LOCUS       NM_001013183            2045 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cytosolic iron-sulfur assembly component 3
            (Ciao3), mRNA.
ACCESSION   NM_001013183 XM_340770
VERSION     NM_001013183.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2045)
  AUTHORS   Paul,V.D. and Lill,R.
  TITLE     Biogenesis of cytosolic and nuclear iron-sulfur proteins and their
            role in genome stability
  JOURNAL   Biochim Biophys Acta 1853 (6), 1528-1539 (2015)
   PUBMED   25583461
  REMARK    Review article
REFERENCE   2  (bases 1 to 2045)
  AUTHORS   Maio,N. and Rouault,T.A.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   3  (bases 1 to 2045)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   4  (bases 1 to 2045)
  AUTHORS   Seki,M., Takeda,Y., Iwai,K. and Tanaka,K.
  TITLE     IOP1 protein is an external component of the human cytosolic
            iron-sulfur cluster assembly (CIA) machinery and functions in the
            MMS19 protein-dependent CIA pathway
  JOURNAL   J Biol Chem 288 (23), 16680-16689 (2013)
   PUBMED   23585563
REFERENCE   5  (bases 1 to 2045)
  AUTHORS   Stehling,O., Vashisht,A.A., Mascarenhas,J., Jonsson,Z.O.,
            Sharma,T., Netz,D.J., Pierik,A.J., Wohlschlegel,J.A. and Lill,R.
  TITLE     MMS19 assembles iron-sulfur proteins required for DNA metabolism
            and genomic integrity
  JOURNAL   Science 337 (6091), 195-199 (2012)
   PUBMED   22678362
REFERENCE   6  (bases 1 to 2045)
  AUTHORS   Gari,K., Leon Ortiz,A.M., Borel,V., Flynn,H., Skehel,J.M. and
            Boulton,S.J.
  TITLE     MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA
            metabolism
  JOURNAL   Science 337 (6091), 243-245 (2012)
   PUBMED   22678361
REFERENCE   7  (bases 1 to 2045)
  AUTHORS   Song,D. and Lee,F.S.
  TITLE     Mouse knock-out of IOP1 protein reveals its essential role in
            mammalian cytosolic iron-sulfur protein biogenesis
  JOURNAL   J Biol Chem 286 (18), 15797-15805 (2011)
   PUBMED   21367862
REFERENCE   8  (bases 1 to 2045)
  AUTHORS   Song,D. and Lee,F.S.
  TITLE     A role for IOP1 in mammalian cytosolic iron-sulfur protein
            biogenesis
  JOURNAL   J Biol Chem 283 (14), 9231-9238 (2008)
   PUBMED   18270200
REFERENCE   9  (bases 1 to 2045)
  AUTHORS   Huang,J., Song,D., Flores,A., Zhao,Q., Mooney,S.M., Shaw,L.M. and
            Lee,F.S.
  TITLE     IOP1, a novel hydrogenase-like protein that modulates
            hypoxia-inducible factor-1alpha activity
  JOURNAL   Biochem J 401 (1), 341-352 (2007)
   PUBMED   16956324
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091240.1.
            
            On Apr 20, 2005 this sequence version replaced XM_340770.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091240.1, SRR8487227.123584.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2045
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2045
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /note="cytosolic iron-sulfur assembly component 3"
                     /db_xref="GeneID:360496"
                     /db_xref="RGD:1305982"
     CDS             1..1431
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /note="cytosolic Fe-S cluster assembly factor NARFL; IOP1;
                     iron-only hydrogenase-like protein 1; nuclear prelamin A
                     recognition factor-like protein"
                     /codon_start=1
                     /product="cytosolic iron-sulfur assembly component 3"
                     /protein_id="NP_001013201.1"
                     /db_xref="GeneID:360496"
                     /db_xref="RGD:1305982"
                     /translation="MASPFSGALQLTDLDDFIGPSQSCIKPVTVAKKPGSGIAKIHIE
                     DDGSYFQVNPDGRSQKLEKAKVSLNDCLACSGCVTSAETILITQQSHEELRKVLDANK
                     VAAPGQQRLVVVSVSPQSRASLAARFQLDSTDTARKLTSFFKKIGVHFVFDTAFARNF
                     SLLESQKEFVQRFREQANSREALPMLASACPGWICYAEKTHGNFILPYISTARSPQQV
                     MGSLIKDFFAQQQLLTPDKIYHVTVMPCYDKKLEASRPDFFNQEYQTRDVDCVLTTGE
                     VFRLLEEEGVSLSELEPVPLDGLTRSVSAEEPTSHRGGGSGGYLEHVFRHAAQELFGI
                     HVADVTYQPMRNKDFQEVTLEREGQVLLRFAVAYGFRNIQNLVQKLKRGRCPYHYVEV
                     MACPSGCLNGGGQLKAPDTEGRELLQQVERLYSMVRTEAPEDAPGVQELYQHWLQGED
                     SERASHLLHTQYHAVEKINSGLSIRW"
     exon            1..66
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /inference="alignment:Splign:2.1.0"
     exon            67..162
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /inference="alignment:Splign:2.1.0"
     exon            163..306
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /inference="alignment:Splign:2.1.0"
     exon            307..439
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /inference="alignment:Splign:2.1.0"
     exon            440..574
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /inference="alignment:Splign:2.1.0"
     exon            575..693
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /inference="alignment:Splign:2.1.0"
     exon            694..823
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /inference="alignment:Splign:2.1.0"
     exon            824..896
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1034
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1192
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1985
                     /gene="Ciao3"
                     /gene_synonym="Narfl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgtcgc ccttcagtgg ggcactacag ctgaccgacc tggatgactt catcgggccg
       61 tctcagagtt gcatcaagcc ggtgacggtg gctaagaagc ctggaagtgg gatagccaag
      121 atccacatcg aagatgatgg cagttacttc caagtgaacc cagatggaag aagccagaag
      181 ctggagaagg ccaaggtctc cctgaacgac tgcctggcct gcagtggctg tgtcacttca
      241 gcagagacga tactcatcac ccagcagagt cacgaggaac tgcggaaggt tctagatgct
      301 aataaggtgg cagcaccggg tcagcagcgg ctcgtggtcg tgtccgtctc accgcagtct
      361 agagcgtcac tggctgccag gtttcagcta gactccacag acaccgccag gaaattaact
      421 tcattcttca aaaaaatagg ggtgcacttc gtcttcgata ctgccttcgc aaggaacttc
      481 agccttttgg agagccagaa agagtttgtg cagcgattcc gagaacaagc caactccaga
      541 gaggccttgc ccatgctggc ttccgcctgc ccaggctgga tctgctatgc tgagaagact
      601 catggcaact tcattctccc ctacatcagt acagcccgat ccccacagca ggttatgggc
      661 tccctgatca aagacttctt tgcacagcaa cagctcctga ctcctgacaa gatctaccac
      721 gtaactgtga tgccctgcta tgacaaaaaa ctagaagcat ccagacctga cttcttcaac
      781 caggagtacc agacccgtga cgtggactgt gtccttacaa caggagaagt cttcagactg
      841 ctggaggaag aaggagtctc cctctcagag ctggagcctg tgcccctgga tggcttaacc
      901 aggagtgtgt ctgctgagga gcccaccagc catcggggcg gaggctcagg agggtacctg
      961 gagcacgtgt tccggcacgc agcccaagag ctgtttggaa tccatgtggc tgacgtcacc
     1021 taccaaccca tgaggaacaa ggacttccag gaagtgacac tggagaggga aggccaggtg
     1081 ctgttgcgct ttgctgtggc ctatggcttc cgcaacatcc agaacctcgt gcagaagtta
     1141 aaacgaggcc gctgtcccta ccattacgtg gaagtaatgg cctgcccttc aggctgcttg
     1201 aatggagggg gtcagctcaa ggctccagat acggaaggca gggagctcct ccagcaagtg
     1261 gaaagactgt acagcatggt gaggaccgag gcgcccgaag atgcccctgg ggtccaggag
     1321 ctgtaccagc attggctgca aggcgaggac tcagagcggg ccagccacct gctgcacacg
     1381 cagtaccatg ctgtggagaa gatcaactca ggcctcagca tcaggtggta ggaggccctg
     1441 agtctgtgag agccctgggg gcagcaccaa ggctcccagg aagactgtgt gggtatccgc
     1501 cacaaggccc acgcagaaca tgccagaggt cctcagttca aggagagctc catggacggt
     1561 tggattcttt gctccagtgg ggcactagct gcacatgggt ccttgaccat acatgatctg
     1621 tgtctctggc tggtaatgtt gcctgcagcc cacacacctc cagggtccac actgagatat
     1681 gcaaggtgaa gtgcaggcag gatcagagat acccaagtag gttcaatgag actccagact
     1741 cttcctctgg cctgccttcc ggctgtaggt gtctgagtat aaggggtttc atttctgtgg
     1801 ctcaccccca aaactacaac gtgtagggca gatatcaagc ctgaacctag tggggcacac
     1861 aatcttctac aaactgcctg tttgctaggg tcttgggctc tggcagtctg tcagctccca
     1921 gcctctatgg ctttgagaac gtcagagctg ggtctcacca ctaataaaca ggtctgcacc
     1981 tctgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaa
//
