LOCUS       NM_012529               1463 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus creatine kinase B (Ckb), mRNA.
ACCESSION   NM_012529
VERSION     NM_012529.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1463)
  AUTHORS   Gemelli,T., de Andrade,R.B., Rojas,D.B., Bonorino,N.F.,
            Mazzola,P.N., Tortorelli,L.S., Funchal,C., Filho,C.S. and
            Wannmacher,C.M.
  TITLE     Effects of beta-alanine administration on selected parameters of
            oxidative stress and phosphoryltransfer network in cerebral cortex
            and cerebellum of rats
  JOURNAL   Mol Cell Biochem 380 (1-2), 161-170 (2013)
   PUBMED   23620342
  REMARK    GeneRIF: Data indicate that the beta-alanine administration was
            able to inhibit the enzyme pyruvate kinase, cytosolic creatine
            kinase, and adenylate kinase activities in cerebral cortex, and
            increase in cerebellum.
REFERENCE   2  (bases 1 to 1463)
  AUTHORS   Kobayashi,M., Hamanoue,M., Masaki,T., Furuta,Y. and Takamatsu,K.
  TITLE     Hippocalcin mediates calcium-dependent translocation of brain-type
            creatine kinase (BB-CK) in hippocampal neurons
  JOURNAL   Biochem Biophys Res Commun 429 (3-4), 142-147 (2012)
   PUBMED   23142228
  REMARK    GeneRIF: These results indicate that Hpca associates with BB-CK and
            that together they translocate to membrane compartments in a
            Ca(2+)-dependent manner.
REFERENCE   3  (bases 1 to 1463)
  AUTHORS   Chen,S., Lu,F.F., Seeman,P. and Liu,F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   4  (bases 1 to 1463)
  AUTHORS   Wong,A.C., Velamoor,S., Skelton,M.R., Thorne,P.R. and
            Vlajkovic,S.M.
  TITLE     Expression and distribution of creatine transporter and creatine
            kinase (brain isoform) in developing and mature rat cochlear
            tissues
  JOURNAL   Histochem Cell Biol 137 (5), 599-613 (2012)
   PUBMED   22307408
  REMARK    GeneRIF: The expression of CK in cochlear tissues during
            development may reflect differential requirements for
            creatine-phosphocreatine buffering to replenish ATP consumed during
            energy-dependent metabolic processes.
REFERENCE   5  (bases 1 to 1463)
  AUTHORS   Davison,E.J., Pennington,K., Hung,C.C., Peng,J., Rafiq,R.,
            Ostareck-Lederer,A., Ostareck,D.H., Ardley,H.C., Banks,R.E. and
            Robinson,P.A.
  TITLE     Proteomic analysis of increased Parkin expression and its
            interactants provides evidence for a role in modulation of
            mitochondrial function
  JOURNAL   Proteomics 9 (18), 4284-4297 (2009)
   PUBMED   19725078
REFERENCE   6  (bases 1 to 1463)
  AUTHORS   Friedman,D.L. and Perryman,M.B.
  TITLE     Compartmentation of multiple forms of creatine kinase in the distal
            nephron of the rat kidney
  JOURNAL   J Biol Chem 266 (33), 22404-22410 (1991)
   PUBMED   1939264
REFERENCE   7  (bases 1 to 1463)
  AUTHORS   Pentecost,B.T., Mattheiss,L., Dickerman,H.W. and Kumar,S.A.
  TITLE     Estrogen regulation of creatine kinase-B in the rat uterus
  JOURNAL   Mol Endocrinol 4 (7), 1000-1010 (1990)
   PUBMED   2284002
REFERENCE   8  (bases 1 to 1463)
  AUTHORS   Benfield,P.A., Graf,D., Korolkoff,P.N., Hobson,G. and Pearson,M.L.
  TITLE     Isolation of four rat creatine kinase genes and identification of
            multiple potential promoter sequences within the rat brain creatine
            kinase promoter region
  JOURNAL   Gene 63 (2), 227-243 (1988)
   PUBMED   2838389
REFERENCE   9  (bases 1 to 1463)
  AUTHORS   Benfield,P.A., Henderson,L. and Pearson,M.L.
  TITLE     Expression of a rat brain creatine kinase-beta-galactosidase fusion
            protein in Escherichia coli and derivation of the complete amino
            acid sequence of rat brain creatine kinase
  JOURNAL   Gene 39 (2-3), 263-267 (1985)
   PUBMED   3005113
REFERENCE   10 (bases 1 to 1463)
  AUTHORS   Mahadevan,L.C., Whatley,S.A., Leung,T.K. and Lim,L.
  TITLE     The brain isoform of a key ATP-regulating enzyme, creatine kinase,
            is a phosphoprotein
  JOURNAL   Biochem J 222 (1), 139-144 (1984)
   PUBMED   6477506
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM060701.1 and BC127477.1.
            
            On Aug 16, 2012 this sequence version replaced NM_012529.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087656.1, BC065307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               FM060701.1         6-305
            301-1463            BC127477.1         291-1453
FEATURES             Location/Qualifiers
     source          1..1463
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1463
                     /gene="Ckb"
                     /gene_synonym="Ckbb; Ckbr; CPK-B"
                     /note="creatine kinase B"
                     /db_xref="GeneID:24264"
                     /db_xref="RGD:2357"
     exon            1..62
                     /gene="Ckb"
                     /gene_synonym="Ckbb; Ckbr; CPK-B"
                     /inference="alignment:Splign:2.1.0"
     exon            63..276
                     /gene="Ckb"
                     /gene_synonym="Ckbb; Ckbr; CPK-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1229
                     /gene="Ckb"
                     /gene_synonym="Ckbb; Ckbr; CPK-B"
                     /EC_number="2.7.3.2"
                     /note="B-CK; creatine kinase B chain; brain creatine
                     kinase; creatine kinase, brain; creatine phosphokinase
                     M-type"
                     /codon_start=1
                     /product="creatine kinase B-type"
                     /protein_id="NP_036661.3"
                     /db_xref="GeneID:24264"
                     /db_xref="RGD:2357"
                     /translation="MPFSNSHNTQKLRFPAEDEFPDLSSHNNHMAKVLTPELYAELRA
                     KCTPSGFTLDDAIQTGVDNPGHPYIMTVGAVAGDEESYDVFKDLFDPIIEDRHGGYQP
                     SDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVE
                     ALSSLDGDLSGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIW
                     HNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKNYEFMWNPH
                     LGYILTCPSNLGTGLRAGVHIKLPHLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVF
                     DVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQPIDDLMPAQK"
     exon            277..431
                     /gene="Ckb"
                     /gene_synonym="Ckbb; Ckbr; CPK-B"
                     /inference="alignment:Splign:2.1.0"
     exon            432..564
                     /gene="Ckb"
                     /gene_synonym="Ckbb; Ckbr; CPK-B"
                     /inference="alignment:Splign:2.1.0"
     exon            565..736
                     /gene="Ckb"
                     /gene_synonym="Ckbb; Ckbr; CPK-B"
                     /inference="alignment:Splign:2.1.0"
     exon            737..860
                     /gene="Ckb"
                     /gene_synonym="Ckbb; Ckbr; CPK-B"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1050
                     /gene="Ckb"
                     /gene_synonym="Ckbb; Ckbr; CPK-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1430
                     /gene="Ckb"
                     /gene_synonym="Ckbb; Ckbr; CPK-B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcgctgcg cccggagctg caagcacaag cagtctgcgt tcctgctccg tccggaatcc
       61 cgcctgccgc cgccgccgcc gccatgccct tctccaacag ccacaacacg cagaagctgc
      121 gcttcccggc cgaggatgaa ttccctgatc tgagcagcca caacaaccat atggccaagg
      181 tgctgacccc cgagctgtac gcggagctcc gtgccaagtg cacgccgagc ggctttacgt
      241 tggacgacgc catccagact ggcgtagaca atccgggcca cccgtacatc atgacagtgg
      301 gtgcagtggc gggcgacgag gagagttacg acgtattcaa ggaccttttc gaccccatca
      361 tcgaggaccg gcacggcggc taccagccca gtgatgagca caagactgac ctcaacccag
      421 acaacctgca gggcggcgat gacctggacc ccaactacgt gctgagctcg cgggtgcgca
      481 caggccgaag catccgcggc ttctgcctcc cccctcactg cagccgtggg gagcgccgcg
      541 ccatcgagaa gctggcagta gaagccctgt ccagcctaga tggcgacctg tctggcaggt
      601 actatgcgct caagagcatg accgaggcgg agcagcagca gctcattgac gaccacttcc
      661 tcttcgacaa gcctgtgtcg cctctgctgc tggcctccgg catggcccgc gactggccgg
      721 atgctcgcgg catttggcac aatgacaata agacgttcct ggtgtggatc aacgaggagg
      781 accacctgcg ggttatctcc atgcagaaag ggggcaacat gaaggaagtt ttcacgcgat
      841 tctgcactgg cctcactcag attgaaactc tcttcaagtc taagaactat gagttcatgt
      901 ggaaccctca cctgggctac atcctcacgt gcccatccaa cctgggcact gggcttcggg
      961 caggcgtgca catcaagctg ccccacctgg gaaagcacga gaagttctcg gaggtgctca
     1021 agcgactgcg gcttcagaag cgaggcacag gtggtgtgga caccgctgct gtgggtggag
     1081 tttttgatgt ctccaacgct gaccgcctgg gcttctcgga ggtggagctg gtgcagatgg
     1141 tggtggacgg agtgaagcta ctcattgaga tggagcagcg gcttgagcag ggtcagccca
     1201 ttgacgacct catgcctgcc cagaagtgaa gcctggccct agccaccacc aggctgccgc
     1261 ttcctaactt attacccggg cagtgcccgc catgcatcct tgatgtttgc cgcctggcgg
     1321 ctgagccctt agcctcgctg tagagacttc tgtcgccctg ggtagagttt atttttctga
     1381 tggctaagct gttgcagaca ctgaaataaa ttagggtttg gcctgcccta aaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaa
//
