LOCUS       NM_133597               2606 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus cholinergic receptor nicotinic beta 3 subunit
            (Chrnb3), mRNA.
ACCESSION   NM_133597
VERSION     NM_133597.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2606)
  AUTHORS   Shi,J., Chen,N., Wang,Z., Wang,F., Tan,Y., Tan,S., Tong,J., An,H.,
            Guo,X., Zuo,L., Wang,X., Yang,F. and Luo,X.
  TITLE     Cholinergic receptor nicotinic beta 3 subunit polymorphisms and
            smoking in male Chinese patients with schizophrenia
  JOURNAL   EC Psychol Psychiatr 10 (7), 11-23 (2021)
   PUBMED   34368810
REFERENCE   2  (bases 1 to 2606)
  AUTHORS   Wen,L., Han,H., Liu,Q., Su,K., Yang,Z., Cui,W., Yuan,W., Ma,Y.,
            Fan,R., Chen,J., Jiang,K., Jiang,X., Payne,T.J., Wang,J. and
            Li,M.D.
  TITLE     Significant association of the CHRNB3-CHRNA6 gene cluster with
            nicotine dependence in the Chinese Han population
  JOURNAL   Sci Rep 7 (1), 9745 (2017)
   PUBMED   28851948
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2606)
  AUTHORS   Han,S., Yang,S.H., Kim,J.Y., Mo,S., Yang,E., Song,K.M., Ham,B.J.,
            Mechawar,N., Turecki,G., Lee,H.W. and Kim,H.
  TITLE     Down-regulation of cholinergic signaling in the habenula induces
            anhedonia-like behavior
  JOURNAL   Sci Rep 7 (1), 900 (2017)
   PUBMED   28420875
  REMARK    Erratum:[Sci Rep. 2017 Dec 1;7(1):17090. doi:
            10.1038/s41598-017-16991-1.. PMID: 29196669]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2606)
  AUTHORS   Bar-Shira,A., Gana-Weisz,M., Gan-Or,Z., Giladi,E., Giladi,N. and
            Orr-Urtreger,A.
  TITLE     CHRNB3 c.-57A>G functional promoter change affects Parkinson's
            disease and smoking
  JOURNAL   Neurobiol Aging 35 (9), 2179 (2014)
   PUBMED   24731518
REFERENCE   5  (bases 1 to 2606)
  AUTHORS   Meixner,M., Atanasova,S., Padberg,W. and Grau,V.
  TITLE     Expression of acetylcholine receptors by experimental rat renal
            allografts
  JOURNAL   Biomed Res Int 2014, 289656 (2014)
   PUBMED   25121092
REFERENCE   6  (bases 1 to 2606)
  AUTHORS   Cox,B.C., Marritt,A.M., Perry,D.C. and Kellar,K.J.
  TITLE     Transport of multiple nicotinic acetylcholine receptors in the rat
            optic nerve: high densities of receptors containing alpha6 and
            beta3 subunits
  JOURNAL   J Neurochem 105 (5), 1924-1938 (2008)
   PUBMED   18266937
  REMARK    GeneRIF: The concentration of beta3- and alpha6- containing
            neuronal nicotinic acetylcholine receptors (nAChRs) is higher in
            the optic nerve than in any other area of the rat brain.
REFERENCE   7  (bases 1 to 2606)
  AUTHORS   Marritt,A.M., Cox,B.C., Yasuda,R.P., McIntosh,J.M., Xiao,Y.,
            Wolfe,B.B. and Kellar,K.J.
  TITLE     Nicotinic cholinergic receptors in the rat retina: simple and mixed
            heteromeric subtypes
  JOURNAL   Mol Pharmacol 68 (6), 1656-1668 (2005)
   PUBMED   16129735
REFERENCE   8  (bases 1 to 2606)
  AUTHORS   Cui,C., Booker,T.K., Allen,R.S., Grady,S.R., Whiteaker,P.,
            Marks,M.J., Salminen,O., Tritto,T., Butt,C.M., Allen,W.R.,
            Stitzel,J.A., McIntosh,J.M., Boulter,J., Collins,A.C. and
            Heinemann,S.F.
  TITLE     The beta3 nicotinic receptor subunit: a component of
            alpha-conotoxin MII-binding nicotinic acetylcholine receptors that
            modulate dopamine release and related behaviors
  JOURNAL   J Neurosci 23 (35), 11045-11053 (2003)
   PUBMED   14657161
REFERENCE   9  (bases 1 to 2606)
  AUTHORS   Forsayeth,J.R. and Kobrin,E.
  TITLE     Formation of oligomers containing the beta3 and beta4 subunits of
            the rat nicotinic receptor
  JOURNAL   J Neurosci 17 (5), 1531-1538 (1997)
   PUBMED   9030613
REFERENCE   10 (bases 1 to 2606)
  AUTHORS   Deneris,E.S., Boulter,J., Swanson,L.W., Patrick,J. and Heinemann,S.
  TITLE     Beta 3: a new member of nicotinic acetylcholine receptor gene
            family is expressed in brain
  JOURNAL   J Biol Chem 264 (11), 6268-6272 (1989)
   PUBMED   2703489
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Dec 5, 2020 this sequence version replaced NM_133597.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04636.1, AY574259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000016.1  71454031-71454225   c
            196-368             JAXUCZ010000016.1  71438793-71438965   c
            369-413             JAXUCZ010000016.1  71428145-71428189   c
            414-523             JAXUCZ010000016.1  71421888-71421997   c
            524-1406            JAXUCZ010000016.1  71420815-71421697   c
            1407-2606           JAXUCZ010000016.1  71417039-71418238   c
FEATURES             Location/Qualifiers
     source          1..2606
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.3"
     gene            1..2606
                     /gene="Chrnb3"
                     /note="cholinergic receptor nicotinic beta 3 subunit"
                     /db_xref="GeneID:171131"
                     /db_xref="RGD:621544"
     exon            1..195
                     /gene="Chrnb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1541
                     /gene="Chrnb3"
                     /note="neuronal acetylcholine receptor subunit beta-3;
                     cholinergic receptor, nicotinic, beta polypeptide 3;
                     cholinergic receptor, nicotinic, beta 3 (neuronal);
                     cholinergic receptor, nicotinic beta 3"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit beta-3
                     precursor"
                     /protein_id="NP_598281.1"
                     /db_xref="GeneID:171131"
                     /db_xref="RGD:621544"
                     /translation="MTGFLRVFLVLSATLSGSWVTLTATAGLSSVAEHEDALLRHLFQ
                     GYQKWVRPVLNSSDIIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDQKLRWNPEE
                     YGGINSIKVPSESLWLPDIVLFENADGRFEGSLMTKAIVKSSGTVSWTPPASYKSSCT
                     MDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKGMKGN
                     RREGFYSYPFVTYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTS
                     VLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTY
                     HPMAPWVKRLFLQRLPRWLCMKDPMDRFSFPDGKESDTAVRGKVSGKRKQTPASDGER
                     VLVAFLEKASESIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIASVLGSIL
                     IFIPALKMWIHRFH"
     exon            196..368
                     /gene="Chrnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            369..413
                     /gene="Chrnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            414..523
                     /gene="Chrnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            524..1406
                     /gene="Chrnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..2606
                     /gene="Chrnb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgactatttt catcaggcag ctggtcacgg tccccttggg tttcatcagg ctttgaacca
       61 ctcacatttt gtttttttaa accctgatcc tttccagtgg aaacactctg cgcttgaaag
      121 gaaaatgtct ctctgaagca gacgtcatga caggcttcct aagggtcttc ttggttctca
      181 gtgccactct ctcaggttcc tgggtgactc ttacggccac tgcaggactc agctcagtgg
      241 ctgaacacga agacgcactc ctcagacatt tgttccaagg ttaccagaaa tgggtccgcc
      301 ctgtgttgaa ttccagtgac atcataaaag tgtattttgg attaaaaata tcccagcttg
      361 tggatgtgga tgaaaagaat cagctgatga cgacaaatgt gtggctgaag caggaatgga
      421 cagaccaaaa attacgctgg aatccggaag aatatggtgg aattaattcg ataaaggttc
      481 catcagaatc gctctggctg ccggacatag ttctctttga aaatgctgac ggacgttttg
      541 agggctccct catgaccaag gccattgtga agtccagtgg aaccgtcagc tggactcctc
      601 ccgccagcta caagagttcc tgcaccatgg atgtcacatt tttcccgttc gacaggcaga
      661 actgctcgat gaagtttgga tcctggactt acgacggtac catggttgac ctcattctaa
      721 tcaatgaaaa cgttgaccgg aaagactttt ttgataacgg agagtgggag atactcaacg
      781 caaaggggat gaagggcaac agaagagaag gcttttactc ctatccgttt gttacctact
      841 cttttgtcct gagacgcctg cccttgtttt acacgctctt tttgataatc ccctgcctgg
      901 ggttgtcttt tctcacggtc ctggtgttct acctaccctc ggacgaaggg gaaaaactct
      961 cattatccac ctccgttttg gtctctttga cggtgtttct tttagtgatt gaagaaataa
     1021 tcccgtcctc ttcgaaggtc atccccctca ttggcgagta cctcctcttc attatgattt
     1081 ttgtcacgct gtctattatc gtcacggttt ttgtaattaa tgtccaccac agatcttcct
     1141 caacgtacca tcccatggcc ccctgggtga agaggctgtt tctacaaaga ctcccgagat
     1201 ggctttgcat gaaggacccc atggaccgct tctctttccc ggatggaaag gagagtgata
     1261 cagccgtgag ggggaaagtc tcaggcaaaa ggaaacagac tcccgccagc gatggagaaa
     1321 gagttctggt cgctttcctc gagaaggcct ccgagtccat cagatacatt tcgaggcatg
     1381 tgaaaaagga acacttcatc agccaggtag tgcaagactg gaaatttgtg gctcaagttc
     1441 tggaccgcat cttcctgtgg ctctttctga tagcttctgt gttgggttcc attctgattt
     1501 ttattccagc cttgaagatg tggatacatc gtttccacta ggagccactc tctggaccca
     1561 tttagaagac atacatagag acaatcccac cttaggactg acagcggctg gcatgctgac
     1621 aggaagcaga gccatgcaat cgtagtggtg cccttgtctt gtcctgggag ctttctgtga
     1681 ttgcagggca ctgagagaat gtgggtttga gttagtgaga tggtggctgc cattagaggt
     1741 gtagttgggc aatttggaga cgtctccatg ttatattgtt atgtgggagt tcctgaacta
     1801 ctccctctgc tcatccctga acgcactggg gctatgtggt atttctctag cagtgtgcgt
     1861 gaacgcattt tgacaatagt ttcaggaatt acgcaggtac aactctccac acacaggtca
     1921 aatttgccac ttgtcaacga gtgtcccaca aatagggtca ttgaagatga ccttgaatgg
     1981 ctatgacagt tctctaaggc aggtgttact ggaagtttgc tcactgacct gcgaactttt
     2041 cgaatgcagg taggaactcg ggtgatttct agcttgctgt aaggttccat caaaataact
     2101 taccccagaa aaacagccat tcgctagtag aactgtattt attcacacac atctcttttt
     2161 tttctcttag ggaattaaaa gtgttgaata ttctttgatt gtggttttgg aaggcctctt
     2221 agccagtgtt ctattactgt gaagagatac catgaccatg gcaaaaagat cagaggttta
     2281 gtccactttc attacagtgg gaagcatggt gccgctcggc agatacggtg ctagacatgt
     2341 acatctggat ctgcaggcag caggaagaga gagactggcc tgggtttttg aaatcccaaa
     2401 gcacatcccc agtgacacac ttcatccagc aaaactccac ctctaggtcc ttctcaagta
     2461 gtgccaagcc ctgatgacta agtactagga tacaggaacc taggggggcc atccctattc
     2521 gagccatttc agatagaact ggttttcaca gagtcatctg ccttcgcctt cctctccctg
     2581 tgtctccctc ctttccacat ctcacc
//
