LOCUS       NM_053408               6043 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Rattus norvegicus carbohydrate sulfotransferase 3 (Chst3), mRNA.
ACCESSION   NM_053408 XM_006256427
VERSION     NM_053408.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6043)
  AUTHORS   Liu,J., Chau,C.H., Liu,H., Jang,B.R., Li,X., Chan,Y.S. and
            Shum,D.K.
  TITLE     Upregulation of chondroitin 6-sulphotransferase-1 facilitates
            Schwann cell migration during axonal growth
  JOURNAL   J Cell Sci 119 (Pt 5), 933-942 (2006)
   PUBMED   16495484
  REMARK    Erratum:[J Cell Sci. 2006 Mar 15;119(Pt 6):1196. Chan, Ying-Shang
            [corrected to Chan, Ying-Shing]]
REFERENCE   2  (bases 1 to 6043)
  AUTHORS   Yamada,T., Ohtake,S., Sato,M. and Habuchi,O.
  TITLE     Chondroitin 4-sulphotransferase-1 and chondroitin
            6-sulphotransferase-1 are affected differently by uronic acid
            residues neighbouring the acceptor GalNAc residues
  JOURNAL   Biochem J 384 (Pt 3), 567-575 (2004)
   PUBMED   15324304
REFERENCE   3  (bases 1 to 6043)
  AUTHORS   Thiele,H., Sakano,M., Kitagawa,H., Sugahara,K., Rajab,A., Hohne,W.,
            Ritter,H., Leschik,G., Nurnberg,P. and Mundlos,S.
  TITLE     Loss of chondroitin 6-O-sulfotransferase-1 function results in
            severe human chondrodysplasia with progressive spinal involvement
  JOURNAL   Proc Natl Acad Sci U S A 101 (27), 10155-10160 (2004)
   PUBMED   15215498
REFERENCE   4  (bases 1 to 6043)
  AUTHORS   Uchimura,K., Kadomatsu,K., Nishimura,H., Muramatsu,H., Nakamura,E.,
            Kurosawa,N., Habuchi,O., El-Fasakhany,F.M., Yoshikai,Y. and
            Muramatsu,T.
  TITLE     Functional analysis of the chondroitin 6-sulfotransferase gene in
            relation to lymphocyte subpopulations, brain development, and
            oversulfated chondroitin sulfates
  JOURNAL   J Biol Chem 277 (2), 1443-1450 (2002)
   PUBMED   11696535
REFERENCE   5  (bases 1 to 6043)
  AUTHORS   Tsutsumi,K., Shimakawa,H., Kitagawa,H. and Sugahara,K.
  TITLE     Functional expression and genomic structure of human chondroitin
            6-sulfotransferase
  JOURNAL   FEBS Lett 441 (2), 235-241 (1998)
   PUBMED   9883891
REFERENCE   6  (bases 1 to 6043)
  AUTHORS   Uchimura,K., Kadomatsu,K., Fan,Q.W., Muramatsu,H., Kurosawa,N.,
            Kaname,T., Yamamura,K., Fukuta,M., Habuchi,O. and Muramatsu,T.
  TITLE     Mouse chondroitin 6-sulfotransferase: molecular cloning,
            characterization and chromosomal mapping
  JOURNAL   Glycobiology 8 (5), 489-496 (1998)
   PUBMED   9597547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Sep 22, 2022 this sequence version replaced NM_053408.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.708373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-472               JAXUCZ010000020.1  28694055-28694526   c
            473-719             JAXUCZ010000020.1  28663750-28663996   c
            720-6043            JAXUCZ010000020.1  28657308-28662631   c
FEATURES             Location/Qualifiers
     source          1..6043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..6043
                     /gene="Chst3"
                     /note="carbohydrate sulfotransferase 3"
                     /db_xref="GeneID:84468"
                     /db_xref="RGD:620355"
     exon            1..472
                     /gene="Chst3"
                     /inference="alignment:Splign:2.1.0"
     exon            473..719
                     /gene="Chst3"
                     /inference="alignment:Splign:2.1.0"
     CDS             580..2004
                     /gene="Chst3"
                     /EC_number="2.8.2.17"
                     /EC_number="2.8.2.21"
                     /note="chondroitin 6-sulfotransferase 3; GST-0; C6ST-1;
                     chondroitin 6-O-sulfotransferase 1;
                     galactose/N-acetylglucosamine/N-acetylglucosamine
                     6-O-sulfotransferase 0; carbohydrate (chondroitin
                     6/keratan) sulfotransferase 3; carbohydrate (chondroitin
                     6) sulfotransferase 3"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 3"
                     /protein_id="NP_445860.3"
                     /db_xref="GeneID:84468"
                     /db_xref="RGD:620355"
                     /translation="MEKGLALPQDCRDLVHNLKIRGRYVLFLAFVVIVFIFIEKENKI
                     ISRVSDKLKQIPQFVADANSTDPALLLSENASLLSLSELDSTFSHLRSRLHNLSLQLG
                     IAPAMEAQGQEAVAEKPSQQAGAGTRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEP
                     LWHIERTVFFQQGGASAAGSALVYRDVLKQLLLCDLYVLEPFISPPPEDHLTQFLFRR
                     GSSRSLCEDPVCTPFVKKVFEKYHCRNRHCGPLNVTLAAEACRRKDHMALKVVRIRQL
                     EFLQPLAEDPRLDLRVIQLVRDPRAVLASRMVAFAGKYESWKKWLSEGQDQLSENEVQ
                     RLRGNCENIRLSAELGLRQPAWLRGRYMLVRYEDVARRPLQKAREMYRFAGIPLTPQV
                     EDWIQKNTQAARDSSDVYSTQKNSSEQFEKWRFSIPFKLAQVVQAVCGPAMHLFGYKL
                     AKDAASLTNRSISLLEERGTFWVT"
     exon            720..6043
                     /gene="Chst3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctgccc tccctcccgg ctcctccctc ctcctgcgtc ctccgcctcc tccatcctct
       61 ctgagaggcc gggtgggcgg ccgcgccaac ttcaccgagc gtccccaagt tgccgggtgc
      121 gcgtgtggag tgaggcgggg agcttggcgg agaggcgagg ggttcccgaa gccttggctg
      181 tgtcttagga ggccgcctcc agccgctagc gggatcggaa tcgtgggtag gacggatcgt
      241 tcccctgcag ctgggacacc gcccgcctgg cgccgcttcc cgcccagtga agggaccagc
      301 ccggccgcgc ctccctcccc gaactcgccg gggacacaga gtgggcgccg aggggagcgc
      361 ggccccagca tcttctgaac cgagagcgca gttgggggcg gatgctgccc gggctggacg
      421 ccggcctccg gagagtcgga tccgcccgcc gggaggagga ggcttggtcg gggatgaagg
      481 tgtctcccac ctgaagagga caggttgggt cccgagctct gctcctgagc tgagtgcctg
      541 cagccagact caggagcttc catggcgccc cctgtctcca tggagaaagg actcgctttg
      601 cctcaggatt gccgggacct tgtgcacaac ctgaagattc gaggcagata tgtcctgttc
      661 ttggcatttg tggtcatagt ttttatcttc attgaaaagg aaaataaaat catatccagg
      721 gtctccgaca agctgaagca gatccctcag tttgtggcag atgccaacag caccgaccca
      781 gccctgctct tatcggaaaa tgcatctctc ttgtccctga gcgagctgga ttccaccttc
      841 tcccatctgc ggagccgcct gcacaacttg agcctgcagc tgggcatagc gccagcaatg
      901 gaggcccagg gccaggaggc tgtggcagag aagccatccc agcaggctgg agcagggacc
      961 cggcgccacg tgctcctcat ggccaccact cgcaccggct cctcattcgt gggcgagttc
     1021 ttcaaccagc aaggcaatat cttttacctc tttgagccac tgtggcacat cgagcgcacc
     1081 gtgttcttcc agcagggagg tgccagcgcg gcgggctcag cgttggtcta ccgcgatgtc
     1141 ctcaagcagc tattgctgtg tgacctgtat gtgctagagc ccttcatcag ccctccgccc
     1201 gaggaccact tgactcagtt cctgtttcgc cggggatcca gccgctcgct ctgcgaggat
     1261 ccggtgtgca cacccttcgt caagaaggtc ttcgagaagt accactgcag gaaccgtcat
     1321 tgcgggccac tcaacgtgac cttggccgcc gaggcctgcc gccgcaagga ccacatggcc
     1381 ctcaaggtcg tgcgcatccg tcagctggag ttcctgcagc ctctggctga ggacccaagg
     1441 ctggacctgc gagtcatcca gctggtgcgc gacccccggg ccgtgctggc ttcacgcatg
     1501 gtggcctttg cgggcaagta tgagagctgg aagaagtggc tgtccgaggg ccaggaccag
     1561 ctgagcgaga atgaggtgca gcggttgcgg ggcaactgtg agaacatccg cctgtctgca
     1621 gagctgggct tgcggcagcc agcctggctg cgcggtcggt acatgctggt gcgctacgag
     1681 gatgtggcac gcaggccact acagaaggcc cgagagatgt atcgcttcgc aggcatcccc
     1741 ttgaccccgc aggtggagga ctggatccag aagaacacgc aggcggcgcg cgacagcagc
     1801 gacgtctact ccactcagaa gaactcctcg gagcagtttg agaagtggcg cttcagcata
     1861 cccttcaagc tggcacaggt ggtgcaggct gtctgcggcc cggccatgca cctcttcggc
     1921 tacaagttgg caaaggatgc cgcctcactc accaaccgct ccatcagcct gctggaggag
     1981 cggggcacct tctgggtcac gtagtggggg ttgttcagga cccttggaac cccttcttat
     2041 gaaaggctgg ccctgcttcc ctcacaccca gcctggcagt gagacacagc cctggcagag
     2101 agtcaaatgg gggagctgtg ataggagagg tgataggata cacccctggc tatagcacta
     2161 ggctccctgc cagctcaatt ccccagcgca gctagggcct tggggctcct ctaaggacag
     2221 caggaccctg tctccttagt ggtgcagtgt ccccagcagg cccaggtagg ttcctgtggt
     2281 gtggacacgc ctccctggcc ccttacacag tcacataaac atacacgaag cacataaagg
     2341 cctgtgggct ctgtgggcca gagtccaagt gtttaacagc cagaaggggc ttaggccttc
     2401 tccagtcgct cagacctcct actgtattaa gtgttaacct cttccgctct gagtcagaga
     2461 agcctggctg agtcctggga aggaggagga gtgcagccta gggtgaggaa gggggcattt
     2521 gaagttcctc ggggaacaat ggctgtttac cagctgatag aaaatggtcc gggtagctgt
     2581 tctaaattgt catgaatatc atcagcctgt gtagaacaag acacacaaag tgcatgtaaa
     2641 accgacgagg ctgggggatg gctcggtggt aaagcccttg cctcgcatgc ctagggctct
     2701 gggtatgatt cccagcacta caaatataag ggaagggaag gcatccacat atgtgcagca
     2761 ccgagagaaa cagaaaagcg tcataaaaac attccctcct tccccccacc ctctctcaca
     2821 cacacacaca cacacacaca cacacacaca cacacacaca cacacactac acactggtac
     2881 agaaaagctt ctcttctcta ttctttatgc tcaccgtgat tttgttgttt ttttgtttgt
     2941 ttgtttgttt ttctgtatct aaacaaggag ccttaaatca catattttag gattatgtgg
     3001 agagggcaca tattcaagga caatgacact ttgccctgac cagagctgaa aaggaataat
     3061 ggtctctgag ccaccgctga gcatcttagg ttgtcatggc tacctcctcg gacccatcca
     3121 catgctccag ctggcaggca gaatatttag agatggcatg ggtagccttc atatgactat
     3181 ggtccaaagg cttctcctac ccactcctgg ggagcatggc tggttttgaa ggctttctga
     3241 ggcctaacca gcaggcttag cttcggctcc tggaagggaa agacagctca tggactttct
     3301 gtctctagcc aggcctcccc tggggctagc caagaacttc agagtgctcc acgggggaaa
     3361 gtcacattag gacatagctt ccctcagcag cctgccattt ctctcctagt tgacagaggt
     3421 cagccctcag gttgccatgg ctacagctag tgtctaagaa aaagtctgct ttagggcttt
     3481 gggaagagat aggctgaact caggacaggc aggtatctta tttgggttct taagtttatt
     3541 tatagcgtgg tgctgtattt gactttattt ctgtaaaact actcagaagc tgttggttgt
     3601 gaggagcagg gaaggctaat gccagcaggg agcagctggc tcctggtaaa aggacagacc
     3661 agaaaggact tcccatagga ggactggagt catgcagagc ccctagggtc ccgcatgttc
     3721 ccacatgaga catcggatgt gtagcttgga agtgggccca gcacgggtgc ggacggcagt
     3781 gaccgaactc cccatgtgcc gggtttgtta accacctgct cagctgctgg gtcccaagca
     3841 taggtgctct tccctcactc aagccagcct ccgctcttga tttggacaat ggaagaacaa
     3901 gtgtataggg gacaaagaga caccggttct tcatacttga cgaggacagg atgttgtggg
     3961 caggctcagg agtgttaccc tctctccaag atcgtcatcc aggccatagt cccttctctg
     4021 cactgcaagt ggggtgggag gggctgagct gggcgttccc ttccttcttc cctatggggt
     4081 gtgggcacaa ggcctccatc tctcctctct ctaaggacag atccccgcca cggacctttg
     4141 gaacttctca ggacattgac aatgtcgtgt gcactgcaag ttgactttat ttattttgta
     4201 ggacaaagag acagtattct ttgcagggac ctaaaactgt accctaactg agaagtacaa
     4261 ttagtaatgt tattattatt aataataggg atgattcaca ggccacacac acacacatac
     4321 acacacacac acacacacac acacacacac acacacacac ctgggaacac ccaaggagca
     4381 tgtaggagat gagatagaac caggtcatgg aagcccagga tgctgaagag ggtctgtggg
     4441 tctgttattg atcaggagat acaatatggg ggctcaggtg tctgtaacaa cagagcagtt
     4501 caggtgggtg gatgggcagg cagatgtagc ctcgaaacac atccccagag gcttggccat
     4561 cctcaaagtc cggaaaggga cagagtaggg caaactactg ggcgtcttgc ctggtgatgt
     4621 gttagaattg tgttttagtg tgaatctaga tagagaaagt ggccatgctg gtggcatggg
     4681 acaactgctg atccaactcc aaagatcaaa aggcatccag gtaacctatg acagtgacac
     4741 tctttcctat cattaaaagt gtctgcctca tgttggaaga tgcccccact gaaaaccatg
     4801 ggatttcttg ccctaagtgg ggtaggaagg acttaggggt actagatggc ttgatcccat
     4861 ccccaaatcc ttcagctgtc ttgtgtatta gttgaccatg gacttgcccc ttgagacatc
     4921 ctggactttg gaaggacagg agcatcccca aggcagtccc tcacagaggc agagggatca
     4981 tactaaggga gggaaggaaa ggagttgggg ccagaccccc aagaagccaa gtgggtccgc
     5041 ttaacctgta cacaggagaa ggaagaaaca tcactaaaat cgggcctgga gctggggtgt
     5101 tgttcatgag atcctgtggt gtggctgggt gcggatgttt tctgagcatg ctcacacccc
     5161 tcccaacttc acatccttag aaatagtggg gccggggcca tgatgccttc cctcaaaagg
     5221 atgaggcgaa gcctgcaact cccagtgtct taagaccttc agggtccttt gagctgtgtc
     5281 cttgtctcta catggggaca gactccttag gtgttcctgc agtcccaccc ttacttcttg
     5341 tgccaaggat cagcttctta ctgggcatat aaggcagctg tgtcactgtt tccacctgat
     5401 tgaactttgc ctcctgtcca gtctccatct ctcccggata gtctagtccc tgggtctaac
     5461 caccaccctc cacttcctga tggctcccgc aagtgcggtc tttgtggcag taccatgtcc
     5521 tgcctcatgg ctaaatggta caggacattt tcccagtctg agtggtccta acatgtgcat
     5581 gtgtgctcat gaatacatac atgctgtggg tgggtagagg ggtgcattct gttctgcctt
     5641 tggtgcagcc acacagccac aacctcttgc tgtcattgac cctcttgttc ttgtggccac
     5701 agacaatctt ccgatgcccg gtgctgccgt tctcctccga gggctgacaa cctggtgttc
     5761 agagtagagt tcatgaacta ggatgtgaag cccttctcct tactgaactt atttaattaa
     5821 aaatgaacat gtaggggttg gaaagatggc tcagtggtta agagcactgg ctgcttttgc
     5881 agaggacctg cattcaattc ccagcaaaca catggtggct cacaactgtt tgtaatgact
     5941 tctgggggcc tcttctggca cgcaggtgta tctgcagata gagcactcat gcataaaata
     6001 aataaatctt aaaaataaat aaacaaacaa acgtgctgta aat
//
