LOCUS       NM_019297               2198 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Rattus norvegicus cholinergic receptor nicotinic beta 2 subunit
            (Chrnb2), mRNA.
ACCESSION   NM_019297
VERSION     NM_019297.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2198)
  AUTHORS   Crews,F.T., Fisher,R.P., Qin,L. and Vetreno,R.P.
  TITLE     HMGB1 neuroimmune signaling and REST-G9a gene repression contribute
            to ethanol-induced reversible suppression of the cholinergic neuron
            phenotype
  JOURNAL   Mol Psychiatry 28 (12), 5159-5172 (2023)
   PUBMED   37402853
REFERENCE   2  (bases 1 to 2198)
  AUTHORS   Siciliano,C.A., McIntosh,J.M., Jones,S.R. and Ferris,M.J.
  TITLE     alpha6beta2 subunit containing nicotinic acetylcholine receptors
            exert opposing actions on rapid dopamine signaling in the nucleus
            accumbens of rats with high-versus low-response to novelty
  JOURNAL   Neuropharmacology 126, 281-291 (2017)
   PUBMED   28666811
  REMARK    GeneRIF: Study shows that alpha6beta2 subunit containing nicotinic
            acetylcholine receptors exert opposing actions on rapid dopamine
            signaling in the nucleus accumbens of rats with high-versus
            low-response to novelty
REFERENCE   3  (bases 1 to 2198)
  AUTHORS   Suresh,A. and Hung,A.
  TITLE     Molecular simulation study of the unbinding of alpha-conotoxin
            [Upsilon4E]GID at the alpha7 and alpha4beta2 neuronal nicotinic
            acetylcholine receptors
  JOURNAL   J Mol Graph Model 70, 109-121 (2016)
   PUBMED   27721068
  REMARK    GeneRIF: the mechanism of interaction between [Upsilon4E]GID and
            the agonist binding pockets of the alpha4beta2 and the halpha7
            receptors, and to estimate their relative binding affinities, was
            investigated.
REFERENCE   4  (bases 1 to 2198)
  AUTHORS   Xiao,Y., Zhao,L., Kuang,S.X. and Guan,Z.Z.
  TITLE     Inhibited Expression of alpha4beta2 Nicotinic Acetylcholine
            Receptor in Blood Leukocytes of Chinese Patients with Vascular
            Dementia and in Blood Leukocytes as Well as the Hippocampus of
            Brain from Ischemic Rats
  JOURNAL   Cell Mol Neurobiol 36 (8), 1377-1387 (2016)
   PUBMED   26858154
  REMARK    GeneRIF: findings indicate that alterations in expression of the
            alpha4beta2 subtype of nAChR may be involved in the molecular
            mechanism(s) underlying the cognitive deficit associated with
            vascular dementia
REFERENCE   5  (bases 1 to 2198)
  AUTHORS   Wu,M., Puddifoot,C.A., Taylor,P. and Joiner,W.J.
  TITLE     Mechanisms of inhibition and potentiation of alpha4beta2 nicotinic
            acetylcholine receptors by members of the Ly6 protein family
  JOURNAL   J Biol Chem 290 (40), 24509-24518 (2015)
   PUBMED   26276394
REFERENCE   6  (bases 1 to 2198)
  AUTHORS   Elliott,K.J., Ellis,S.B., Berckhan,K.J., Urrutia,A.,
            Chavez-Noriega,L.E., Johnson,E.C., Velicelebi,G. and Harpold,M.M.
  TITLE     Comparative structure of human neuronal alpha 2-alpha 7 and beta
            2-beta 4 nicotinic acetylcholine receptor subunits and functional
            expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and
            beta 4 subunits
  JOURNAL   J Mol Neurosci 7 (3), 217-228 (1996)
   PUBMED   8906617
REFERENCE   7  (bases 1 to 2198)
  AUTHORS   Picciotto,M.R., Zoli,M., Lena,C., Bessis,A., Lallemand,Y., Le
            Novere,N., Vincent,P., Pich,E.M., Brulet,P. and Changeux,J.P.
  TITLE     Abnormal avoidance learning in mice lacking functional
            high-affinity nicotine receptor in the brain
  JOURNAL   Nature 374 (6517), 65-67 (1995)
   PUBMED   7870173
REFERENCE   8  (bases 1 to 2198)
  AUTHORS   Loring,R.H., Sah,D.W., Landis,S.C. and Zigmond,R.E.
  TITLE     The ultrastructural distribution of putative nicotinic receptors on
            cultured neurons from the rat superior cervical ganglion
  JOURNAL   Neuroscience 24 (3), 1071-1080 (1988)
   PUBMED   3380297
REFERENCE   9  (bases 1 to 2198)
  AUTHORS   Deneris,E.S., Connolly,J., Boulter,J., Wada,E., Wada,K.,
            Swanson,L.W., Patrick,J. and Heinemann,S.
  TITLE     Primary structure and expression of beta 2: a novel subunit of
            neuronal nicotinic acetylcholine receptors
  JOURNAL   Neuron 1 (1), 45-54 (1988)
   PUBMED   3272154
REFERENCE   10 (bases 1 to 2198)
  AUTHORS   Boulter,J., Connolly,J., Deneris,E., Goldman,D., Heinemann,S. and
            Patrick,J.
  TITLE     Functional expression of two neuronal nicotinic acetylcholine
            receptors from cDNA clones identifies a gene family
  JOURNAL   Proc Natl Acad Sci U S A 84 (21), 7763-7767 (1987)
   PUBMED   2444984
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019297.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L31622.1, AY574258.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               JAXUCZ010000002.1  177487057-177487306 c
            251-396             JAXUCZ010000002.1  177485930-177486075 c
            397-441             JAXUCZ010000002.1  177485713-177485757 c
            442-551             JAXUCZ010000002.1  177485131-177485240 c
            552-1521            JAXUCZ010000002.1  177483423-177484392 c
            1522-2198           JAXUCZ010000002.1  177479091-177479767 c
FEATURES             Location/Qualifiers
     source          1..2198
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2198
                     /gene="Chrnb2"
                     /note="cholinergic receptor nicotinic beta 2 subunit"
                     /db_xref="GeneID:54239"
                     /db_xref="RGD:2350"
     exon            1..250
                     /gene="Chrnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            251..396
                     /gene="Chrnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            397..441
                     /gene="Chrnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            442..551
                     /gene="Chrnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..1521
                     /gene="Chrnb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..2198
                     /gene="Chrnb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagagcaa ccgggaccgg caagaagccg ggacctcccc tcgttgcagg aactgcccgt
       61 tcagtgagca ctttagacct ggaggccgcg agccccaccc gggagcaggc ggctgcgcgg
      121 cttcagcacc acggacagcg ctcgacccgc agccctagta tccgagaggc tgcgcgctat
      181 gctggctgca tggccgggca ctccaactca atggcgctgt tcagcttcag ccttctttgg
      241 ctgtgctcag gggttttggg aactgacaca gaggagcggc tagtggagca tctcttagat
      301 ccctcccgct ataacaagct gattcgtcca gctactaacg gctctgagct ggtgactgta
      361 cagctcatgg tatcattggc tcagctcatt agtgtgcacg agcgggagca gatcatgacc
      421 accaatgtct ggctgaccca ggagtgggaa gattaccgcc tcacatggaa gcctgaggac
      481 ttcgacaata tgaagaaagt ccggctccct tccaaacaca tctggctccc agatgtggtt
      541 ctatacaaca atgctgacgg catgtacgaa gtctccttct attccaatgc tgtggtctcc
      601 tatgatggca gcatcttttg gctaccacct gccatctaca agagtgcatg caagattgag
      661 gtgaagcact tcccatttga ccagcagaat tgcaccatga agtttcgctc atggacctac
      721 gaccgtactg agattgacct ggtgctcaaa agtgatgtgg ccagtctgga tgacttcaca
      781 cccagcgggg agtgggacat catcgcactg ccaggccgac gcaacgagaa cccagacgac
      841 tccacctatg tggacatcac ctatgacttc atcattcgtc gcaaaccact cttctacact
      901 atcaacctca tcatcccctg cgtactcatc acctcgctgg ccatcctggt cttctacctg
      961 ccctcagact gtggtgaaaa gatgacactt tgtatttctg tgctgctagc actcacggtg
     1021 ttcctgctgc tcatctccaa gattgtgcct cccacctccc tcgatgtacc gctggtgggc
     1081 aagtacctca tgttcaccat ggtgctagtc accttctcca tcgtcaccag cgtgtgtgtg
     1141 ctcaatgtgc accaccgctc gcctaccacg cacaccatgg ccccctgggt caaggtggtc
     1201 ttcctggaga agctgcccac cctgctcttc ctgcagcagc cacgccaccg ctgtgcacgt
     1261 cagcgtctgc gcttgaggag gcgccagcga gagcgtgagg gcgcaggcgc gcttttcttc
     1321 cgtgaaggtc ctgcggctga cccatgtacc tgctttgtca accctgcatc agtgcagggc
     1381 ttggctgggg ctttccgagc tgagcccact gcagccggcc cggggcgctc tgtggggcca
     1441 tgcagctgtg gcctccggga agcagtggat ggcgtacgct tcattgcgga ccacatgcga
     1501 agtgaggatg atgaccagag tgtgagggag gactggaaat acgttgccat ggtgatcgac
     1561 cgcctgttcc tgtggatctt tgtctttgtc tgtgtctttg ggaccgtcgg catgttcctg
     1621 cagcctctct tccagaacta cactgccact accttcctcc accctgacca ctcagctccc
     1681 agctccaagt gaggtctcat tcatttgcag ctcctcaccc cgtgacccct gcggttcagt
     1741 actgggtgca agatggatct ctccccactc cactgaagcc tgcttcacac ctccgttcac
     1801 acatagtcct ccagcctgga ggctggaccc gctgccttgt ggtcgagcct tctcctttcc
     1861 ctctgagctc gttcaggcag gagtgccaat ggtgggggcc acggctggta agtagaggcc
     1921 agagatcaca gagccaccta ccccgatgag ggtgctggag aaggcgccaa gaaagagaca
     1981 gagttatctg tgacctccaa gtcatcggag aggaggaggt aggataaggg gctcagactc
     2041 tggcagagtg cggctagtac ttggcgccca cccacttaag tgagcgacac tggtctggga
     2101 ggactcgaag tgttggggag ctctcttggg agctcggtct cccaccctgt acctcagagg
     2161 gctccagacc cgggcttcag gttcccttct gccagtgc
//
