LOCUS       NM_001106268            3758 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus chondroitin sulfate synthase 1 (Chsy1), mRNA.
ACCESSION   NM_001106268 XM_001059243 XM_218759
VERSION     NM_001106268.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3758)
  AUTHORS   Hu B, Shi C, Tian Y, Zhang Y, Xu C, Chen H, Cao P and Yuan W.
  TITLE     TGF-beta Induces Up-Regulation of Chondroitin Sulfate Synthase 1
            (CHSY1) in Nucleus Pulposus Cells Through MAPK Signaling
  JOURNAL   Cell Physiol Biochem 37 (2), 793-804 (2015)
   PUBMED   26356269
  REMARK    GeneRIF: Results suggest that TGF-beta (specifically TGF-beta3)
            induced CHSY1 expression in the nucleus pulposus through the
            activation of MAPK signaling.
REFERENCE   2  (bases 1 to 3758)
  AUTHORS   Wilson DG, Phamluong K, Lin WY, Barck K, Carano RA, Diehl L,
            Peterson AS, Martin F and Solloway MJ.
  TITLE     Chondroitin sulfate synthase 1 (Chsy1) is required for bone
            development and digit patterning
  JOURNAL   Dev Biol 363 (2), 413-425 (2012)
   PUBMED   22280990
REFERENCE   3  (bases 1 to 3758)
  AUTHORS   Ogawa H, Hatano S, Sugiura N, Nagai N, Sato T, Shimizu K, Kimata K,
            Narimatsu H and Watanabe H.
  TITLE     Chondroitin sulfate synthase-2 is necessary for chain extension of
            chondroitin sulfate but not critical for skeletal development
  JOURNAL   PLoS One 7 (8), e43806 (2012)
   PUBMED   22952769
REFERENCE   4  (bases 1 to 3758)
  AUTHORS   Tian J, Ling L, Shboul M, Lee H, O'Connor B, Merriman B, Nelson SF,
            Cool S, Ababneh OH, Al-Hadidy A, Masri A, Hamamy H and Reversade B.
  TITLE     Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic
            brachydactyly in humans via increased NOTCH signaling
  JOURNAL   Am J Hum Genet 87 (6), 768-778 (2010)
   PUBMED   21129727
REFERENCE   5  (bases 1 to 3758)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3758)
  AUTHORS   Titze J, Shakibaei M, Schafflhuber M, Schulze-Tanzil G, Porst M,
            Schwind KH, Dietsch P and Hilgers KF.
  TITLE     Glycosaminoglycan polymerization may enable osmotically inactive
            Na+ storage in the skin
  JOURNAL   Am J Physiol Heart Circ Physiol 287 (1), H203-H208 (2004)
   PUBMED   14975935
  REMARK    Erratum:[Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1433]
REFERENCE   7  (bases 1 to 3758)
  AUTHORS   Kitagawa H, Uyama T and Sugahara K.
  TITLE     Molecular cloning and expression of a human chondroitin synthase
  JOURNAL   J Biol Chem 276 (42), 38721-38726 (2001)
   PUBMED   11514575
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001059243.1, XM_218759.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3758
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3758
                     /gene="Chsy1"
                     /note="chondroitin sulfate synthase 1"
                     /db_xref="GeneID:292999"
                     /db_xref="RGD:1311904"
     exon            1..310
                     /gene="Chsy1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..806
                     /gene="Chsy1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..3758
                     /gene="Chsy1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcggccg gcgcgcctgg ctcagcatgc tgctcgggct cgtgctgggc ttcgtgctgg
       61 cctcgcgact cgtcctgccc cgcgcctcgg agctgaagcg agtgggcccg cggcggcgcc
      121 ccaatcccga gggatgccgg ccaggacagg cagcgtcgca gcccggcggt gctccggggg
      181 atgcgcgcgg ggcgcagctc tggccgcagg gctcggccgc ggagggcgtc ccgcgcgaca
      241 ggaactttct cttcgtggga gtcatgaccg cccagaaata cctgcagact cgcgccgtgg
      301 ccgcttacag aacatggtcc aagacaattc ccgggaaggt tgagttcttc tctagtgagg
      361 gttcagacac atctataccc attccagtag tgccactgag gggtgtggac gactcctatc
      421 ccccccagaa gaagtctttc atgatgctca agtacatgca cgatcactac ttggacaagt
      481 acgaatggtt tatgagagca gatgatgatg tctacatcaa gggagatcgt ctggagagct
      541 ttctgaggag tttgaatagc agcgagcccc tctttctcgg gcagacagga ctgggcacca
      601 ctgaagaaat ggggaaactg gctcttgagc ctggagagaa cttctgcatg gggggacctg
      661 gtgtgattct gagccgggaa gtgcttcgga gaatggcacc acacattggc aagtgtctcc
      721 gggaaatgta caccacccac gaggatgtag aggtggggag gtgcgtccgg agattcgcag
      781 gcgtgcagtg cgtctggtca tatgagatgc agcagctttt ttacgagaat tatgaacaga
      841 acaagaaagg gtacattaga gatctccata gcagtaaaat ccaccgagcg atcactttac
      901 accccaacaa aaacccgccc taccagtaca ggctacacag ttacatgctc agccgcaaga
      961 tcgctgagct gcgccatcgc acaatccagc tgcaccggga gatcgtcctg atgagcaagt
     1021 acagcagcac ggaaatccag aaggaagacc tccagctggg catccctccc tccttcatgc
     1081 gctttcaggc ccgccagcga gaggagatcc tggagtggga gtttctgact gggaaatact
     1141 tatattcagc cacggaaggc cagcctcccc ggagagggat ggactcagcg cagagggagg
     1201 ccttggatga cattgtcctg caagtgatgg agatgatcaa tgccaatgcc aagacccggg
     1261 gccgcatcat cgacttcaag gagatccagt atggctacag acgcgtgaat cccatgtacg
     1321 gggcagagta catcctggat ctgctgctcc tgtataagaa gcacaaaggg aagaagatga
     1381 cggtccctgt gaggaggcac gcgtacctgc agcagacctt cagcaagatc cagtttgtgg
     1441 agcatgaggg cctggatgca caagagctcg ctgacagaat caaccaggac tctgggtccc
     1501 tgtcattcct ctccaattcc ttgaagaagc tcgttccctt ccagcttcct ggatccaaga
     1561 tggagcacaa agagcccaaa gaaaagaaga taaacattct gatccctttg tctggacgct
     1621 tcgacatgtt tgtgaggttc atgggaaact ttgagaagac gtgtctcatt ccaaatctga
     1681 acgtgaagct ggtcattctg cttttcaatt ctgactctaa ccccgacaag gccaagcagg
     1741 tcgagctgat gcgagattac cgagtcaagt acccgaaggc tgacatgcaa gttttgcctg
     1801 tgtctggagg gttttcgaga gcactggccc tagaagtagg ctcttcgcag tttagtaatg
     1861 agtctctgct cttcttctgt gatgtggacc tggtgtttac agcggagttc ctgcagaggt
     1921 gccgagccaa cactgtgctg ggccagcaga tctacttccc aatcatcttt agccagtacg
     1981 atccaaagat tgtctatagt gggaaggttc ccagtgacaa ccattttgcc tttactcaaa
     2041 aaaccggctt ctggagaaac tatgggtttg gcattacttg tatctataag ggagatcttg
     2101 tcagagtggg aggcttcgat gtctccatcc agggctgggg gctggaggat gtggacctct
     2161 ttaacaaggt cgtccaggca ggattgaaga cattccggag ccaggaggtc ggggttgttc
     2221 acgtccacca ccctgtcttc tgtgacccga atctggaccc caagcagtat aaaatgtgcc
     2281 tggggtcgaa ggcgtcaaca ttcgggtcca cacagcagtt ggctgaaatg tggctggaga
     2341 agaatgaccc cagttacagc agaggcggca acggctcggc caggacagtc tgattccggc
     2401 ccgctgcgaa ggacagtttt aattgcctaa tttattttta aaaaattttt gtataatcag
     2461 tttttgaagt ccgtacaagg atatattttc caagtggttt tcttacacag gactccttta
     2521 agattgagct ttttgaacaa aaatgtgatc aatgtttgcc tttgaacaca ccttgctgaa
     2581 cactatgtag caccggctta gtcctgactt gaagcccacc caatgagcaa aacttttcta
     2641 taagaatttt ttggtctttg gtttttacat ttcttttcca gacaactccc ctttttctct
     2701 ctagtcctaa ggcagaaaaa acgtgaacat tcctaagaag tattatcgtg ataagaacac
     2761 tgtaaccctg gtggatgtcc tgttgagact gttgacctgt ctctggtaaa tgtcctgttg
     2821 tgactgttaa cctgttgcct ttgcacaaat tctacctttt tcctgttttt ttttttaaac
     2881 agtttggttt ttttttttaa agccatcctg agttccagtc acaaagtaaa gagatgtgat
     2941 agtggttgta ttgtcattct ctccaggaga gccttccaaa tcagattact tccccgctgt
     3001 gctccacccc ccactgtcac aggtttttcc cacccagccc gtggtgggtg ggggatggag
     3061 gaaggcacgc atgtgctgac ccctctctaa tcctgcgacc cagacggacc tggcactgaa
     3121 gtccaagaag gactcggcat tttctctgcc ccgcccttct ctgtagaggg tacagtatta
     3181 ttagggtgac aaagaacggc tggtagcagt ggaatgaatg caagcttaca gacaaacccc
     3241 tgatggacgt gtgagggaag ttggcgcttt gttctctgtc ctgtgttgtg gatggagatg
     3301 actgctccat tttttaatta ctggtttttc tatcttgtta tctgcaatac ctttaattta
     3361 tttaatacca ttgtttagat ctctgccatt ttgagtactt gtcagtcact agtatttatg
     3421 tgtaccatga gtgtggttag aacgttttat ttgcagtaaa ctgatctcca aagatttcct
     3481 tttgaaaaca cttttccctc atccttaatt tttacattcc cgtcttacta aagattaagt
     3541 gttctttgat aattttggtg ctcatgtgtt ttggggacaa aggtgaaatg agtctgttgt
     3601 tataccagag tgtttgtttt caacttacag atccaatgtg ccttaataat ttgttttcat
     3661 ttagagttca gacagttgat agagttgcca tttttaatat acatcattgg agatctgctt
     3721 atctgtaaat agcctgttgc acatccgaac aaataaac
//
