LOCUS       NM_001372079            8268 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus capicua transcriptional repressor (Cic),
            transcript variant 1, mRNA.
ACCESSION   NM_001372079 XM_008758934
VERSION     NM_001372079.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8268)
  AUTHORS   Lu,H.C., Tan,Q., Rousseaux,M.W., Wang,W., Kim,J.Y., Richman,R.,
            Wan,Y.W., Yeh,S.Y., Patel,J.M., Liu,X., Lin,T., Lee,Y., Fryer,J.D.,
            Han,J., Chahrour,M., Finnell,R.H., Lei,Y., Zurita-Jimenez,M.E.,
            Ahimaz,P., Anyane-Yeboa,K., Van Maldergem,L., Lehalle,D.,
            Jean-Marcais,N., Mosca-Boidron,A.L., Thevenon,J., Cousin,M.A.,
            Bro,D.E., Lanpher,B.C., Klee,E.W., Alexander,N., Bainbridge,M.N.,
            Orr,H.T., Sillitoe,R.V., Ljungberg,M.C., Liu,Z., Schaaf,C.P. and
            Zoghbi,H.Y.
  TITLE     Disruption of the ATXN1-CIC complex causes a spectrum of
            neurobehavioral phenotypes in mice and humans
  JOURNAL   Nat Genet 49 (4), 527-536 (2017)
   PUBMED   28288114
REFERENCE   2  (bases 1 to 8268)
  AUTHORS   Lee,Y., Fryer,J.D., Kang,H., Crespo-Barreto,J., Bowman,A.B.,
            Gao,Y., Kahle,J.J., Hong,J.S., Kheradmand,F., Orr,H.T.,
            Finegold,M.J. and Zoghbi,H.Y.
  TITLE     ATXN1 protein family and CIC regulate extracellular matrix
            remodeling and lung alveolarization
  JOURNAL   Dev Cell 21 (4), 746-757 (2011)
   PUBMED   22014525
REFERENCE   3  (bases 1 to 8268)
  AUTHORS   Crespo-Barreto,J., Fryer,J.D., Shaw,C.A., Orr,H.T. and Zoghbi,H.Y.
  TITLE     Partial loss of ataxin-1 function contributes to transcriptional
            dysregulation in spinocerebellar ataxia type 1 pathogenesis
  JOURNAL   PLoS Genet 6 (7), e1001021 (2010)
   PUBMED   20628574
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8268)
  AUTHORS   Damiano,F., Gnoni,G.V. and Siculella,L.
  TITLE     Functional analysis of rat liver citrate carrier promoter:
            differential responsiveness to polyunsaturated fatty acids
  JOURNAL   Biochem J 417 (2), 561-571 (2009)
   PUBMED   18795892
  REMARK    GeneRIF: suggesting differential mechanisms in the Cic gene
            regulation by different polyunsaturated fatty acids
REFERENCE   5  (bases 1 to 8268)
  AUTHORS   Lim,J., Crespo-Barreto,J., Jafar-Nejad,P., Bowman,A.B., Richman,R.,
            Hill,D.E., Orr,H.T. and Zoghbi,H.Y.
  TITLE     Opposing effects of polyglutamine expansion on native protein
            complexes contribute to SCA1
  JOURNAL   Nature 452 (7188), 713-718 (2008)
   PUBMED   18337722
REFERENCE   6  (bases 1 to 8268)
  AUTHORS   Lee,C.J., Chan,W.I. and Scotting,P.J.
  TITLE     CIC, a gene involved in cerebellar development and ErbB signaling,
            is significantly expressed in medulloblastomas
  JOURNAL   J Neurooncol 73 (2), 101-108 (2005)
   PUBMED   15981098
  REMARK    GeneRIF: Expression analysis of the human and mouse Cic orthologs
            in tumor cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and AI029769.1.
            
            On Aug 7, 2019 this sequence version replaced XM_008758934.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000001.1  89981743-89981830
            89-2884             JAXUCZ010000001.1  89984873-89987668
            2885-3034           JAXUCZ010000001.1  89999068-89999217
            3035-3269           JAXUCZ010000001.1  89999300-89999534
            3270-3399           JAXUCZ010000001.1  89999629-89999758
            3400-3582           JAXUCZ010000001.1  89999855-90000037
            3583-3748           JAXUCZ010000001.1  90000116-90000281
            3749-3951           JAXUCZ010000001.1  90001006-90001208
            3952-4177           JAXUCZ010000001.1  90001301-90001526
            4178-4281           JAXUCZ010000001.1  90001941-90002044
            4282-5506           JAXUCZ010000001.1  90002317-90003541
            5507-5694           JAXUCZ010000001.1  90003628-90003815
            5695-5816           JAXUCZ010000001.1  90004835-90004956
            5817-5983           JAXUCZ010000001.1  90005057-90005223
            5984-6274           JAXUCZ010000001.1  90005309-90005599
            6275-6597           JAXUCZ010000001.1  90005704-90006026
            6598-6854           JAXUCZ010000001.1  90006274-90006530
            6855-7009           JAXUCZ010000001.1  90006629-90006783
            7010-7141           JAXUCZ010000001.1  90006861-90006992
            7142-7273           JAXUCZ010000001.1  90007173-90007304
            7274-8251           JAXUCZ010000001.1  90007379-90008356
            8252-8268           AI029769.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..8268
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..8268
                     /gene="Cic"
                     /note="capicua transcriptional repressor"
                     /db_xref="GeneID:308435"
                     /db_xref="RGD:1310706"
     exon            1..88
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            89..2884
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..7641
                     /gene="Cic"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein capicua homolog"
                     /codon_start=1
                     /product="protein capicua homolog isoform 1"
                     /protein_id="NP_001359008.1"
                     /db_xref="GeneID:308435"
                     /db_xref="RGD:1310706"
                     /translation="MKPMKKVCPGLAGSTSGSKSPPATRAKALRRRGAGEGDKPEEED
                     EQAQPQQQTGPEEAEEGEEAEAERDPGAEGSHPELQPNDLTAGLAEDPKGDGEAGRWE
                     PSLSRKTATFKSRAPKKKYVEEHGTGGLVGAPEERERTPEDASALGVPPQPPTSTRSS
                     STDTASEHSADLEDEPPEACGPGPWPSAGTSGGYDLRQLRSQRVLARRGDGLFLPAVV
                     RQVRRSQDLGVQFPGDRALTFYEGVPGGGVDVVLDATPPPGALMVGTAVCTCVEPGVA
                     AYREGVVVEVATKPAAYKVRLNPGPSSHAGSPGTLPQAQQPLHREPEEAIWVTRSSLR
                     LLRPPWEPEALLRKHPAGPEEEQAEPGATLPPCSSSLEPKQPEDAEVSNISFGSNLGT
                     HCEEGEERHPPALGTPVLLPLPPPQLLSPPPKSPAFGGPGRPSEQPSPCQEGSQGGSR
                     SSSVASLEKGAAPAARARTPLTAAQQKYKKGDVVCTPNGIRKKFNGKQWRRLCSRDGC
                     MKESQRRGYCSRHLSMRTKEMEGLADSGPGGAGRPAAVAAREGSTEFDWGDETSRDSE
                     ASSVAARGDSRPRLVAPADLSRFEFDECEAAVMLVSLGSSRSGTPSFSPVSTQSPFSP
                     APSPSPSPLFGFRPANFSPINASPVIQRTAVRSRHLSASTPKAGVLTPPDLGPHPPPP
                     APRERHSSGILPTFQTNLTFTVPISPGRRKTELLPHPGTLGASGAGGGGAAPDFPKSD
                     SLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPSPLLLLPPPAGLTSDPGPSVRR
                     VPAVQRDSPVIVRNPDVPLPSKFPGEVGAAGEARAGGPGRGCRETPVPPGVASGKPSL
                     PPPLPAPVPITVPPAAPTAVAQPMPTLGLASSPFQPVAFHPSPAALLPVLVPSSYPSH
                     PAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHPV
                     ASNQSKEPAESAAVAHEQPPGGTGGADPGRPPGATCPESPGPGPPLTLGGVDPGKSLP
                     PTTEEEAPGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSALPKERD
                     SSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYA
                     LGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPASLGLAGGHKETRER
                     SMSETGTAAAPGVSSELLSAAAQTLLSSDTKAPGSGPCGAERLHAVGGPGSARPRAFS
                     HSGVHSLDGGEVDSQALQELTQMVSGPTSFSGPKPSPQYGAPGSFAAPGEGGNLATSG
                     RPPLLPSRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDSFGTTDIDLKCKERVT
                     DSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPTLDPEPPGPPDPPAAFSKGYGP
                     TPSSSSSPASTSVSVSTSFSLGSGTFKTQESGQGSTAVPLRPPPPGAGGPTTPSKATR
                     FLPTDSATFRRKRPESVGSLEAPGSSVIAAPPSGGGNILQTLVLPPSKEDREGTRVPS
                     APAPSLAYGAPAAPLCRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASSNDTVGA
                     RTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLV
                     GTPGYGAPASPAVQFIAQGAPGSATPAGSGASAGSGPNGPVPLGILQPGALGKAGGIT
                     QVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATA
                     PTAGIPILQSVPSAPPPKAQSVSPVQATPSGGSAQLLPGKVLVPLAAPSMSVRGGGAG
                     QPLPLVSSPFSVPVQNGAQQPSKIIQLTPVPVSTPSGLVPPLSPATMPGPTSQPQKVL
                     LPSSTRITYVQSAGGHTLPLGTSSACSQTGTVTSYGPASSVALGFTSLGPSGPAFVQP
                     LLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQA
                     PPSLVYTVATSTTPPAAAILPKGPPASATATPAPTSPFPSATAGSMTYSLVAPKAQRP
                     SPKAPQKVKAAIASIPVGSFESGTTGRTGPTPRQSLDSGVAREPAAPESELEGQPTPP
                     APPPPTETWPPTARSSPPPPLPAEERPGTKGPETASKFPSSSSDWRVPGLGLESRGEP
                     PTPPSPAPAPATGPSGSSSGSSEGSSGRAAGDTPERKEVTSSGKKMKVRPPPLKKTFD
                     SVDNRVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNSTDLD
                     SAPEDPTSPKRKMRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTETEDVLGELEYEKVP
                     YSSLRRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQK
                     IMQAATPTEQPPGAEASLPGPPPTGMAATPVPTPSPAGGPDPTSPGSDSGTAQVAPPL
                     PPPPEPGPGQPGWEGAPQPSPPPSGPSTAATGR"
     exon            2885..3034
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3269
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3399
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3582
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            3583..3748
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..3951
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4177
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            4178..4281
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..5506
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            5507..5694
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            5695..5816
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            5817..5983
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            5984..6274
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            6275..6597
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            6598..6854
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            6855..7009
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            7010..7141
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            7142..7273
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
     exon            7274..8252
                     /gene="Cic"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcggttggct gctctttgca cctccccctc gtgccgcttc agccgccact gcgaggagcc
       61 actggcgacg ccagagccag gaatccgggt ggacagacga tgaagccaat gaagaaggtg
      121 tgccctggcc ttgcaggttc caccagtggc agcaagtccc caccagctac cagggccaag
      181 gctttgagac ggcgaggggc cggggagggt gacaagccag aggaggagga tgagcaggca
      241 cagccacagc agcagacagg gccagaagag gctgaagagg gtgaggaggc agaggctgag
      301 cgggaccctg gagctgaggg atcacatcca gagctgcagc ccaatgacct tactgcaggc
      361 ctagccgagg accctaaggg ggatggggag gcaggccgct gggagccctc actcagtcgc
      421 aagacagcca cattcaagtc tcgagcgccc aagaagaagt atgtggagga gcatggcact
      481 ggtggtttgg tcggagcccc tgaggagcgc gagcggaccc ctgaggacgc cagtgccctg
      541 ggtgtgcctc ctcagccacc cacctccact aggtcctcct ctactgacac agccagtgag
      601 cactcagccg acctggagga tgagccccct gaggcgtgtg gtccaggccc ctggccctct
      661 gctggcacta gtggaggcta tgacctgcgg cagctaaggt ctcagcgggt actggctcgg
      721 cgtggtgatg gcctcttcct gccggctgtc gtgcgccagg tgcgccgtag ccaggacttg
      781 ggtgtgcagt tccctgggga ccgagccttg actttctatg aaggagtacc aggtgggggt
      841 gtggatgtcg tgctggatgc cacaccacct ccaggtgccc tgatggtggg cacagctgtc
      901 tgcacttgtg tggagcctgg cgtggctgcc taccgagagg gtgtagtggt ggaggtggcc
      961 actaaaccag ctgcctataa ggtccgcctc aaccctggcc ccagctccca tgcaggctca
     1021 ccaggcactc tgccacaagc acaacagcca ctgcaccgtg agcccgagga ggccatctgg
     1081 gttacccgct ccagcctgcg cctgcttcgg cccccctggg aacctgaggc cttgctgagg
     1141 aagcaccctg caggcccaga ggaagagcag gctgagcctg gggccacttt gcctccttgc
     1201 tcttcttcct tggagcccaa acagcctgaa gatgctgagg tctccaacat cagctttggt
     1261 agcaacctgg ggactcactg tgaggagggt gaggagaggc acccaccagc cctgggcacc
     1321 ccagtcctgc tcccactgcc accaccccag ctcctgtcac cacccccaaa gtccccagcc
     1381 tttggtggcc ctggccgccc tagcgagcag ccttcaccct gccaggaagg gagccagggt
     1441 ggcagccgca gtagcagcgt ggcctcactg gagaagggag ctgcaccagc agcccgtgct
     1501 cgcacgccat tgactgcagc ccagcagaag tacaagaagg gcgacgtggt ttgcacaccc
     1561 aatggcatcc ggaagaagtt caacggcaag cagtggcgcc ggctgtgctc tcgggacggc
     1621 tgcatgaagg agtcccaacg gcgggggtac tgctcacgcc acctgtccat gagaaccaaa
     1681 gagatggagg gcctggcaga cagtgggcca ggcggggctg ggcggcctgc tgctgtggca
     1741 gcccgagaag gaagcactga gtttgactgg ggtgatgaga cttcgaggga cagtgaagcc
     1801 agcagtgtag cggcccgggg agactcccgc ccacgcctgg tggcgcctgc cgacctgtca
     1861 cgcttcgaat ttgatgagtg tgaggcggcg gtgatgttgg tgtcattggg cagctcccgc
     1921 tcaggcacac cctccttctc gccagtctcc acacagtcgc ccttctcccc ggccccctca
     1981 ccttcaccct caccgctctt cggcttccgc cctgccaact tcagccccat aaatgcctca
     2041 cctgtcatcc agcgcactgc tgttcgcagc cgccacctga gtgccagcac ccctaaagca
     2101 ggtgtgctga caccaccaga cctgggtccc catccaccgc cacctgcccc tcgtgagcgc
     2161 cattcctctg gcatcctacc caccttccag accaacctaa cctttactgt gcccattagc
     2221 cctgggcgga ggaagacaga actgctgccc caccctggga cattgggggc ctctggagca
     2281 ggaggtgggg gagccgcacc agacttcccc aagagtgaca gcttagactc cggagtggac
     2341 tcagtgtccc acacacctac cccctccaca ccggctggct tccgagctgt gtcacccgct
     2401 gtgcccttct ctcgctcccg ccagccttct ccattgctgc tgttgccccc acctgctgga
     2461 ctcacctcag atccagggcc ctctgtgcgg agggtacctg ctgtgcagcg ggactcacct
     2521 gtcattgtcc gcaaccctga tgtgccgctg ccctccaaat tccctggaga ggtgggcgct
     2581 gccggtgagg cacgggctgg ggggcctggg cggggttgcc gtgagacccc ggtcccccct
     2641 ggggtggcca gcgggaaacc cagcctgcct ccacctctgc ctgcccccgt gcccatcact
     2701 gtgcctccag ccgcaccgac tgctgtggcc cagccgatgc ccaccttggg cctggcttct
     2761 tcacccttcc agcccgtggc ctttcaccct tcacctgctg ccctgttgcc agttctagtg
     2821 cccagcagct atcccagcca ccctgccccc aagaaggaag tcatcatggg caggcccgga
     2881 acagtgtgga caaatgtcga acctcgttct gtggctgtgt tcccctggca ctccttagtc
     2941 cccttcctgg cacccagcca gcctgacccc tctgtgcagc ctagtgaggc ccagcaacct
     3001 gccagccacc ctgtggcctc caaccagagc aaagaacctg ctgagtcagc tgctgttgct
     3061 catgagcagc caccaggagg gacagggggt gctgaccctg ggcgaccccc tggagcaaca
     3121 tgccctgaga gcccagggcc tggacctcca ctcactttgg gtggtgtgga tcctggtaaa
     3181 agtctccctc ccaccactga ggaggaggct cctggccctc cgggagagcc ccggctggac
     3241 agtgagacag agagtgacca tgatgatgcc ttcctctcga tcatgtctcc tgagatccag
     3301 ctgcctctgc cacctggaaa gcgccgcacc cagtctctga gtgccttgcc caaggaacga
     3361 gactcatctt ctgagaagga tggacgaagc cctaacaagc gggagaagga ccatattcgt
     3421 cggcccatga atgccttcat gatcttcagc aagcggcacc gggccttggt ccaccagcgg
     3481 caccccaacc aggacaaccg gactgtcagc aagatcctgg gagagtggtg gtatgctctg
     3541 gggcccaagg agaagcagaa ataccacgat ctggccttcc aggtgaaaga ggcccacttc
     3601 aaggcccacc cagattggaa gtggtgcaac aaggaccgaa agaagtccag ctcagaggcc
     3661 aagcctgcga gcctgggtct ggcaggaggg cacaaggaga cgcgggaacg gagcatgtcg
     3721 gagacgggaa ctgctgctgc ccctggggtg tcttctgagc tcctgtccgc tgctgcccag
     3781 acgctcttga gctcggacac caaggctcca gggagtggcc cctgtggagc agaacggcta
     3841 catgcagttg ggggacctgg ctcagcccga cccagagcct tctcccacag tggggtacac
     3901 agtcttgatg gtggggaagt agacagccaa gcactgcaag aactgaccca gatggtttct
     3961 ggccccacct cattctccgg cccaaagcca tccccccagt atggcgctcc aggatctttt
     4021 gcagctcctg gtgaaggagg taacttggcc actagtgggc ggcctccact gttgccctct
     4081 cgagcctctc gttcccagcg tgcagctagt gaagacatga ccagtgatga ggagcggatg
     4141 gtcatctgtg aggaagaagg ggatgacgac gtcattgctg atgacagctt tggtaccact
     4201 gacattgatc tcaagtgtaa ggaacgggtg accgacagcg agagtggaga cagctctggg
     4261 gaggacccag agggcaacaa gggctttggc cgtaaggtgt tttcacctgt catccgctcc
     4321 tcctttaccc attgccgtcc aaccctggac cctgagcctc cagggccccc ggatccacct
     4381 gcagccttca gcaaaggcta tggtcccacc ccatcatcct cctcttcacc tgcttccacc
     4441 tcagtctcag tctccacctc cttttcactg ggctctggaa cctttaaaac gcaggagtct
     4501 ggtcagggca gcacagcggt gccactacgg cccccacctc ctggagctgg gggcccaaca
     4561 acaccttcca aggccactcg gtttcttcct acggattctg ccacctttcg gcgcaagaga
     4621 cctgaaagtg ttggtagcct ggaggcacca ggctcttcag tcattgcagc acctcccagt
     4681 gggggaggaa acattctgca gacactggtt ctgcctccga gtaaggagga tcgagagggt
     4741 acacgagtgc cctcagcccc agccccatca ctggcctatg gggctccagc agcccctttg
     4801 tgccgccctg ctgctaccat ggtcaccaat gtggtacggc ctgtcagcag cactccagtg
     4861 cccattgcct ctaagccctt tcccacctct ggccgggctg aggcatcttc aaatgacaca
     4921 gtaggtgcca ggactgaaat gggcactgga tctcgggtgc ctgggggctc cccattgggt
     4981 gtcagtttag tgtattcaga taagaagtca gcagcagcca cctcaccagc tccacatttg
     5041 gtagctggac ccctattggg cactgtgggg aaggcacctg ctactgtcac caacctactg
     5101 gtgggcaccc caggctatgg ggctcctgca tcgcctgctg ttcagtttat tgcccaggga
     5161 gccccaggca gtgcaacccc tgcaggctca ggagcaagtg ctgggagtgg ccccaatggg
     5221 cctgtacctc tgggcattct gcagccaggt gccctaggca aggctggggg aatcacacag
     5281 gtgcagtaca tcctgcccac actgccccaa cagcttcaag tggcacctgc cccagcacca
     5341 gcccctggga ccaaggcagc agctcccagt ggccctgcac ccaccaccag catccgtttc
     5401 actctccctc cgggcacctc gaccaacggc aaggtcctgg ctgccactgc gcccactgct
     5461 ggcatcccta tcctgcagtc cgtaccctca gccccacccc ctaaagccca gtcagtttct
     5521 cctgtccagg ccacaccttc aggtggctca gcccagctgc tgcctgggaa ggtgctagtc
     5581 cccctggctg cccctagcat gtcagttcga ggtggagggg ctggtcagcc actgcccctg
     5641 gttagctcgc ctttctcagt acctgtccaa aatggtgccc aacaacctag caagattatc
     5701 cagctgactc ctgttcctgt gagcacacct agtggcctgg taccacccct gagcccagcc
     5761 acaatgccag gacccacatc acagcctcag aaggtcctgt tgccttcttc cacaagaatc
     5821 acctatgtac agtcagcagg tgggcatact ctgcctctag gcaccagttc tgcatgcagt
     5881 cagactggaa cagtgacctc atatgggccc gccagctctg tagctctggg cttcacatcg
     5941 ttggggccca gtggtcctgc ctttgttcag ccactgctct cagcaggcca agctccattg
     6001 ctggctcctg gccaggtggg cgtgtcacct gtgcctagcc cccagttgcc tcctgcctgt
     6061 acagcccctg gaggtcctgt cataacagca ttttaccctg gtagccctgc acccacttca
     6121 gcacccctgg gcccaccttc ccaagctccg ccaagcctgg tctacactgt agccaccagc
     6181 accaccccac ctgctgctgc cattcttcct aagggcccac cagcctctgc cactgccact
     6241 ccagccccta ccagtccttt ccctagtgcc acagcaggct ccatgaccta cagcttagtg
     6301 gctcccaagg cccagcgacc cagcccaaaa gccccccaga aagtaaaggc agccatcgcc
     6361 agcattcctg tggggtcttt tgaatcgggt accactgggc ggactggacc tacaccccga
     6421 cagtctttgg attctggtgt agcccgagag ccagctgccc cagaatcaga gcttgagggg
     6481 cagcccacac ccccagcccc cccaccccca acagagacct ggcctcccac tgcccggagc
     6541 agccccccac cccccctgcc tgctgaggaa cgacctggca ctaaaggccc cgagactgcc
     6601 agcaaattcc ccagttcatc ttcagactgg cgggttcctg ggctgggcct ggagagtcgt
     6661 ggggagcctc ccactcctcc cagcccagct ccagctccag ccacaggccc tagtggaagc
     6721 agcagtggca gcagtgaggg cagtagtggg agggcagctg gggacacacc tgagcgcaag
     6781 gaagtgacta gttccggcaa gaagatgaag gtgcggcccc cgcccctgaa gaagaccttt
     6841 gactctgtgg acaacagggt cctgtcagaa gtggactttg aagagcggtt tgctgagctg
     6901 cccgagttta gaccagagga ggtgctgccc tcacccaccc tacagtctct ggccacctct
     6961 cctcgggcta tccttggctc ctaccgaaag aagaggaaga attccacgga cctggactcg
     7021 gcgcctgagg atcccacttc acccaagcgt aagatgagga gacgttcgag ctgcagctca
     7081 gagcccaaca ccccaaagag tgccaagtgc gagggggaca tcttcacctt cgaccgcaca
     7141 ggtactgaaa cggaggatgt gcttggggag ctggagtatg agaaggtgcc ctactcatca
     7201 ctgcggcgca ccctggacca acggcgggcc ctggtcatgc agctcttcca ggaccatggc
     7261 ttcttcccct cggcccaggc cacagcagcc ttccaggccc gctacgcaga catctttcca
     7321 tccaaggtgt gtctgcaatt aaagatccga gaagtccgcc agaagatcat gcaggcagcc
     7381 actcccacag agcagccccc tggggctgaa gcctccctcc ctggaccacc ccctactggc
     7441 atggctgcta ctcctgtccc cactcccagc cctgctgggg gccctgaccc cacctctcca
     7501 ggctcggact ctggcactgc ccaagttgcc ccgccactgc ctccaccccc cgagcctggg
     7561 cctggacagc ctggctggga gggggctccc caaccttctc cccctccctc tggcccttcc
     7621 acagctgcca caggcaggtg aggggccctt gaatagaccc caggacccac agtacctacc
     7681 ccctcaggat atggacagta tatagatggc aggaattggg ggccagacag tgggatagtt
     7741 gcctcctctc caggaagcca tttcgtcctt tccagtttgg tgcggaatgt ggcctgtttc
     7801 ccttgtatat atccctccct gtgctggagg gcagcagggg cagataccct ccactgagct
     7861 cttgtatata taacctgaag tgtgtgacct tcagagcttt tcacttgtac tttatgcaga
     7921 atggctcctg tgagggctgc aagctggagg gtagtatgag ccttgggcca cagggagaag
     7981 atgcctgtgg agtagtgggg agttcatgca cccccctttt tccccagagg ggctggactc
     8041 aggttagttt ggggtggggg ggctcctgca ctttgccaca ggcatgggga ggattctccc
     8101 caccctctgc cctcccaact tgggttgtac tttctaagaa ggtgattccc ctaccattgt
     8161 ccccattccc agaacaaaac atgttgatca tgtgcaatat ttcttactgt gccgagaagc
     8221 cgcaatgacc gagattaaag ctgtttaaca caaaaaaaaa aaaaaaaa
//
