LOCUS       NM_001402377            3188 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus ciliated left-right organizer metallopeptidase
            (Cirop), mRNA.
ACCESSION   NM_001402377 XM_008770711
VERSION     NM_001402377.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3188)
  AUTHORS   Szenker-Ravi,E., Ott,T., Khatoo,M., Moreau de Bellaing,A.,
            Goh,W.X., Chong,Y.L., Beckers,A., Kannesan,D., Louvel,G.,
            Anujan,P., Ravi,V., Bonnard,C., Moutton,S., Schoen,P., Fradin,M.,
            Colin,E., Megarbane,A., Daou,L., Chehab,G., Di Filippo,S.,
            Rooryck,C., Deleuze,J.F., Boland,A., Arribard,N., Eker,R.,
            Tohari,S., Ng,A.Y., Rio,M., Lim,C.T., Eisenhaber,B., Eisenhaber,F.,
            Venkatesh,B., Amiel,J., Crollius,H.R., Gordon,C.T., Gossler,A.,
            Roy,S., Attie-Bitach,T., Blum,M., Bouvagnet,P. and Reversade,B.
  TITLE     Discovery of a genetic module essential for assigning left-right
            asymmetry in humans and ancestral vertebrates
  JOURNAL   Nat Genet 54 (1), 62-72 (2022)
   PUBMED   34903892
  REMARK    Erratum:[Nat Genet. 2022 Jun;54(6):906. PMID: 35304595]
REFERENCE   2  (bases 1 to 3188)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Mar 11, 2022 this sequence version replaced XM_008770711.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000015.1  32127847-32128152   c
            307-400             JAXUCZ010000015.1  32127636-32127729   c
            401-452             JAXUCZ010000015.1  32126718-32126769   c
            453-596             JAXUCZ010000015.1  32126166-32126309   c
            597-722             JAXUCZ010000015.1  32125751-32125876   c
            723-807             JAXUCZ010000015.1  32125490-32125574   c
            808-953             JAXUCZ010000015.1  32125217-32125362   c
            954-1125            JAXUCZ010000015.1  32124965-32125136   c
            1126-1195           JAXUCZ010000015.1  32124488-32124557   c
            1196-1292           JAXUCZ010000015.1  32124314-32124410   c
            1293-1562           JAXUCZ010000015.1  32123945-32124214   c
            1563-1789           JAXUCZ010000015.1  32123300-32123526   c
            1790-1969           JAXUCZ010000015.1  32122958-32123137   c
            1970-3188           JAXUCZ010000015.1  32121021-32122239   c
FEATURES             Location/Qualifiers
     source          1..3188
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..3188
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /note="ciliated left-right organizer metallopeptidase"
                     /db_xref="GeneID:361039"
                     /db_xref="RGD:1560492"
     exon            1..306
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2120
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /note="leishmanolysin-like peptidase; leishmanolysin like
                     peptidase 2"
                     /codon_start=1
                     /product="ciliated left-right organizer metallopeptidase
                     precursor"
                     /protein_id="NP_001389306.1"
                     /db_xref="GeneID:361039"
                     /db_xref="RGD:1560492"
                     /translation="MWWLLLLGAAASRCLHEETQKSVRLLRPPFPQMSTHFRSSILPL
                     PGSPEPQPLRIQTHYTRGPVPSEARDLDGEARALAAVKETTRRIQGILAVLPVRGPLL
                     LSRDPAQYCHAVWGDPDTPNYHRCSLLNPGYKGESCLGVKIPDAHLRGYSLWPEHGLP
                     QLIQPDGPGVQNTDFLLYVRVAHTSRCHREPSVIAYAACCQLDSEDRPLAGTIVYCAQ
                     HLSSPSLGHDDIVMATLHELLHALGFSGQLFKMWRDCPSGLSARENCSTRKQVTRRDE
                     GGQLLLTTPAVSRSLAKHLGVPGTSLGVPLEEEGSLSSHWESRLLQGSIMTAAFDGAQ
                     HTRLDPITLAAFEDSGWYQVNHSAAEELLWGQGSGPDFGLVSTCRNGSSDFFCTGSGL
                     GCHYLHLDKGRCSSDPMLEGCRMYKPSANGSECWKESGLHTRAENPRGEIYHMHSRCF
                     LGNLTSQVLSKDKTSQSSAAPLYLEEGPTGCCYLHQCTHKGAYEVQVKGSPWIPCLPG
                     KAVQIPGYHGLLYCPQGRLCLSEGVSVATSQPMSFTTQDLVFQLSLRLTGTLGHSLGK
                     GQREELAEVVLEALVIRAGTSRCYFYSPSITTSLVFTVSMWKPSGCQGPSTAMLHRTL
                     TLILQKKPLQVHHGEAIFTTEYSKLQTSLDHSSSVAELLLYTGFCLLLLILLGALGTL
                     AYQKRARLQVEPSTT"
     exon            307..400
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     exon            401..452
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     exon            453..596
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     exon            597..722
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     exon            723..807
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     exon            808..953
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1125
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1195
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1292
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1562
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1789
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1969
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..3188
                     /gene="Cirop"
                     /gene_synonym="Lmln2; RGD1560492"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaggccgag gagacacaga ataaagatgt ggtggctact cctccttggg gcggccgcaa
       61 gcagatgtct gcatgaggaa acccagaagt ctgtgcgcct tcttaggcct cctttccccc
      121 agatgtccac acacttccgc tcctcaatcc ttcctctccc tggctcccct gagcctcaac
      181 cccttagaat ccaaacgcac tatacaagag gtcctgtacc cagtgaggct cgggatcttg
      241 acggggaagc tcgagccctg gctgcagtga aagagaccac tcgaaggatt caggggatcc
      301 tagcagttct tccggtacga ggacctctgc ttctgagccg agaccctgca caatactgcc
      361 atgctgtctg gggagacccc gataccccaa actaccatag gtgcagcctc ttgaacccag
      421 ggtacaaagg agagagttgc ctcggagtaa agatacctga tgcccacctg cgtggttatt
      481 ccttgtggcc agagcatggt ctgccccaac taatccagcc agatggccct ggcgtccaaa
      541 acactgattt tctcctgtat gtgcgggttg cccacacttc cagatgtcac agagagccct
      601 ctgtcatagc ctatgctgcc tgctgccagc tggactcaga agacaggccc ctcgctggta
      661 ccattgtcta ctgtgcccaa catctcagca gcccgagcct cggccacgac gatattgtca
      721 tggctacact gcatgaactg ctgcacgctc tgggtttttc tggacagctc ttcaagatgt
      781 ggcgagactg tccctcagga ctcagtgcta gagagaattg ttctacaaga aaacaggtga
      841 ccagacgaga tgaaggggga caactgcttc tcaccactcc agctgtcagc cgcagcctag
      901 ccaaacactt gggggtgccc gggacttcgc tgggagttcc tttggaagaa gagggctctt
      961 tgtcttcaca ctgggagtcc agattacttc agggctctat aatgaccgct gccttcgatg
     1021 gtgcccagca cactcgactt gacccaataa cccttgctgc cttcgaagat tcaggctggt
     1081 atcaggtcaa ccacagtgca gcagaggaac ttttgtgggg ccagggctct ggcccagact
     1141 ttggtctggt gagcacatgc aggaatggat cctcagactt cttctgcact ggcagtgggc
     1201 tgggctgtca ctacctgcac ctggacaaag gaaggtgttc ctcagaccca atgctagaag
     1261 gctgccgcat gtacaaaccc tcagccaatg ggagtgaatg ctggaaggag agtggactcc
     1321 acaccagagc ggaaaacccc cgcggggaga tctaccatat gcacagccgc tgcttccttg
     1381 gcaaccttac ctcccaagtg ctctccaaag acaagaccag ccaatcctca gcagcaccac
     1441 tctaccttga agaaggtccc acgggctgtt gttatttaca tcaatgcacc cacaagggag
     1501 cctacgaggt tcaagtgaag ggatcaccgt ggatcccctg ccttccgggg aaggctgttc
     1561 agatacctgg gtaccatggc cttctctact gtccccaagg ccggctgtgt ctgagtgaag
     1621 gtgtcagtgt tgccacttct caaccgatga gctttacaac ccaagacctg gtattccagc
     1681 tgtctctaag actaacaggg accctgggcc actctctggg gaagggacag agagaagagc
     1741 ttgctgaggt agttctggag gctctggtga taagagctgg cactagcagg tgttatttct
     1801 acagcccatc catcaccacg agcttggtat tcactgtgag tatgtggaag ccttctggct
     1861 gccaagggcc gtccactgct atgctacata ggaccctgac cctgattctt cagaagaaac
     1921 ccctccaagt acaccacgga gaagccatct ttaccacaga atacagcaag ctgcagactt
     1981 ccttggacca tagctcctct gtggctgagc tacttctgta cactggcttc tgtctgctgt
     2041 tgctaattct gctgggtgca ctgggaactc tggcttatca gaaacgagcg aggcttcaag
     2101 tggaaccatc tactacttaa ccatcacagg aactgtatgg tacaagagat caggttaaag
     2161 cagatgtgat gccacttgga acgtaactgc caaatgtcag ccagcaagat gaccacctga
     2221 attgattcct aaggagccac aatgtggaga aaaccggttc cacaaggtgt cctgacttct
     2281 tcatgtgcat ggtggctcat gagtactcct acacagatgt gtatgcacac agtcagagtg
     2341 gctcttgtag aagacccaag caccaccaac attccataac tgtagttcca ggggatctga
     2401 cattgttctt tcctctgtga gcactatcat gtaaatggta catacacgta acatgtaggc
     2461 cctcacgcat atatgtaatt ataagtaaaa gagctctgga tgggaaaacc tactcacttt
     2521 aaacgctcta cttcctctag aacagacttt gccaggttgt cagctttatc gcagctttgc
     2581 catgtgtaaa tgtggagcct cgcggtaaag agcagtcttt attatgatac cctctccccc
     2641 aaatcaacag tttcacttgt gaagactcct gtccaccagc cccaggaggc cgcgcatgct
     2701 ttgacgaggg tgctcctatt taatacttac ctggttttca ttgctgctca gagccaaacg
     2761 atgtgaataa tagtaattat ttctttccct caattttcct taattttatt aaatcaccgc
     2821 tgggaaaccc agcagttggg aaattacata attatgttag agttgggtag atgtggtaaa
     2881 agcagccaca tctgggccag ctctggactc gagttacaag atactggttc ctgttagtta
     2941 tagtgacaaa agcagtcatt aaattcttga gatttagaca tctcctgtaa aaaaaatcag
     3001 atttgctaaa aatggagaga gtccaagtga cgtactgcca gggtacaaca gtgttagcac
     3061 tcaacaggaa gtccatgcca aaaaaatctt tttaaaggca gagtctcact ttgtactgct
     3121 ggctggcctg gaacttgcta tgtagaccag gctgcctcct gggtgctgga ataaacggtg
     3181 gaccacta
//
