LOCUS       NM_001398894            6143 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus carbohydrate sulfotransferase 2 (Chst2), mRNA.
ACCESSION   NM_001398894 XM_006243553
VERSION     NM_001398894.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6143)
  AUTHORS   de Graffenried,C.L. and Bertozzi,C.R.
  TITLE     Golgi localization of carbohydrate sulfotransferases is a
            determinant of L-selectin ligand biosynthesis
  JOURNAL   J Biol Chem 278 (41), 40282-40295 (2003)
   PUBMED   12855678
REFERENCE   2  (bases 1 to 6143)
  AUTHORS   Sakaguchi,H., Kitagawa,H. and Sugahara,K.
  TITLE     Functional expression and genomic structure of human
            N-acetylglucosamine-6-O-sulfotransferase that transfers sulfate to
            beta-N-acetylglucosamine at the nonreducing end of an
            N-acetyllactosamine sequence
  JOURNAL   Biochim Biophys Acta 1523 (2-3), 269-276 (2000)
   PUBMED   11042394
REFERENCE   3  (bases 1 to 6143)
  AUTHORS   Uchimura,K., Muramatsu,H., Kaname,T., Ogawa,H., Yamakawa,T.,
            Fan,Q.W., Mitsuoka,C., Kannagi,R., Habuchi,O., Yokoyama,I.,
            Yamamura,K., Ozaki,T., Nakagawara,A., Kadomatsu,K. and Muramatsu,T.
  TITLE     Human N-acetylglucosamine-6-O-sulfotransferase involved in the
            biosynthesis of 6-sulfo sialyl Lewis X: molecular cloning,
            chromosomal mapping, and expression in various organs and tumor
            cells
  JOURNAL   J Biochem 124 (3), 670-678 (1998)
   PUBMED   9722682
REFERENCE   4  (bases 1 to 6143)
  AUTHORS   Uchimura,K., Muramatsu,H., Kadomatsu,K., Fan,Q.W., Kurosawa,N.,
            Mitsuoka,C., Kannagi,R., Habuchi,O. and Muramatsu,T.
  TITLE     Molecular cloning and characterization of an
            N-acetylglucosamine-6-O-sulfotransferase
  JOURNAL   J Biol Chem 273 (35), 22577-22583 (1998)
   PUBMED   9712885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 28, 2021 this sequence version replaced XM_006243553.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.1119834.1,
                                           SRR26360176.1463527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840107
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-652               JAXUCZ010000008.1  104845310-104845961 c
            653-6143            JAXUCZ010000008.1  104839716-104845206 c
FEATURES             Location/Qualifiers
     source          1..6143
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..6143
                     /gene="Chst2"
                     /note="carbohydrate sulfotransferase 2"
                     /db_xref="GeneID:367145"
                     /db_xref="RGD:1306988"
     exon            1..652
                     /gene="Chst2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..6143
                     /gene="Chst2"
                     /inference="alignment:Splign:2.1.0"
     CDS             826..2418
                     /gene="Chst2"
                     /note="carbohydrate (N-acetylglucosamine-6-O)
                     sulfotransferase 2"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 2"
                     /protein_id="NP_001385823.1"
                     /db_xref="GeneID:367145"
                     /db_xref="RGD:1306988"
                     /translation="MSRSSPRALPPGALPRPLPAAPAAVQRALLPPWPRRAGRRWPAS
                     PLGMKVFRRKALVLCAGYALLLVLTMLNLLDYKWHKEPLQQCNPDGPLGAAVGAAGAG
                     WGRPGSPPAAPPRAHSRMDPRTPYRPPAAGVGAVPAAAAGSVGAAASLGNATRGTRGG
                     GDKRQLVYVFTTWRSGSSFFGELFNQNPEVFFLYEPVWHVWQKLYPGDAVSLQGAARD
                     MLSALYRCDLSVFQLYSPAGSGGRNLTTLGIFGAATNKVVCSSPLCPAYRKEVVGLVD
                     DRVCKKCPPQRLARFEEECRKYRTLVIKGVRVFDVAVLAPLLKDPALDLKVIHLVRDP
                     RAVASSRIRSRHGLIRESLQVVRSRDPRAHRMPFLEAAGHKLGAKKEGMGGPADYHAL
                     GAMEVICNSMAKTLQTALQPPDWLQGHYLVVRYEDLVGDPVKTLRRVYDFVGLLVSPE
                     MEQFALNMTSGSGSSSKPFVVSARNATQAANAWRTALTFQQIKQVEEFCYQPMAVLGY
                     ERVNSPEEVKDLSKSLLRKPRL"
ORIGIN      
        1 gcggccgcgg cgggggcttc ctctgcctcg ggacctcgaa gggcagaagc ggccggtgac
       61 gctgggatcc cgctcttttg cctccagcta cccgtacaga gtcttttctg ggccagtctg
      121 cggccacgga gcaccggggc tcgcccgagc cgccctcccg gacatcctcc gggtgatgga
      181 agaagcagcc gccgctgcgg ggccgctctg caccctattc gccaccgccg gagggatggg
      241 aaggttcgct atgtggaggc cgagagagca cgatggagaa cagaatatcc tggagctggg
      301 acataaataa gctacccccc actgtcgcct cctgcctgct tcgtgcccca gagccgggag
      361 ggaagctgcg gtcccgagag actggaggag acgtcgctgg agccgggacg cgccgcgctc
      421 ggtggagcgc agagctgggc tccgggcccg gtgaaagttt cccctcccgg ggtgcagggc
      481 gcccgctgct ggaaaactct gcctagggct agggcggcgg agtcccgcgg ctgcctcgaa
      541 ggcttgggga cccctagcag aagagaaccg gagagaaacc gaggagagcg ctagccggac
      601 agtccgccgg tcggggatcc ggggacgctc cgaggtgcac cctccgctcc aggtcctcgg
      661 agccgctgcc atgggagagc cagccctggg cgccggggac cagccgcctc tgccgccgcg
      721 cccgcctcgg atcggcggcc ccagtcccgg cgcccgcagc cggcctgcag cgtccccctc
      781 ccgggctgca gggccgcctc cgccgcgccg ccggccccgg ctgtgatgag ccgcagctcg
      841 ccgcgagctc tgcccccggg cgcgcttccc cggccgctgc cggccgcgcc tgccgccgtg
      901 cagcgggccc tgctcccgcc gtggccccgg cgcgcaggac gccgctggcc tgcgtccccg
      961 ctcgggatga aggtgtttcg caggaaggcg ctggtgctgt gcgcgggcta tgcactgctg
     1021 ctggtgctca cgatgctcaa cctcctggac tacaagtggc ataaagagcc gctgcagcag
     1081 tgcaaccccg acgggcctct gggtgccgcg gtgggggcgg ccggggccgg ttggggacga
     1141 ccagggtcgc ctcctgcagc gccaccccgc gctcactctc gcatggaccc ccgcacccca
     1201 taccggcctc ctgccgctgg cgtgggggca gttcccgcag ccgcggctgg gagtgtagga
     1261 gctgcggcct ctctgggcaa tgctactcga ggcaccaggg gtggagggga caagcggcag
     1321 ttggtgtatg tgttcaccac gtggcgctcg ggctcatcct tcttcggcga gctcttcaac
     1381 cagaaccctg aggtgttctt cctctatgaa cctgtgtggc acgtgtggca aaaactgtac
     1441 cccggggacg cggtttccct gcagggggca gcgcgggaca tgctgagcgc tctctaccgc
     1501 tgtgatcttt cggttttcca gctgtatagt cccgcaggca gtggggggcg caacctcacc
     1561 actctgggca tctttggggc agccacaaac aaggtggtat gctcctcgcc actctgtcct
     1621 gcctaccgca aagaggtcgt cggactggtg gacgaccgcg tgtgcaagaa gtgcccacct
     1681 caacgcctgg cacgcttcga ggaggagtgc cgcaagtacc gcacgttggt tatcaagggc
     1741 gtgcgggtct tcgatgtggc tgtgttggcg ccgctgctta aagatccagc cttggacctc
     1801 aaggtcatcc acctagtgcg tgatcctcgt gctgttgcca gctcccgcat ccgctcccgc
     1861 catggcctca tccgggaaag cctacaggtg gtgcgaagcc gggatccaag agctcatcgc
     1921 atgcccttcc tggaggctgc tggccacaag ctgggtgcca agaaggaggg tatgggtggg
     1981 ccagcagact accatgctct gggtgcaatg gaggtcatct gcaacagtat ggccaaaacg
     2041 ctgcagacag ccctgcagcc tcctgactgg ctgcagggac attacttagt ggtgaggtac
     2101 gaggatctgg tgggagaccc cgttaagacc ctacggaggg tgtatgactt tgtggggctg
     2161 ctggtgagtc ccgaaatgga gcagtttgcc ctgaacatga ctagtggttc gggctcctcc
     2221 tccaagcctt ttgtggtgtc agctcgcaat gccactcagg ccgccaatgc ctggcggacc
     2281 gcactcacct tccagcagat caaacaggtg gaggagtttt gctaccagcc catggcagtg
     2341 ttgggctacg agcgggttaa cagtcctgag gaggtcaaag acctcagcaa gagcttgctc
     2401 aggaaacccc ggctttgaga agggttccca agagatctga cactctcccg agacacccac
     2461 aaagaggatg gtgctgtgtt taaacaaaca cagcccagac ccaagctgag gaagcccaca
     2521 tattctatta tagatatata atataaataa ccacacaggc acttgctgtc aacgttttga
     2581 gtcagtgaat ttcaaggaac ggcctcaact cacgcgcgtg cgtgcacaca cctcagaaaa
     2641 ggcaagactt gaaagttctg acgaattgcc ctgtgtccct gtctcttctc cctctctcct
     2701 catcctctat cccccctccc ttccgtactg aagtggaatg ttgataaaac gagttccagt
     2761 aacccaaatc ttgtttacaa aattttcgtg gtatctgtga atgtgtaaga gtaaatttgg
     2821 atgtggggtg gggtgggtgg agaagaggga agtgttccca gagcagaaag cccccactgg
     2881 gctggtaaac caaggaggca gtcttaagaa gtagactttt gtgtcagccg aggttatatg
     2941 tgagtattaa taaagaagag aattaatatt cttttttata tttgcctcca ttactctggg
     3001 tttaccagtg ttccttgtct tcgtagcttc aggtggactc tcctcccttc ccacctctcc
     3061 ctccctttcc agccatctac gtgctaagct gggagaagcc tttgccttcg tgataactgg
     3121 gagttctttt ctcacatgtg aatcattgcc tgccaggtgc ccaggaatgg aacaagtcta
     3181 cgggcaaaac caaacagggc agagaagaaa gagtacacac tactctcctg ttcagctttg
     3241 agtacagaaa ggaagaaaca agccctggag agttgaaggc attcggtttt gattactact
     3301 gtattgagtt gggacagggt acctcgaagc agagcctggt gtttttgttc tgatgctagt
     3361 tcaggggaaa agaaaaagga caaaaaagaa aaaaaaacgc aaaggaaaaa ttgaaagcat
     3421 ataattttta aaaaaaagtt ctgatgacta gaatacggtt ttcaaaatga agtgagcact
     3481 tttggtggtg gtagcagcaa cttcggtcag tgggatgaga gaaatgtctg gagcgttctt
     3541 ctctatgaca cagaagtcag agtcatatga aagcaaagac gttttaaccg aggaccggag
     3601 gggcacttgt aggttttctc tctcctctgt cccatccgaa ttgatactac taaagggcag
     3661 gaatttgaac tagtttactt gggacttggg gtgccctgag gataggactc tttttatttc
     3721 ctaaagtcaa attttcaaaa caaagtacat gtctcagaca gtgtagggct ttagctaaga
     3781 atagttaggt actaaaatgg tcacgaagaa caggaaacag atgcaggtga gcgtgtaggg
     3841 ttttgaaatt tgctactttt cagtgaggaa accattccca gcagaggtga tgaggtgatg
     3901 atactcctat gtcctgaatt cgtgttgtgc tgaagtgttc tgtatggtgt cgtgttatga
     3961 taagcaatta tgaagcccaa ataggaaaag cagacagtat agttgtatat tgtatattat
     4021 attaaacacg gtacaagtcc aatatccttg cagccttatt ttagtgtaat ttattataag
     4081 attctgaaaa gctaacaaat gtgggttaaa tgctgaggac ttctaacaaa aagataatgt
     4141 gtacataaat gttttaacac aaggcgattc tggagtttaa ttatcattac catgtgaaac
     4201 ccaagatgaa gaagcacttt tttttaaagg tgtattagaa tggttatttc ttaatctact
     4261 aaaattgttt cccatgtctt gttattgagg tagacttgct acgataacac cgatcaaggt
     4321 ttccatggca tttttttatg gcagagcatc ttcagcagca ggggaatctt tgtaagagct
     4381 ctaatttaag catactttaa aattaaatga acaaaataaa tattaatgct gggtgactaa
     4441 agatggagaa ggcttagcag caagttaagg tagtgtcatt aaaagacgat gactctggat
     4501 aaaataacca tttaaaaaca aatttgatag ggcgttcgaa tcagctctta tcagccacag
     4561 agaaattcat ttcttgttga gcaaaagatt tttaagcagt tgacttcatc cttctccagt
     4621 atatccatac acttggactg cactagaata gaattatgta ttggtatctt gtgtttaaga
     4681 cgtattagat gctatacagg gccttgaggc ttacagagca ttcgtggcct ctgctaagag
     4741 gaaattctca gccaccgcca acagttctcc ctgcctctgt ttgcacagtt tctgtctgct
     4801 ttttccttgt tttttagcag ctgccttctt tctactctgc cgctcctggg ctctgcaatt
     4861 tgaaaaggtg aattgttgct cctggagatt tgtacctagc tgcattctag gaaagtgaga
     4921 tgggtgttgt tcccactgga ggctgagata gtcatatcag tgacatttag ctgccagagc
     4981 ttgggagaag ggggaagcat tttttggcgt taacaagctc ttgtcagccc ctggtgcaag
     5041 cagacctggg ccacgacaaa ctgcaacaga gctgtgaccg tttctgaggc agggtgtatg
     5101 aaagctagcc tttcagattt cctaacctgg caggatgtcc atcatcaggg agaactactc
     5161 ctcagagtgg cttagctatc aggttctgtt gtaagttctg ccttactggt agcatgcttg
     5221 gcttggccct tagactttgg aatgtactcg ttaattagaa agttccattt agtcaacagt
     5281 acattaagtc aaccatttag ggatttggac caaagcagag gcacaggctg ggtgcttgag
     5341 tttcaggaat ttcagagcca atcaaaggct gcatttatac tgactctgag tatggggacg
     5401 ggagcaactt ggtgtcctca gtatctacac acaatgagtg cttgctaagt atttgttaag
     5461 taggtgaacg agatgtgtaa ctatcaaata ctgaaaatgt ttagagggga agagaggaag
     5521 attgtgttaa gctgtacaga ggaagtgcca tgcttctggc tgaggttgta gttcataggc
     5581 tctgtgtaga tgcctggagt gagcagtggg gcatctgcag tgtttccaaa gtgacacaga
     5641 tctttaattt ccaccaagga attaggaaga aatgcataat ttattaacgt ggagaggcaa
     5701 aaatttcaaa gtaagaaatt aaattttcag tattagtttc ctaaaccata ccaacacaga
     5761 agggtgggga tctggcataa ctgtggttcc aaatcgccca ggtacctaga ggtggtctgt
     5821 acagtccata tgtgaagaaa caatgagatg tttaccgttt cgagtgctgt gaatgcctag
     5881 actgaagaat catggtatag actgtggcca aacagcaatg gctactgtca gaaagtccat
     5941 ccatcccacg gtggatgctg agtgggacaa gttctgtcca agtcttttct ttcttttttt
     6001 cttttttctt ttttgtcaac acactgtata gttgtggctg gattctgcta ttggcgtgaa
     6061 atgaatgtga atttgggtga agctatgaag ttaatattcc ctgggaactt gagcaattaa
     6121 ataaagatca tctttgaaac aca
//
