LOCUS       NP_062171                517 aa            linear   ROD 02-APR-2024
DEFINITION  acetylcholine receptor subunit delta precursor [Rattus norvegicus].
ACCESSION   NP_062171
VERSION     NP_062171.1
DBSOURCE    REFSEQ: accession NM_019298.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 517)
  AUTHORS   Witzemann,V., Chevessier,F., Pacifici,P.G. and Yampolsky,P.
  TITLE     The neuromuscular junction: selective remodeling of synaptic
            regulators at the nerve/muscle interface
  JOURNAL   Mech Dev 130 (6-8), 402-411 (2013)
   PUBMED   23032192
  REMARK    Review article
REFERENCE   2  (residues 1 to 517)
  AUTHORS   Rasoulpour,R.J., Ellis-Hutchings,R.G., Terry,C., Millar,N.S.,
            Zablotny,C.L., Gibb,A., Marshall,V., Collins,T., Carney,E.W. and
            Billington,R.
  TITLE     A novel mode-of-action mediated by the fetal muscle nicotinic
            acetylcholine receptor resulting in developmental toxicity in rats
  JOURNAL   Toxicol Sci 127 (2), 522-534 (2012)
   PUBMED   22461452
REFERENCE   3  (residues 1 to 517)
  AUTHORS   Alberola-Die,A., Martinez-Pinna,J., Gonzalez-Ros,J.M., Ivorra,I.
            and Morales,A.
  TITLE     Multiple inhibitory actions of lidocaine on Torpedo nicotinic
            acetylcholine receptors transplanted to Xenopus oocytes
  JOURNAL   J Neurochem 117 (6), 1009-1019 (2011)
   PUBMED   21480901
REFERENCE   4  (residues 1 to 517)
  AUTHORS   Albuquerque,E.X., Pereira,E.F., Alkondon,M. and Rogers,S.W.
  TITLE     Mammalian nicotinic acetylcholine receptors: from structure to
            function
  JOURNAL   Physiol Rev 89 (1), 73-120 (2009)
   PUBMED   19126755
  REMARK    Review article
REFERENCE   5  (residues 1 to 517)
  AUTHORS   Michalk,A., Stricker,S., Becker,J., Rupps,R., Pantzar,T.,
            Miertus,J., Botta,G., Naretto,V.G., Janetzki,C., Yaqoob,N.,
            Ott,C.E., Seelow,D., Wieczorek,D., Fiebig,B., Wirth,B.,
            Hoopmann,M., Walther,M., Korber,F., Blankenburg,M., Mundlos,S.,
            Heller,R. and Hoffmann,K.
  TITLE     Acetylcholine receptor pathway mutations explain various fetal
            akinesia deformation sequence disorders
  JOURNAL   Am J Hum Genet 82 (2), 464-476 (2008)
   PUBMED   18252226
REFERENCE   6  (residues 1 to 517)
  AUTHORS   Keller,S.H., Lindstrom,J. and Taylor,P.
  TITLE     Involvement of the chaperone protein calnexin and the acetylcholine
            receptor beta-subunit in the assembly and cell surface expression
            of the receptor
  JOURNAL   J Biol Chem 271 (37), 22871-22877 (1996)
   PUBMED   8798466
REFERENCE   7  (residues 1 to 517)
  AUTHORS   Chahine,K.G., Walke,W. and Goldman,D.
  TITLE     A 102 base pair sequence of the nicotinic acetylcholine receptor
            delta-subunit gene confers regulation by muscle electrical activity
  JOURNAL   Development 115 (1), 213-219 (1992)
   PUBMED   1638981
REFERENCE   8  (residues 1 to 517)
  AUTHORS   Witzemann,V., Stein,E., Barg,B., Konno,T., Koenen,M., Kues,W.,
            Criado,M., Hofmann,M. and Sakmann,B.
  TITLE     Primary structure and functional expression of the alpha-, beta-,
            gamma-, delta- and epsilon-subunits of the acetylcholine receptor
            from rat muscle
  JOURNAL   Eur J Biochem 194 (2), 437-448 (1990)
   PUBMED   1702709
REFERENCE   9  (residues 1 to 517)
  AUTHORS   Gu,Y., Franco,A. Jr., Gardner,P.D., Lansman,J.B., Forsayeth,J.R.
            and Hall,Z.W.
  TITLE     Properties of embryonic and adult muscle acetylcholine receptors
            transiently expressed in COS cells
  JOURNAL   Neuron 5 (2), 147-157 (1990)
   PUBMED   2383398
REFERENCE   10 (residues 1 to 517)
  AUTHORS   Porter,C.W., Barnard,E.A. and Chiu,T.H.
  TITLE     The ultrastructural localization and quantitation of cholinergic
            receptors at the mouse motor endplate
  JOURNAL   J Membr Biol 14 (4), 383-402 (1973)
   PUBMED   4781450
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X74835.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X74835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     Protein         1..517
                     /product="acetylcholine receptor subunit delta precursor"
                     /note="cholinergic receptor, nicotinic, delta polypeptide;
                     nicotinic acetylcholine receptor delta-subunit;
                     acetylcholine receptor subunit delta; cholinergic
                     receptor, nicotinic, delta (muscle); cholinergic receptor,
                     nicotinic delta"
                     /calculated_mol_wt=56890
     sig_peptide     1..21
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P25110.1)"
                     /calculated_mol_wt=2012
     mat_peptide     22..517
                     /product="acetylcholine receptor subunit delta"
                     /calculated_mol_wt=56890
     Region          26..246
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(62,64,70..71,78,100,102,111..112,114,116..117,
                     128..130,132,142,144,146,150,172,245)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349829"
     Site            97
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P25110.1)"
     Site            164
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P25110.1)"
     Site            190
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P25110.1)"
     Site            246..270
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P25110.1)"
     Region          253..489
                     /region_name="Neur_chan_memb"
                     /note="Neurotransmitter-gated ion-channel transmembrane
                     region; pfam02932"
                     /db_xref="CDD:460753"
     Site            278..296
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P25110.1)"
     Site            312..333
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P25110.1)"
     Site            390
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by Tyr-kinases.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P25110.1)"
     Site            472..490
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P25110.1)"
     CDS             1..517
                     /gene="Chrnd"
                     /coded_by="NM_019298.1:1..1554"
                     /db_xref="GeneID:54240"
                     /db_xref="RGD:2352"
ORIGIN      
        1 magpvptlgl laalvvcgsw glneeqrliq hlfeekgynk elrpvarked ivdvalsltl
       61 snlislkeve etlttnvwid hawidsrlqw nanefgnitv lrlpsdmvwl peivlennnd
      121 gsfqisyacn vlvsdsghvt wlppaifrss cpisvtyfpf dwqncslkfs slkytakeir
      181 lslkqeeedn rsypiewiii dpegftenge weivhraakv nvdpsvpmds tnhqdvtfyl
      241 iirrkplfyi inilvpcvli sfminlvfyl pgdcgektsv aisvllaqsv fllliskrlp
      301 atsmaiplvg kfllfgmvlv tmvvvicviv lnihfrtpst hvlsegvkkf fletlpkllh
      361 msrpeeedpg pralirrtss lgyiskaeey fslksrsdlm fekqserhgl arrlttarkp
      421 passeqvqqe lfnemkpavd ganfivnhmr dqnsyneekd nwnqvartvd rlclfvvtpv
      481 mvvgtawifl qgvynqpppq pfpgdpfsyd eqdrrfi
//
