LOCUS       NP_001231726             238 aa            linear   ROD 04-JUN-2024
DEFINITION  lipid transferase CIDEC isoform 2 [Rattus norvegicus].
ACCESSION   NP_001231726
VERSION     NP_001231726.1
DBSOURCE    REFSEQ: accession NM_001244797.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 238)
  AUTHORS   Zheng,G.S., Tan,Y.M., Shang,Y.Y., Liu,Y.P., Hu,B.A., Wang,D.,
            Han,L., Wang,Z.H., Zhang,W., Ti,Y. and Zhong,M.
  TITLE     CIDEC silencing attenuates diabetic nephropathy via inhibiting
            apoptosis and promoting autophagy
  JOURNAL   J Diabetes Investig 12 (8), 1336-1345 (2021)
   PUBMED   33655702
  REMARK    GeneRIF: CIDEC silencing attenuates diabetic nephropathy via
            inhibiting apoptosis and promoting autophagy.
REFERENCE   2  (residues 1 to 238)
  AUTHORS   Hu,J., Wang,M., Zhou,Y., Zhang,X., He,B., Liu,L., Ma,R., Zhang,T.,
            Liu,K., Wang,Y. and Liu,J.
  TITLE     Bariatric Surgery in Rats Upregulates FSP27 Expression in Fat
            Tissue to Affect Fat Hydrolysis and Metabolism
  JOURNAL   Biomed Res Int 2019, 6415732 (2019)
   PUBMED   31205943
  REMARK    GeneRIF: FSP27 is associated with rat lipid metabolism and its
            expression varies with energy and nutrient supply. It can inhibit
            excessive hydrolysis and fat accumulation by regulating HSL and
            ATGL expression and by mediating LDs formation.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 238)
  AUTHORS   Sui,D.X., Zhou,H.M., Wang,F., Zhong,M., Zhang,W. and Ti,Y.
  TITLE     Cell death-inducing DFF45-like effector C gene silencing alleviates
            pulmonary vascular remodeling in a type 2 diabetic rat model
  JOURNAL   J Diabetes Investig 9 (4), 741-752 (2018)
   PUBMED   29078040
  REMARK    GeneRIF: Study shows that cell death-inducing DFF45-like effector C
            gene silencing alleviates pulmonary vascular remodeling in a type 2
            diabetic rat model. The CIDEC/5' monophosphate-activated protein
            kinase signaling pathway could be a potential therapeutic candidate
            against pulmonary vascular diseases in type 2 diabetes patients.
REFERENCE   4  (residues 1 to 238)
  AUTHORS   Wang,S.X., Wei,J.G., Chen,L.L., Hu,X. and Kong,W.
  TITLE     The role of expression imbalance between adipose synthesis and
            storage mediated by PPAR-gamma/FSP27 in the formation of insulin
            resistance in catch up growth
  JOURNAL   Lipids Health Dis 15 (1), 173 (2016)
   PUBMED   27716232
  REMARK    GeneRIF: esveratrol can correct fat formation and storage imbalance
            status by up-regulating FSP27 and down-regulating PPAR-gamma
            expression level, ameliorating insulin sensitivity.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 238)
  AUTHORS   Yu,F., Su,L., Ji,S., Zhang,S., Yu,P., Zheng,Y. and Zhang,Q.
  TITLE     Inhibition of hepatic stellate cell activation and liver fibrosis
            by fat-specific protein 27
  JOURNAL   Mol Cell Biochem 369 (1-2), 35-43 (2012)
   PUBMED   22752386
  REMARK    GeneRIF: From these findings, it can be concluded that Fsp27
            expression suppressed HSC activation in vitro and liver
            fibrogenesis in vivo
REFERENCE   6  (residues 1 to 238)
  AUTHORS   Karbowska,J. and Kochan,Z.
  TITLE     Intermittent fasting up-regulates Fsp27/Cidec gene expression in
            white adipose tissue
  JOURNAL   Nutrition 28 (3), 294-299 (2012)
   PUBMED   21996045
  REMARK    GeneRIF: Long-term intermittent fasting, in contrast to other
            dietary manipulations, significantly up-regulated Fsp27 gene
            expression in white adipose tissue.
REFERENCE   7  (residues 1 to 238)
  AUTHORS   Rubio-Cabezas,O., Puri,V., Murano,I., Saudek,V., Semple,R.K.,
            Dash,S., Hyden,C.S., Bottomley,W., Vigouroux,C., Magre,J.,
            Raymond-Barker,P., Murgatroyd,P.R., Chawla,A., Skepper,J.N.,
            Chatterjee,V.K., Suliman,S., Patch,A.M., Agarwal,A.K., Garg,A.,
            Barroso,I., Cinti,S., Czech,M.P., Argente,J., O'Rahilly,S. and
            Savage,D.B.
  CONSRTM   LD Screening Consortium
  TITLE     Partial lipodystrophy and insulin resistant diabetes in a patient
            with a homozygous nonsense mutation in CIDEC
  JOURNAL   EMBO Mol Med 1 (5), 280-287 (2009)
   PUBMED   20049731
REFERENCE   8  (residues 1 to 238)
  AUTHORS   Liang,L., Zhao,M., Xu,Z., Yokoyama,K.K. and Li,T.
  TITLE     Molecular cloning and characterization of CIDE-3, a novel member of
            the cell-death-inducing DNA-fragmentation-factor (DFF45)-like
            effector family
  JOURNAL   Biochem J 370 (Pt 1), 195-203 (2003)
   PUBMED   12429024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM103335.1, FM043477.1, BC083860.1 and BQ194098.1.
            
            Transcript Variant: This variant (2) differs in the 5' exon, which
            results in a downstream AUG start codon, compared to variant 1. The
            resulting isoform (2) is shorter at the N-terminus than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM104144.1, FM043477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..238
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     Protein         1..238
                     /product="lipid transferase CIDEC isoform 2"
                     /note="cell death activator CIDE-3; fat-specific protein
                     FSP27; cell death-inducing DFFA-like effector protein C;
                     lipid transferase CIDEC"
                     /calculated_mol_wt=27083
     Region          1..35
                     /region_name="Required for liquid-liquid phase separation
                     (LLPS). /evidence=ECO:0000250|UniProtKB:P56198"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XI33.1)"
     Region          41..120
                     /region_name="CIDE_N"
                     /note="CIDE_N domain, found at the N-terminus of the CIDE
                     (cell death-inducing DFF45-like effector) proteins, as
                     well as CAD nuclease (caspase-activated DNase/DNA
                     fragmentation factor, DFF40) and its inhibitor,
                     ICAD(DFF45). These proteins are associated with...;
                     cl02541"
                     /db_xref="CDD:470607"
     Site            order(46,55..56,58..59,69,73,88,90..91,96..97,116,118)
                     /site_type="other"
                     /note="putative heterodimer interaction sites [polypeptide
                     binding]"
                     /db_xref="CDD:119367"
     CDS             1..238
                     /gene="Cidec"
                     /coded_by="NM_001244797.1:61..777"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:500292"
                     /db_xref="RGD:1562113"
ORIGIN      
        1 mdyamkslsl lyprslsrhv avstavvtqq lvsepsretp rarpcrvsta drkvrkgima
       61 hsledllgkv qdilklkdkp fslvleedgt iveteeyfqa lprdtvfmvl qkgqkwksps
      121 eqrkkkaqls lsqkptkkid varvtfdlyk lnpqdfigcl nvkatlydty slsydlhcyr
      181 akrivkemlr wtlfsmqatg hmllgtssym qqfldateee qpskakasll paclkmlq
//
