LOCUS       NM_139111                667 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus chemokine-like factor (Cklf), mRNA.
ACCESSION   NM_139111
VERSION     NM_139111.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 667)
  AUTHORS   Zhou,X., Zhang,Y.N., Li,F.F., Zhang,Z., Cui,L.Y., He,H.Y., Yan,X.,
            He,W.B., Sun,H.S., Feng,Z.P., Chu,S.F. and Chen,N.H.
  TITLE     Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1
            polarization of microglia in rat brain after stroke
  JOURNAL   Acta Pharmacol Sin 43 (5), 1217-1230 (2022)
   PUBMED   34385606
  REMARK    GeneRIF: Neuronal chemokine-like-factor 1 (CKLF1) up-regulation
            promotes M1 polarization of microglia in rat brain after stroke.
REFERENCE   2  (bases 1 to 667)
  AUTHORS   Li,F.F., Zhou,X., Chu,S.F. and Chen,N.H.
  TITLE     Inhibition of CKLF1 ameliorates hepatic ischemia-reperfusion injury
            via MAPK pathway
  JOURNAL   Cytokine 141, 155429 (2021)
   PUBMED   33578361
  REMARK    GeneRIF: Inhibition of CKLF1 ameliorates hepatic
            ischemia-reperfusion injury via MAPK pathway.
REFERENCE   3  (bases 1 to 667)
  AUTHORS   Chen,C., Chu,S.F., Ai,Q.D., Zhang,Z. and Chen,N.H.
  TITLE     CKLF1/CCR5 axis is involved in neutrophils migration of rats with
            transient cerebral ischemia
  JOURNAL   Int Immunopharmacol 85, 106577 (2020)
   PUBMED   32446198
  REMARK    GeneRIF: CKLF1/CCR5 axis is involved in neutrophils migration of
            rats with transient cerebral ischemia.
REFERENCE   4  (bases 1 to 667)
  AUTHORS   Duan,Y., Zhang,Y., Qu,C., Yu,W., Tana and Shen,C.
  TITLE     CKLF1 aggravates neointimal hyperplasia by inhibiting apoptosis of
            vascular smooth muscle cells through PI3K/AKT/NF-kappaB signaling
  JOURNAL   Biomed Pharmacother 117, 108986 (2019)
   PUBMED   31387172
  REMARK    GeneRIF: New treatment strategies to limit restenosis based on
            CKLF1 as a future target.
REFERENCE   5  (bases 1 to 667)
  AUTHORS   Kong,L.L., Wang,Z.Y., Hu,J.F., Yuan,Y.H., Li,H. and Chen,N.H.
  TITLE     Inhibition of chemokine-like factor 1 improves blood-brain barrier
            dysfunction in rats following focal cerebral ischemia
  JOURNAL   Neurosci Lett 627, 192-198 (2016)
   PUBMED   27283776
  REMARK    GeneRIF: Chemokine-like factor 1 (CKLF1) is involved in blood-brain
            barrier disruption after reperfusion. Inhibition of CKLF1 protects
            against cerebral ischemia by maintaining BBB integrity, possibly
            via inhibiting the expression of aquaporin-4 and matrix
            metalloproteinase-9, and increasing the expression of tight
            junction protein.
REFERENCE   6  (bases 1 to 667)
  AUTHORS   Zhang,T., Qiao,Z., Chen,F., Zhang,X., Xiong,J., Jia,X., Chen,J.,
            Shen,C. and Guo,W.
  TITLE     Antagonistic effect of C19 on migration of vascular smooth muscle
            cells and intimal hyperplasia induced by chemokine-like factor 1
  JOURNAL   Mol Biol Rep 40 (4), 2939-2946 (2013)
   PUBMED   23203409
  REMARK    GeneRIF: These data suggest that CKLF1 has a pivotal role in
            intimal hyperplasia by mediating VSMC migration. C19 was
            demonstrated to inhibit CKLF1-mediatated chemotaxis
REFERENCE   7  (bases 1 to 667)
  AUTHORS   Kong,L.L., Hu,J.F., Zhang,W., Yuan,Y.H., Ma,K.L., Han,N. and
            Chen,N.H.
  TITLE     Expression of chemokine-like factor 1 after focal cerebral ischemia
            in the rat
  JOURNAL   Neurosci Lett 505 (1), 14-18 (2011)
   PUBMED   21964493
  REMARK    GeneRIF: This study demonstrated that the expression of CKLF1
            increases after focal cerebral ischemia in rat brain.
REFERENCE   8  (bases 1 to 667)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 667)
  AUTHORS   Lou,Y., Xia,D., Han,W., Wang,Y., Li,X., Li,Y., Rui,M., Ding,P.,
            Song,Q., Zhang,Y. and Ma,D.
  TITLE     Molecular cloning and characterization of rat chemokine-like factor
            1 and 2
  JOURNAL   Gene 307, 125-132 (2003)
   PUBMED   12706894
REFERENCE   10 (bases 1 to 667)
  AUTHORS   Han,W., Lou,Y., Tang,J., Zhang,Y., Chen,Y., Li,Y., Gu,W., Huang,J.,
            Gui,L., Tang,Y., Li,F., Song,Q., Di,C., Wang,L., Shi,Q., Sun,R.,
            Xia,D., Rui,M., Tang,J. and Ma,D.
  TITLE     Molecular cloning and characterization of chemokine-like factor 1
            (CKLF1), a novel human cytokine with unique structure and potential
            chemotactic activity
  JOURNAL   Biochem J 357 (Pt 1), 127-135 (2001)
   PUBMED   11415443
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139111.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF253065.2, FM105377.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840117,
                                           SAMN16676786 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               JAXUCZ010000019.1  712756-712998       c
            244-402             JAXUCZ010000019.1  710419-710577       c
            403-498             JAXUCZ010000019.1  706364-706459       c
            499-667             JAXUCZ010000019.1  704528-704696       c
FEATURES             Location/Qualifiers
     source          1..667
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p14"
     gene            1..667
                     /gene="Cklf"
                     /gene_synonym="Cklf1"
                     /note="chemokine-like factor"
                     /db_xref="GeneID:245978"
                     /db_xref="RGD:620708"
     exon            1..243
                     /gene="Cklf"
                     /gene_synonym="Cklf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..621
                     /gene="Cklf"
                     /gene_synonym="Cklf1"
                     /note="chemokine-like factor 1"
                     /codon_start=1
                     /product="chemokine-like factor"
                     /protein_id="NP_620811.1"
                     /db_xref="GeneID:245978"
                     /db_xref="RGD:620708"
                     /translation="MDSPQKVVDHQPFCLSLKCFVKTLRLVVTVASMIFFIVAQAPEP
                     YIVITGFEVTIILFLIALYMCSLDKTMRSFFWPLLDVINSVVTTLFMLIVSVSALIPE
                     TSTMIMVGGVFGFLTVICTVADCALMCQKLRFRPHGPYQNRSATDVDDS"
     exon            244..402
                     /gene="Cklf"
                     /gene_synonym="Cklf1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..498
                     /gene="Cklf"
                     /gene_synonym="Cklf1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..667
                     /gene="Cklf"
                     /gene_synonym="Cklf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagccattg ggcggtccgc gctagtgcgc acgcgcgtct ggacttaggt ggaccgaagt
       61 actgctggcc cagcaccggc agttgaagtt gttgcgcgag tcctggagag caattaactg
      121 agaaggcttg aaagagaagc gttgactgtt gggtctgtgg gcaagatgga ctctccacag
      181 aaggtcgtag accatcagcc cttctgcctc agtctgaaat gctttgtgaa gacgctgcgg
      241 ttggtggtaa ctgtggcctc tatgatcttt ttcatcgtgg cacaagcccc tgaaccgtat
      301 atcgttatca ctgggtttga agtcaccatc attctctttc tcatagcctt atatatgtgc
      361 agtcttgaca agacaatgag atctttcttt tggcctttgc ttgatgttat caactcggtg
      421 gtaacaacac tattcatgct tattgtgtct gtgtcggctc taataccaga aacctcaaca
      481 atgataatgg ttggaggggt gtttggtttc ctgacagtaa tatgtactgt tgctgattgt
      541 gcccttatgt gccagaaact ccggtttcgt ccacatggac cttatcagaa caggtctgct
      601 actgatgtag atgacagtta attttatact catttttact agttattaaa ttctttatac
      661 ttccata
//
