LOCUS       NM_138886               2350 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ciliogenesis associated kinase 1 (Cilk1), mRNA.
ACCESSION   NM_138886
VERSION     NM_138886.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2350)
  AUTHORS   Broekhuis,J.R., Verhey,K.J. and Jansen,G.
  TITLE     Regulation of cilium length and intraflagellar transport by the
            RCK-kinases ICK and MOK in renal epithelial cells
  JOURNAL   PLoS One 9 (9), e108470 (2014)
   PUBMED   25243405
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2350)
  AUTHORS   Moon,H., Song,J., Shin,J.O., Lee,H., Kim,H.K., Eggenschwiller,J.T.,
            Bok,J. and Ko,H.W.
  TITLE     Intestinal cell kinase, a protein associated with
            endocrine-cerebro-osteodysplasia syndrome, is a key regulator of
            cilia length and Hedgehog signaling
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8541-8546 (2014)
   PUBMED   24853502
REFERENCE   3  (bases 1 to 2350)
  AUTHORS   Chaya,T., Omori,Y., Kuwahara,R. and Furukawa,T.
  TITLE     ICK is essential for cell type-specific ciliogenesis and the
            regulation of ciliary transport
  JOURNAL   EMBO J 33 (11), 1227-1242 (2014)
   PUBMED   24797473
REFERENCE   4  (bases 1 to 2350)
  AUTHORS   Lahiry,P., Wang,J., Robinson,J.F., Turowec,J.P., Litchfield,D.W.,
            Lanktree,M.B., Gloor,G.B., Puffenberger,E.G., Strauss,K.A.,
            Martens,M.B., Ramsay,D.A., Rupar,C.A., Siu,V. and Hegele,R.A.
  TITLE     A multiplex human syndrome implicates a key role for intestinal
            cell kinase in development of central nervous, skeletal, and
            endocrine systems
  JOURNAL   Am J Hum Genet 84 (2), 134-147 (2009)
   PUBMED   19185282
  REMARK    Erratum:[Am J Hum Genet. 2009 Jun;84(6):822]
REFERENCE   5  (bases 1 to 2350)
  AUTHORS   Togawa,K., Yan,Y.X., Inomoto,T., Slaugenhaupt,S. and Rustgi,A.K.
  TITLE     Intestinal cell kinase (ICK) localizes to the crypt region and
            requires a dual phosphorylation site found in map kinases
  JOURNAL   J Cell Physiol 183 (1), 129-139 (2000)
   PUBMED   10699974
REFERENCE   6  (bases 1 to 2350)
  AUTHORS   Abe,S., Yagi,T., Ishiyama,S., Hiroe,M., Marumo,F. and Ikawa,Y.
  TITLE     Molecular cloning of a novel serine/threonine kinase, MRK, possibly
            involved in cardiac development
  JOURNAL   Oncogene 11 (11), 2187-2195 (1995)
   PUBMED   8570168
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D26178.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D26178.1, SRR8487231.123755.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132294
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..2350
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /note="ciliogenesis associated kinase 1"
                     /db_xref="GeneID:84411"
                     /db_xref="RGD:71050"
     exon            1..124
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     exon            125..397
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..2186
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /EC_number="2.7.11.1"
                     /note="MRK; MAK-related kinase; heart serine-threonine
                     protein kinase; intestinal cell (MAK-like) kinase;
                     intestinal cell kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase ICK"
                     /protein_id="NP_620241.1"
                     /db_xref="GeneID:84411"
                     /db_xref="RGD:71050"
                     /translation="MNRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEE
                     CMNLREVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAI
                     RNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYV
                     STRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGT
                     PKKTDWPEGYQLSSAMNFIWPQCIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTAS
                     QALRYPYFQIGHPLGISTQDSGKPQKDVQDKTGPPPYVKPAPPAQAPTKAHTLISSRP
                     NQASQPHQHFVYPYKGEASRTEQLSHVQEGQPNPPFFPSLHNKNLPPKILAGLEQKSG
                     DMKPKSRRRWGLISRSTKGSDDWADLADLDFSSSLTRIDVKNKKRQSDDPLCRFESVL
                     DLKPSEPVGTGTSVSTQASSQRRDTPTLQSTAKQHYLKHSRYLPGINIRNGVLPNPGK
                     DFLPSSSWSSSGLSGKSSGTVSVVSKITSVGSGSTSSTGLTGSYIPSFLKKEVGSVMQ
                     RVQLAPLAAPSPGYSSLKAVRPHPGRPFFHTQPRSTPGLIPRPPAVQPVHGRIDWSSK
                     YPSRR"
     exon            398..452
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     exon            453..574
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     exon            575..654
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     exon            655..787
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     exon            788..959
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1127
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1439
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1630
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1779
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1908
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2031
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2350
                     /gene="Cilk1"
                     /gene_synonym="Ick"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2350
                     /gene="Cilk1"
                     /gene_synonym="Ick"
ORIGIN      
        1 gggttcctgc tggatgccac gcgctgccgg gtgtggactt gccgggttcg cccgctcgga
       61 tcccactgcc cttgcctgcc gggcccgctc gggtgcacgc gccgcccggc tgtgatcgcc
      121 gccagcagaa gactgatctt tgaaaatatg tatttgggag ataatcacgt tctgttgaat
      181 actttgtgct ggtgctgcca tcgaaaaatc tggttacagt ccggggaggc ctgctaccat
      241 tgcaggactg aaccgcctcg gccctgagat gagtgtcccg acagagcagg cgcaccatga
      301 atagatacac aacgatcaaa cagcttgggg atgggaccta tggttctgtc ctgctgggga
      361 gaagcattga atctggagaa ctaattgcca ttaaaaaaat gaaaagaaag ttttactcct
      421 gggaagaatg catgaacctt cgggaggtta agtctttaaa gaagctcaac catgccaata
      481 tagtgaagtt aaaagaggtt atcagggaga acgaccatct ctatttcatc ttcgagtaca
      541 tgaaggaaaa cctttaccag ctcattaaag aaagaaataa gttgttccca gagtctgcaa
      601 taaggaatat aatgtatcag atattgcaag gactggcgtt cattcacaaa catggtttct
      661 tccaccggga cttaaagcct gagaacctcc tctgcatggg accagaactt gtgaaaatcg
      721 cggacttcgg attggcccga gaaatccgat caagacctcc atacacagac tatgtgtcta
      781 ctagatggta tagggctcca gaagtactcc tgagatctac caactacagc tcccccattg
      841 atgtctgggc cgtgggctgc atcatggcag aggtgtacac cctccggcct cttttccctg
      901 gggccagtga aattgacacg attttcaaaa tttgccaagt gttgggaaca ccgaagaaga
      961 ctgactggcc tgaaggctac cagctgtcaa gtgctatgaa tttcatctgg ccccagtgca
     1021 tacccaataa cttaaagaca ctaattccaa atgctagcag cgaagcaatt cagctcctga
     1081 gagacttgct tcagtgggat cccaagaaac gaccaactgc tagtcaggca cttcgatacc
     1141 cttacttcca gatcggacac ccactgggca tcagcacaca ggactcggga aagccacaga
     1201 aagatgtcca agacaagaca ggcccacctc cttacgtcaa gccagcccct cctgcccagg
     1261 ccccaaccaa ggcgcataca ctgatttctt cacgaccaaa ccaagccagt caaccccatc
     1321 agcattttgt atatccctac aagggcgaag cctctaggac agagcagctg agccacgtgc
     1381 aggagggcca gccaaaccca ccattcttcc cgtccctcca caacaagaat ctcccgccaa
     1441 aaatcctagc tggcctggaa cagaaaagcg gtgacatgaa accaaagagc aggagaagat
     1501 ggggtctcat ttccaggtca accaagggtt ctgatgattg ggccgacttg gctgacttag
     1561 atttcagttc ctctctcacc agaatagatg tcaaaaacaa gaagagacag agtgacgacc
     1621 ccctctgcag gtttgaaagt gttttggacc tgaagccatc tgagccggtg ggtacaggaa
     1681 ctagtgtctc cacccaggct tcctcccaga ggagagacac gccgaccctg cagtccacag
     1741 caaagcagca ctacttgaag cactctcgct acctgcctgg aataaatata agaaatggcg
     1801 tgctcccaaa tccaggcaag gactttcttc catcaagttc atggtccagt tctggtttgt
     1861 ctggaaaatc ttcaggaacg gtatcagtag tgagcaaaat aacttcagtt ggctcaggct
     1921 ccacgagctc tactggactg actggaagct acatcccttc ctttctgaag aaggaagtcg
     1981 gctctgtcat gcagagggtc cagctggcgc ctctcgcagc cccttccccc ggctactctt
     2041 ccctcaaggc cgtgagacct cacccaggga ggccattctt tcacacccag cctaggagca
     2101 cgcctggctt gattccacga cctccagctg tgcagcctgt gcacggcagg atagactggt
     2161 cttccaagta cccatctcgg cggtgactgt cccagctgac tccgttgtac ccccacaacc
     2221 acgtggcggt gtaaaagcac ccacacttac agcagttctg aactaacaca tttcaatatt
     2281 tcttttaaat gtttttttaa acattgattt gaatgcaata ccctcttttt gtataaaatt
     2341 attttattct
//
