LOCUS       NM_001106385             759 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus CDGSH iron sulfur domain 1 (Cisd1), mRNA.
ACCESSION   NM_001106385 XM_001073750 XM_215378
VERSION     NM_001106385.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 759)
  AUTHORS   Tam,E., Sung,H.K. and Sweeney,G.
  TITLE     MitoNEET prevents iron overload-induced insulin resistance in H9c2
            cells through regulation of mitochondrial iron
  JOURNAL   J Cell Physiol 238 (8), 1867-1875 (2023)
   PUBMED   37269467
  REMARK    GeneRIF: MitoNEET prevents iron overload-induced insulin resistance
            in H9c2 cells through regulation of mitochondrial iron.
            Erratum:[J Cell Physiol. 2024 Dec;239(12):e31456. doi:
            10.1002/jcp.31456.. PMID: 39350514]
REFERENCE   2  (bases 1 to 759)
  AUTHORS   Zhang,Z.B., Xiong,L.L., Xue,L.L., Deng,Y.P., Du,R.L., Hu,Q., Xu,Y.,
            Yang,S.J. and Wang,T.H.
  TITLE     MiR-127-3p targeting CISD1 regulates autophagy in hypoxic-ischemic
            cortex
  JOURNAL   Cell Death Dis 12 (3), 279 (2021)
   PUBMED   33723216
  REMARK    GeneRIF: MiR-127-3p targeting CISD1 regulates autophagy in
            hypoxic-ischemic cortex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 759)
  AUTHORS   He,Q.Q., Xiong,L.L., Liu,F., He,X., Feng,G.Y., Shang,F.F.,
            Xia,Q.J., Wang,Y.C., Qiu,D.L., Luo,C.Z., Liu,J. and Wang,T.H.
  TITLE     MicroRNA-127 targeting of mitoNEET inhibits neurite outgrowth,
            induces cell apoptosis and contributes to physiological dysfunction
            after spinal cord transection
  JOURNAL   Sci Rep 6, 35205 (2016)
   PUBMED   27748416
  REMARK    GeneRIF: MicroRNA-127 targets mitoNEET, which inhibits neurite
            outgrowth, induces cell apoptosis and contributes to physiological
            dysfunction after spinal cord transection
            Erratum:[Sci Rep. 2017 Jan 19;7:39570. doi: 10.1038/srep39570..
            PMID: 28102200]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 759)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   5  (bases 1 to 759)
  AUTHORS   Wiley,S.E., Rardin,M.J. and Dixon,J.E.
  TITLE     Chapter 13 Localization and function of the 2Fe-2S outer
            mitochondrial membrane protein mitoNEET
  JOURNAL   Methods Enzymol 456, 233-246 (2009)
   PUBMED   19348892
  REMARK    GeneRIF: describes methods for isolating mitochondrial membrane
            fractions that are enriched in mitoNEET, generating constructs for
            the expression of recombinant mitoNEET protein and analyzing the
            2Fe-2S cluster of mitoNEET in vitro
REFERENCE   6  (bases 1 to 759)
  AUTHORS   Lin,J., Zhou,T., Ye,K. and Wang,J.
  TITLE     Crystal structure of human mitoNEET reveals distinct groups of iron
            sulfur proteins
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14640-14645 (2007)
   PUBMED   17766439
REFERENCE   7  (bases 1 to 759)
  AUTHORS   Paddock,M.L., Wiley,S.E., Axelrod,H.L., Cohen,A.E., Roy,M.,
            Abresch,E.C., Capraro,D., Murphy,A.N., Nechushtai,R., Dixon,J.E.
            and Jennings,P.A.
  TITLE     MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane
            protein stabilized by pioglitazone
  JOURNAL   Proc Natl Acad Sci U S A 104 (36), 14342-14347 (2007)
   PUBMED   17766440
REFERENCE   8  (bases 1 to 759)
  AUTHORS   Wiley,S.E., Murphy,A.N., Ross,S.A., van der Geer,P. and Dixon,J.E.
  TITLE     MitoNEET is an iron-containing outer mitochondrial membrane protein
            that regulates oxidative capacity
  JOURNAL   Proc Natl Acad Sci U S A 104 (13), 5318-5323 (2007)
   PUBMED   17376863
  REMARK    GeneRIF: mito- NEET is an important iron-containing protein
            involved in the control of maximal mitochondrial respiratory rates
            [mitoNEET]
REFERENCE   9  (bases 1 to 759)
  AUTHORS   Colca,J.R., McDonald,W.G., Waldon,D.J., Leone,J.W., Lull,J.M.,
            Bannow,C.A., Lund,E.T. and Mathews,W.R.
  TITLE     Identification of a novel mitochondrial protein ('mitoNEET')
            cross-linked specifically by a thiazolidinedione photoprobe
  JOURNAL   Am J Physiol Endocrinol Metab 286 (2), E252-E260 (2004)
   PUBMED   14570702
  REMARK    GeneRIF: mitoNEET is located in mitochondrial fraction of rat
            brain, liver and skeletal muscle.
REFERENCE   10 (bases 1 to 759)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC159419.1.
            
            On Feb 17, 2008 this sequence version replaced NM_001106385.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC159419.1, DY319784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..759
                     /gene="Cisd1"
                     /gene_synonym="MitoNEET; RGD1309529"
                     /note="CDGSH iron sulfur domain 1"
                     /db_xref="GeneID:294362"
                     /db_xref="RGD:1309529"
     exon            1..117
                     /gene="Cisd1"
                     /gene_synonym="MitoNEET; RGD1309529"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..413
                     /gene="Cisd1"
                     /gene_synonym="MitoNEET; RGD1309529"
                     /EC_number="2.6.1.3"
                     /note="cysteine transaminase CISD1"
                     /codon_start=1
                     /product="CDGSH iron-sulfur domain-containing protein 1"
                     /protein_id="NP_001099855.1"
                     /db_xref="GeneID:294362"
                     /db_xref="RGD:1309529"
                     /translation="MGLSSDSPVRVEWIAAVTFAAGTAALGYLAYKKFYAKESRTKAM
                     VNLQIQKDNPKVVHAFDMEDLGDKAVYCRCWRSKKFPFCDGAHIKHNEETGDNVGPLI
                     IKKKET"
     exon            118..323
                     /gene="Cisd1"
                     /gene_synonym="MitoNEET; RGD1309529"
                     /inference="alignment:Splign:2.1.0"
     exon            324..734
                     /gene="Cisd1"
                     /gene_synonym="MitoNEET; RGD1309529"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgaggtcg cgtctttccc ccaggtctcc gcggtcccca gcgctcgccc gcgcggtcct
       61 gccacggcct tcctgctgcc cgcgccatgg gcctcagctc cgactcccct gtgcgagttg
      121 agtggatcgc cgccgtgacc tttgctgctg gcacagccgc tctcggttac ctggcttaca
      181 agaagttcta cgctaaagag agtcgcacca aagctatggt gaaccttcag atccagaaag
      241 acaacccgaa ggttgtgcac gccttcgaca tggaggatct gggggataag gccgtgtatt
      301 gccggtgctg gaggtctaaa aagttcccgt tctgcgatgg ggctcacata aagcacaatg
      361 aggagactgg agacaacgtg ggacctctga tcatcaagaa aaaagaaact taatggacag
      421 ttgcgaggct acaccccagc gtgttgtgat gtcacctgat catttaatta gaatggcacc
      481 caacccactg tctggttggc ctcccaggtt ctggtgtggt tggtacttgc aaatcgcagc
      541 tttcatgttc acggcatcgg ccttgccatt gaaacatcgt ggtgcacatt tgttgaaaga
      601 agaagaaaag gaaaggctga accaacctca tgctctgtgg gttatcttgg tctcgtaagg
      661 atccgttcct ttaaaataat ggtcttagaa tagagttatg tcttgaggtt atatattaaa
      721 ttattccaaa atcaaaaaaa aaaaaaaaaa aaaaaaaaa
//
