LOCUS       NM_173310               1701 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus carbohydrate sulfotransferase 15 (Chst15), mRNA.
ACCESSION   NM_173310
VERSION     NM_173310.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1701)
  AUTHORS   Karumbaiah,L., Anand,S., Thazhath,R., Zhong,Y., McKeon,R.J. and
            Bellamkonda,R.V.
  TITLE     Targeted downregulation of N-acetylgalactosamine 4-sulfate
            6-O-sulfotransferase significantly mitigates chondroitin sulfate
            proteoglycan-mediated inhibition
  JOURNAL   Glia 59 (6), 981-996 (2011)
   PUBMED   21456043
  REMARK    GeneRIF: Downregulation of N-acetylgalactosamine 4-sulfate
            6-O-sulfotransferase (CS-E) via siRNA targeting of GalNAc4S6ST
            mitigates chondroitin sulfate proteoglycan-mediated inhibition of
            neurons, potentially offering an intervention strategy for brain
            injury.
REFERENCE   2  (bases 1 to 1701)
  AUTHORS   Ohtake,S., Ito,Y., Fukuta,M. and Habuchi,O.
  TITLE     Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is
            related to human B cell recombination activating gene-associated
            gene
  JOURNAL   J Biol Chem 276 (47), 43894-43900 (2001)
   PUBMED   11572857
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB086953.1.
            
            On Aug 12, 2007 this sequence version replaced NM_173310.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB086953.1, SRR8487230.151441.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN14984024
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1701
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1701
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /note="carbohydrate sulfotransferase 15"
                     /db_xref="GeneID:286974"
                     /db_xref="RGD:628881"
     exon            1..561
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1701
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /EC_number="2.8.2.33"
                     /note="B cell RAG associated protein;
                     N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase;
                     carbohydrate (N-acetylgalactosamine 4-sulfate 6-O)
                     sulfotransferase 15"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 15"
                     /protein_id="NP_775432.3"
                     /db_xref="GeneID:286974"
                     /db_xref="RGD:628881"
                     /translation="MRHCINCCIQLFPEDAHKQQVACQGGPHHSHQACPSCKGEDKIL
                     FRVDSKQMNLLAVLEVRTEGNENWGGFLRFRKGKRCSLVFGLIIMTLVMASYILSGAH
                     QELLISSPFHYGGFPSNPSVMDSESPSDVKEHHYQPSVNNISYVKDYPNIKLIIDSIA
                     ARNEFTTRQLPDLQDLKRQELHMFSVIPNKFLPTSKSPCWYEEFSGRNTTDPYLTNSY
                     VLYSKRFRSTFDTLRKAFWGHLSHVHGKHFRLRCLPHFYIIGQPKCGTTDLYDRLRLH
                     PEVKFSAIKEPHWWTRKRFGIVRLRDGLRDRYPVEDYLDLFDLAAHQIHQGLQAASAE
                     QTSKMNRIIIGEASASTMWDNNAWTFFYDNSTDGEPPFLTQDFIHAFQPEAKLLVMLR
                     DPVERLYSDYLYFASSNKSADDFHEKVTEALQLFENCMLDYSLRACVYNNTLNNAMPV
                     RLQVGLYAVYLLDWLTVFSKEQFLILRLEDHASNVKYTMHKVFQFLNLGPLSEKQEAL
                     MTKSPASNTRRPEDRSLGPMWPITQKILRDFYGPFNTRLAQVLDDEAFAWKTT"
     exon            562..901
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1048
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1205
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1362
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1510
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1701
                     /gene="Chst15"
                     /gene_synonym="Galnac4s-6st; GalNAc4S6ST"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccaaggtct ctaccatgag gcactgcatt aattgctgca tacagctgtt ccccgaagac
       61 gcacacaaac agcaggttgc ctgccaagga ggcccccatc acagtcatca ggcgtgcccc
      121 agttgcaaag gagaagacaa aattctgttc cgggtggaca gtaagcagat gaacttgctt
      181 gctgttctcg aagtgaggac tgagggcaac gaaaactggg gcgggttttt gcgcttcagg
      241 aaagggaagc gatgtagcct ggtctttgga ttgataataa tgaccttggt gatggcttct
      301 tacatccttt ccggggctca tcaggaactt ctaatttcat cccctttcca ttatgggggc
      361 tttcccagca accccagcgt gatggacagt gagagcccta gtgatgtgaa agagcatcac
      421 taccagcctt cggtaaataa catctcctat gtgaaggatt atcccaacat taaactgatt
      481 attgacagca tcgctgccag gaatgagttc acaaccaggc agctcccgga cttacaagat
      541 ctcaagagac aagagttgca catgttttct gtgatcccca ataaattcct tccgactagc
      601 aagagccctt gttggtatga ggaattctcc ggcaggaaca ccactgaccc ctacctgacc
      661 aattcctacg tgctctactc caagcgcttc cgctctacct ttgacactct gcgaaaggct
      721 ttctggggcc acctgtccca tgtgcatggc aagcatttcc gcctgcgctg cctgccacac
      781 ttctacatca ttgggcagcc caagtgcgga accactgacc tctatgaccg ccttcggctg
      841 catccagaag tgaaattctc agccatcaag gagccccact ggtggacccg gaagcgcttt
      901 ggaattgtcc gcctgaggga tgggctacga gaccgctacc ctgtggaaga ttacctggac
      961 ctctttgact tggctgcaca ccagatccat caaggactgc aggctgcctc tgcagagcag
     1021 acgagcaaga tgaataggat cattatcgga gaggccagcg cctctacaat gtgggataac
     1081 aatgcctgga ccttcttcta tgacaacagc acagacggcg agccaccgtt cctgacccaa
     1141 gacttcatcc atgcctttca gcctgaagcc aagctccttg tcatgctcag ggatcccgtg
     1201 gagaggttgt actcagacta tctctacttt gcaagttcaa ataaatccgc cgatgacttc
     1261 cacgagaagg tgacggaggc tctgcagctg tttgaaaatt gcatgctgga ttattcactg
     1321 cgcgcctgcg tctacaacaa caccctgaac aatgccatgc ccgtgaggct ccaggtcggt
     1381 ctgtatgctg tgtatctcct ggactggctc actgtcttca gtaaggagca gttcctcatt
     1441 ctacgtctgg aagaccatgc atccaatgtc aagtacacca tgcacaaggt cttccagttt
     1501 ctaaacctgg ggcctctaag tgagaagcaa gaagctttga tgaccaagag ccccgcgtcc
     1561 aacacacggc gtcctgagga tcgtagtctg ggacccatgt ggccgatcac tcagaagatc
     1621 ctgcgggact tctacgggcc tttcaacaca aggctggcac aggtcctgga tgatgaggcg
     1681 tttgcgtgga agacgacgtg a
//
