LOCUS       NM_012528               2290 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus cholinergic receptor nicotinic beta 1 subunit
            (Chrnb1), transcript variant 2, mRNA.
ACCESSION   NM_012528
VERSION     NM_012528.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2290)
  AUTHORS   Wang,H., Zhao,X., Yun,W., Chen,L.H. and Li,S.T.
  TITLE     Effect of Inhibiting p38 on HuR Involving in beta-AChR
            Post-transcriptional Mechanisms in Denervated Skeletal Muscle
  JOURNAL   Cell Mol Neurobiol 39 (7), 1029-1037 (2019)
   PUBMED   31172341
  REMARK    GeneRIF: inhibition of p38 can post-transcriptionally inhibit
            beta-AChR upregulation via HuR in denervated skeletal muscle.
REFERENCE   2  (bases 1 to 2290)
  AUTHORS   Witzemann,V., Chevessier,F., Pacifici,P.G. and Yampolsky,P.
  TITLE     The neuromuscular junction: selective remodeling of synaptic
            regulators at the nerve/muscle interface
  JOURNAL   Mech Dev 130 (6-8), 402-411 (2013)
   PUBMED   23032192
  REMARK    Review article
REFERENCE   3  (bases 1 to 2290)
  AUTHORS   Rasoulpour,R.J., Ellis-Hutchings,R.G., Terry,C., Millar,N.S.,
            Zablotny,C.L., Gibb,A., Marshall,V., Collins,T., Carney,E.W. and
            Billington,R.
  TITLE     A novel mode-of-action mediated by the fetal muscle nicotinic
            acetylcholine receptor resulting in developmental toxicity in rats
  JOURNAL   Toxicol Sci 127 (2), 522-534 (2012)
   PUBMED   22461452
REFERENCE   4  (bases 1 to 2290)
  AUTHORS   Alberola-Die,A., Martinez-Pinna,J., Gonzalez-Ros,J.M., Ivorra,I.
            and Morales,A.
  TITLE     Multiple inhibitory actions of lidocaine on Torpedo nicotinic
            acetylcholine receptors transplanted to Xenopus oocytes
  JOURNAL   J Neurochem 117 (6), 1009-1019 (2011)
   PUBMED   21480901
REFERENCE   5  (bases 1 to 2290)
  AUTHORS   Albuquerque,E.X., Pereira,E.F., Alkondon,M. and Rogers,S.W.
  TITLE     Mammalian nicotinic acetylcholine receptors: from structure to
            function
  JOURNAL   Physiol Rev 89 (1), 73-120 (2009)
   PUBMED   19126755
  REMARK    Review article
REFERENCE   6  (bases 1 to 2290)
  AUTHORS   Gomez,C.M., Maselli,R., Gammack,J., Lasalde,J., Tamamizu,S.,
            Cornblath,D.R., Lehar,M., McNamee,M. and Kuncl,R.W.
  TITLE     A beta-subunit mutation in the acetylcholine receptor channel gate
            causes severe slow-channel syndrome
  JOURNAL   Ann Neurol 39 (6), 712-723 (1996)
   PUBMED   8651643
REFERENCE   7  (bases 1 to 2290)
  AUTHORS   Ohno,K., Hutchinson,D.O., Milone,M., Brengman,J.M., Bouzat,C.,
            Sine,S.M. and Engel,A.G.
  TITLE     Congenital myasthenic syndrome caused by prolonged acetylcholine
            receptor channel openings due to a mutation in the M2 domain of the
            epsilon subunit
  JOURNAL   Proc Natl Acad Sci U S A 92 (3), 758-762 (1995)
   PUBMED   7531341
REFERENCE   8  (bases 1 to 2290)
  AUTHORS   Witzemann,V., Stein,E., Barg,B., Konno,T., Koenen,M., Kues,W.,
            Criado,M., Hofmann,M. and Sakmann,B.
  TITLE     Primary structure and functional expression of the alpha-, beta-,
            gamma-, delta- and epsilon-subunits of the acetylcholine receptor
            from rat muscle
  JOURNAL   Eur J Biochem 194 (2), 437-448 (1990)
   PUBMED   1702709
REFERENCE   9  (bases 1 to 2290)
  AUTHORS   Gu,Y., Franco,A. Jr., Gardner,P.D., Lansman,J.B., Forsayeth,J.R.
            and Hall,Z.W.
  TITLE     Properties of embryonic and adult muscle acetylcholine receptors
            transiently expressed in COS cells
  JOURNAL   Neuron 5 (2), 147-157 (1990)
   PUBMED   2383398
REFERENCE   10 (bases 1 to 2290)
  AUTHORS   Porter,C.W., Barnard,E.A. and Chiu,T.H.
  TITLE     The ultrastructural localization and quantitation of cholinergic
            receptors at the mouse motor endplate
  JOURNAL   J Membr Biol 14 (4), 383-402 (1973)
   PUBMED   4781450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_012528.3.
            
            On Jun 3, 2021 this sequence version replaced NM_012528.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X74833.1, SRR8487227.208056.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JACYVU010000220.1  11341114-11341241   c
            129-268             JACYVU010000220.1  11340887-11341026   c
            269-313             JACYVU010000220.1  11340303-11340347   c
            314-423             JACYVU010000220.1  11339277-11339386   c
            424-532             JACYVU010000220.1  11339020-11339128   c
            533-680             JACYVU010000220.1  11338589-11338736   c
            681-890             JACYVU010000220.1  11337630-11337839   c
            891-1114            JACYVU010000220.1  11331528-11331751   c
            1115-1287           JACYVU010000220.1  11330345-11330517   c
            1288-1435           JACYVU010000220.1  11329866-11330013   c
            1436-2290           JACYVU010000220.1  11328712-11329566   c
FEATURES             Location/Qualifiers
     source          1..2290
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2290
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /note="cholinergic receptor nicotinic beta 1 subunit"
                     /db_xref="GeneID:24261"
                     /db_xref="RGD:2349"
     exon            1..128
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1576
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; acetylcholine receptor subunit beta;
                     cholinergic receptor, nicotinic beta 1; Acetylcholine
                     receptor beta; cholinergic receptor, nicotinic, beta
                     polypeptide 1 (muscle); cholinergic receptor nicotinic
                     beta polypeptide 1; cholinergic receptor, nicotinic, beta
                     1 (muscle); n acetylcholine receptor"
                     /codon_start=1
                     /product="acetylcholine receptor subunit beta isoform 2
                     precursor"
                     /protein_id="NP_036660.1"
                     /db_xref="GeneID:24261"
                     /db_xref="RGD:2349"
                     /translation="MALGALLLILGILGTPLAPGARGSEAEGQLLKKLFSDYDSSVRP
                     AQEVGDRVGVSIGLTLAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIESLR
                     VTAESVWLPDVVLLNNNDGNFDVALDINVVVSFEGSVRWQPPGLYRSSCSIQVTYFPF
                     DWQNCTMVFSSYSYDSSEVSLKTGPDPDGQERQEIYIHEGTFIENGQWEIIHKPSRLI
                     HLPGDRRGGKEGHREEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEK
                     MGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMILVTFSVILSVVVLNLHH
                     RSPHTHQMPFWVRQIFIHKLPPYLGLKRPKPERDQLPEPHHSFSPRSGWGRGTDEYFI
                     RKPPCDFLFPKLNRFQPESPAPDLRRFIDGPPRAVGLPQELREVISSISYMARQLQEQ
                     EDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVIFLDATYHLPPPEPFP"
     exon            129..268
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            269..313
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            314..423
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..532
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..680
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..890
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1114
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1287
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1435
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..2290
                     /gene="Chrnb1"
                     /gene_synonym="Acrb; nAChR; RNACRB1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcacttcc cctggcctgg cggcctcggc cgctcttcgg acaaacccac tgagcgaaat
       61 cggcagggcc atggccttag gggcgctgct tctgattctg gggatactcg ggacgcccct
      121 cgccccagga gcccgcgggt cggaagccga aggccaactg cttaagaaac ttttctcgga
      181 ttatgatagc tcagtaaggc cggcgcagga ggtgggagac cgcgtcgggg tcagcatcgg
      241 cctcaccctg gcgcaactca tcagcctgaa cgagaaggat gaagaaatga gcacaaaggt
      301 gtacttagac ctggagtgga ccgactacag gttaagctgg gaccccgcag aacacgatgg
      361 catcgagtct ctccgtgtca ctgctgaatc tgtttggctc ccggacgtgg tgctgctgaa
      421 caacaatgat ggaaactttg acgttgccct ggacattaat gtcgtggtgt cctttgaggg
      481 ctctgtgcgc tggcaacccc ctggcctgta tcgcagcagc tgcagcatcc aggtcaccta
      541 cttccccttt gactggcaga attgcaccat ggtgtttagt tcctacagct atgacagctc
      601 tgaggtcagc ctgaagacag gcccagatcc tgatggacag gagaggcagg aaatctacat
      661 ccatgaaggg accttcatcg agaatggtca atgggagatt atccacaaac cctctaggtt
      721 aatccacctt ccaggggatc gaagaggagg gaaggaagga catcgtgagg aagttatctt
      781 ctatctcatt attcggagga agcctctctt ctacctggtc aatgtcattg ccccgtgcat
      841 cctcatcacc ctcctggcca tctttgtttt ctaccttcca ccagatgcag gagagaagat
      901 ggggctctcc atctttgccc tgctgaccct cactgtgttc ttgctgctgc tggccgacaa
      961 agtgcctgag acctccctgg cggtccccat catcatcaag tatctcatgt ttaccatgat
     1021 ccttgtcacc ttctcagtta tccttagcgt tgtggtcctc aacttgcacc atcgctcacc
     1081 ccacacccac caaatgccct tttgggtccg ccagatcttc attcacaagc tccctccata
     1141 cctgggtctg aagaggccca aacccgagag agaccaacta cccgaaccac atcactcctt
     1201 ctccccaagg agtggctggg gccgaggaac tgatgaatat ttcatacgga agcctccatg
     1261 tgattttctt ttccctaaac ttaacaggtt tcagcctgaa tcacctgctc cggacctgag
     1321 acgatttatc gatggtccac cccgggctgt aggtctgcct caggagctac gcgaggtcat
     1381 ttcttccatc agctacatgg cccgacaact tcaggaacag gaggaccacg atgcactgaa
     1441 ggaggactgg cagtttgtcg ccatggttgt ggaccgtctt tttctgtgga cattcatcgt
     1501 tttcacaagc gtcgggacgc tagtcatttt cctagatgcc acgtaccatt tgccccctcc
     1561 tgaacctttt ccttgaggac cctccggtca tttttgccaa gtgctgcagg tactctcacg
     1621 ctgtatagcg cttggctcct gtaagaatct tgttcttgtt tctgggaaga cgttgaagtg
     1681 ggacttgggg ggtgagcagg gtgccttgga cttcaacaaa tgtccttcaa cccattagtt
     1741 ttgttcttct gcagctttgt ttttgttggt tttttttttg ttgttgttgt ttttgccccc
     1801 cccccccccc cgggctgggg agcgaaccca ggatcttgcg cttcctaggt agaagcgctc
     1861 taccactgag ccaaatcccc aaccccgttt ttgttgtttt tgagacagag tctcactctg
     1921 tgtcccaggc tagcctggaa ctatgaagtc caggctggcc tcaaactccc agcagtgtta
     1981 cttccttagc ttaccaaatg ttggaatggc aggtctggta agccagcgca cttggatttt
     2041 gtttcttgaa actacacaga atgtcacaac ttagatatct agtgaaagag aattataagc
     2101 aactagtagc ttgaaagcct ttggaggaca ggaaatctgt tggctactgt aacgtcccca
     2161 gcaatgcgca caggtcctac cccataagtg cttaacattt gttgaagagg gaaaaaaatc
     2221 cggaaggaaa tacaaaataa tactgcctac aattgcatgt attgaaatta aaatgtagag
     2281 aaatgattga
//
