LOCUS       NM_001015010            1433 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus calcium and integrin binding family member 2
            (Cib2), mRNA.
ACCESSION   NM_001015010 XM_217165
VERSION     NM_001015010.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1433)
  AUTHORS   Seco,C.Z., Giese,A.P., Shafique,S., Schraders,M., Oonk,A.M.,
            Grossheim,M., Oostrik,J., Strom,T., Hegde,R., van Wijk,E.,
            Frolenkov,G.I., Azam,M., Yntema,H.G., Free,R.H., Riazuddin,S.,
            Verheij,J.B., Admiraal,R.J., Qamar,R., Ahmed,Z.M. and Kremer,H.
  TITLE     Novel and recurrent CIB2 variants, associated with nonsyndromic
            deafness, do not affect calcium buffering and localization in hair
            cells
  JOURNAL   Eur J Hum Genet 24 (4), 542-549 (2016)
   PUBMED   26173970
REFERENCE   2  (bases 1 to 1433)
  AUTHORS   Patel,K., Giese,A.P., Grossheim,J.M., Hegde,R.S., Delio,M.,
            Samanich,J., Riazuddin,S., Frolenkov,G.I., Cai,J., Ahmed,Z.M. and
            Morrow,B.E.
  TITLE     A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2)
            Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic
            Family
  JOURNAL   PLoS One 10 (10), e0133082 (2015)
   PUBMED   26426422
  REMARK    Erratum:[PLoS One. 2015 Oct 16;10(10):e0141259. doi:
            10.1371/journal.pone.0141259.. Hegde, Rashima S [corrected to
            Hegde, Rashmi S]. PMID: 26473954]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1433)
  AUTHORS   Riazuddin,S., Belyantseva,I.A., Giese,A.P., Lee,K.,
            Indzhykulian,A.A., Nandamuri,S.P., Yousaf,R., Sinha,G.P., Lee,S.,
            Terrell,D., Hegde,R.S., Ali,R.A., Anwar,S., Andrade-Elizondo,P.B.,
            Sirmaci,A., Parise,L.V., Basit,S., Wali,A., Ayub,M., Ansar,M.,
            Ahmad,W., Khan,S.N., Akram,J., Tekin,M., Riazuddin,S., Cook,T.,
            Buschbeck,E.K., Frolenkov,G.I., Leal,S.M., Friedman,T.B. and
            Ahmed,Z.M.
  TITLE     Alterations of the CIB2 calcium- and integrin-binding protein cause
            Usher syndrome type 1J and nonsyndromic deafness DFNB48
  JOURNAL   Nat Genet 44 (11), 1265-1271 (2012)
   PUBMED   23023331
REFERENCE   4  (bases 1 to 1433)
  AUTHORS   Huang,H., Bogstie,J.N. and Vogel,H.J.
  TITLE     Biophysical and structural studies of the human calcium- and
            integrin-binding protein family: understanding their functional
            similarities and differences
  JOURNAL   Biochem Cell Biol 90 (5), 646-656 (2012)
   PUBMED   22779914
REFERENCE   5  (bases 1 to 1433)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   6  (bases 1 to 1433)
  AUTHORS   Blazejczyk,M., Sobczak,A., Debowska,K., Wisniewska,M.B.,
            Kirilenko,A., Pikula,S., Jaworski,J., Kuznicki,J. and Wojda,U.
  TITLE     Biochemical characterization and expression analysis of a novel
            EF-hand Ca2+ binding protein calmyrin2 (Cib2) in brain indicates
            its function in NMDA receptor mediated Ca2+ signaling
  JOURNAL   Arch Biochem Biophys 487 (1), 66-78 (2009)
   PUBMED   19433056
  REMARK    GeneRIF: CaMy2 binds Ca2+ and exhibits Ca2+/conformational switch.
            Moreover, CaMy2 undergoes N-myristoylation without Ca2+/myristoyl
            switch, is membrane-associated and localizes in neurons together
            with Golgi apparatus and dendrite markers.
REFERENCE   7  (bases 1 to 1433)
  AUTHORS   Hager,M., Bigotti,M.G., Meszaros,R., Carmignac,V., Holmberg,J.,
            Allamand,V., Akerlund,M., Kalamajski,S., Brancaccio,A., Mayer,U.
            and Durbeej,M.
  TITLE     Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2
            chain-deficient muscular dystrophy
  JOURNAL   J Biol Chem 283 (36), 24760-24769 (2008)
   PUBMED   18611855
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092630.1.
            
            On Apr 20, 2005 this sequence version replaced XM_217165.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092630.1, CO394498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984043 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1433
                     /gene="Cib2"
                     /note="calcium and integrin binding family member 2"
                     /db_xref="GeneID:300719"
                     /db_xref="RGD:1308718"
     exon            1..230
                     /gene="Cib2"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..743
                     /gene="Cib2"
                     /codon_start=1
                     /product="calcium and integrin-binding family member 2"
                     /protein_id="NP_001015010.1"
                     /db_xref="GeneID:300719"
                     /db_xref="RGD:1308718"
                     /translation="MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHARFYELAPNLVPM
                     DYRKSPIVHVPMSLIIQMPELRENPFKERIVEAFSEDGEGNLTFNDFVDMFSVLCESA
                     PRELKANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEDEVVLVCDKVIEEADLDG
                     DGKLGFADFEDMIAKAPDFLSTFHIRI"
     exon            231..265
                     /gene="Cib2"
                     /inference="alignment:Splign:2.1.0"
     exon            266..377
                     /gene="Cib2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..525
                     /gene="Cib2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..721
                     /gene="Cib2"
                     /inference="alignment:Splign:2.1.0"
     exon            722..1408
                     /gene="Cib2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctcccact gaactgcagg accaagcgga gcgggcaagc ctaggctggc gacgctgccc
       61 gctcccgggc ttgcaagggc cgcgggcgcg gggctcgggg ctccagaagc cgccgatggg
      121 aagcagcaat cgaaagggcg agagacgccg ccgcggccat ccataccacc gcggttacca
      181 tggggaataa gcagaccatc ttcacagaag agcagctgga caactaccag gactgcactt
      241 tcttcaataa gaaggacatc ctcaagcttc atgcacggtt ctatgagctg gctcccaacc
      301 tcgtcccgat ggactacagg aagagcccca tcgtccacgt gcccatgagc ctcatcattc
      361 agatgccgga gctccgggag aatcctttca aggagaggat tgtggaggct ttctctgagg
      421 acggtgaggg gaacctcacc ttcaatgact ttgtggacat gttctctgtg ctctgtgagt
      481 cggcgcctcg ggagctcaag gcgaactatg ccttcaagat ctatgacttc aacactgaca
      541 atttcatctg taaagaagac ttagagctga cactggccag acttactaag tcagagctgg
      601 atgaagatga ggtagtgctt gtgtgtgaca aagtcattga agaagctgac ctggacggtg
      661 atggcaagct aggctttgcc gactttgagg acatgatcgc caaggcccct gactttctca
      721 gcactttcca catccgaatc tgaggacact gccaaggctg tggggccccg gactccgtcc
      781 tctggcctgc tgtctacgca ggtatggttt tcaagtgctc cagggaagga gctgtggcct
      841 ttggggttct cacccgtgga catttcctgt ggccctttca gcaaaaaata atcaattaat
      901 aaattaaaaa taaaaatgaa tagaaaacct aactgcaatg gggttgtgaa gagcaggacc
      961 cttctccagg cctccagtgt ctaccctcaa gacctgcatt tcccctgcag gccctctcac
     1021 ccaccccctt gcccagttct tttctcacct gggaggggaa ggtagaaaaa ccttgcagga
     1081 gaggtaaggc tgaattatct gtgtgctggg caggcactcc agtcacccag gggtaagtgc
     1141 aaaaaccaaa caaacaaaga aacaaaggaa acagagcctg gggttctatg caatctttta
     1201 ccaaagccaa ggctgggctg tacccacctc caaccccatg ctttcccaat gtgaagttgt
     1261 atacgaagtt aggtccaaag ggctctgccc ccatgtcacg aacactactc caccccaccc
     1321 caccccatcc ccgatgacgt ggtatcactg atgtgtgctg acctcagatt tgtgaattcc
     1381 tagaaataaa gcacttttgt gtcctgcaaa aaaaaaaaaa aaaaaaaaaa aaa
//
