ggccggcgat gaggagtcct acactgtttt caaggacctg
      361 tttgacccca tcatccagga ccgccatggt ggcttcaaac ccacagacaa gcataagacc
      421 gacctcaacc acgagaacct caagggtgga gacgatctgg accccaacta tgtgctgagc
      481 agccgcgtgc gcactggccg cagcatcaag ggctacactc tgcccccgca ctgctcccgc
      541 ggagagcgcc gtgctgtaga gaagctgtcc gtggaagctc tcaacagcct gacaggcgag
      601 ttcaagggca aatactaccc tctgaagagc atgacagagc aggagcagca gcagctcatt
      661 gatgaccact tcctgtttga caagcccgtg tcacctctgc tgctggcctc aggcatggcc
      721 cgagactggc ccgacgcccg tggcatctgg cacaacgaca acaaaagctt cctggtgtgg
      781 gtgaatgagg aggaccacct tcgcgtgatc tccatggaga aaggaggcaa tatgaaggaa
      841 gttttccgcc gcttctgcgt gggcctgcag aagattgagg agatcttcaa gaaggctggt
      901 caccccttca tgtggaacga gcacctgggc tacgtgctca cctgcccctc caacctgggc
      961 accgggctgc gcggaggcgt gcacgtgaag ctggcgaacc tgagcaagca ccccaagttt
     1021 gaggagattc tcacccgcct tcgtctgcag aagcgcggca caggtggcgt ggacaccgct
     1081 gcggtgggcg ccgtgttcga catctccaac gccgatcggc tgggctcttc cgaggtcgaa
     1141 caggtgcagc tggtggtgga tggcgtaaag cttatggtgg agatggagaa gaagctggaa
     1201 aaaggccagt ccatcgacga catgatccct gcgcagaagt aggcgccgca cagagcgcac
     1261 cagtcagcgg cttgcagctg gagccccgcc ccctggaagt ccaaccaacc gactttgccc
     1321 tctgggttct ggccaatgag aacctgcctc tccggggccc cgcccgcctg ctggaactcc
     1381 tgcacttggg cgctgcttcc ccacgccctg ccttaaataa aagtccgtgg tggtctta
//
