LOCUS       NM_001144854             693 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cytosolic iron-sulfur assembly component 2B
            (Ciao2b), mRNA.
ACCESSION   NM_001144854 XM_001058416
VERSION     NM_001144854.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 693)
  AUTHORS   Paul,V.D. and Lill,R.
  TITLE     Biogenesis of cytosolic and nuclear iron-sulfur proteins and their
            role in genome stability
  JOURNAL   Biochim Biophys Acta 1853 (6), 1528-1539 (2015)
   PUBMED   25583461
  REMARK    Review article
REFERENCE   2  (bases 1 to 693)
  AUTHORS   Maio,N. and Rouault,T.A.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   3  (bases 1 to 693)
  AUTHORS   Stehling,O., Mascarenhas,J., Vashisht,A.A., Sheftel,A.D.,
            Niggemeyer,B., Rosser,R., Pierik,A.J., Wohlschlegel,J.A. and
            Lill,R.
  TITLE     Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and
            maturation of different subsets of cytosolic-nuclear iron-sulfur
            proteins
  JOURNAL   Cell Metab 18 (2), 187-198 (2013)
   PUBMED   23891004
  REMARK    Erratum:[Cell Metab. 2018 Jan 9;27(1):263. PMID: 29320706]
REFERENCE   4  (bases 1 to 693)
  AUTHORS   Seki,M., Takeda,Y., Iwai,K. and Tanaka,K.
  TITLE     IOP1 protein is an external component of the human cytosolic
            iron-sulfur cluster assembly (CIA) machinery and functions in the
            MMS19 protein-dependent CIA pathway
  JOURNAL   J Biol Chem 288 (23), 16680-16689 (2013)
   PUBMED   23585563
REFERENCE   5  (bases 1 to 693)
  AUTHORS   Stehling,O., Vashisht,A.A., Mascarenhas,J., Jonsson,Z.O.,
            Sharma,T., Netz,D.J., Pierik,A.J., Wohlschlegel,J.A. and Lill,R.
  TITLE     MMS19 assembles iron-sulfur proteins required for DNA metabolism
            and genomic integrity
  JOURNAL   Science 337 (6091), 195-199 (2012)
   PUBMED   22678362
REFERENCE   6  (bases 1 to 693)
  AUTHORS   Gari,K., Leon Ortiz,A.M., Borel,V., Flynn,H., Skehel,J.M. and
            Boulton,S.J.
  TITLE     MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA
            metabolism
  JOURNAL   Science 337 (6091), 243-245 (2012)
   PUBMED   22678361
REFERENCE   7  (bases 1 to 693)
  AUTHORS   Ito,S., Tan,L.J., Andoh,D., Narita,T., Seki,M., Hirano,Y.,
            Narita,K., Kuraoka,I., Hiraoka,Y. and Tanaka,K.
  TITLE     MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in
            chromosome segregation
  JOURNAL   Mol Cell 39 (4), 632-640 (2010)
   PUBMED   20797633
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000019.1.
            
            On Jan 26, 2009 this sequence version replaced XM_001058416.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB324704.1, CK845451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               JAXUCZ010000019.1  350653-350838
            187-266             JAXUCZ010000019.1  350996-351075
            267-392             JAXUCZ010000019.1  351317-351442
            393-438             JAXUCZ010000019.1  351820-351865
            439-693             JAXUCZ010000019.1  352264-352518
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p14"
     gene            1..693
                     /gene="Ciao2b"
                     /gene_synonym="Fam96b; RGD1311762"
                     /note="cytosolic iron-sulfur assembly component 2B"
                     /db_xref="GeneID:680987"
                     /db_xref="RGD:1585802"
     exon            1..186
                     /gene="Ciao2b"
                     /gene_synonym="Fam96b; RGD1311762"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..536
                     /gene="Ciao2b"
                     /gene_synonym="Fam96b; RGD1311762"
                     /note="mitotic spindle-associated MMXD complex subunit
                     MIP18; family with sequence similarity 96, member B"
                     /codon_start=1
                     /product="cytosolic iron-sulfur assembly component 2B"
                     /protein_id="NP_001138326.1"
                     /db_xref="GeneID:680987"
                     /db_xref="RGD:1585802"
                     /translation="MVGGGGGGGGGGLLENANPLIYERSGERPVTAGEEDEEVPDSID
                     AREIFDLIRSINDPEHPLTLEELNVVEQVRIQVSDPESTVAVAFTPTIPHCSMATLIG
                     LSIKVKLLRSLPQRFKMDVHITPGTHASEHAVNKQLADKERVAAALENTHLLEVVNQC
                     LSARS"
     exon            187..266
                     /gene="Ciao2b"
                     /gene_synonym="Fam96b; RGD1311762"
                     /inference="alignment:Splign:2.1.0"
     exon            267..392
                     /gene="Ciao2b"
                     /gene_synonym="Fam96b; RGD1311762"
                     /inference="alignment:Splign:2.1.0"
     exon            393..438
                     /gene="Ciao2b"
                     /gene_synonym="Fam96b; RGD1311762"
                     /inference="alignment:Splign:2.1.0"
     exon            439..693
                     /gene="Ciao2b"
                     /gene_synonym="Fam96b; RGD1311762"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacaccacc agggggttgt gggaactgcg gttccgggat ggtgggcggt ggtggcggcg
       61 gcggcggcgg cgggctccta gagaatgcta accccctcat ctatgagcga tcgggggagc
      121 ggccggtgac ggcgggtgaa gaagatgagg aagtgccgga cagcatcgat gcccgggaga
      181 tcttcgatct tattcgctcc attaatgacc cggagcatcc actgacactg gaggaattga
      241 acgtagtaga gcaggttcga attcaggtta gcgacccgga gagcacagta gcagtggcct
      301 tcacacccac catccctcac tgcagcatgg ccacacttat aggcctttct atcaaagtca
      361 agcttctgcg atcccttccc cagcggttca agatggatgt gcacattacg ccgggcaccc
      421 acgcctcaga gcatgcagtg aacaaacaac ttgcagataa ggagcgagtg gcagctgccc
      481 tggagaatac ccacctgcta gaggtcgtta atcagtgtct gtctgcccgc tcatgagcct
      541 ggcttttgac caccagcctg cacacagagg tcctggcttc ggctccacaa aaggcttctg
      601 gctttgtttt cttgaatcac tgacaaggag aaacttaaca ctttttattt tgtaataaac
      661 ccttaattta tattcatttc ccagcatgcc tta
//
