LOCUS       NM_001008766            1458 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus cytosolic iron-sulfur assembly component 1
            (Ciao1), mRNA.
ACCESSION   NM_001008766 XM_215837
VERSION     NM_001008766.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1458)
  AUTHORS   Paul,V.D. and Lill,R.
  TITLE     Biogenesis of cytosolic and nuclear iron-sulfur proteins and their
            role in genome stability
  JOURNAL   Biochim Biophys Acta 1853 (6), 1528-1539 (2015)
   PUBMED   25583461
  REMARK    Review article
REFERENCE   2  (bases 1 to 1458)
  AUTHORS   Maio,N. and Rouault,T.A.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   3  (bases 1 to 1458)
  AUTHORS   Stehling,O., Mascarenhas,J., Vashisht,A.A., Sheftel,A.D.,
            Niggemeyer,B., Rosser,R., Pierik,A.J., Wohlschlegel,J.A. and
            Lill,R.
  TITLE     Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and
            maturation of different subsets of cytosolic-nuclear iron-sulfur
            proteins
  JOURNAL   Cell Metab 18 (2), 187-198 (2013)
   PUBMED   23891004
  REMARK    Erratum:[Cell Metab. 2018 Jan 9;27(1):263. doi:
            10.1016/j.cmet.2017.12.009.. PMID: 29320706]
REFERENCE   4  (bases 1 to 1458)
  AUTHORS   Seki,M., Takeda,Y., Iwai,K. and Tanaka,K.
  TITLE     IOP1 protein is an external component of the human cytosolic
            iron-sulfur cluster assembly (CIA) machinery and functions in the
            MMS19 protein-dependent CIA pathway
  JOURNAL   J Biol Chem 288 (23), 16680-16689 (2013)
   PUBMED   23585563
REFERENCE   5  (bases 1 to 1458)
  AUTHORS   Stehling,O., Vashisht,A.A., Mascarenhas,J., Jonsson,Z.O.,
            Sharma,T., Netz,D.J., Pierik,A.J., Wohlschlegel,J.A. and Lill,R.
  TITLE     MMS19 assembles iron-sulfur proteins required for DNA metabolism
            and genomic integrity
  JOURNAL   Science 337 (6091), 195-199 (2012)
   PUBMED   22678362
REFERENCE   6  (bases 1 to 1458)
  AUTHORS   Gari,K., Leon Ortiz,A.M., Borel,V., Flynn,H., Skehel,J.M. and
            Boulton,S.J.
  TITLE     MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA
            metabolism
  JOURNAL   Science 337 (6091), 243-245 (2012)
   PUBMED   22678361
REFERENCE   7  (bases 1 to 1458)
  AUTHORS   Ito,S., Tan,L.J., Andoh,D., Narita,T., Seki,M., Hirano,Y.,
            Narita,K., Kuraoka,I., Hiraoka,Y. and Tanaka,K.
  TITLE     MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in
            chromosome segregation
  JOURNAL   Mol Cell 39 (4), 632-640 (2010)
   PUBMED   20797633
REFERENCE   8  (bases 1 to 1458)
  AUTHORS   Srinivasan,V., Netz,D.J., Webert,H., Mascarenhas,J., Pierik,A.J.,
            Michel,H. and Lill,R.
  TITLE     Structure of the yeast WD40 domain protein Cia1, a component acting
            late in iron-sulfur protein biogenesis
  JOURNAL   Structure 15 (10), 1246-1257 (2007)
   PUBMED   17937914
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088474.1.
            
            On Jan 1, 2005 this sequence version replaced XM_215837.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088474.1, FQ231672.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1458
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1458
                     /gene="Ciao1"
                     /gene_synonym="Wdr39"
                     /note="cytosolic iron-sulfur assembly component 1"
                     /db_xref="GeneID:29231"
                     /db_xref="RGD:1307285"
     exon            1..214
                     /gene="Ciao1"
                     /gene_synonym="Wdr39"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1095
                     /gene="Ciao1"
                     /gene_synonym="Wdr39"
                     /note="WD repeat domain 39; WD40 protein Ciao1; WD
                     repeat-containing protein 39; cytosolic iron-sulfur
                     protein assembly 1"
                     /codon_start=1
                     /product="probable cytosolic iron-sulfur protein assembly
                     protein CIAO1"
                     /protein_id="NP_001008766.1"
                     /db_xref="GeneID:29231"
                     /db_xref="RGD:1307285"
                     /translation="MKDALVLQSRVPAHPDSRCWFLAWNPTGTLLASCGGDRKIRIWG
                     TEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLE
                     GHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHP
                     SQELLASASYDDTVKLYQEEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTV
                     RIWRQYLPGNEQGVACSGSDPSWKCVCTLSGFHTRTIYDVAWCQLTGALATACGDDAI
                     RVFEEDPGSDPQQPTFSLTAHLRQAHSQDVNCVAWNPKEAGLLASCSDDGEVAFWEYH
                     QPAGL"
     exon            215..363
                     /gene="Ciao1"
                     /gene_synonym="Wdr39"
                     /inference="alignment:Splign:2.1.0"
     exon            364..475
                     /gene="Ciao1"
                     /gene_synonym="Wdr39"
                     /inference="alignment:Splign:2.1.0"
     exon            476..564
                     /gene="Ciao1"
                     /gene_synonym="Wdr39"
                     /inference="alignment:Splign:2.1.0"
     exon            565..766
                     /gene="Ciao1"
                     /gene_synonym="Wdr39"
                     /inference="alignment:Splign:2.1.0"
     exon            767..854
                     /gene="Ciao1"
                     /gene_synonym="Wdr39"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1430
                     /gene="Ciao1"
                     /gene_synonym="Wdr39"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtcctata gtggccagtg ggttctgcgc gttgcttctc ttggcatctt ccttcctcat
       61 cctaaaacag tcaccatgaa ggatgcgctg gtactgcaga gccgcgtccc ggcgcacccg
      121 gattcccgct gctggttcct ggcctggaac cccacgggaa ccttgttggc ctcatgcgga
      181 ggcgaccgta aaattcgcat ctggggcacc gagggtgaca gctggatttg caagtctgtc
      241 ctttctgaag gccatcagcg caccgttagg aaagtggcct ggtccccctg tggaaattac
      301 ctggcatctg ccagctttga tgctactact tgcatttgga agaagaacca ggatgacttt
      361 gagtgtgtga ccactcttga gggtcatgag aatgaggtca agtcagtggc ttgggcccca
      421 tctggcaacc tcttggctac ctgcagcaga gataagagcg tgtgggtctg ggaagttgat
      481 gaagaagatg agtatgaatg cgtcagtgtc ctcaattctc acacacagga tgttaagcat
      541 gtggtttggc acccaagcca ggagctttta gcttctgcta gctatgatga cacagtgaag
      601 ctataccagg aagaagggga tgactgggtc tgctgtgcta cccttgaagg tcacgagtcc
      661 actgtatgga gcatagcctt tgatcccagc ggccagcgtc tggcatcttg cagtgatgac
      721 cgaactgtgc gcatctggcg ccagtatcta cctggcaatg aacaaggggt ggcatgcagt
      781 ggctccgacc ccagctggaa atgtgtttgc actttgtcgg gcttccatac caggaccatc
      841 tacgacgttg cttggtgtca gctgacaggg gccctggcta cagcttgtgg agatgatgcc
      901 atccgagtgt ttgaggaaga tccaggctca gacccacagc agcccacctt ctctttgaca
      961 gcccatcttc gtcaggccca ttcccaggat gtcaactgtg tggcttggaa ccccaaggag
     1021 gcagggctcc tggcctcttg tagtgatgat ggggaggtag ccttctggga gtatcatcag
     1081 cctgcaggtc tctgagctgc agcttgactt ggggatcttg attcccacag aaaatgtcct
     1141 aagacttttc ctagtcactg agaagacctg aagcatcctt gactttcatt tagctcagga
     1201 ccattcactg tttcctttga tgtgagaaag ccattggcag agccacggaa cagcagaata
     1261 ttaaatattt aatatttaat attaaatatt aaagttttgc ttgatttagg gcaggtgtta
     1321 cattttgggg gtaaatatat ttataaaata taatcagtat atatgtatga atgaatgttt
     1381 gagaactttt gaaattgtga gctttataga aataatccat ctgtgccgca aaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaaa
//
