LOCUS       NM_019298               1696 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus cholinergic receptor nicotinic delta subunit
            (Chrnd), mRNA.
ACCESSION   NM_019298
VERSION     NM_019298.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1696)
  AUTHORS   Witzemann,V., Chevessier,F., Pacifici,P.G. and Yampolsky,P.
  TITLE     The neuromuscular junction: selective remodeling of synaptic
            regulators at the nerve/muscle interface
  JOURNAL   Mech Dev 130 (6-8), 402-411 (2013)
   PUBMED   23032192
  REMARK    Review article
REFERENCE   2  (bases 1 to 1696)
  AUTHORS   Rasoulpour,R.J., Ellis-Hutchings,R.G., Terry,C., Millar,N.S.,
            Zablotny,C.L., Gibb,A., Marshall,V., Collins,T., Carney,E.W. and
            Billington,R.
  TITLE     A novel mode-of-action mediated by the fetal muscle nicotinic
            acetylcholine receptor resulting in developmental toxicity in rats
  JOURNAL   Toxicol Sci 127 (2), 522-534 (2012)
   PUBMED   22461452
REFERENCE   3  (bases 1 to 1696)
  AUTHORS   Alberola-Die,A., Martinez-Pinna,J., Gonzalez-Ros,J.M., Ivorra,I.
            and Morales,A.
  TITLE     Multiple inhibitory actions of lidocaine on Torpedo nicotinic
            acetylcholine receptors transplanted to Xenopus oocytes
  JOURNAL   J Neurochem 117 (6), 1009-1019 (2011)
   PUBMED   21480901
REFERENCE   4  (bases 1 to 1696)
  AUTHORS   Albuquerque,E.X., Pereira,E.F., Alkondon,M. and Rogers,S.W.
  TITLE     Mammalian nicotinic acetylcholine receptors: from structure to
            function
  JOURNAL   Physiol Rev 89 (1), 73-120 (2009)
   PUBMED   19126755
  REMARK    Review article
REFERENCE   5  (bases 1 to 1696)
  AUTHORS   Michalk,A., Stricker,S., Becker,J., Rupps,R., Pantzar,T.,
            Miertus,J., Botta,G., Naretto,V.G., Janetzki,C., Yaqoob,N.,
            Ott,C.E., Seelow,D., Wieczorek,D., Fiebig,B., Wirth,B.,
            Hoopmann,M., Walther,M., Korber,F., Blankenburg,M., Mundlos,S.,
            Heller,R. and Hoffmann,K.
  TITLE     Acetylcholine receptor pathway mutations explain various fetal
            akinesia deformation sequence disorders
  JOURNAL   Am J Hum Genet 82 (2), 464-476 (2008)
   PUBMED   18252226
REFERENCE   6  (bases 1 to 1696)
  AUTHORS   Keller,S.H., Lindstrom,J. and Taylor,P.
  TITLE     Involvement of the chaperone protein calnexin and the acetylcholine
            receptor beta-subunit in the assembly and cell surface expression
            of the receptor
  JOURNAL   J Biol Chem 271 (37), 22871-22877 (1996)
   PUBMED   8798466
REFERENCE   7  (bases 1 to 1696)
  AUTHORS   Chahine,K.G., Walke,W. and Goldman,D.
  TITLE     A 102 base pair sequence of the nicotinic acetylcholine receptor
            delta-subunit gene confers regulation by muscle electrical activity
  JOURNAL   Development 115 (1), 213-219 (1992)
   PUBMED   1638981
REFERENCE   8  (bases 1 to 1696)
  AUTHORS   Witzemann,V., Stein,E., Barg,B., Konno,T., Koenen,M., Kues,W.,
            Criado,M., Hofmann,M. and Sakmann,B.
  TITLE     Primary structure and functional expression of the alpha-, beta-,
            gamma-, delta- and epsilon-subunits of the acetylcholine receptor
            from rat muscle
  JOURNAL   Eur J Biochem 194 (2), 437-448 (1990)
   PUBMED   1702709
REFERENCE   9  (bases 1 to 1696)
  AUTHORS   Gu,Y., Franco,A. Jr., Gardner,P.D., Lansman,J.B., Forsayeth,J.R.
            and Hall,Z.W.
  TITLE     Properties of embryonic and adult muscle acetylcholine receptors
            transiently expressed in COS cells
  JOURNAL   Neuron 5 (2), 147-157 (1990)
   PUBMED   2383398
REFERENCE   10 (bases 1 to 1696)
  AUTHORS   Porter,C.W., Barnard,E.A. and Chiu,T.H.
  TITLE     The ultrastructural localization and quantitation of cholinergic
            receptors at the mouse motor endplate
  JOURNAL   J Membr Biol 14 (4), 383-402 (1973)
   PUBMED   4781450
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X74835.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X74835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..1696
                     /gene="Chrnd"
                     /note="cholinergic receptor nicotinic delta subunit"
                     /db_xref="GeneID:54240"
                     /db_xref="RGD:2352"
     CDS             1..1554
                     /gene="Chrnd"
                     /note="cholinergic receptor, nicotinic, delta polypeptide;
                     nicotinic acetylcholine receptor delta-subunit;
                     acetylcholine receptor subunit delta; cholinergic
                     receptor, nicotinic, delta (muscle); cholinergic receptor,
                     nicotinic delta"
                     /codon_start=1
                     /product="acetylcholine receptor subunit delta precursor"
                     /protein_id="NP_062171.1"
                     /db_xref="GeneID:54240"
                     /db_xref="RGD:2352"
                     /translation="MAGPVPTLGLLAALVVCGSWGLNEEQRLIQHLFEEKGYNKELRP
                     VARKEDIVDVALSLTLSNLISLKEVEETLTTNVWIDHAWIDSRLQWNANEFGNITVLR
                     LPSDMVWLPEIVLENNNDGSFQISYACNVLVSDSGHVTWLPPAIFRSSCPISVTYFPF
                     DWQNCSLKFSSLKYTAKEIRLSLKQEEEDNRSYPIEWIIIDPEGFTENGEWEIVHRAA
                     KVNVDPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVPCVLISFMINLVFYLPGDCGE
                     KTSVAISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVTMVVVICVIVLNIH
                     FRTPSTHVLSEGVKKFFLETLPKLLHMSRPEEEDPGPRALIRRTSSLGYISKAEEYFS
                     LKSRSDLMFEKQSERHGLARRLTTARKPPASSEQVQQELFNEMKPAVDGANFIVNHMR
                     DQNSYNEEKDNWNQVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPFS
                     YDEQDRRFI"
     exon            1..52
                     /gene="Chrnd"
                     /inference="alignment:Splign:2.1.0"
     exon            53..198
                     /gene="Chrnd"
                     /inference="alignment:Splign:2.1.0"
     exon            199..243
                     /gene="Chrnd"
                     /inference="alignment:Splign:2.1.0"
     exon            244..353
                     /gene="Chrnd"
                     /inference="alignment:Splign:2.1.0"
     exon            354..509
                     /gene="Chrnd"
                     /inference="alignment:Splign:2.1.0"
     exon            510..619
                     /gene="Chrnd"
                     /inference="alignment:Splign:2.1.0"
     exon            620..820
                     /gene="Chrnd"
                     /inference="alignment:Splign:2.1.0"
     exon            821..932
                     /gene="Chrnd"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1047
                     /gene="Chrnd"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1252
                     /gene="Chrnd"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1371
                     /gene="Chrnd"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1696
                     /gene="Chrnd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcagggc ctgtgcccac actggggctg ctggctgccc ttgttgtgtg tggcagctgg
       61 ggcctgaatg aggaacaaag gctgatccag cacctgtttg aggaaaaagg ctacaacaaa
      121 gaacttcggc cggtggctcg aaaggaggac atagtggatg tcgccttaag tctgaccctc
      181 tccaacctca tctccctgaa agaagtggag gagaccctca ccaccaatgt gtggatagat
      241 catgcatgga tagacagccg gctacaatgg aatgccaacg agtttgggaa catcaccgtc
      301 ctgcgcctgc cctctgacat ggtgtggcta ccagaaattg tactggagaa caacaatgac
      361 ggctcattcc agatttctta cgcctgcaat gtgcttgttt ctgactcggg ccatgtgacc
      421 tggctgccac ccgccatctt ccgctcctcc tgccccatct cggtcaccta cttccctttc
      481 gattggcaga actgctccct caaattcagt tcactcaagt ataccgccaa ggagatcaga
      541 cttagcctga agcaggagga ggaagacaac cgcagttacc ccattgagtg gatcatcatt
      601 gaccctgagg gtttcacaga gaacggtgag tgggaaatag ttcaccgggc agccaaggtc
      661 aacgtggacc ccagtgtccc aatggacagc accaaccacc aagacgtcac cttctacctc
      721 atcatccgcc gcaagccgct cttctacatc atcaacatcc tggtaccctg tgtgctcatc
      781 tccttcatga tcaacctggt cttctacctg ccaggcgact gtggagagaa gacctcggtg
      841 gccatctcag tgctcctggc ccaatctgtc ttcctgttgc ttatctccaa gaggctgccg
      901 gccacatcca tggccattcc tttggtaggc aagttcctgc tttttggcat ggtgctggtc
      961 accatggttg tggtgatctg cgtcatcgtg ctcaacatcc acttccgaac acccagcacg
     1021 catgttctgt ctgagggagt caagaagttc ttcctggaga ccctgcccaa actcctgcac
     1081 atgtcccgcc cagaagagga agacccgggc cccagggctc tcatccggag gaccagctct
     1141 ctgggataca tctccaaggc agaggagtac ttctcactta agtcccgcag tgacctcatg
     1201 tttgagaagc aatcagagcg gcatgggctg gcccggcgcc tcaccacagc ccgcaagcca
     1261 ccagcaagct ctgagcaggt ccaacaggag cttttcaatg agatgaagcc agccgtggat
     1321 ggggcgaact tcatcgtcaa ccacatgagg gaccagaaca gttacaatga ggagaaggac
     1381 aactggaacc aggtggcccg cacagtggac cgtctctgct tgtttgtggt gacgcccgtc
     1441 atggtggtgg gcacagcctg gatcttcctg cagggtgtct acaaccagcc cccaccccag
     1501 cctttccctg gggacccctt ctcctatgat gaacaggaca ggcgcttcat ttagagcagg
     1561 catgagtaaa acagtcaggc agacggcggt ctgagaattg tccttgagct tgtgcctatc
     1621 tggggctgtg tggctgggca gaggtcatgg gaggaagagc tccctcccag gagcaattcc
     1681 tttctaaata aaggag
//
