LOCUS       NM_031804               1879 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus cytokine inducible SH2-containing protein (Cish),
            mRNA.
ACCESSION   NM_031804 XM_001074104 XM_343472
VERSION     NM_031804.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1879)
  AUTHORS   Anderson,S.T., Barclay,J.L., Fanning,K.J., Kusters,D.H.,
            Waters,M.J. and Curlewis,J.D.
  TITLE     Mechanisms underlying the diminished sensitivity to prolactin
            negative feedback during lactation: reduced STAT5 signaling and
            up-regulation of cytokine-inducible SH2 domain-containing protein
            (CIS) expression in tuberoinfundibular dopaminergic neurons
  JOURNAL   Endocrinology 147 (3), 1195-1202 (2006)
   PUBMED   16357045
  REMARK    GeneRIF: during lactation, STAT5 signaling is reduced and CIS is
            upregulated in tuberoinfundibular dopaminergic neurons
REFERENCE   2  (bases 1 to 1879)
  AUTHORS   Landsman,T. and Waxman,D.J.
  TITLE     Role of the cytokine-induced SH2 domain-containing protein CIS in
            growth hormone receptor internalization
  JOURNAL   J Biol Chem 280 (45), 37471-37480 (2005)
   PUBMED   16154995
  REMARK    GeneRIF: The growth hormone(GH)-responsive rat liver cell line
            CWSV-1 was used to investigate the role of CIS and the proteasome
            in GH-induced GHR internalization.
REFERENCE   3  (bases 1 to 1879)
  AUTHORS   Ji,K.A., Yang,M.S., Jou,I., Shong,M.H. and Joe,E.H.
  TITLE     Thrombin induces expression of cytokine-induced SH2 protein (CIS)
            in rat brain astrocytes: involvement of phospholipase A2,
            cyclooxygenase, and lipoxygenase
  JOURNAL   Glia 48 (2), 102-111 (2004)
   PUBMED   15378659
  REMARK    GeneRIF: Thrombin-stimulation of reactive oxygen species,
            prostaglandin and leukotriene production in astrocytes results in
            cytokine-induced SH2 protein [CIS] expression which may be a
            feedback mechanism preventing prolonged inflammatory responses
REFERENCE   4  (bases 1 to 1879)
  AUTHORS   Kasagi,Y., Tokita,R., Nakata,T., Imaki,T. and Minami,S.
  TITLE     Human growth hormone induces SOCS3 and CIS mRNA increase in the
            hypothalamic neurons of hypophysectomized rats
  JOURNAL   Endocr J 51 (2), 145-154 (2004)
   PUBMED   15118263
  REMARK    GeneRIF: HGH acts directly on the neurons in the hypothalamus, and
            increases SOCS3 and CIS mRNAs, suggesting that these negative
            regulators may be involved in the mechanism that turns off the hGH
            action in the hypothalamic neurons.
REFERENCE   5  (bases 1 to 1879)
  AUTHORS   Chen,S., Anderson,P.O., Li,L., Sjogren,H.O., Wang,P. and Li,S.L.
  TITLE     Functional association of cytokine-induced SH2 protein and protein
            kinase C in activated T cells
  JOURNAL   Int Immunol 15 (3), 403-409 (2003)
   PUBMED   12618484
REFERENCE   6  (bases 1 to 1879)
  AUTHORS   Morales,O., Faulds,M.H., Lindgren,U.J. and Haldosen,L.A.
  TITLE     1Alpha,25-dihydroxyvitamin D3 inhibits GH-induced expression of
            SOCS-3 and CIS and prolongs growth hormone signaling via the Janus
            kinase (JAK2)/signal transducers and activators of transcription
            (STAT5) system in osteoblast-like cells
  JOURNAL   J Biol Chem 277 (38), 34879-34884 (2002)
   PUBMED   12107179
  REMARK    GeneRIF: inhibition of GH-induced expression in osteoblast-like
            cells
REFERENCE   7  (bases 1 to 1879)
  AUTHORS   Mao,Y., Ling,P.R., Fitzgibbons,T.P., McCowen,K.C., Frick,G.P.,
            Bistrian,B.R. and Smith,R.J.
  TITLE     Endotoxin-induced inhibition of growth hormone receptor signaling
            in rat liver in vivo
  JOURNAL   Endocrinology 140 (12), 5505-5515 (1999)
   PUBMED   10579313
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161930.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_001074104.1, XM_343472.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161930.1, AF065161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132275, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1879
                     /gene="Cish"
                     /gene_synonym="Cis"
                     /note="cytokine inducible SH2-containing protein"
                     /db_xref="GeneID:83681"
                     /db_xref="RGD:69261"
     exon            1..135
                     /gene="Cish"
                     /gene_synonym="Cis"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..889
                     /gene="Cish"
                     /gene_synonym="Cis"
                     /note="SOCS; CIS-1; suppressor of cytokine signaling;
                     cytokine inducible SH2-containing protein 1"
                     /codon_start=1
                     /product="cytokine-inducible SH2-containing protein"
                     /protein_id="NP_113992.1"
                     /db_xref="GeneID:83681"
                     /db_xref="RGD:69261"
                     /translation="MVLCVQGSCPLLVVEQIGQRPLWAQSLELPGPAMQPLPTGAFPE
                     EVTEETPVQSENEPKVLDPEGDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEG
                     TFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLV
                     QHYVASCTADTRSDSPDPAPTPALPVPKPDAPGDPVLPIPVATAVHLKLVQPFVRRSS
                     ARSLQHLCRLVINRLVTDVDCLPLPRRMADYLRQYPFQL"
     exon            136..356
                     /gene="Cish"
                     /gene_synonym="Cis"
                     /inference="alignment:Splign:2.1.0"
     exon            357..1858
                     /gene="Cish"
                     /gene_synonym="Cis"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgatcgccgc cggtacgccc cgggaccctg accttcgcac ccctggcacc cactggctcc
       61 tttcttcttc cgtcccgccg aactccgact ctcgagccgc cgttgcctct aggacatggt
      121 cctctgcgta cagggatctt gtcctttgct ggttgtggag caaattgggc agcggcctct
      181 gtgggcccag tccctggagc tgcccgggcc agccatgcag cccttaccca ctggggcatt
      241 cccagaggag gtgacagagg agacccctgt ccagtcagag aatgaaccga aggtgctaga
      301 ccctgaggga gatctgctgt gcatagccaa gacgttctcc tacctccggg aatctggttg
      361 gtactggggt tccattacag ccagtgaggc ccggcagcat ctacagaaga tgccggaggg
      421 cacattcctc gtgcgagaca gcacccaccc cagctacctg tttacattgt cagtcaaaac
      481 cacccgtggc cccaccaatg tacgcatcga gtatgccgac tctagcttcc gactggactc
      541 caattgcttg tcgagacctc gaatcctggc cttcccagat gtggtcagcc ttgtgcagca
      601 ttacgtggcc tcctgtacgg ctgacacccg gagtgacagc ccagatcctg ctcccacccc
      661 agccctgcct gtgccgaagc cagatgcacc tggtgaccca gtactgccta tccccgtggc
      721 tactgctgtg cacctgaaat tggtgcagcc ctttgtgcgc aggagcagcg cccgcagctt
      781 acaacacctg tgtcggctag tcatcaaccg actggtgacc gatgtggact gcctacccct
      841 gccccggcgc atggccgact acctccgaca gtacccgttc cagctctgac tgggccaggc
      901 accctgccct gcctcacaca gtgacatccc ggaggggaca caggccccca gctggacttg
      961 gggttctgct gtcccttcct cagtcatcct ggtgcctgca tgcatgtgac agctggacca
     1021 gaaagtgcca gcaagaacaa agcaggtgga ggaggggtta tcatacaact ctgaggccag
     1081 tgcctctcca ggtcccatat ggctttgtgg taagccctat cagagcagag ggagacaggc
     1141 agggcctcgt ctctccccag aggctggacc taggcctcca ttcacttgcc cctcctagcc
     1201 acttgaactg tgtctattct cccagccctg gtttctcaat ctgctgagta gggcaggccc
     1261 cctacccatc tatagagtag ccagcctgtt tctgggagac tgtcagccac aggttgatca
     1321 tgccaaggcc ccttgtcggg gagcaggctg ggctagagga ctacacagtt atacagtatt
     1381 tatttattta ttctccttgc agggtttggg ggtggggtga tggtgtgagc catcccgctt
     1441 ctctgcccta tgccctgggt ggtccaaaga cccccagctc tggttcttcc ctgtggagac
     1501 ccccatcccg agacattgtt gggcccaaag tagtcccaaa tgccttaggc ctgccaacct
     1561 gcctgcttgt ttctcccaag cctcttttgg gagactgagt gaccagacag acaggagcca
     1621 gaaacacaag ggctcccacc catctcctca cagggcagcg ccacggcttc atagagctgg
     1681 gttctctatg gtacagcccc tgctgaggtg catgtgctgg gtcaggaaga ggatgctagt
     1741 ccaagggctg cagctgcagc tcttttgtgt ctgcttcctg cccaggaaac tgcctgcacg
     1801 tgagagaggg agaaatacat acctaactag actttataaa acaagtatta taacacaaaa
     1861 aaaaaaaaaa aaaaaaaaa
//
