LOCUS       NM_001244797            1666 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cell death-inducing DFFA-like effector c (Cidec),
            transcript variant 2, mRNA.
ACCESSION   NM_001244797
VERSION     NM_001244797.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1666)
  AUTHORS   Zheng,G.S., Tan,Y.M., Shang,Y.Y., Liu,Y.P., Hu,B.A., Wang,D.,
            Han,L., Wang,Z.H., Zhang,W., Ti,Y. and Zhong,M.
  TITLE     CIDEC silencing attenuates diabetic nephropathy via inhibiting
            apoptosis and promoting autophagy
  JOURNAL   J Diabetes Investig 12 (8), 1336-1345 (2021)
   PUBMED   33655702
  REMARK    GeneRIF: CIDEC silencing attenuates diabetic nephropathy via
            inhibiting apoptosis and promoting autophagy.
REFERENCE   2  (bases 1 to 1666)
  AUTHORS   Hu,J., Wang,M., Zhou,Y., Zhang,X., He,B., Liu,L., Ma,R., Zhang,T.,
            Liu,K., Wang,Y. and Liu,J.
  TITLE     Bariatric Surgery in Rats Upregulates FSP27 Expression in Fat
            Tissue to Affect Fat Hydrolysis and Metabolism
  JOURNAL   Biomed Res Int 2019, 6415732 (2019)
   PUBMED   31205943
  REMARK    GeneRIF: FSP27 is associated with rat lipid metabolism and its
            expression varies with energy and nutrient supply. It can inhibit
            excessive hydrolysis and fat accumulation by regulating HSL and
            ATGL expression and by mediating LDs formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1666)
  AUTHORS   Sui,D.X., Zhou,H.M., Wang,F., Zhong,M., Zhang,W. and Ti,Y.
  TITLE     Cell death-inducing DFF45-like effector C gene silencing alleviates
            pulmonary vascular remodeling in a type 2 diabetic rat model
  JOURNAL   J Diabetes Investig 9 (4), 741-752 (2018)
   PUBMED   29078040
  REMARK    GeneRIF: Study shows that cell death-inducing DFF45-like effector C
            gene silencing alleviates pulmonary vascular remodeling in a type 2
            diabetic rat model. The CIDEC/5' monophosphate-activated protein
            kinase signaling pathway could be a potential therapeutic candidate
            against pulmonary vascular diseases in type 2 diabetes patients.
REFERENCE   4  (bases 1 to 1666)
  AUTHORS   Wang,S.X., Wei,J.G., Chen,L.L., Hu,X. and Kong,W.
  TITLE     The role of expression imbalance between adipose synthesis and
            storage mediated by PPAR-gamma/FSP27 in the formation of insulin
            resistance in catch up growth
  JOURNAL   Lipids Health Dis 15 (1), 173 (2016)
   PUBMED   27716232
  REMARK    GeneRIF: esveratrol can correct fat formation and storage imbalance
            status by up-regulating FSP27 and down-regulating PPAR-gamma
            expression level, ameliorating insulin sensitivity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1666)
  AUTHORS   Yu,F., Su,L., Ji,S., Zhang,S., Yu,P., Zheng,Y. and Zhang,Q.
  TITLE     Inhibition of hepatic stellate cell activation and liver fibrosis
            by fat-specific protein 27
  JOURNAL   Mol Cell Biochem 369 (1-2), 35-43 (2012)
   PUBMED   22752386
  REMARK    GeneRIF: From these findings, it can be concluded that Fsp27
            expression suppressed HSC activation in vitro and liver
            fibrogenesis in vivo
REFERENCE   6  (bases 1 to 1666)
  AUTHORS   Karbowska,J. and Kochan,Z.
  TITLE     Intermittent fasting up-regulates Fsp27/Cidec gene expression in
            white adipose tissue
  JOURNAL   Nutrition 28 (3), 294-299 (2012)
   PUBMED   21996045
  REMARK    GeneRIF: Long-term intermittent fasting, in contrast to other
            dietary manipulations, significantly up-regulated Fsp27 gene
            expression in white adipose tissue.
REFERENCE   7  (bases 1 to 1666)
  AUTHORS   Rubio-Cabezas,O., Puri,V., Murano,I., Saudek,V., Semple,R.K.,
            Dash,S., Hyden,C.S., Bottomley,W., Vigouroux,C., Magre,J.,
            Raymond-Barker,P., Murgatroyd,P.R., Chawla,A., Skepper,J.N.,
            Chatterjee,V.K., Suliman,S., Patch,A.M., Agarwal,A.K., Garg,A.,
            Barroso,I., Cinti,S., Czech,M.P., Argente,J., O'Rahilly,S. and
            Savage,D.B.
  CONSRTM   LD Screening Consortium
  TITLE     Partial lipodystrophy and insulin resistant diabetes in a patient
            with a homozygous nonsense mutation in CIDEC
  JOURNAL   EMBO Mol Med 1 (5), 280-287 (2009)
   PUBMED   20049731
REFERENCE   8  (bases 1 to 1666)
  AUTHORS   Liang,L., Zhao,M., Xu,Z., Yokoyama,K.K. and Li,T.
  TITLE     Molecular cloning and characterization of CIDE-3, a novel member of
            the cell-death-inducing DNA-fragmentation-factor (DFF45)-like
            effector family
  JOURNAL   Biochem J 370 (Pt 1), 195-203 (2003)
   PUBMED   12429024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM103335.1, FM043477.1, BC083860.1 and BQ194098.1.
            
            Transcript Variant: This variant (2) differs in the 5' exon, which
            results in a downstream AUG start codon, compared to variant 1. The
            resulting isoform (2) is shorter at the N-terminus than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM104144.1, FM043477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 FM103335.1         1-3
            4-675               FM043477.1         1-672
            676-1644            BC083860.1         664-1632
            1645-1666           BQ194098.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1666
                     /gene="Cidec"
                     /note="cell death-inducing DFFA-like effector c"
                     /db_xref="GeneID:500292"
                     /db_xref="RGD:1562113"
     exon            1..35
                     /gene="Cidec"
                     /inference="alignment:Splign:2.1.0"
     exon            36..113
                     /gene="Cidec"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..777
                     /gene="Cidec"
                     /note="isoform 2 is encoded by transcript variant 2; cell
                     death activator CIDE-3; fat-specific protein FSP27; cell
                     death-inducing DFFA-like effector protein C; lipid
                     transferase CIDEC"
                     /codon_start=1
                     /product="lipid transferase CIDEC isoform 2"
                     /protein_id="NP_001231726.1"
                     /db_xref="GeneID:500292"
                     /db_xref="RGD:1562113"
                     /translation="MDYAMKSLSLLYPRSLSRHVAVSTAVVTQQLVSEPSRETPRARP
                     CRVSTADRKVRKGIMAHSLEDLLGKVQDILKLKDKPFSLVLEEDGTIVETEEYFQALP
                     RDTVFMVLQKGQKWKSPSEQRKKKAQLSLSQKPTKKIDVARVTFDLYKLNPQDFIGCL
                     NVKATLYDTYSLSYDLHCYRAKRIVKEMLRWTLFSMQATGHMLLGTSSYMQQFLDATE
                     EEQPSKAKASLLPACLKMLQ"
     exon            114..267
                     /gene="Cidec"
                     /inference="alignment:Splign:2.1.0"
     exon            268..426
                     /gene="Cidec"
                     /inference="alignment:Splign:2.1.0"
     exon            427..617
                     /gene="Cidec"
                     /inference="alignment:Splign:2.1.0"
     exon            618..1649
                     /gene="Cidec"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcggtattgc caggaggctg ggaggtgagg gggaggtcta acacaatcca gctgacaaga
       61 atggactatg ctatgaagtc tctcagcctt ctctacccta ggtcactgtc caggcatgta
      121 gcagtgagca ctgcagtggt gacccaacag ctggtgtctg agcccagccg ggagaccccc
      181 agggcaagac cctgtcgtgt tagcaccgca gatcggaagg ttcgcaaagg catcatggcc
      241 cacagcttgg aggacctcct gggcaaggtc caagacatct tgaagcttaa agacaagccc
      301 ttctccctgg tgttggagga agatggcaca atcgtggaga cagaagaata cttccaagcc
      361 ctaccaagag atacagtgtt catggtcctg cagaaggggc agaagtggaa gtccccatca
      421 gaacagcgca agaagaaagc ccagctatcc ctttcccaga agccaactaa gaagatcgac
      481 gtggcccggg taacctttga cctgtacaag ctgaaccctc aggacttcat cggctgcctg
      541 aacgtgaagg caaccctcta tgacacatac tcgctttcat atgacctgca ctgctacagg
      601 gccaaacgca tcgtgaagga aatgctccgc tggactctct tcagtatgca agccacaggc
      661 cacatgctgc ttggcacctc cagttacatg cagcagttcc tggatgccac tgaggaagaa
      721 cagccctcca aggccaaggc ctccctcctc cctgcctgtc tgaagatgct gcaatgaaga
      781 ccccagtcct cctcggccac agatgtgact ggggaccctg cgctctgcta gtagcaccca
      841 caagcctggc agttggagag cttctcaccc gcctacacct ctctcacagc acagcatcaa
      901 ggaaatctca ggaagggctg gagccctgga gtgggctggt cacaggagga cttcctgggc
      961 tgcctcagtt ccttctgttc tatctcaggt accttagagg accaacactt gcccctggca
     1021 ggcaccaagt ctgcccctgt gtcgccatgt gctgtcctct gtgccactcc ctccttggtg
     1081 ctcctcggtg tccggctgcc tacgttcatc atgcagcaga catcgctatg gtggccccca
     1141 tcataccttg gccccagtca aggcagcaaa acgagcaaca tgccacggca ccagtcatac
     1201 ctatggctat ggtaccagag cggttagcac tccgtagtag aagaaaagga gggggcctcg
     1261 ggggttctct cacctgggat tccaattact ccctccaagc ccccgctaca catgatcatg
     1321 aggtgtgctg gggggggggg ttagaggtag agttaagtga tgcagatttg gggggtcctg
     1381 acctgtgcca gccagggagg aacttttagg gaacgcagat gaatctgctt cacccaggcc
     1441 ccccataaga aacccagtaa gctcataggt tcaccaagct ggacttggat ggaatgtggc
     1501 tttgcctgtc attcatgctc ttcctgaact gaatggacat agttcatgat ctccagggaa
     1561 agtcacacgg tcacctctcc tgttctcatt ttccactaac gaatgaacag cattagagtc
     1621 tgcggtaaat tatttatgct gacacctcaa aaaaaaaaaa aaaaaa
//
