LOCUS       NM_001107588            3526 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus component of inhibitor of nuclear factor kappa B
            kinase complex (Chuk), mRNA.
ACCESSION   NM_001107588 XM_001061709 XM_219857
VERSION     NM_001107588.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3526)
  AUTHORS   Wang,N. and Chang,L.L.
  TITLE     The potential function of IKKalpha in gastric precancerous lesion
            via mediating Maspin
  JOURNAL   Tissue Cell 65, 101349 (2020)
   PUBMED   32746986
  REMARK    GeneRIF: The potential function of IKKalpha in gastric precancerous
            lesion via mediating Maspin.
REFERENCE   2  (bases 1 to 3526)
  AUTHORS   Dondelinger,Y., Delanghe,T., Priem,D., Wynosky-Dolfi,M.A.,
            Sorobetea,D., Rojas-Rivera,D., Giansanti,P., Roelandt,R.,
            Gropengiesser,J., Ruckdeschel,K., Savvides,S.N., Heck,A.J.R.,
            Vandenabeele,P., Brodsky,I.E. and Bertrand,M.J.M.
  TITLE     Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell
            death in models of infection and inflammation
  JOURNAL   Nat Commun 10 (1), 1729 (2019)
   PUBMED   30988283
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3526)
  AUTHORS   Fullam,A., Gu,L., Hohn,Y. and Schroder,M.
  TITLE     DDX3 directly facilitates IKKalpha activation and regulates
            downstream signalling pathways
  JOURNAL   Biochem J 475 (22), 3595-3607 (2018)
   PUBMED   30341167
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3526)
  AUTHORS   An,J., Wu,M., Xin,X., Lin,Z., Li,X., Zheng,Q., Gui,X., Li,T.,
            Pu,H., Li,H. and Lu,D.
  TITLE     Inflammatory related gene IKKalpha, IKKbeta, IKKgamma cooperates to
            determine liver cancer stem cells progression by altering telomere
            via heterochromatin protein 1-HOTAIR axis
  JOURNAL   Oncotarget 7 (31), 50131-50149 (2016)
   PUBMED   27367027
REFERENCE   5  (bases 1 to 3526)
  AUTHORS   Lian,S., Xia,Y., Khoi,P.N., Ung,T.T., Yoon,H.J., Kim,N.H., Kim,K.K.
            and Jung,Y.D.
  TITLE     Cadmium induces matrix metalloproteinase-9 expression via
            ROS-dependent EGFR, NF-small ka, CyrillicB, and AP-1 pathways in
            human endothelial cells
  JOURNAL   Toxicology 338, 104-116 (2015)
   PUBMED   26514923
REFERENCE   6  (bases 1 to 3526)
  AUTHORS   Bruno,M.E., Borchers,C.H., Dial,J.M., Walker,N.J., Hartis,J.E.,
            Wetmore,B.A., Carl Barrett,J.C., Tomer,K.B. and Merrick,B.A.
  TITLE     Effects of TCDD upon IkappaB and IKK subunits localized in
            microsomes by proteomics
  JOURNAL   Arch Biochem Biophys 406 (2), 153-164 (2002)
   PUBMED   12361703
REFERENCE   7  (bases 1 to 3526)
  AUTHORS   Cao,Y., Bonizzi,G., Seagroves,T.N., Greten,F.R., Johnson,R.,
            Schmidt,E.V. and Karin,M.
  TITLE     IKKalpha provides an essential link between RANK signaling and
            cyclin D1 expression during mammary gland development
  JOURNAL   Cell 107 (6), 763-775 (2001)
   PUBMED   11747812
REFERENCE   8  (bases 1 to 3526)
  AUTHORS   Canicio,J., Ruiz-Lozano,P., Carrasco,M., Palacin,M., Chien,K.,
            Zorzano,A. and Kaliman,P.
  TITLE     Nuclear factor kappa B-inducing kinase and Ikappa B kinase-alpha
            signal skeletal muscle cell differentiation
  JOURNAL   J Biol Chem 276 (23), 20228-20233 (2001)
   PUBMED   11279241
REFERENCE   9  (bases 1 to 3526)
  AUTHORS   Druilhe,A., Srinivasula,S.M., Razmara,M., Ahmad,M. and Alnemri,E.S.
  TITLE     Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two
            dominant negative caspase recruitment domain proteins
  JOURNAL   Cell Death Differ 8 (6), 649-657 (2001)
   PUBMED   11536016
REFERENCE   10 (bases 1 to 3526)
  AUTHORS   Ling,L., Cao,Z. and Goeddel,D.V.
  TITLE     NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of
            Ser-176
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3792-3797 (1998)
   PUBMED   9520446
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219857.4, XM_001061709.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3526
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3526
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /note="component of inhibitor of nuclear factor kappa B
                     kinase complex"
                     /db_xref="GeneID:309361"
                     /db_xref="RGD:1306661"
     exon            1..203
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2336
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /EC_number="2.7.11.10"
                     /note="conserved helix-loop-helix ubiquitous kinase"
                     /codon_start=1
                     /product="inhibitor of nuclear factor kappa-B kinase
                     subunit alpha"
                     /protein_id="NP_001101058.1"
                     /db_xref="GeneID:309361"
                     /db_xref="RGD:1306661"
                     /translation="MERPPGLRPGAGGPWEMRERLGTGGFGNVSLYQHRELDLKIAIK
                     SCRLELSTKNRERWCHEIQIMKKLNHANVVKACDVPEELNFLINDVPLLAMEYCSGGD
                     LRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIM
                     HKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGY
                     RPFLHHLQPFTWHEKIKKKDPKCIFACEEMTGEVRFSSHLPQPNNLCSLIVEPMESWL
                     QLMLNWDPQQRGGPIDPPLKQPKCFVLMDNILNLKIVHILNMTSAKIISFLLPYDESL
                     HSLQSRIERETGINTGSQELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKT
                     VYEGPFASRSLSDCVNYIVQDSKIQLPVTQLRKVWAEAVHYVSGLKEDYSRLFQGQRA
                     AMLSLLRYNANLTKMKNTLISASQQLKAKLEFFRKSIQLDLERYSEQMTYGISSEKML
                     KAWKEMEEKAIHYSEVGVIGYLEDQIMSLHTEIMELQKSPYGRRQGDLMESLEQRAID
                     LYKQLKHRPTDHSYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPK
                     VEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQSSARSLVGSSLEGTVTPPVSAW
                     LPPTLADREHPLTCVVTPQDGETLAQMIEENLNCLGHLSTIIREANEDQSSSMMSLDW
                     SWLAE"
     exon            204..298
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            299..413
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            414..483
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            484..572
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            573..662
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            663..787
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            788..895
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1031
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1226
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1329
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1453
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1605
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1667
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1777
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1827
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1924
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2072
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2206
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2306
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..3526
                     /gene="Chuk"
                     /gene_synonym="Ikbka; Ikka"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgacgcagtc tcgcgagaag gaggactcgc aagcctcggc ggcccggaac cggcctcgga
       61 ctggtggcag tgcctgaggc ggctggcgct cccgccccat ggagcggccc ccggggctgc
      121 ggcctggcgc cggcggcccc tgggagatgc gggagaggct tggcaccggc ggcttcggga
      181 acgtcagtct gtaccagcac cgggaacttg atctcaaaat agcaattaag tcttgtcgct
      241 tagagctaag taccaaaaac agagaacgat ggtgccatga aatccagatc atgaaaaagt
      301 tgaaccatgc aaatgttgta aaggcctgtg atgttcctga ggaattgaat tttttaatta
      361 acgatgtgcc tcttctagca atggagtact gttctggagg ggacctccgg aagctactca
      421 acaaaccaga aaattgttgt ggacttaaag agagccagat cctttcttta ctgagtgaca
      481 taggatctgg gattcgttat ttgcatgaaa acaaaattat acatcgagat ctaaaacctg
      541 aaaatatagt gcttcaagat gttggtggga agataatgca taaaataatt gatttgggtt
      601 atgccaaaga tgtcgatcaa ggaagtctct gtacatcttt tgtgggaaca ttacagtatt
      661 tggccccaga gctctttgaa aataagccat acacagccac tgtggattat tggagctttg
      721 ggaccatggt gtttgaatgt attgctggat ataggccttt tttgcatcat ctgcagccat
      781 ttacctggca tgaaaagatt aagaagaaag atccaaagtg tatatttgct tgtgaagaga
      841 tgaccggaga agttcggttt agtagccatt tacctcagcc aaacaacctt tgtagtttaa
      901 tagtagagcc aatggaaagc tggctacagt tgatgctgaa ttgggaccca cagcagagag
      961 ggggacctat tgaccctcct ttgaagcagc caaaatgctt tgtgttaatg gataacatcc
     1021 tcaacttgaa gatagtgcac atcctaaata tgacttctgc aaaaatcatt tcttttctgt
     1081 taccatatga tgaaagtctc cattcactac agtctcgaat tgagcgtgaa acaggaataa
     1141 atacaggttc tcaagaactt ctgtcagaga caggaatttc tctggatcct cggaaaccag
     1201 cctctcaatg tgttctagat ggagtgagag gctgtgatag ctacatggtt tatttgtttg
     1261 ataaaagtaa gactgtatat gaaggaccat ttgcatccag aagtttatct gattgtgtaa
     1321 attatattgt gcaagacagc aagatacagc ttccagttac acagcttcgc aaagtgtggg
     1381 ctgaagcagt gcactatgta tctgggctaa aggaggacta cagcaggctc tttcagggac
     1441 aaagagcagc aatgttaagt cttcttagat ataatgctaa cttgacaaaa atgaagaata
     1501 ctttgatctc agcatcacag caactcaaag ctaaattgga gttttttcgc aaaagcattc
     1561 agcttgactt ggagagatat agtgagcaga tgacttatgg gatatcttca gaaaaaatgc
     1621 tgaaagcatg gaaagaaatg gaagaaaagg ccattcacta ttctgaggtt ggtgtcattg
     1681 gataccttga ggatcaaatt atgtctttgc acactgaaat catggagctg cagaagagcc
     1741 cctatgggag acgccaggga gacctgatgg aatccctgga acagcgtgcc attgatctct
     1801 ataagcagct aaaacacaga cccaccgatc actcctacag tgacagcacg gagatggtga
     1861 agatcattgt gcacactgtg cagagtcagg accgagttct caaggagctg tttggtcacc
     1921 tgagcaagtt gttgggctgc aagcagaaga ttattgatct actccccaag gtggaagtgg
     1981 ccctcagtaa catcaaagaa gctgacaata ctgtcatgtt tatgcaggga aagaggcaga
     2041 aagaaatttg gcacctcctt aaaattgctt gtacacagag ttctgctcgc tctcttgtag
     2101 gatccagtct agaaggcaca gtaacccctc cagtatcagc atggctgccc cctactctag
     2161 cagaccgtga acatcctctg acatgtgtgg taactcctca agatggcgag acgttagcac
     2221 aaatgataga agaaaatctg aactgtcttg gccatttaag tactattatt cgtgaagcaa
     2281 atgaggacca gagcagtagt atgatgagtc ttgattggag ttggttagca gaatgacaca
     2341 tcattcgtgc actgttctcg agtctttgaa gctgttccag cacttactgt ggtcatcttt
     2401 cctgcggaag ccattcttca ctcaccagtc catggaggag acagctgtga tcagaaacta
     2461 caaatgactt tacacacacc cgagcttggt gttttgtttt taaataattg tgatctctga
     2521 acagatagga ttttataaca aatcagtgaa attaattttt ctttctaaca cctcaactaa
     2581 ttaaggagat tattagtgac ctgcttaaaa tcttataaaa ttgaaaaaat attactagtt
     2641 tagctgatga aaaagataat cttttaaagg tctaaatttt acgcataagg cccaacatag
     2701 tattaatata gagatgaaaa attcatccag tgttcatttt aagtaaaatt tgtctatgga
     2761 gtttctgtgc ttcctgaaga tgaagccccg cctccttgtg ttgctctcag caagtgctct
     2821 tcttggtgcc ccatggaggt agatgaatcc catctttaac cccacattta atagagtcct
     2881 cttcttatat aagggatgga catatgtgcc tttgatatca gctgaccata atgaattgtg
     2941 tcctgtgcta tatgtatatg tatttaaggt gtacatttaa taatatcaca gagaggatgc
     3001 ctgttaattt ataatgtatt tgaaggttgt atgttttaca tttgtaaaaa tgggtcactt
     3061 gtttaaacaa tcttttatgt cttgtcatac aagtttcaaa ggtctgcatt cctttatctg
     3121 taattatagt ctcaaaatcc aagaagttct gataacaagg ttttcataag cttgataaca
     3181 aaagtcattt gcctctggat gtattctaat ctgacactga atctgcttat cccattagtg
     3241 tgaatattca tttattttgt tgcataaata ttaatgtgta tgattattgg ggtgtgctgc
     3301 cacaaactct tttgagggtt gatatagtat ggtgtatgca ctgaattacc tttctaaaat
     3361 ctgaaaattt ctcattctga aacatctaga cttagggttt cagataaaag attgtggatc
     3421 tctgccttat gttaaataat ttaaaaggtg ttattttgtt tttaaaaaat gtgaaatgct
     3481 tttatattct agtttttcac tttgcatatt aaatgatttt aaaatt
//
