LOCUS       NM_053698               1969 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus Cbp/p300-interacting transactivator, with
            Glu/Asp-rich carboxy-terminal domain, 2 (Cited2), mRNA.
ACCESSION   NM_053698
VERSION     NM_053698.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Kuna,M. and Soares,M.J.
  TITLE     Cited2 is a key regulator of placental development and plasticity
  JOURNAL   Bioessays 46 (8), e2300118 (2024)
   PUBMED   38922923
  REMARK    GeneRIF: Cited2 is a key regulator of placental development and
            plasticity.
            Review article
REFERENCE   2  (bases 1 to 1969)
  AUTHORS   Jank,M., Schwartz,J., Miyake,Y., Ozturk Aptekmann,A., Patel,D.,
            Boettcher,M. and Keijzer,R.
  TITLE     Dysregulation of CITED2 in abnormal lung development in the
            nitrofen rat model
  JOURNAL   Pediatr Surg Int 40 (1), 43 (2024)
   PUBMED   38291157
  REMARK    GeneRIF: Dysregulation of CITED2 in abnormal lung development in
            the nitrofen rat model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1969)
  AUTHORS   Kuna,M., Dhakal,P., Iqbal,K., Dominguez,E.M., Kent,L.N., Muto,M.,
            Moreno-Irusta,A., Kozai,K., Varberg,K.M., Okae,H., Arima,T.,
            Sucov,H.M. and Soares,M.J.
  TITLE     CITED2 is a conserved regulator of the uterine-placental interface
  JOURNAL   Proc Natl Acad Sci U S A 120 (3), e2213622120 (2023)
   PUBMED   36626551
  REMARK    GeneRIF: CITED2 is a conserved regulator of the uterine-placental
            interface.
REFERENCE   4  (bases 1 to 1969)
  AUTHORS   Su,D., Song,J.X., Gao,Q., Guan,L., Li,Q., Shi,C. and Ma,X.
  TITLE     Cited2 participates in cardiomyocyte apoptosis and maternal
            diabetes-induced congenital heart abnormality
  JOURNAL   Biochem Biophys Res Commun 479 (4), 887-892 (2016)
   PUBMED   27680315
  REMARK    GeneRIF: Gestational diabetes mellitus is a risk factor for
            abnormal heart development. Cited2 expression decreased in the
            heart tissues of diabetic-exposed embryos comparing with the
            control.
REFERENCE   5  (bases 1 to 1969)
  AUTHORS   Clark,A.L. and Naya,F.J.
  TITLE     MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated
            Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation
            by Targeting the Transcriptional Coactivator Cited2
  JOURNAL   J Biol Chem 290 (38), 23162-23172 (2015)
   PUBMED   26240138
  REMARK    GeneRIF: MicroRNAs in the Myocyte Enhancer Factor 2
            (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote
            Cardiomyocyte Proliferation by Targeting the Transcriptional
            Coactivator Cited2.
REFERENCE   6  (bases 1 to 1969)
  AUTHORS   Glenn,D.J. and Maurer,R.A.
  TITLE     MRG1 binds to the LIM domain of Lhx2 and may function as a
            coactivator to stimulate glycoprotein hormone alpha-subunit gene
            expression
  JOURNAL   J Biol Chem 274 (51), 36159-36167 (1999)
   PUBMED   10593900
REFERENCE   7  (bases 1 to 1969)
  AUTHORS   Leung,M.K., Jones,T., Michels,C.L., Livingston,D.M. and
            Bhattacharya,S.
  TITLE     Molecular cloning and chromosomal localization of the human CITED2
            gene encoding p35srj/Mrg1
  JOURNAL   Genomics 61 (3), 307-313 (1999)
   PUBMED   10552932
REFERENCE   8  (bases 1 to 1969)
  AUTHORS   Bhattacharya,S., Michels,C.L., Leung,M.K., Arany,Z.P., Kung,A.L.
            and Livingston,D.M.
  TITLE     Functional role of p35srj, a novel p300/CBP binding protein, during
            transactivation by HIF-1
  JOURNAL   Genes Dev 13 (1), 64-75 (1999)
   PUBMED   9887100
REFERENCE   9  (bases 1 to 1969)
  AUTHORS   Sun,H.B., Zhu,Y.X., Yin,T., Sledge,G. and Yang,Y.C.
  TITLE     MRG1, the product of a melanocyte-specific gene related gene, is a
            cytokine-inducible transcription factor with transformation
            activity
  JOURNAL   Proc Natl Acad Sci U S A 95 (23), 13555-13560 (1998)
   PUBMED   9811838
REFERENCE   10 (bases 1 to 1969)
  AUTHORS   Shioda,T., Fenner,M.H. and Isselbacher,K.J.
  TITLE     MSG1 and its related protein MRG1 share a transcription activating
            domain
  JOURNAL   Gene 204 (1-2), 235-241 (1997)
   PUBMED   9434189
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053698.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087005.1, AF361476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JAXUCZ010000001.1  14132303-14132528
            227-1969            JAXUCZ010000001.1  14133004-14134746
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1969
                     /gene="Cited2"
                     /gene_synonym="Mrg1"
                     /note="Cbp/p300-interacting transactivator, with
                     Glu/Asp-rich carboxy-terminal domain, 2"
                     /db_xref="GeneID:114490"
                     /db_xref="RGD:620112"
     exon            1..226
                     /gene="Cited2"
                     /gene_synonym="Mrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..1969
                     /gene="Cited2"
                     /gene_synonym="Mrg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1044
                     /gene="Cited2"
                     /gene_synonym="Mrg1"
                     /codon_start=1
                     /product="cbp/p300-interacting transactivator 2"
                     /protein_id="NP_446150.1"
                     /db_xref="GeneID:114490"
                     /db_xref="RGD:620112"
                     /translation="MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQP
                     QHAFNALMGEHIHYGAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPP
                     VASQGGSLPASMQLQKLNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKH
                     SGGSSTPGGAGGSGTPGGSGGTSGGAGGSSAGGSGGGSTMPASVAHVPAAMLPPNVID
                     TDFIDEEVLMSLVIEMGLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC"
ORIGIN      
        1 ttgttggcag ctgcctggcg gtcctgagga gcggctaggg cagcggaggg aaagaaaagg
       61 gaacggctcg gaatttgctc cagcggctgc tgcaagacct cggcgccaac ctcgcaccag
      121 cgagcgcccc acagcccttc ggctgcccct ctatgtgctg ctgagccggt cctggacccg
      181 acgagcccgc cttcggtgtt ccgagccgaa atcgcaaaga cggaaggact ggaaatggca
      241 gaccatatga tggccatgaa ccacggtcgc ttccccgacg gcaccaacgg gctgcaccac
      301 caccctgccc accgcatggg catggggcag ttcccgagcc cgcatcacca ccagcagcag
      361 cagccccagc acgccttcaa cgccctcatg ggcgagcaca tacactacgg cgcgggcaac
      421 atgaatgcca cgagcggcat caggcacgcc atggggccgg ggactgtgaa cggggggcac
      481 cccccgagcg ctctggcccc ggccgccagg tttaacaact cccagttcat gggtccccct
      541 gtggccagcc agggaggctc cctgccggcc agcatgcagc tgcagaagct caacaaccag
      601 tatttcaacc atcaccccta cccccacaac cactacatgc cggatttgca ccccgctgca
      661 ggccaccaga tgaacgggac aaaccagcac ttccgagatt gcaaccccaa gcacagtgga
      721 ggcagcagca cccctggcgg cgcgggtggc agcggcaccc ccggcggctc cggcggcacc
      781 tcgggcggcg cgggtggcag cagcgcgggc ggcagtggcg gtggcagcac catgcccgcc
      841 tcggtggctc acgtccccgc ggcaatgctg ccgcccaatg tcatagacac tgatttcatc
      901 gacgaggaag tgcttatgtc cttagtgata gagatgggtt tggaccgcat caaggagctg
      961 ccagaactct ggctgggcca aaatgagttt gattttatga cggacttcgt gtgcaaacag
     1021 cagcccagca gagtcagctg ttgactcggt taacctcgcg gctgaaagaa atcaccctcc
     1081 ctgcccccac ccccaacttc ttcggtgtga attaaaaaaa atcaaaaaca aacaaaaaaa
     1141 aaacaaaaaa acaaaaacat tcccttagac gcagtatctc acttttcaga tcctgaaagg
     1201 tttgagaacc tggaaacaaa gtaaactata aacttgtaca aattggttta aaaaaaaaaa
     1261 agattgctgc cactttttcc tgttcttgtt tcgtttttgt agacttgaca tccacctccc
     1321 ttatgtagtt gaaagtatct agctaacttg gtcttttttg ttgtttgttt ttactccttg
     1381 tttcctcact ttctcccgtg ctcaactgtt agatattaag cttggcaaac tgcttaatct
     1441 tgtggatttt gtagatggtt tcaaatgact gcgcactgca ttcagattta tgagtgaaag
     1501 gaaaaattgc atttcttggc tgcatgaact ttgaagggca gatattactg cacaaactgc
     1561 cgtctcgctt catttttttt ttaaactatg cattcgagta cagacttaag ttttcaaata
     1621 tgctaaactg gaagattaaa acagatgtgg gccaaaccgt tctggatcag gaaaagtcat
     1681 accgttcact ttcaagttgg ctgtctcccc ctcccccata tgtacagaca ataaataggg
     1741 tgtggaatgt cgtcagtggc aaacatttca cagattttta ttttgtttct gtcttcaaca
     1801 tttttgacac tgtgctaata gttatattca gtacatgaaa agatactact gtgttgaaag
     1861 ctttttagga aattttgaca gtatttttgt acaaaacatt tttttgaaaa aatacttgtt
     1921 aatttattct attttaattt gccaatgtca ataaaaagtt aagaaataa
//
