LOCUS       NM_001108161            4131 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cartilage intermediate layer protein (Cilp),
            mRNA.
ACCESSION   NM_001108161 XM_001076441 XM_236348
VERSION     NM_001108161.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4131)
  AUTHORS   van Nieuwenhoven,F.A., Munts,C., Op't Veld,R.C., Gonzalez,A.,
            Diez,J., Heymans,S., Schroen,B. and van Bilsen,M.
  TITLE     Cartilage intermediate layer protein 1 (CILP1): A novel mediator of
            cardiac extracellular matrix remodelling
  JOURNAL   Sci Rep 7 (1), 16042 (2017)
   PUBMED   29167509
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4131)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   3  (bases 1 to 4131)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 4131)
  AUTHORS   Valdes,A.M., Hart,D.J., Jones,K.A., Surdulescu,G., Swarbrick,P.,
            Doyle,D.V., Schafer,A.J. and Spector,T.D.
  TITLE     Association study of candidate genes for the prevalence and
            progression of knee osteoarthritis
  JOURNAL   Arthritis Rheum 50 (8), 2497-2507 (2004)
   PUBMED   15334463
REFERENCE   5  (bases 1 to 4131)
  AUTHORS   Johnson,K., Farley,D., Hu,S.I. and Terkeltaub,R.
  TITLE     One of two chondrocyte-expressed isoforms of cartilage
            intermediate-layer protein functions as an insulin-like growth
            factor 1 antagonist
  JOURNAL   Arthritis Rheum 48 (5), 1302-1314 (2003)
   PUBMED   12746903
REFERENCE   6  (bases 1 to 4131)
  AUTHORS   Lorenzo,P., Neame,P., Sommarin,Y. and Heinegard,D.
  TITLE     Cloning and deduced amino acid sequence of a novel cartilage
            protein (CILP) identifies a proform including a nucleotide
            pyrophosphohydrolase
  JOURNAL   J Biol Chem 273 (36), 23469-23475 (1998)
   PUBMED   9722584
REFERENCE   7  (bases 1 to 4131)
  AUTHORS   Lorenzo,P., Bayliss,M.T. and Heinegard,D.
  TITLE     A novel cartilage protein (CILP) present in the mid-zone of human
            articular cartilage increases with age
  JOURNAL   J Biol Chem 273 (36), 23463-23468 (1998)
   PUBMED   9722583
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001076441.1, XM_236348.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132293 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4131
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4131
                     /gene="Cilp"
                     /note="cartilage intermediate layer protein"
                     /db_xref="GeneID:315761"
                     /db_xref="RGD:1305124"
     exon            1..49
                     /gene="Cilp"
                     /inference="alignment:Splign:2.1.0"
     exon            50..205
                     /gene="Cilp"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..3699
                     /gene="Cilp"
                     /note="cartilage intermediate layer protein 1; cartilage
                     intermediate layer protein, nucleotide
                     pyrophosphohydrolase"
                     /codon_start=1
                     /product="cartilage intermediate layer protein 1
                     precursor"
                     /protein_id="NP_001101631.1"
                     /db_xref="GeneID:315761"
                     /db_xref="RGD:1305124"
                     /translation="MAATKTWVLSFLVLEVTTVLGRQMMLTQSARRVQPVKRTPKILT
                     KPVNSQESPGEWTTWFNIDHPGGQGDYERLDAIRFYYGERVCARPLRLEARTTDWMPA
                     GITGQVVHGSPREGFWCLNKEQRPGQNCSNYTVRFLCPPGSLRRDTEHIWSSWSPWSA
                     CSAACGHTGVQTRTRTCLAQTVSLCNEATEEGQLCMSQACTACDLTCPMGQVNADCDA
                     CMCQDFMLHGAISLPGGGPAPGATVYLLAKAPKMLTQTDSSGSFRVPGLCPDGKTVLK
                     VTKSKFAPIMITMPKTSLKSATINAEFVRAETPYIVMNPETKARRAGQSVSLCCKATG
                     KPSPDKYFWYHNNTLLDPSLYKHQSKLVLRNLQQDQAGEYFCKAQSDAGAVKSKVTQL
                     TVIAHDEAPCNPTPESYLIRLPHDCFQNATNSFYYDVGRCPIKTCAGQQDNGIRCQDA
                     VENCCGISRTEEREIQCSGYTLPTKVAMECSCQRCAETRSIVRGRVTAADDGEPMRFG
                     HVYMGNNRVSMTGYKGTFTLHVPQDTERLVLTFVDRLQKFVNTTKVLPFNKKGSAVFH
                     EIKMLRQKEPITLEATETNIIPLGEVAGEDPVAELEIPPKSFYKQNGEPFTGKVKASV
                     TFLDPRNVSTATATQSDLNFINDEGDTFPLRTYGMFSVDFRDEATSESLNAGKVKVHL
                     DSTQVKMPEHARAMKLWSLNPNTGLWEEEGDFKFESQRRNKREERTFLVGNMEIRERR
                     LFNLDVPESRRCFIKVRTYRSERFLPSEQIQGVVVSVINLEPRTGFSSNPRAWGRFDS
                     VITGPNGACLPAFCDDQSPDAYSVYVLASLSGEELEAVESSPKFNPNAIGVPQPYLNK
                     LKYRRTDHEDPRVKKTAFQISMAKPRPNSAEESNGPIYAFENLRACEEAPPSAAHFRF
                     YQIEGDRYDYNTVPFNEDDPMSWTEDYLAWWPKPMEFRACYIKVKIVGPLEVNVRSRN
                     MGGTHRQTVGKLYGIRDVKSTRDRDQPNVSSACLEFKCSGMLYDQDRVDRTLVKVIPQ
                     GSCHRASVNSMLHEYLVNHLPLAVNNDTSEYTMLAPLDPLGHNYGIYTVTDQDPGTAK
                     EIALGRCFDGTSDGSSRIMKSNVGVALTFNCAERQVGRQSAFQYLQSTPARSPATGTV
                     QGRVPAMRQQRASRGGLRRRGSMAPLRFSGVAQQPLSN"
     exon            206..298
                     /gene="Cilp"
                     /inference="alignment:Splign:2.1.0"
     exon            299..568
                     /gene="Cilp"
                     /inference="alignment:Splign:2.1.0"
     exon            569..748
                     /gene="Cilp"
                     /inference="alignment:Splign:2.1.0"
     exon            749..1063
                     /gene="Cilp"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1172
                     /gene="Cilp"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1330
                     /gene="Cilp"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..4131
                     /gene="Cilp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaaaagac agcttctctt tccttctgca ccggacttag tgatcaaaga tcattgactc
       61 tatgaaacat tcctggggag ccacaggtcc aactttgtga agcagcgtca cctgtctgac
      121 atttatacgg ggcctgaggg agagatggca gcaaccaaga cctgggtact ctctttcctg
      181 gtccttgaag tcaccaccgt gctggggaga cagatgatgc ttacccagtc agcaagaaga
      241 gtccagcctg tgaagaggac ccctaagatc ctcaccaagc ctgttaactc ccaggagagt
      301 cctggagagt ggacgacttg gtttaacatc gaccacccag gtgggcaggg tgactatgag
      361 cgactggatg ccattcgatt ctactacggg gagcgcgtgt gcgcccgtcc cctccggcta
      421 gaggctcgga ccactgactg gatgcctgcg ggcatcactg gccaggtggt ccatggcagt
      481 ccccgtgagg gcttctggtg cctcaacaag gaacagagac caggccagaa ctgttccaat
      541 tacacagtgc gcttcctctg cccaccaggg tccttgcgga gagatacaga gcatatctgg
      601 agttcctggt ctccctggag cgcgtgctca gccgcctgtg gtcacaccgg ggtccagacc
      661 cgtacccgca cctgcttggc acagacagtg tcactatgta atgaggccac tgaggaggga
      721 cagctctgca tgagccaggc ctgcacagct tgtgacctga cctgccccat gggccaggta
      781 aatgctgact gtgatgcctg catgtgtcag gacttcatgc ttcacggggc catctccctc
      841 cctggaggtg gcccagctcc aggggccact gtctacctgc tggctaaggc accaaagatg
      901 ctgacccaaa cagacagcag cggaagtttc cgagttcctg gcttgtgtcc tgatggcaaa
      961 accgtcctga aagttaccaa gagcaagttt gccccaatta tgatcacgat gcccaagact
     1021 agcctgaagt cagccaccat caacgcagag tttgtgaggg cagagacccc atacattgta
     1081 atgaaccctg agacgaaagc acgtcgggct gggcagagtg tgtctctgtg ctgcaaggcc
     1141 acagggaaac ctagtccaga caagtacttc tggtaccaca acaacacatt gctggatcct
     1201 tccctctata aacaccagag caagctggtg ctgaggaacc tgcagcagga ccaagcaggg
     1261 gagtacttct gtaaggcgca gagtgatgct ggggctgtga agtccaaggt cacccaactc
     1321 actgtcattg cacacgatga ggctccttgc aacccaaccc cagagagcta ccttatccgg
     1381 ctgccccatg attgcttcca gaatgccacc aactccttct actatgatgt aggccgctgc
     1441 cccatcaaga cctgtgcagg gcagcaagac aatgggatcc ggtgccaaga tgccgtggag
     1501 aactgctgtg gtatttccag aacagaggag agggagatcc agtgcagtgg gtacacactg
     1561 cccaccaagg tggccatgga gtgcagctgt caacgatgtg cagagacacg gagcatcgtt
     1621 cggggccggg tcactgctgc tgacgatggg gagcccatgc gctttggcca cgtgtacatg
     1681 gggaataacc gtgtgagcat gactggctac aaaggcacat tcaccctcca cgtcccccag
     1741 gacacggaga ggctggtgct cacgtttgtg gacaggctgc agaaatttgt caacactacc
     1801 aaagtgctgc ccttcaacaa gaaagggagc gcagtgttcc atgagatcaa gatgcttcgg
     1861 cagaaagagc ccatcacgtt ggaagccacg gaaaccaaca ttatccccct gggagaggtg
     1921 gctggtgagg atcctgtggc tgaactggag attccaccca aaagtttcta taagcagaat
     1981 ggggagccct tcacaggaaa agtaaaggcc agtgtgacct tcctggatcc tcggaatgtc
     2041 tctacggcca cagccaccca aagtgacctg aacttcatta atgatgaagg agacaccttt
     2101 ccccttagaa catacgggat gttttctgtg gacttcagag atgaggccac ttcggagtca
     2161 cttaatgctg gcaaggtgaa ggtccatctt gactcgaccc aggtcaaaat gccagagcat
     2221 gcgcgggcca tgaaactctg gtcgctcaac ccaaacacgg ggctgtggga agaggaaggc
     2281 gatttcaaat ttgaaagcca gaggaggaac aagagggaag agagaacctt cctagtggga
     2341 aatatggaga tccgtgagag aaggctcttt aacctggatg tcccagaaag cagaaggtgc
     2401 ttcatcaagg tgaggactta tcggagtgag aggttcctgc ccagtgagca aatccagggg
     2461 gttgtagtct cagtgatcaa cctggagccc agaactggct tttcatctaa ccccagggcc
     2521 tggggccgat ttgacagtgt catcacaggg cccaatggag cctgcctgcc tgccttctgt
     2581 gacgatcagt cccctgatgc ctactctgtc tatgttttgg caagcctttc tggagaagaa
     2641 ctagaggcag ttgagtcttc tcctaaattc aacccaaatg caatcggtgt ccctcagcct
     2701 tacctcaaca aacttaaata ccgtcggaca gaccatgagg atccacgggt taaaaagacg
     2761 gctttccaaa tcagtatggc caaaccaagg cccaactcag ctgaggagag caatgggccc
     2821 atctatgcct ttgagaacct tcgggcatgc gaggaggcac cacccagtgc agctcacttc
     2881 cggttctatc agattgaggg ggatcgctat gactataaca cagttccttt caatgaagat
     2941 gaccctatga gctggactga agactacctg gcatggtggc ccaagccaat ggagttcaga
     3001 gcctgctaca tcaaggtaaa gattgtgggg ccacttgagg tgaatgtacg atcccgtaac
     3061 atgggcggca cccaccggca gactgtgggg aagctctatg ggatccggga tgtgaaaagt
     3121 actcgggaca gagaccaacc taatgtctca tctgcctgtc tggagttcaa gtgcagtgga
     3181 atgctgtatg accaagaccg tgtagaccgc acattagtga aggtcatccc ccagggcagc
     3241 tgccatcgag ccagtgttaa ctctatgctg cacgagtacc tggtcaacca ccttcccctg
     3301 gcagtcaaca atgacaccag cgagtatacc atgctggcac ccctggaccc tctgggccac
     3361 aattacggta tctatactgt cactgaccag gaccctggta cagctaagga gattgcgctt
     3421 ggccggtgct ttgacggcac ttctgatggc tcctccagaa tcatgaagag caacgtggga
     3481 gtcgccctga cctttaactg tgcagaaagg caggtaggcc gccagagcgc cttccagtac
     3541 ctccaaagca ccccggcccg gtccccagct acaggcactg tccaaggaag agtacccgcc
     3601 atgaggcaac aacgggcaag caggggtggc ctacgccggc gtggaagcat ggcccctctg
     3661 agattttctg gtgtcgctca acaacctctg agcaactaag tcttatgatt ctttgtagtc
     3721 ctctctgtcc acctcatgag acagccatcg tgagactgat gcacacattg tcacttgtta
     3781 atttaaacac atctggttta gtgcagtttt cttctttgtg cctttacttc ctgtctctgt
     3841 cttgtgatac tgattggcac aaggccccca agatgacaaa acagagatct cctcttagaa
     3901 agaaacaaaa ggaattggta aatgcccgag gctttgtctg gaaacacttc ctattggatg
     3961 gttttgccaa ccttcgcacc aatgataatc taataccgag gtgcaagtga gcaataaaac
     4021 atttttcttg tcggtgttca caagatgtag gcagagcctc tgtcacaatc cattatataa
     4081 aaatggtggt gaataaggaa ataaacaatg tttttatgtg agacgtgttt a
//
