LOCUS       NM_019145               1832 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus cholinergic receptor nicotinic gamma subunit
            (Chrng), mRNA.
ACCESSION   NM_019145
VERSION     NM_019145.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1832)
  AUTHORS   Witzemann,V., Chevessier,F., Pacifici,P.G. and Yampolsky,P.
  TITLE     The neuromuscular junction: selective remodeling of synaptic
            regulators at the nerve/muscle interface
  JOURNAL   Mech Dev 130 (6-8), 402-411 (2013)
   PUBMED   23032192
  REMARK    Review article
REFERENCE   2  (bases 1 to 1832)
  AUTHORS   Rasoulpour,R.J., Ellis-Hutchings,R.G., Terry,C., Millar,N.S.,
            Zablotny,C.L., Gibb,A., Marshall,V., Collins,T., Carney,E.W. and
            Billington,R.
  TITLE     A novel mode-of-action mediated by the fetal muscle nicotinic
            acetylcholine receptor resulting in developmental toxicity in rats
  JOURNAL   Toxicol Sci 127 (2), 522-534 (2012)
   PUBMED   22461452
REFERENCE   3  (bases 1 to 1832)
  AUTHORS   Alberola-Die,A., Martinez-Pinna,J., Gonzalez-Ros,J.M., Ivorra,I.
            and Morales,A.
  TITLE     Multiple inhibitory actions of lidocaine on Torpedo nicotinic
            acetylcholine receptors transplanted to Xenopus oocytes
  JOURNAL   J Neurochem 117 (6), 1009-1019 (2011)
   PUBMED   21480901
REFERENCE   4  (bases 1 to 1832)
  AUTHORS   Albuquerque,E.X., Pereira,E.F., Alkondon,M. and Rogers,S.W.
  TITLE     Mammalian nicotinic acetylcholine receptors: from structure to
            function
  JOURNAL   Physiol Rev 89 (1), 73-120 (2009)
   PUBMED   19126755
  REMARK    Review article
REFERENCE   5  (bases 1 to 1832)
  AUTHORS   Yumoto,N., Wakatsuki,S. and Sehara-Fujisawa,A.
  TITLE     The acetylcholine receptor gamma-to-epsilon switch occurs in
            individual endplates
  JOURNAL   Biochem Biophys Res Commun 331 (4), 1522-1527 (2005)
   PUBMED   15883046
REFERENCE   6  (bases 1 to 1832)
  AUTHORS   Marchand,S., Devillers-Thiery,A., Pons,S., Changeux,J.P. and
            Cartaud,J.
  TITLE     Rapsyn escorts the nicotinic acetylcholine receptor along the
            exocytic pathway via association with lipid rafts
  JOURNAL   J Neurosci 22 (20), 8891-8901 (2002)
   PUBMED   12388596
REFERENCE   7  (bases 1 to 1832)
  AUTHORS   Keller,S.H., Lindstrom,J. and Taylor,P.
  TITLE     Involvement of the chaperone protein calnexin and the acetylcholine
            receptor beta-subunit in the assembly and cell surface expression
            of the receptor
  JOURNAL   J Biol Chem 271 (37), 22871-22877 (1996)
   PUBMED   8798466
REFERENCE   8  (bases 1 to 1832)
  AUTHORS   Witzemann,V., Stein,E., Barg,B., Konno,T., Koenen,M., Kues,W.,
            Criado,M., Hofmann,M. and Sakmann,B.
  TITLE     Primary structure and functional expression of the alpha-, beta-,
            gamma-, delta- and epsilon-subunits of the acetylcholine receptor
            from rat muscle
  JOURNAL   Eur J Biochem 194 (2), 437-448 (1990)
   PUBMED   1702709
REFERENCE   9  (bases 1 to 1832)
  AUTHORS   Gu,Y., Franco,A. Jr., Gardner,P.D., Lansman,J.B., Forsayeth,J.R.
            and Hall,Z.W.
  TITLE     Properties of embryonic and adult muscle acetylcholine receptors
            transiently expressed in COS cells
  JOURNAL   Neuron 5 (2), 147-157 (1990)
   PUBMED   2383398
REFERENCE   10 (bases 1 to 1832)
  AUTHORS   Witzemann,V., Barg,B., Nishikawa,Y., Sakmann,B. and Numa,S.
  TITLE     Differential regulation of muscle acetylcholine receptor gamma- and
            epsilon-subunit mRNAs
  JOURNAL   FEBS Lett 223 (1), 104-112 (1987)
   PUBMED   3666131
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X74834.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X74834.1, SRR8487230.73989.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1832
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..1832
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /note="cholinergic receptor nicotinic gamma subunit"
                     /db_xref="GeneID:25753"
                     /db_xref="RGD:2354"
     exon            1..187
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1692
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /note="acetylcholine receptor subunit gamma; cholinergic
                     receptor, nicotinic, gamma (muscle); cholinergic receptor,
                     nicotinic gamma; cholinergic receptor, nicotinic, gamma
                     polypeptide; AChR gamma subunit"
                     /codon_start=1
                     /product="acetylcholine receptor subunit gamma precursor"
                     /protein_id="NP_062018.1"
                     /db_xref="GeneID:25753"
                     /db_xref="RGD:2354"
                     /translation="MHGGQGPQLLLLLLATCLGAQSRNQEERLLADLMRNYDPHLRPA
                     ERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPKDYEGLWILRV
                     PSTMVWQPDIVLGNNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSSCSISVTYFPFD
                     WQNCSLVFQSQTYSTSEINLQLSQEDGQAIEWIFIDPEAFTENGEWAIRHRPAKMLLD
                     PVTPAEEAGHQKVVFYLLIQRKPLFYVINIIVPCVLISSVAILIYFLPAKAGGQKCTV
                     ATNVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLRSP
                     HTHSMARGVRKVFLRLLPQLLRMHVHPRAPAAVQDARLRLQNGSSSGWPIMTREEGDL
                     CLPRSELLFRQRQRNGLVQAVLEKLENGPEMRQSQEFCGSLKQASPAIQACVDACNLM
                     ARARHQQSHFDSGNEEWLLVGRVLDRVCFLAMLSLFICGTAGIFLMAHYNQVPDLPFP
                     GDPRPYLPLPD"
     exon            188..327
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /inference="alignment:Splign:2.1.0"
     exon            328..372
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /inference="alignment:Splign:2.1.0"
     exon            373..482
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /inference="alignment:Splign:2.1.0"
     exon            483..638
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /inference="alignment:Splign:2.1.0"
     exon            639..736
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /inference="alignment:Splign:2.1.0"
     exon            737..937
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1052
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1167
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1384
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1518
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1832
                     /gene="Chrng"
                     /gene_synonym="ACHRG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggtggggc ctgatagagc tggcagggtt ggctgggagg ggcgtgtagg ctgacacagg
       61 acactccaac cccccaaccc caagacctgt aaagctactg tcctactcat cactgggcag
      121 aactgaggca ccatgcacgg gggccaggga cctcagctcc tcttgctgct gctggctacc
      181 tgcctggggg cccagagccg caaccaagag gagcggctgc ttgcggacct gatgcgcaac
      241 tacgaccccc atctgcggcc ggctgagcgt gactcagatg tggttaatgt cagcctgaag
      301 cttaccttaa ccaacctcat ctcccttaat gagcgagagg aggccctcac gactaatgtc
      361 tggatagaaa tgcaatggtg cgactatcgc ctacgctggg acccgaaaga ctacgaaggc
      421 ctgtggatat tgagggtgcc atctaccatg gtctggcagc ccgatatcgt gctgggaaac
      481 aatgtggacg gtgtcttcga ggtggcgctc tactgcaatg tgctcgtgtc ccctgatggt
      541 tgtatctact ggctgccgcc tgccatcttc cgctcctcct gctccatctc tgtcacctac
      601 ttccccttcg attggcagaa ctgctccctc gtcttccagt cccagactta cagcaccagc
      661 gagatcaact tgcagctgag ccaggaggat gggcaagcca ttgagtggat cttcattgac
      721 cccgaggctt tcacagagaa tggggaatgg gccatccggc atcgaccagc caaaatgcta
      781 ctggatcctg tgactccagc agaggaggca ggccaccaga aggtggtgtt ctacctgctc
      841 atccaacgca agcccctctt ctatgtcatc aacatcatcg tcccctgtgt gctcatctcc
      901 tcagttgcga tcctcatcta cttccttcct gccaaggcgg gcggccagaa gtgcacagtg
      961 gccaccaacg tgctcctggc ccagaccgtc ttccttttcc tcgtggctaa gaaggtgcct
     1021 gagacctccc aggcagtgcc gctcatcagc aagtacctga ccttcctcat ggtggtgacc
     1081 atcctcatcg ttgtgaactc tgtggtcgtg ctcaatgtgt ccttgaggtc cccacacaca
     1141 cactccatgg cccggggggt ccgcaaggtg tttttgaggc tcctgcccca gctgttacgg
     1201 atgcatgtgc atcctcgggc tcctgctgct gtccaggatg cccggctgcg actccagaat
     1261 ggctcttcct cagggtggcc catcatgact cgagaggaag gggacctctg tttgcctcga
     1321 agcgaactcc tctttaggca aaggcagcgc aatggattgg tgcaggcagt actggagaag
     1381 ttagagaatg gtccagaaat gaggcagagc caggagttct gtggcagcct gaagcaagcc
     1441 tccccggcca tccaggcctg tgtggatgcc tgtaacctca tggcgcgtgc ccgacaccag
     1501 caaagtcact ttgacagtgg gaatgaggag tggttgctgg tgggccgagt gctggaccga
     1561 gtctgtttcc tagccatgct ctccctcttc atctgcggca ctgctggcat cttcctcatg
     1621 gcccactaca accaggtgcc tgacctgcca ttccctggag acccccgccc ctacttgcct
     1681 ttgccagact gagccaacca atcactcctg cgccctggag tcagccatgt gggtcatgct
     1741 gtttatggag ctgtattctc tgttgatcct gatgggctcc tggggagcaa tcattcttgg
     1801 gagaagatag aggaataaag gaataggaat aa
//
