LOCUS       NM_001191608            2879 bp    mRNA    linear   ROD 19-APR-2019
DEFINITION  Rattus norvegicus CDGSH iron sulfur domain 2 (Cisd2), mRNA.
ACCESSION   NM_001191608 XM_215704
VERSION     NM_001191608.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2879)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 2879)
  AUTHORS   Chang NC, Nguyen M, Germain M and Shore GC.
  TITLE     Antagonism of Beclin 1-dependent autophagy by BCL-2 at the
            endoplasmic reticulum requires NAF-1
  JOURNAL   EMBO J. 29 (3), 606-618 (2010)
   PUBMED   20010695
REFERENCE   3  (bases 1 to 2879)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2879)
  AUTHORS   Conlan AR, Axelrod HL, Cohen AE, Abresch EC, Zuris J, Yee D,
            Nechushtai R, Jennings PA and Paddock ML.
  TITLE     Crystal structure of Miner1: The redox-active 2Fe-2S protein
            causative in Wolfram Syndrome 2
  JOURNAL   J. Mol. Biol. 392 (1), 143-153 (2009)
   PUBMED   19580816
REFERENCE   5  (bases 1 to 2879)
  AUTHORS   Chen YF, Kao CH, Chen YT, Wang CH, Wu CY, Tsai CY, Liu FC, Yang CW,
            Wei YH, Hsu MT, Tsai SF and Tsai TF.
  TITLE     Cisd2 deficiency drives premature aging and causes
            mitochondria-mediated defects in mice
  JOURNAL   Genes Dev. 23 (10), 1183-1194 (2009)
   PUBMED   19451219
REFERENCE   6  (bases 1 to 2879)
  AUTHORS   Amr S, Heisey C, Zhang M, Xia XJ, Shows KH, Ajlouni K, Pandya A,
            Satin LS, El-Shanti H and Shiang R.
  TITLE     A homozygous mutation in a novel zinc-finger protein, ERIS, is
            responsible for Wolfram syndrome 2
  JOURNAL   Am. J. Hum. Genet. 81 (4), 673-683 (2007)
   PUBMED   17846994
REFERENCE   7  (bases 1 to 2879)
  AUTHORS   Wiley SE, Murphy AN, Ross SA, van der Geer P and Dixon JE.
  TITLE     MitoNEET is an iron-containing outer mitochondrial membrane protein
            that regulates oxidative capacity
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 104 (13), 5318-5323 (2007)
   PUBMED   17376863
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC120718.4.
            
            [WARNING] On Jun 29, 2023 this sequence was replaced by
            NM_001191608.2.
            
            On Jul 17, 2010 this sequence version replaced XM_215704.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217940.1, FM060130.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00052296, SAMN01906347
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC120718.4         83909-84044         c
            137-351             AC120718.4         70001-70215         c
            352-2879            AC120718.4         59238-61765         c
FEATURES             Location/Qualifiers
     source          1..2879
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="mixed"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..2879
                     /gene="Cisd2"
                     /gene_synonym="RGD1566242"
                     /note="CDGSH iron sulfur domain 2"
                     /db_xref="GeneID:295457"
                     /db_xref="RGD:1566242"
     exon            1..136
                     /gene="Cisd2"
                     /gene_synonym="RGD1566242"
                     /inference="alignment:Splign:2.0.8"
     CDS             34..441
                     /gene="Cisd2"
                     /gene_synonym="RGD1566242"
                     /codon_start=1
                     /product="CDGSH iron-sulfur domain-containing protein 2"
                     /protein_id="NP_001178537.1"
                     /db_xref="GeneID:295457"
                     /db_xref="RGD:1566242"
                     /translation="MVLDSVARIVKVQLPAYLKQLPLPDSITGFARLTVAEWLRLLPF
                     LGVLALLGYLAVRPFFPKKKQQKDSLINLKIQKENPKVVNEINIEDLNLTKAAYCRCW
                     RSKTFPACDGSHNKHNELTGDNVGPLILRKKEV"
     exon            137..351
                     /gene="Cisd2"
                     /gene_synonym="RGD1566242"
                     /inference="alignment:Splign:2.0.8"
     exon            352..2879
                     /gene="Cisd2"
                     /gene_synonym="RGD1566242"
                     /inference="alignment:Splign:2.0.8"
ORIGIN      
        1 cgcagcagcc gggcagcgga cgccgccggc aggatggtcc tggacagcgt ggcccgcatc
       61 gtgaaggtgc agctgcccgc ctacctcaag cagctcccgc tccccgacag cattaccggg
      121 ttcgcccgcc tcacagttgc agaatggctc cgcttactgc ccttccttgg tgtacttgca
      181 ctcctcggct accttgcagt tcgtccattc ttcccgaaga agaagcaaca gaaggatagc
      241 ttgattaacc ttaagataca gaaagaaaat cccaaagtgg tgaacgaaat aaacattgaa
      301 gacctgaatc ttacgaaagc agcttattgt aggtgttggc gctccaagac gttccctgcc
      361 tgtgacgggt cccacaataa gcacaatgag ttgacaggcg ataacgtggg tcctctcatc
      421 ctgaggaaga aagaagtata gcagtagcca cggagacgaa cctctggcaa cgtttccgcc
      481 cttgttgtgc atagaaaaag atctttgcaa gttttaacta ttggtactgg ctgaataatt
      541 attctgccag ttattttctt gctacactac tgcttatatt tggtacttta tatattcagt
      601 catttgtaca gaaatcaaat ggtcaagtct gattctgaaa tcaagtttaa tgtgtctttc
      661 aacaataaag tcagcacttc aaattttaat taattgggaa tttaaagttt gactgtgggg
      721 caaaagttat ttctttgcat atcagcattt caacagaatg tatatttaaa aagaaaattc
      781 tcccttgttc tgttaaatgt atcttcttca tattgtcatg ctttgctcat ttgaagtcat
      841 ttgccatttt ttggctttct gtggaactct cctgctttta gaagaattgt ggtaaatatt
      901 gccatcaaga atactttgag gcataaaacc ccttgtttta tcttattaca atgattattc
      961 caatttctaa agagtaaatt ttcagtgaga aacaactatt ttcatcataa aaatgattca
     1021 ccttacaaaa gctttgttgt gcgtgcgtgc gtgcgtgcgt gcgtgcgtgt gtgcggtgcc
     1081 taactcggtg actgctgggt ggcaagagca cttatgagct acagtttgaa gatcacttag
     1141 atataaagca tatctgaatt tgcattaaga tgatgcatag ttcattgccc aaaattgttt
     1201 tatcttttgt gtagttaatt atagagaaat gacaacaggg tattaagtta cttgtactcc
     1261 agtggattga atttgtacat actgagggaa aatattttga tcttttttta aaaagagata
     1321 acttctttat tgtatttttt taacttcaca aaatatagat aaaacacttg tgtatgcatg
     1381 atggcagaaa aagtctggaa agaaggacgt atgacagtat aatcggcccg cacagataag
     1441 gacgaggact tagcaagggt tactgctttt actttctatt tctctcttgt tcctctccaa
     1501 caaacatttc tataccttta atagtttttt taagttgagg ctttgaataa aattgtcatg
     1561 gcacagttag gctcttcagg cccatatgat gagacctttg attgattgtc tgaagataga
     1621 gtggagtcag cattacagca agcataatca caaatggatt agacctcggc tgtgcacgga
     1681 aaggaagcca cacctgtgtt acacggcaaa tactgaaaaa aaacaaaaaa caaacactca
     1741 ttttactttc cagctcctaa gtgaatgata cgtcaagggt atatatagga tatagaaaga
     1801 aggtgaggtt tacaaagtaa ttcagctctg acacagaacc acatttcctc cagaaacaga
     1861 gtaaaagcaa gacagttaga tttggggacc ctcatttgtg aaggctgctg ggttaggtgg
     1921 gccatctcca ggattcctta tttactcaac gagcacatag tgagccggtg ccacatgcag
     1981 tctgtgtgtt ctcttttttt ttgggttttt tttttttttt ttttttggag ctagggactg
     2041 aacccagggc cttgcgcttc ctaggcaagc actctaccac tgagctaaat ccccaactcg
     2101 tgttctcttt ctttagctac catatctagc agtttgagaa agactagtga cggcaagctg
     2161 aaaatgatta cgagtcaact tgtcacataa ttaagttaca ctgacacatt ttatagtctt
     2221 agtttgtgta ttgtgaagtg tacatgttaa agcaaataga tatgttttag aaagacttat
     2281 ttcatgtgtg tgagtgtgtg agagtgtgtg tgtgtgtgtg tgtgtgtgtg tgcgtgcatc
     2341 atgcacatgc ctggtgcccg aggaacccag agagaatgct ggatcccctg gaactggaac
     2401 taacagacag ttgtgagcca ccctgtgggt gctgggaact gaaccctggt cttctacaag
     2461 aacagccagt gctattaaca actgagccat ctctctaacc ctgtaaaacc tttaataaaa
     2521 gaggctgtga ttggtttgaa gtaacagctg aagtgtggaa ggaatcgtat aatattacgg
     2581 aaggtaaaag tggtacagtt gtgtttgtct gctcacttac tctcgtggta ctaagggtgg
     2641 aacccagggc ctcacacatt ctggtaatag ccctttacac tgaactccat cttgtgtcgt
     2701 atctttttaa tagtatacac cattgaaaca aaatacaaaa aggttttcca tataggttta
     2761 ctggaatttt tgaattattt gtaattttag cctactatca gaagtctttt tagttttatt
     2821 ttacacatct catgtaatag ctatccttaa aatattaaag atatcaccca cttggttca
//
