LOCUS       NM_001399723            2991 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus chromatin target of PRMT1 (Chtop), transcript
            variant 1, mRNA.
ACCESSION   NM_001399723 XM_006232711
VERSION     NM_001399723.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2991)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2991)
  AUTHORS   Takai,H., Masuda,K., Sato,T., Sakaguchi,Y., Suzuki,T., Suzuki,T.,
            Koyama-Nasu,R., Nasu-Nishimura,Y., Katou,Y., Ogawa,H.,
            Morishita,Y., Kozuka-Hata,H., Oyama,M., Todo,T., Ino,Y., Mukasa,A.,
            Saito,N., Toyoshima,C., Shirahige,K. and Akiyama,T.
  TITLE     5-Hydroxymethylcytosine plays a critical role in
            glioblastomagenesis by recruiting the CHTOP-methylosome complex
  JOURNAL   Cell Rep 9 (1), 48-60 (2014)
   PUBMED   25284789
REFERENCE   3  (bases 1 to 2991)
  AUTHORS   Chang,C.T., Hautbergue,G.M., Walsh,M.J., Viphakone,N., van
            Dijk,T.B., Philipsen,S. and Wilson,S.A.
  TITLE     Chtop is a component of the dynamic TREX mRNA export complex
  JOURNAL   EMBO J 32 (3), 473-486 (2013)
   PUBMED   23299939
REFERENCE   4  (bases 1 to 2991)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2991)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 13, 2022 this sequence version replaced XM_006232711.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.6796.1,
                                           SRR26360194.133150.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               JAXUCZ010000002.1  178290063-178290348 c
            287-368             JAXUCZ010000002.1  178288473-178288554 c
            369-522             JAXUCZ010000002.1  178287019-178287172 c
            523-709             JAXUCZ010000002.1  178284025-178284211 c
            710-847             JAXUCZ010000002.1  178282954-178283091 c
            848-2991            JAXUCZ010000002.1  178278848-178280991 c
FEATURES             Location/Qualifiers
     source          1..2991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2991
                     /gene="Chtop"
                     /gene_synonym="Fop; SRAG"
                     /note="chromatin target of PRMT1"
                     /db_xref="GeneID:361990"
                     /db_xref="RGD:1359407"
     exon            1..286
                     /gene="Chtop"
                     /gene_synonym="Fop; SRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            287..368
                     /gene="Chtop"
                     /gene_synonym="Fop; SRAG"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..1053
                     /gene="Chtop"
                     /gene_synonym="Fop; SRAG"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Friend of PRMT1 protein; small arginine- and glycine-rich
                     protein; chromatin target of PRMT1 protein"
                     /codon_start=1
                     /product="chromatin target of PRMT1 protein isoform 1"
                     /protein_id="NP_001386652.1"
                     /db_xref="GeneID:361990"
                     /db_xref="RGD:1359407"
                     /translation="MAAQSAPKVVLKSTTKMSLNERFTNMLKNKQPMPVNIWASMQQQ
                     QQLASARNRRLAQQMENRPSVQAALKLKQKSLKQRLGKSNIQARLGRPIGALARGAIG
                     GRSLPIIQRGLPRGGLRGGRATRTLLRGGMSLRGQNLLRGGRAVAPRMGLRRGGVRGR
                     GGPGRGGLGRGAMGRGGIGGRGRGMIGRGRGGFGGRGRGRGRGRGALTRPVLTKEQLD
                     NQLDAYMSKTKGHLDAELDAYMAQTDPETND"
     exon            369..522
                     /gene="Chtop"
                     /gene_synonym="Fop; SRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            523..709
                     /gene="Chtop"
                     /gene_synonym="Fop; SRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            710..847
                     /gene="Chtop"
                     /gene_synonym="Fop; SRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            848..2991
                     /gene="Chtop"
                     /gene_synonym="Fop; SRAG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcggcca ttttgttttg gacaccaagc gggagttggc ggcgccggct gtggtggcac
       61 agacgaaagg caggaaaagg ctggcttgac gagcgggagg atcagtcggc taaatactca
      121 acccacaaca agggagcctc gcaacctacc gtttaagcat ctaacccaac cgcccagcta
      181 gttaacccga gcggtccgcc gtcagctcgg gttcggccgg cctccggccc gcccgccgca
      241 gccgtggtgg caaccccggg aggagcgctg gcgtccatct ccttcgattc tcgggatttg
      301 aagatggctg cacagtcagc gccgaaagtt gtgctaaaaa gcaccaccaa gatgtctcta
      361 aatgagcgct ttactaatat gctgaagaac aaacagccga tgccagtgaa tatttgggct
      421 tcgatgcagc agcagcagca gctagccagt gccagaaaca gaagactggc ccagcagatg
      481 gagaatagac cctctgtcca ggcagcatta aaacttaagc agaagagctt aaagcagcgc
      541 ctgggtaaga gtaatatcca ggcacggtta ggccgaccca taggtgctct ggccagggga
      601 gcaattggag gaagaagcct tcccataatc cagagaggct tgccccgagg aggactacgt
      661 gggggacgtg ccaccagaac cctgcttagg ggtgggatgt cgctccgagg tcaaaacctg
      721 ctccgaggtg gacgagccgt agctccccga atgggcttaa gaagaggtgg tgttcgaggt
      781 cgtggaggtc ctgggagagg gggcctaggg cgtggagcta tgggtcgtgg cggaatcggt
      841 ggtagaggtc ggggtatgat aggtcgggga agagggggct ttggaggcag aggccgaggt
      901 cgtggccgag ggagaggtgc cctcactcgc cctgtattga ccaaggagca gctggacaac
      961 caattggatg catacatgtc gaaaactaaa ggacacctgg atgctgaatt ggatgcctac
     1021 atggcacaga cagatcctga aaccaatgat tgaagcctgc ctgcctgcct gcccacctgt
     1081 tagactcttg ttaaagtcac cacatctata caacaacctt gagaaaacat gagaagaaac
     1141 gtgatcgatg ctggaaggac atgtcacaat aggctgtgga cttacctgcc accaattggt
     1201 gcatttagtc ccttccgtct actttttgat actgtgttat atgaaaccct attttccttt
     1261 aatttggttg agtttgtttt gttgtttatt cagtcaccca gacttctatt tgaacaggaa
     1321 tgcgttggcc ttgtgagtag aacaattttc caacctctgc ctgtcatata ctcttgacat
     1381 ttttaaatat ttcctctgtt gatttgtatg atcccaggag gagccagtat tctcactatt
     1441 gggtggtctt tgggatagag ttctacatct ttctttaaaa gcttcttgtt aatagctgga
     1501 actaaaggtg tgtgtgctgt gttgatagtg aaggtagtaa attggaaacg ttggtattgc
     1561 tactgggcca cagaatgggt tacatagggt ggcaactttg ttctggtcaa agttggtgcc
     1621 gcctacattg aaaccacata gatggtaact aacaagctaa attggaattt ccaccctaag
     1681 aaaaggtttt taagctctcc ttttagcttt ctgtcatacc caagaggctt ctgcacctct
     1741 ctatagaaga agcagccttt ggtgtggctt agtggcagat gagacaaggg ttggaaactg
     1801 gttccaaact gactgctggg aaggctcctg tgctgttcat gctgaaatgc agttccctgt
     1861 gtttgtccag aagcagcctg ggtctgatcc acttcactgg ctttattggg ccctcttgaa
     1921 ggtttaagtt caaccatatt ttgtcagcta ttcagtttca gtggaatctt gtatttctgg
     1981 ttcattataa caaattgttc tctcatttaa cccaggcttt ctgtttattt tgggggggtc
     2041 cttaaaatgt tatatagcca tttttgtggt gtgttaaaat tcctgggatg ataacaaacc
     2101 tttaatccta ccacttggta agcataggca ggtggttatc tgtgggttcc aaggccagct
     2161 tggtctcaga gttagttaca ggataaccag ggctacacca gccctgtctt ggaaaaaaga
     2221 aatattctag gggtagggga aatgttgctt tgtggtagaa agtaaaactt ggactctcct
     2281 ttgacgaaac tcttaggaag tgtacacctg cctagaaagt actagtggac tgtactatgg
     2341 ctgtttaggg gaaaagatca caaccctctt aactgtgctg tgcatttaag agccaggaag
     2401 gaaataattg aagatcacct gaatttgaat ccttacttgt ttgagatggg gaatctctgg
     2461 gacccaggga agatggactc tgtggtatag gaagcgggtg cttaagggta gatctcagca
     2521 aagggaagtg atgactctag accccctttc tactgactgt cattcctact ttgtgaaaaa
     2581 gttcaattcc cctaccaacc ataggccctt cagcttcagg tctacctgct gtgtgcagtc
     2641 ctcagagtct cctaaggtct tgttgtccac cattgctttc ctctttcctg gtgatgcctc
     2701 aggtggacca gagagcaaac ctgactccta tcttctgagg acttgccttc catccaaggt
     2761 ctcactcatg gtgtcacaga agtgcattgg gagaacagag gaaagatttg accagctaga
     2821 gctgaagctc aggaaagttt aaagataggt gggaagagtt aggacaaggg caaaaaaaat
     2881 tgtgatacca ctgtggagat tgcatataag tttgaggcta gcctgggtta tatgtcaaag
     2941 aagtttcaag caaaggcaat aaatactgtg gttaccacat agacagagaa a
//
