LOCUS       NM_001029911            6291 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus citron rho-interacting serine/threonine kinase
            (Cit), mRNA.
ACCESSION   NM_001029911 XM_573407
VERSION     NM_001029911.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6291)
  AUTHORS   Basit,S., Al-Harbi,K.M., Alhijji,S.A., Albalawi,A.M., Alharby,E.,
            Eldardear,A. and Samman,M.I.
  TITLE     CIT, a gene involved in neurogenic cytokinesis, is mutated in human
            primary microcephaly
  JOURNAL   Hum Genet 135 (10), 1199-1207 (2016)
   PUBMED   27519304
REFERENCE   2  (bases 1 to 6291)
  AUTHORS   Shaheen,R., Hashem,A., Abdel-Salam,G.M., Al-Fadhli,F., Ewida,N. and
            Alkuraya,F.S.
  TITLE     Mutations in CIT, encoding citron rho-interacting serine/threonine
            kinase, cause severe primary microcephaly in humans
  JOURNAL   Hum Genet 135 (10), 1191-1197 (2016)
   PUBMED   27503289
REFERENCE   3  (bases 1 to 6291)
  AUTHORS   Li,H., Bielas,S.L., Zaki,M.S., Ismail,S., Farfara,D., Um,K.,
            Rosti,R.O., Scott,E.C., Tu,S., Chi,N.C., Gabriel,S.,
            Erson-Omay,E.Z., Ercan-Sencicek,A.G., Yasuno,K., Caglayan,A.O.,
            Kaymakcalan,H., Ekici,B., Bilguvar,K., Gunel,M. and Gleeson,J.G.
  TITLE     Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to
            Human Primary Microcephaly
  JOURNAL   Am J Hum Genet 99 (2), 501-510 (2016)
   PUBMED   27453578
REFERENCE   4  (bases 1 to 6291)
  AUTHORS   Karunakaran,D.K., Chhaya,N., Lemoine,C., Congdon,S., Black,A. and
            Kanadia,R.
  TITLE     Loss of citron kinase affects a subset of progenitor cells that
            alters late but not early neurogenesis in the developing rat retina
  JOURNAL   Invest Ophthalmol Vis Sci 56 (2), 787-798 (2015)
   PUBMED   25593024
  REMARK    GeneRIF: CitK is not required for a subset of RPCs before E14, but
            is necessary for RPC survival post E14.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6291)
  AUTHORS   Ahmed,Z., Douglas,M.R., Read,M.L., Berry,M. and Logan,A.
  TITLE     Citron kinase regulates axon growth through a pathway that
            converges on cofilin downstream of RhoA
  JOURNAL   Neurobiol Dis 41 (2), 421-429 (2011)
   PUBMED   20971191
  REMARK    GeneRIF: Citron-K regulates actin polymerization downstream of RhoA
            and may offer a potentially novel therapeutic approach for
            promoting central nervous system axon regeneration.
REFERENCE   6  (bases 1 to 6291)
  AUTHORS   Di Cunto,F., Imarisio,S., Hirsch,E., Broccoli,V., Bulfone,A.,
            Migheli,A., Atzori,C., Turco,E., Triolo,R., Dotto,G.P., Silengo,L.
            and Altruda,F.
  TITLE     Defective neurogenesis in citron kinase knockout mice by altered
            cytokinesis and massive apoptosis
  JOURNAL   Neuron 28 (1), 115-127 (2000)
   PUBMED   11086988
REFERENCE   7  (bases 1 to 6291)
  AUTHORS   Sarkisian,M.R., Rattan,S., D'Mello,S.R. and LoTurco,J.J.
  TITLE     Characterization of seizures in the flathead rat: a new genetic
            model of epilepsy in early postnatal development
  JOURNAL   Epilepsia 40 (4), 394-400 (1999)
   PUBMED   10219263
REFERENCE   8  (bases 1 to 6291)
  AUTHORS   Zhang,W., Vazquez,L., Apperson,M. and Kennedy,M.B.
  TITLE     Citron binds to PSD-95 at glutamatergic synapses on inhibitory
            neurons in the hippocampus
  JOURNAL   J Neurosci 19 (1), 96-108 (1999)
   PUBMED   9870942
REFERENCE   9  (bases 1 to 6291)
  AUTHORS   Di Cunto,F., Calautti,E., Hsiao,J., Ong,L., Topley,G., Turco,E. and
            Dotto,G.P.
  TITLE     Citron rho-interacting kinase, a novel tissue-specific ser/thr
            kinase encompassing the Rho-Rac-binding protein Citron
  JOURNAL   J Biol Chem 273 (45), 29706-29711 (1998)
   PUBMED   9792683
REFERENCE   10 (bases 1 to 6291)
  AUTHORS   Madaule,P., Eda,M., Watanabe,N., Fujisawa,K., Matsuoka,T., Bito,H.,
            Ishizaki,T. and Narumiya,S.
  TITLE     Role of citron kinase as a target of the small GTPase Rho in
            cytokinesis
  JOURNAL   Nature 394 (6692), 491-494 (1998)
   PUBMED   9697773
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Jul 28, 2005 this sequence version replaced XM_573407.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000012.1  46424451-46424656   c
            207-348             JAXUCZ010000012.1  46419600-46419741   c
            349-524             JAXUCZ010000012.1  46411503-46411678   c
            525-626             JAXUCZ010000012.1  46407766-46407867   c
            627-769             JAXUCZ010000012.1  46397015-46397157   c
            770-860             JAXUCZ010000012.1  46395028-46395118   c
            861-1064            JAXUCZ010000012.1  46385509-46385712   c
            1065-1218           JAXUCZ010000012.1  46383965-46384118   c
            1219-1402           JAXUCZ010000012.1  46362657-46362840   c
            1403-1508           JAXUCZ010000012.1  46346277-46346382   c
            1509-1652           JAXUCZ010000012.1  46345161-46345304   c
            1653-1772           JAXUCZ010000012.1  46343782-46343901   c
            1773-1943           JAXUCZ010000012.1  46338983-46339153   c
            1944-1994           JAXUCZ010000012.1  46338679-46338729   c
            1995-2048           JAXUCZ010000012.1  46337937-46337990   c
            2049-2189           JAXUCZ010000012.1  46335986-46336126   c
            2190-2315           JAXUCZ010000012.1  46334133-46334258   c
            2316-2411           JAXUCZ010000012.1  46331015-46331110   c
            2412-2528           JAXUCZ010000012.1  46326611-46326727   c
            2529-2638           JAXUCZ010000012.1  46325596-46325705   c
            2639-2813           JAXUCZ010000012.1  46324371-46324545   c
            2814-3011           JAXUCZ010000012.1  46319876-46320073   c
            3012-3065           JAXUCZ010000012.1  46310048-46310101   c
            3066-3263           JAXUCZ010000012.1  46303355-46303552   c
            3264-3457           JAXUCZ010000012.1  46302518-46302711   c
            3458-3593           JAXUCZ010000012.1  46300737-46300872   c
            3594-3698           JAXUCZ010000012.1  46298586-46298690   c
            3699-3839           JAXUCZ010000012.1  46293023-46293163   c
            3840-3947           JAXUCZ010000012.1  46292591-46292698   c
            3948-4065           JAXUCZ010000012.1  46290648-46290765   c
            4066-4230           JAXUCZ010000012.1  46290200-46290364   c
            4231-4368           JAXUCZ010000012.1  46286986-46287123   c
            4369-4549           JAXUCZ010000012.1  46286471-46286651   c
            4550-4641           JAXUCZ010000012.1  46286240-46286331   c
            4642-4746           JAXUCZ010000012.1  46284988-46285092   c
            4747-4916           JAXUCZ010000012.1  46284590-46284759   c
            4917-4997           JAXUCZ010000012.1  46283335-46283415   c
            4998-5133           JAXUCZ010000012.1  46283051-46283186   c
            5134-5273           JAXUCZ010000012.1  46281114-46281253   c
            5274-5366           JAXUCZ010000012.1  46277951-46278043   c
            5367-5475           JAXUCZ010000012.1  46276491-46276599   c
            5476-5604           JAXUCZ010000012.1  46276250-46276378   c
            5605-5685           JAXUCZ010000012.1  46275648-46275728   c
            5686-5764           JAXUCZ010000012.1  46273399-46273477   c
            5765-5944           JAXUCZ010000012.1  46273128-46273307   c
            5945-6254           JAXUCZ010000012.1  46267385-46267694   c
            6255-6291           JAXUCZ010000012.1  46266369-46266405   c
FEATURES             Location/Qualifiers
     source          1..6291
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..6291
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /note="citron rho-interacting serine/threonine kinase"
                     /db_xref="GeneID:83620"
                     /db_xref="RGD:70878"
     exon            1..206
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..6278
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /EC_number="2.7.11.1"
                     /note="citron kinase; citron (rho-interacting,
                     serine/threonine kinase 21); citron-K kinase; postsynaptic
                     density protein (citron); rho-interacting,
                     serine/threonine-protein kinase 21"
                     /codon_start=1
                     /product="citron rho-interacting kinase"
                     /protein_id="NP_001025082.1"
                     /db_xref="GeneID:83620"
                     /db_xref="RGD:70878"
                     /translation="MLKFKYGVRNPSEASAPEPIASRASRLNLFFQGKPPLMTQQQMS
                     ALSREGVLDALFVLLEECSQPALMKIKHVSSFVRKYSDTIAELRELQPSVRDFEVRSL
                     VGCGHFAEVQVVREKATGDVYAMKIMKKAALRAQEQVSFFEEERNILSQSTSPWIPQL
                     QYAFQDKNNLYLVMEYQPGGDLLSLLNRYEDQLDENMIQFYLAELILAVHSVHQMGYV
                     HRDIKPENILIDRTGHIKLVDFGSAAKMNSNKVDAKLPIGTPDYMAPEVLTVMNEDRR
                     GTYGLDCDWWSVGVVAYEMLYGKTPFTEGTSARTFNNIMNFQRFLKFPDDPKVSSELL
                     DLIQSLLCVQKERLKFEGLCCHPFFARTDWNNIRNSPPPFVPTLKSDDDTSNFDEPEK
                     NSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGYLGRSESVVSGLDSPAKISSMEKKL
                     LIKSKELQDSQDKCHKMEQEMARLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLAT
                     YITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLM
                     MNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKAKDLGKPEVGECS
                     RLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSS
                     EGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEK
                     HREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLETMMQRHEEEAHEKG
                     KILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ
                     KFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELK
                     RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDE
                     IQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRS
                     EVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWR
                     SVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQ
                     ALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM
                     DLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTK
                     LIDFLQAKMDQPAKKKKVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAA
                     HRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKEASTPEEFSRR
                     LKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPAT
                     CGLPAEYATHFTEAFCRDKVSSPGLQSKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYI
                     VLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILK
                     MESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLL
                     KLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHIPGIGAVFQIYIIKDLE
                     KLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDVSPNIFEAVKGCHLFAAGKIENSL
                     CICAAMPSKVVILRYNDNLSKFCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQ
                     YTLEEFLDKNDHSLAPAVFASSTNSFPVSIVQANSTGQREEYLLCFHEFGVFVDSYGR
                     RSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGTPARAYLEIPNPRYL
                     GPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEQHRVPSTSRSSPNKRGPPTYNEH
                     ITKRVASSPAPPEGPSHPREPSTPHRYRDREGRTELRRDKSPGRPLEREKSPGRMLST
                     RRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV"
     exon            207..348
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            349..524
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            525..626
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            627..769
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            770..860
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1064
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1218
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1402
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1508
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1652
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1772
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1943
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..1994
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2048
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2189
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2315
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2411
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2528
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2638
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2813
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..3011
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3065
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3263
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3457
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3593
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3698
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3839
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            3840..3947
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4065
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            4066..4230
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            4231..4368
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            4369..4549
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            4550..4641
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            4642..4746
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            4747..4916
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            4917..4997
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            4998..5133
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            5134..5273
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            5274..5366
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            5367..5475
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            5476..5604
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            5605..5685
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            5686..5764
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            5765..5944
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            5945..6254
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            6255..6291
                     /gene="Cit"
                     /gene_synonym="CRIK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcctggtc gtgatctctt tagggagata cgactctgcc aggcccctcc tgcctcaaat
       61 gtcagtacac acttgactct ttccaatgtt ccttcagcgg tagcggagag atgttgaagt
      121 tcaagtatgg agtgcggaac ccgtccgagg ccagtgcccc cgagcccatt gccagtcggg
      181 cctccaggct aaatctcttc ttccagggga aaccgcccct catgactcaa cagcagatgt
      241 ctgctctttc ccgggaaggg gtgttagatg ccctctttgt tctcttggaa gagtgcagtc
      301 agcctgccct catgaagata aagcacgtga gcagcttcgt ccggaagtat tctgacacga
      361 tagccgagtt acgggagctc cagccgtcgg tgagggactt cgaagtgcga agtcttgtgg
      421 gctgcggtca cttcgccgaa gtgcaggtgg ttagagagaa ggccaccggg gatgtctacg
      481 ccatgaagat catgaagaag gcggctttgc gggcccagga gcaggtttca tttttcgagg
      541 aggagaggaa catattatcc cagagcacga gcccttggat cccccaatta cagtacgcct
      601 ttcaggacaa aaataacctt tacctggtca tggagtatca gcctggaggg gatttgctgt
      661 ctcttctgaa tagatatgag gaccagttag atgaaaacat gattcagttt taccttgctg
      721 agctgatctt ggctgtccac agcgtgcacc agatgggata tgtgcatcga gacatcaagc
      781 cggagaacat cctcattgac cgaacgggac acatcaagct ggtggatttt ggatcagccg
      841 ctaagatgaa ttcaaataag gtggatgcca aactccctat tgggacccca gattacatgg
      901 ctccggaagt gttgactgtg atgaacgagg accgaagggg cacctacggc ctggactgtg
      961 actggtggtc tgtcggagtg gttgcctatg agatgcttta cgggaagacc ccattcacgg
     1021 agggaacctc cgcccggacc ttcaacaaca tcatgaactt ccagcggttt ttgaagttcc
     1081 cggatgaccc caaagttagc agtgagctcc ttgatctgat tcagagtttg ctgtgtgtcc
     1141 agaaagagag actgaagttc gagggtctct gttgccaccc tttctttgcc agaaccgact
     1201 ggaataacat ccggaactct cctcccccct tcgttcccac cctcaagtct gacgatgaca
     1261 cctccaattt tgatgaacca gagaagaatt cgtgggtttc atcctctccg tgccagctga
     1321 gcccttcggg tttctcgggc gaagagctgc cctttgtggg gttttcatac agcaaggcac
     1381 tggggtatct tggtagatct gagtctgttg tgtcgggtct ggactcccct gccaagatta
     1441 gctccatgga aaagaaactt ctcatcaaaa gcaaagagct gcaagactct caggacaagt
     1501 gtcacaagat ggagcaggaa atggcccggt tgcatcgcag agtgtcagag gtggaggctg
     1561 tgcttagtca gaaggaggtg gagctgaagg cctctgagac tcagagatcc ctcctggagc
     1621 aggaccttgc cacctacatc acagaatgca gtagcttaaa gcgaagtctg gagcaagcgc
     1681 ggatggaggt gtctcaggag gatgacaaag ctcttcagct tctccacgac atcagagagc
     1741 agagccggaa gctccaggag atcaaggagc aggagtacca ggctcaggtg gaggagatga
     1801 ggctgatgat gaatcagctg gaagaggacc tcgtgtcagc ccgaagacgc agcgatctct
     1861 acgagtctga gctgagggag tctcggctcg ccgccgagga attcaagcgg aaggcaaacg
     1921 aatgtcagca taaactgatg aaggctaagg acctagggaa gcctgaagtg ggagaatgtt
     1981 ccagactgga gaagatcaat gctgagcagc agctgaagat tcaggagctc caggagaagc
     2041 tggagaaggc tgtaaaagcc agcaccgagg ccacagagct cctgcagaac atccggcagg
     2101 caaaggagcg agctgagagg gagctggaga agctgcacaa cagggaagat tcttccgaag
     2161 gcatcaaaaa gaaactggtg gaagctgagg aacgccgcca ctccctggag aacaaggtaa
     2221 agagactaga gaccatggag cgtagagaga acagactgaa ggatgacatc cagacaaagt
     2281 ccgaacagat ccagcagatg gctgataaaa ttctggagct ggaggagaag catcgggagg
     2341 ctcaggtctc agctcaacac ctagaagtac acctgaagca gaaggaacag cactatgagg
     2401 aaaagatcaa agtgttggac aatcagataa agaaggactt ggccgacaag gagagcctag
     2461 agaccatgat gcagaggcac gaagaggagg cccacgagaa gggcaagatc ctcagcgagc
     2521 agaaggcgat gatcaacgca atggattcca agatcagatc cctggagcag aggattgtgg
     2581 agctgtcaga agccaacaag cttgcggcaa acagcagtct cttcacccag aggaacatga
     2641 aggcccagga agagatgatc tcagaactca ggcagcagaa attttacctg gagacacagg
     2701 ccgggaagct ggaggcccag aaccgaaaac tggaagagca actagagaag atcagccacc
     2761 aagatcacag tgacaagaat cggctgctgg agctggagac aaggttgaga gaggtcagcc
     2821 tggagcatga ggagcagaag ctggagctga agcggcagct cacggagctg cagctgtccc
     2881 tgcaggagcg tgagtcccag ctgacggccc tgcaggccgc ccgggctgcc cttgagagcc
     2941 agctccgcca ggcgaagacg gagctggagg agacaactgc agaagcggag gaggagatcc
     3001 aggcactcac ggcacatcga gatgaaatcc agcgcaaatt cgatgccctt cgcaacagct
     3061 gtactgtcat caccgacctg gaggagcagc tgaaccagct caccgaggac aacgccgagc
     3121 tcaacaacca aaacttctac ctgtccaaac aactcgatga ggcttcgggt gccaacgatg
     3181 agattgtgca gctgcgaagc gaggtggacc atctccgccg tgagatcacg gagcgggaga
     3241 tgcagctcac cagccagaag caaacaatgg aggctctgaa gacgacctgc accatgctgg
     3301 aggagcaggt catggacctg gaggccctga acgacgagct gctggagaag gagcgccagt
     3361 gggaggcctg gaggagcgtc ctcggggacg agaagtctca gtttgagtgt cgagttcgag
     3421 agctacagag gatgctggac accgagaagc agagcagggc tagagctgat cagcggatca
     3481 cggagtctcg ccaggtggtg gagctggcag tgaaggagca caaagccgag attctcgcgc
     3541 tgcagcaggc tctcaaagag cagaagctga aagctgagag cctgtcggac aagctcaacg
     3601 acctggagaa gaagcacgcc atgcttgaga tgaatgcccg gagcttacag cagaaactgg
     3661 agacagagcg ggagctcaaa cagaggcttc tggaggagca agccaagttg cagcagcaga
     3721 tggacctgca gaagaaccac atcttcagac tgacacaagg gctgcaggag gcgctggacc
     3781 gggcggatct gctgaagacc gaaaggagcg acctggaata tcagctggaa aacattcagg
     3841 ttctctactc acacgagaag gtgaaaatgg aaggcactat ttctcaacaa accaaactca
     3901 ttgatttcct gcaagccaaa atggaccagc ccgctaaaaa gaaaaaggtt cctctgcagt
     3961 acaatgagct gaagctcgcc ctggaaaagg agaaagcgcg ctgtgcggag ctggaggaag
     4021 cccttcagaa gacccgcatc gaactccggt ccgcacggga ggaagctgct caccgcaaag
     4081 ccacggacca cccgcaccca tctacgccag ccactgcgag gcagcagatc gccatgtccg
     4141 ccatcgtgcg gtcgcctgag caccagccca gtgccatgag cctgctcgcc ccaccatcca
     4201 gccgcagaaa ggaggcgtca actccagagg agttcagccg gcgtcttaaa gaacgtatgc
     4261 accacaacat tcctcaccgg tttaacgtgg gcctgaatat gcgagccacc aagtgcgccg
     4321 tgtgtctgga tactgtgcac tttggacgcc aggcatccaa atgtctcgaa tgtcaggtga
     4381 tgtgccatcc caagtgttcc acctgcttgc ccgccacctg tggcctacct gccgaatatg
     4441 ccacacactt caccgaggcc ttctgccgag acaaagtgag ctccccgggg ctccagagca
     4501 aggagcccag cagcagcttg cacctggaag ggtggatgaa agtgcccagg aataacaaac
     4561 gaggacagca aggctgggac agaaagtaca ttgtcttaga gggttcaaaa gtcctcatct
     4621 atgacaacga agccagagaa gctggacaga ggccggtgga agaatttgag ctgtgccttc
     4681 ccgatgggga tgtatctatt catggtgccg ttggtgcttc tgaacttgca aatacagcca
     4741 aagcagatgt cccatacata ctgaagatgg agtcccatcc gcataccacc tgctggcctg
     4801 ggagaaccct ctacctgctg gcacccagct ttcctgacaa gcagcgctgg gtcacagccc
     4861 tagagtctgt cgtcgcaggt gggagagttt ctagggaaaa ggcagaggcc gatgctaaat
     4921 tacttggaaa ctctctgctg aagctggaag gtgacgaccg gcttgacatg aactgtaccc
     4981 tgcccttcag cgaccaggtg gtgctggtgg gcaccgagga gggcctctat gcgctgaacg
     5041 tcttgaaaaa ctccttaacc cacatcccag gaatcggagc agtcttccag atttacatca
     5101 tcaaggacct ggagaagctg ctcatgatag caggggaaga gcgggctctg tgtttggtgg
     5161 acgtgaagaa ggtgaagcag tcgttggcac agtcacacct tcctgcccag cctgacgtct
     5221 cccccaacat atttgaagcc gtcaaaggct gccacctgtt tgctgctggc aagatcgaga
     5281 acagcctctg catctgtgcc gccatgccga gcaaagtcgt catcctgcgc tacaacgaca
     5341 acctcagcaa gttctgcatc cgcaaggaga ttgagacctc tgagccctgc agctgtatcc
     5401 acttcaccaa ttacagtatc ctcatcggaa ccaacaagtt ctatgagatc gacatgaaac
     5461 agtacacgct tgaggagttc ctggacaaga atgaccattc cttggcacct gctgtgttcg
     5521 catcctcgac caacagcttc cccgtctcca tcgtgcaggc aaacagcacc gggcagcggg
     5581 aagagtacct gctgtgtttc cacgaatttg gggtgttcgt ggattcttat ggaagacgta
     5641 gccgcacaga cgatctcaag tggagtcgct tacctctggc ctttgcctac agagagcctt
     5701 atctgtttgt gactcacttt aactccctgg aagtaattga gatccaggca cgttcctcac
     5761 tggggacccc tgcccgagcc tatctggaaa tcccaaaccc tcgctacctg ggccccgcaa
     5821 tttcctccgg agcaatttac ctggcctcct cataccagga caagttaagg gtcatatgct
     5881 gcaaaggaaa cctcgtgaag gagtctggca ctgagcagca ccgcgtgccc tccacatccc
     5941 gcagcagccc taacaagcga ggcccaccaa catacaacga gcacatcacc aaacgtgtgg
     6001 cctccagccc agcaccacca gaaggcccca gccatccccg agagccaagc acaccccacc
     6061 gctaccgaga cagagagggc cggacagagc tgcgcaggga caagtctcca ggccgtcctc
     6121 tggagcggga gaagtcgcca ggccggatgc tcagcacgag gagagagcgg tccccgggga
     6181 gactgtttga agacagcagc aggggccggc tgcctgcggg agccgtgagg accccactgt
     6241 cccaggttaa caaggtctgg gaccagtctt cagtataagt ctcagcctga a
//
