LOCUS       NM_001170467             915 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cell death-inducing DFFA-like effector a (Cidea),
            mRNA.
ACCESSION   NM_001170467 XM_214551
VERSION     NM_001170467.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 915)
  AUTHORS   Morishita,Y., Kellogg,A.P., Larkin,D., Chen,W., Vadrevu,S.,
            Satin,L., Liu,M. and Arvan,P.
  TITLE     Cell death-associated lipid droplet protein CIDE-A is a
            noncanonical marker of endoplasmic reticulum stress
  JOURNAL   JCI Insight 6 (7), 143980 (2021)
   PUBMED   33661766
  REMARK    GeneRIF: Cell death-associated lipid droplet protein CIDE-A is a
            noncanonical marker of endoplasmic reticulum stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 915)
  AUTHORS   Bai,Z., Chai,X.R., Yoon,M.J., Kim,H.J., Lo,K.A., Zhang,Z.C., Xu,D.,
            Siang,D.T.C., Walet,A.C.E., Xu,S.H., Chia,S.Y., Chen,P., Yang,H.,
            Ghosh,S. and Sun,L.
  TITLE     Dynamic transcriptome changes during adipose tissue energy
            expenditure reveal critical roles for long noncoding RNA regulators
  JOURNAL   PLoS Biol 15 (8), e2002176 (2017)
   PUBMED   28763438
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 915)
  AUTHORS   Shimizu,T. and Yokotani,K.
  TITLE     Acute cold exposure-induced down-regulation of CIDEA, cell
            death-inducing DNA fragmentation factor-alpha-like effector A, in
            rat interscapular brown adipose tissue by sympathetically activated
            beta3-adrenoreceptors
  JOURNAL   Biochem Biophys Res Commun 387 (2), 294-299 (2009)
   PUBMED   19577538
  REMARK    GeneRIF: These results suggest that acute cold exposure resulted in
            down-regulation of CIDEA in interscapular brown adipose tissue by
            sympathetically activated beta(3)-adrenoreceptor-mediated
            mechanisms in rats.
REFERENCE   4  (bases 1 to 915)
  AUTHORS   Puri,V., Ranjit,S., Konda,S., Nicoloro,S.M., Straubhaar,J.,
            Chawla,A., Chouinard,M., Lin,C., Burkart,A., Corvera,S.,
            Perugini,R.A. and Czech,M.P.
  TITLE     Cidea is associated with lipid droplets and insulin sensitivity in
            humans
  JOURNAL   Proc Natl Acad Sci U S A 105 (22), 7833-7838 (2008)
   PUBMED   18509062
REFERENCE   5  (bases 1 to 915)
  AUTHORS   Iwahana,H., Yakymovych,I., Dubrovska,A., Hellman,U. and
            Souchelnytskyi,S.
  TITLE     Glycoproteome profiling of transforming growth factor-beta
            (TGFbeta) signaling: nonglycosylated cell death-inducing DFF-like
            effector A inhibits TGFbeta1-dependent apoptosis
  JOURNAL   Proteomics 6 (23), 6168-6180 (2006)
   PUBMED   17080483
REFERENCE   6  (bases 1 to 915)
  AUTHORS   Baur,J.A., Pearson,K.J., Price,N.L., Jamieson,H.A., Lerin,C.,
            Kalra,A., Prabhu,V.V., Allard,J.S., Lopez-Lluch,G., Lewis,K.,
            Pistell,P.J., Poosala,S., Becker,K.G., Boss,O., Gwinn,D., Wang,M.,
            Ramaswamy,S., Fishbein,K.W., Spencer,R.G., Lakatta,E.G., Le
            Couteur,D., Shaw,R.J., Navas,P., Puigserver,P., Ingram,D.K., de
            Cabo,R. and Sinclair,D.A.
  TITLE     Resveratrol improves health and survival of mice on a high-calorie
            diet
  JOURNAL   Nature 444 (7117), 337-342 (2006)
   PUBMED   17086191
REFERENCE   7  (bases 1 to 915)
  AUTHORS   Dahlman,I., Kaaman,M., Jiao,H., Kere,J., Laakso,M. and Arner,P.
  TITLE     The CIDEA gene V115F polymorphism is associated with obesity in
            Swedish subjects
  JOURNAL   Diabetes 54 (10), 3032-3034 (2005)
   PUBMED   16186410
REFERENCE   8  (bases 1 to 915)
  AUTHORS   Nordstrom,E.A., Ryden,M., Backlund,E.C., Dahlman,I., Kaaman,M.,
            Blomqvist,L., Cannon,B., Nedergaard,J. and Arner,P.
  TITLE     A human-specific role of cell death-inducing DFFA (DNA
            fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte
            lipolysis and obesity
  JOURNAL   Diabetes 54 (6), 1726-1734 (2005)
   PUBMED   15919794
REFERENCE   9  (bases 1 to 915)
  AUTHORS   Zhou,Z., Yon Toh,S., Chen,Z., Guo,K., Ng,C.P., Ponniah,S.,
            Lin,S.C., Hong,W. and Li,P.
  TITLE     Cidea-deficient mice have lean phenotype and are resistant to
            obesity
  JOURNAL   Nat Genet 35 (1), 49-56 (2003)
   PUBMED   12910269
REFERENCE   10 (bases 1 to 915)
  AUTHORS   Inohara,N., Koseki,T., Chen,S., Wu,X. and Nunez,G.
  TITLE     CIDE, a novel family of cell death activators with homology to the
            45 kDa subunit of the DNA fragmentation factor
  JOURNAL   EMBO J 17 (9), 2526-2533 (1998)
   PUBMED   9564035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM041444.1, BF284899.1 and CR462136.1.
            
            On Dec 20, 2009 this sequence version replaced XM_214551.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132264,
                              SAMD00132266 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-587               FM041444.1         1-587
            588-909             BF284899.1         1-322               c
            910-915             CR462136.1         1-6                 c
FEATURES             Location/Qualifiers
     source          1..915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..915
                     /gene="Cidea"
                     /note="cell death-inducing DFFA-like effector a"
                     /db_xref="GeneID:291541"
                     /db_xref="RGD:1305106"
     exon            1..43
                     /gene="Cidea"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..653
                     /gene="Cidea"
                     /note="cell death-inducing DNA fragmentation factor, alpha
                     subunit-like effector A; cell death activator CIDE-A"
                     /codon_start=1
                     /product="lipid transferase CIDEA"
                     /protein_id="NP_001163938.1"
                     /db_xref="GeneID:291541"
                     /db_xref="RGD:1305106"
                     /translation="METARDYAGALIRPLTFMGLQTKKVLLTPLIHPARPFRVSNHDR
                     SSRRGVMASSLRELISKTLDVLVITTGLVTLVLEEDGTVVDTEEFFQTLRDNTHFMIL
                     EKGQKWTPGNKYVCTQTKKSGIARVTFDLYRLNPKDFLGCLNVKATMYEMYSVSYDIR
                     CTSFKALLRSLLRFASYAAQVTGQFLVYAGAYVLRALGDTEEQPSPKASAKGWFM"
     exon            44..188
                     /gene="Cidea"
                     /inference="alignment:Splign:2.1.0"
     exon            189..335
                     /gene="Cidea"
                     /inference="alignment:Splign:2.1.0"
     exon            336..511
                     /gene="Cidea"
                     /inference="alignment:Splign:2.1.0"
     exon            512..911
                     /gene="Cidea"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccaatgga gaccgccagg gactacgcgg gagccctcat caggcccctg acattcatgg
       61 ggttgcagac gaaaaaggtc ctgcttaccc ccctcataca ccctgctcgt cctttccggg
      121 tttcaaacca tgaccgaagc agccggcgtg gggtgatggc cagcagcctg cgggaactta
      181 tcagcaagac tctggatgtc ttggtcatca caactggcct ggtcacgctg gtgctggagg
      241 aggatggtac cgtggtggac acagaggagt tctttcagac cctaagagac aacacacact
      301 tcatgatctt ggaaaaggga cagaaatgga caccgggcaa taagtatgtc tgcacacaaa
      361 caaagaagtc aggaatagcc agagtcacct tcgacctata caggctgaat cccaaggact
      421 tcctcggctg tctcaatgtc aaagccacca tgtatgagat gtactcagtg tcgtatgata
      481 tccgctgcac aagcttcaag gccttgttaa ggagtctgct gcggttcgca tcctatgctg
      541 cccaggtgac cggacagttc ctggtttatg cgggcgctta tgtgctccga gcactgggtg
      601 acacagaaga gcagccatcc cccaaggcta gcgccaaagg ctggttcatg taatcagatc
      661 acagatacag aggtccaggg acccagcttt cacgcaaatt ctctaccatc tgttacaggc
      721 tgtgggatgt cagaggaagg aacggggttt ggtggtggta cccagggcag gaccgagcag
      781 caggattccc gcaagagaaa ggaggcagat gggcctttca agagctttag gaagcgacta
      841 acagcagagt gtctgggaac atacgaatca gtctcttgca tattgtaata aaccaaacac
      901 aagactcgcc aaaaa
//
