LOCUS       NM_031147               1410 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus cold inducible RNA binding protein (Cirbp),
            transcript variant 1, mRNA.
ACCESSION   NM_031147
VERSION     NM_031147.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Liu,J., Ke,X., Wang,L., Zhang,Y. and Yang,J.
  TITLE     Deficiency of cold-inducible RNA-binding protein exacerbated
            monocrotaline-induced pulmonary artery hypertension through
            Caveolin1 and CAVIN1
  JOURNAL   J Cell Mol Med 25 (10), 4732-4743 (2021)
   PUBMED   33755319
  REMARK    GeneRIF: Deficiency of cold-inducible RNA-binding protein
            exacerbated monocrotaline-induced pulmonary artery hypertension
            through Caveolin1 and CAVIN1.
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Xie,D., Geng,L., Xiong,K., Zhao,T., Wang,S., Xue,J., Wang,C.,
            Wang,G., Feng,Z., Zhou,H., Li,Y., Li,L., Liu,Y., Xue,Z., Yang,J.,
            Ma,H., Liang,D. and Chen,Y.H.
  TITLE     Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate
            Response to Stress by Targeting Phosphodiesterase
  JOURNAL   Circ Res 126 (12), 1706-1720 (2020)
   PUBMED   32212953
  REMARK    GeneRIF: Cold-Inducible RNA-Binding Protein Prevents an Excessive
            Heart Rate Response to Stress by Targeting Phosphodiesterase.
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Xie,D., Geng,L., Wang,S., Xiong,K., Zhao,T., Wang,G., Feng,Z.,
            Lv,F., Wang,C., Liang,D., Shi,D., Ma,X., Liu,Y., Yang,J., Zhang,C.
            and Chen,Y.H.
  TITLE     Cold-inducible RNA-binding protein modulates atrial fibrillation
            onset by targeting multiple ion channels
  JOURNAL   Heart Rhythm 17 (6), 998-1008 (2020)
   PUBMED   31918003
  REMARK    GeneRIF: Cold-inducible RNA-binding protein modulates atrial
            fibrillation onset by targeting multiple ion channels.
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Liu,M., Li,Y., Gao,S., Yan,S., Zhang,Q., Liu,G. and Ji,B.
  TITLE     A novel target to reduce microglial inflammation and neuronal
            damage after deep hypothermic circulatory arrest
  JOURNAL   J Thorac Cardiovasc Surg 159 (6), 2431-2444 (2020)
   PUBMED   31564537
  REMARK    GeneRIF: Enhanced cold-inducible RNA-binding protein in microglia
            aggravates neuronal injury by promoting the release of
            proinflammatory cytokines, which might be mediated through
            Brd2-NF-kappaB signals during deep hypothermic circulatory arrest.
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Su,F., Yang,S., Wang,H., Qiao,Z., Zhao,H. and Qu,Z.
  TITLE     CIRBP Ameliorates Neuronal Amyloid Toxicity via Antioxidative and
            Antiapoptotic Pathways in Primary Cortical Neurons
  JOURNAL   Oxid Med Cell Longev 2020, 2786139 (2020)
   PUBMED   32184914
  REMARK    GeneRIF: CIRBP Ameliorates Neuronal Amyloid Toxicity via
            Antioxidative and Antiapoptotic Pathways in Primary Cortical
            Neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1410)
  AUTHORS   Yang,R., Weber,D.J. and Carrier,F.
  TITLE     Post-transcriptional regulation of thioredoxin by the stress
            inducible heterogenous ribonucleoprotein A18
  JOURNAL   Nucleic Acids Res 34 (4), 1224-1236 (2006)
   PUBMED   16513844
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1410)
  AUTHORS   Yang,C. and Carrier,F.
  TITLE     The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a
            protective role in the genotoxic stress response
  JOURNAL   J Biol Chem 276 (50), 47277-47284 (2001)
   PUBMED   11574538
REFERENCE   8  (bases 1 to 1410)
  AUTHORS   Xue,J.H., Nonoguchi,K., Fukumoto,M., Sato,T., Nishiyama,H.,
            Higashitsuji,H., Itoh,K. and Fujita,J.
  TITLE     Effects of ischemia and H2O2 on the cold stress protein CIRP
            expression in rat neuronal cells
  JOURNAL   Free Radic Biol Med 27 (11-12), 1238-1244 (1999)
   PUBMED   10641716
REFERENCE   9  (bases 1 to 1410)
  AUTHORS   Mao,Y., Ling,P.R., Fitzgibbons,T.P., McCowen,K.C., Frick,G.P.,
            Bistrian,B.R. and Smith,R.J.
  TITLE     Endotoxin-induced inhibition of growth hormone receptor signaling
            in rat liver in vivo
  JOURNAL   Endocrinology 140 (12), 5505-5515 (1999)
   PUBMED   10579313
REFERENCE   10 (bases 1 to 1410)
  AUTHORS   Nishiyama,H., Itoh,K., Kaneko,Y., Kishishita,M., Yoshida,O. and
            Fujita,J.
  TITLE     A glycine-rich RNA-binding protein mediating cold-inducible
            suppression of mammalian cell growth
  JOURNAL   J Cell Biol 137 (4), 899-908 (1997)
   PUBMED   9151692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000177.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_031147.4.
            
            On Nov 27, 2020 this sequence version replaced NM_031147.2.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069219.1, CB315154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JACYVU010000177.1  4697691-4697766     c
            77-268              JACYVU010000177.1  4695726-4695917     c
            269-375             JACYVU010000177.1  4695532-4695638     c
            376-514             JACYVU010000177.1  4695314-4695452     c
            515-596             JACYVU010000177.1  4695148-4695229     c
            597-667             JACYVU010000177.1  4694892-4694962     c
            668-1410            JACYVU010000177.1  4693948-4694690     c
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1410
                     /gene="Cirbp"
                     /note="cold inducible RNA binding protein"
                     /db_xref="GeneID:81825"
                     /db_xref="RGD:620756"
     exon            1..76
                     /gene="Cirbp"
                     /inference="alignment:Splign:2.1.0"
     exon            77..268
                     /gene="Cirbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..684
                     /gene="Cirbp"
                     /note="A18 hnRNP; glycine-rich RNA-binding protein CIRP"
                     /codon_start=1
                     /product="cold-inducible RNA-binding protein"
                     /protein_id="NP_112409.3"
                     /db_xref="GeneID:81825"
                     /db_xref="RGD:620756"
                     /translation="MASDEGKLFVGGLSFDTNEQALEQVFSKYGQISEVVVVKDRETQ
                     RSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRG
                     FFRGGRSRGRGFSRGGGDRGYGGGRFESRSGGYGGSRDYYASRSQGGSYGYRSSGGSY
                     RDSYDSYATHNE"
     exon            269..375
                     /gene="Cirbp"
                     /inference="alignment:Splign:2.1.0"
     exon            376..514
                     /gene="Cirbp"
                     /inference="alignment:Splign:2.1.0"
     exon            515..596
                     /gene="Cirbp"
                     /inference="alignment:Splign:2.1.0"
     exon            597..667
                     /gene="Cirbp"
                     /inference="alignment:Splign:2.1.0"
     exon            668..1410
                     /gene="Cirbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcactcgcgc gttaggaagc ttgggtgtgt gacgcgctgt cttcccgccc gcgtcaggga
       61 cctgcccgac tcagcgaaag gctaagaata cgctatctgg cttcagtttc tggaggggtg
      121 gtggttaagg ccaagcaagc atctgtagtg tgtgcacagg ctgccatggc atcagatgaa
      181 ggcaagcttt tcgtgggagg tctcagcttc gacaccaatg agcaggcgct ggagcaggtc
      241 ttctccaagt atgggcagat ctcggaagtg gtggtggtaa aggacaggga gactcaacga
      301 tcccgaggct tcgggtttgt cacctttgaa aatatcgatg acgctaagga tgccatgatg
      361 gctatgaatg ggaagtctgt ggatgggagg cagatccgag ttgaccaggc tggcaagtct
      421 tctgataacc ggtcccgagg ataccggggt ggctctgctg gaggccgtgg cttcttccgt
      481 gggggacgca gccggggccg agggttctcc agaggaggag gagaccgggg ctatggaggt
      541 ggccgctttg agtcccggag tggtggttat ggaggctcca gagactacta tgccagccgg
      601 agtcagggtg gcagctatgg ctatcggagc tccggtgggt cctacagaga cagctacgac
      661 agctatgcta cacacaacga gtaaaagccc tctgcgtcca gatcgtcctt ccatggctgt
      721 aataagatgg gggagcttcg ctgaacgttg tgtagtgagc accttgttac cacttttgta
      781 gtcctttcgg ttctgaccca tcagcagcct gcttctgacc gagatggcct cgtgactaga
      841 cctgttttta aggaagcgct gtctgttttt aagcattctt aaaaatgttt tggaaagcac
      901 ttcagatttt actgtttacc atgagccatg ggtatttgtg ggggtttttt tgttattttt
      961 ttgtttttgt ttttttccct aaattgtcgg gttgtgtggg ttttcgttac tcgtttttgt
     1021 tttttgaggt tttttggttt tctttttttc ttttttttct ttttcttttt tttttctttc
     1081 tttttttttt tttttttttt tttggtgtgg ttgcccatga agtctggggc cccacccctc
     1141 ctgagatgga atggactcga tttgagcaag ccatagccct ccagctcccc agccctgttg
     1201 cggagtgcag caggtcctgc ccatcgggca catgtctcaa gcccgcaggg agcacagcag
     1261 tccgggaggc tgtggaaatg tttatttata ttgtcctttt ttaccgaaga catgcatact
     1321 ccatcgatgt tgtattcaca gtggctgagg aattcttgta cgcagtttct ttggcttcac
     1381 gaagccgatt aaaagaccgt gtgaaacgaa
//
