LOCUS       NM_012832               5282 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Rattus norvegicus cholinergic receptor nicotinic alpha 7 subunit
            (Chrna7), mRNA.
ACCESSION   NM_012832
VERSION     NM_012832.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5282)
  AUTHORS   Zhang,X., Wang,H., Cai,X., Zhang,A., Liu,E., Li,Z., Jiang,T., Li,D.
            and Ding,W.
  TITLE     alpha7nAChR Activation Combined with Endothelial Progenitor Cell
            Transplantation Attenuates Lung Injury in Diabetic Rats with Sepsis
            through the NF-kappaB Pathway
  JOURNAL   Inflammation 47 (4), 1344-1355 (2024)
   PUBMED   38302679
  REMARK    GeneRIF: alpha7nAChR Activation Combined with Endothelial
            Progenitor Cell Transplantation Attenuates Lung Injury in Diabetic
            Rats with Sepsis through the NF-kappaB Pathway.
REFERENCE   2  (bases 1 to 5282)
  AUTHORS   Sangadi,D.K., Sangadi,A., Placeres-Uray,F., Titus,D.J.,
            Johnstone,T., Hogenkamp,D., Gee,K.W. and Atkins,C.M.
  TITLE     Enhancing cognitive function in chronic TBI: The Role of alpha7
            nicotinic acetylcholine receptor modulation
  JOURNAL   Exp Neurol 372, 114647 (2024)
   PUBMED   38070724
  REMARK    GeneRIF: Enhancing cognitive function in chronic TBI: The Role of
            alpha7 nicotinic acetylcholine receptor modulation.
REFERENCE   3  (bases 1 to 5282)
  AUTHORS   Stratilov,V., Vetrovoy,O., Potapova,S. and Tyulkova,E.
  TITLE     The Prenatal Hypoxic Pathology Associated with Maternal Stress
            Predisposes to Dysregulated Expression of the chrna7 Gene and the
            Subsequent Development of Nicotine Addiction in Adult Offspring
  JOURNAL   Neuroendocrinology 114 (5), 423-438 (2024)
   PUBMED   38198758
  REMARK    GeneRIF: The Prenatal Hypoxic Pathology Associated with Maternal
            Stress Predisposes to Dysregulated Expression of the chrna7 Gene
            and the Subsequent Development of Nicotine Addiction in Adult
            Offspring.
REFERENCE   4  (bases 1 to 5282)
  AUTHORS   Crews,F.T., Fisher,R.P., Qin,L. and Vetreno,R.P.
  TITLE     HMGB1 neuroimmune signaling and REST-G9a gene repression contribute
            to ethanol-induced reversible suppression of the cholinergic neuron
            phenotype
  JOURNAL   Mol Psychiatry 28 (12), 5159-5172 (2023)
   PUBMED   37402853
REFERENCE   5  (bases 1 to 5282)
  AUTHORS   Niu,X.H., Liu,R.H., Lv,X., He,R.L., Lv,F.Z., Wu,S.J., Li,X.Q.,
            Li,L. and Lin,J.F.
  TITLE     Activating alpha7nAChR helps post-myocardial infarction healing by
            regulating macrophage polarization via the STAT3 signaling pathway
  JOURNAL   Inflamm Res 72 (4), 879-892 (2023)
   PUBMED   36912917
  REMARK    GeneRIF: Activating alpha7nAChR helps post-myocardial infarction
            healing by regulating macrophage polarization via the STAT3
            signaling pathway.
REFERENCE   6  (bases 1 to 5282)
  AUTHORS   Freedman,R., Coon,H., Myles-Worsley,M., Orr-Urtreger,A., Olincy,A.,
            Davis,A., Polymeropoulos,M., Holik,J., Hopkins,J., Hoff,M.,
            Rosenthal,J., Waldo,M.C., Reimherr,F., Wender,P., Yaw,J.,
            Young,D.A., Breese,C.R., Adams,C., Patterson,D., Adler,L.E.,
            Kruglyak,L., Leonard,S. and Byerley,W.
  TITLE     Linkage of a neurophysiological deficit in schizophrenia to a
            chromosome 15 locus
  JOURNAL   Proc Natl Acad Sci U S A 94 (2), 587-592 (1997)
   PUBMED   9012828
REFERENCE   7  (bases 1 to 5282)
  AUTHORS   Elliott,K.J., Ellis,S.B., Berckhan,K.J., Urrutia,A.,
            Chavez-Noriega,L.E., Johnson,E.C., Velicelebi,G. and Harpold,M.M.
  TITLE     Comparative structure of human neuronal alpha 2-alpha 7 and beta
            2-beta 4 nicotinic acetylcholine receptor subunits and functional
            expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and
            beta 4 subunits
  JOURNAL   J Mol Neurosci 7 (3), 217-228 (1996)
   PUBMED   8906617
REFERENCE   8  (bases 1 to 5282)
  AUTHORS   Peng,X., Katz,M., Gerzanich,V., Anand,R. and Lindstrom,J.
  TITLE     Human alpha 7 acetylcholine receptor: cloning of the alpha 7
            subunit from the SH-SY5Y cell line and determination of
            pharmacological properties of native receptors and functional alpha
            7 homomers expressed in Xenopus oocytes
  JOURNAL   Mol Pharmacol 45 (3), 546-554 (1994)
   PUBMED   8145738
REFERENCE   9  (bases 1 to 5282)
  AUTHORS   Seguela,P., Wadiche,J., Dineley-Miller,K., Dani,J.A. and
            Patrick,J.W.
  TITLE     Molecular cloning, functional properties, and distribution of rat
            brain alpha 7: a nicotinic cation channel highly permeable to
            calcium
  JOURNAL   J Neurosci 13 (2), 596-604 (1993)
   PUBMED   7678857
REFERENCE   10 (bases 1 to 5282)
  AUTHORS   Schultz,J.R., Gong,E.L., McCall,M.R., Nichols,A.V., Clift,S.M. and
            Rubin,E.M.
  TITLE     Expression of human apolipoprotein A-II and its effect on high
            density lipoproteins in transgenic mice
  JOURNAL   J Biol Chem 267 (30), 21630-21636 (1992)
   PUBMED   1400473
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 13, 2022 this sequence version replaced NM_012832.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L31619.1, AY574256.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000001.1  126249029-126249129 c
            102-241             JAXUCZ010000001.1  126248715-126248854 c
            242-286             JAXUCZ010000001.1  126194364-126194408 c
            287-396             JAXUCZ010000001.1  126183821-126183930 c
            397-476             JAXUCZ010000001.1  126140285-126140364 c
            477-644             JAXUCZ010000001.1  126137227-126137394 c
            645-839             JAXUCZ010000001.1  126135643-126135837 c
            840-926             JAXUCZ010000001.1  126134598-126134684 c
            927-1036            JAXUCZ010000001.1  126133429-126133538 c
            1037-5282           JAXUCZ010000001.1  126123425-126127670 c
FEATURES             Location/Qualifiers
     source          1..5282
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5282
                     /gene="Chrna7"
                     /gene_synonym="BTX; nAChRa7; NARAD"
                     /note="cholinergic receptor nicotinic alpha 7 subunit"
                     /db_xref="GeneID:25302"
                     /db_xref="RGD:2348"
     exon            1..101
                     /gene="Chrna7"
                     /gene_synonym="BTX; nAChRa7; NARAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1555
                     /gene="Chrna7"
                     /gene_synonym="BTX; nAChRa7; NARAD"
                     /note="neuronal acetylcholine receptor subunit alpha-7;
                     neuronal nicotinic acetycholine receptor alpha 7;
                     bungarotoxin alpha; cholinergic receptor, nicotinic, alpha
                     7 (neuronal); C holinergic receptor, nicotinic, alpha
                     polypeptide 7 (neuronal nicotinic acetycholine receptor
                     alpha 7) (bungarotoxin alpha); cholinergic receptor,
                     nicotinic, alpha polypeptide 7; nicotinic receptor alpha 7
                     subunit"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit alpha-7
                     precursor"
                     /protein_id="NP_036964.3"
                     /db_xref="GeneID:25302"
                     /db_xref="RGD:2348"
                     /translation="MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPV
                     ANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRF
                     PDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFD
                     VQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYP
                     DVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFM
                     LLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRII
                     LLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGL
                     EGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQ
                     DESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA"
     exon            102..241
                     /gene="Chrna7"
                     /gene_synonym="BTX; nAChRa7; NARAD"
                     /inference="alignment:Splign:2.1.0"
     exon            242..286
                     /gene="Chrna7"
                     /gene_synonym="BTX; nAChRa7; NARAD"
                     /inference="alignment:Splign:2.1.0"
     exon            287..396
                     /gene="Chrna7"
                     /gene_synonym="BTX; nAChRa7; NARAD"
                     /inference="alignment:Splign:2.1.0"
     exon            397..476
                     /gene="Chrna7"
                     /gene_synonym="BTX; nAChRa7; NARAD"
                     /inference="alignment:Splign:2.1.0"
     exon            477..644
                     /gene="Chrna7"
                     /gene_synonym="BTX; nAChRa7; NARAD"
                     /inference="alignment:Splign:2.1.0"
     exon            645..839
                     /gene="Chrna7"
                     /gene_synonym="BTX; nAChRa7; NARAD"
                     /inference="alignment:Splign:2.1.0"
     exon            840..926
                     /gene="Chrna7"
                     /gene_synonym="BTX; nAChRa7; NARAD"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1036
                     /gene="Chrna7"
                     /gene_synonym="BTX; nAChRa7; NARAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..5282
                     /gene="Chrna7"
                     /gene_synonym="BTX; nAChRa7; NARAD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcacggccc gggcggacgg cgggacgcgg cggcggctcc ggagacatgt gcggcgggcg
       61 gggaggcatc tggctggctc tggccgcggc gctgctgcac gtgtccctgc aaggcgagtt
      121 ccagaggagg ctgtacaagg agctggtcaa gaactacaac ccgctggaga ggccggtggc
      181 caacgactcg cagccgctca ccgtgtactt ctccctgagt ctcctgcaga tcatggatgt
      241 ggatgagaag aaccaagttt taaccaccaa catttggcta caaatgtctt ggacagatca
      301 ctatttgcag tggaacatgt ctgagtaccc cggagtgaag aatgttcgtt ttccagatgg
      361 ccagatttgg aaaccagaca ttctcctcta taacagtgct gatgagcgct ttgatgccac
      421 gttccacacc aatgttttgg tgaatgcatc tgggcattgc cagtatctcc ctccaggcat
      481 attcaagagc tcctgctaca ttgacgttcg ctggttccct tttgatgtgc agcagtgcaa
      541 actgaagttt gggtcctggt cctatggagg gtggtcactg gacctgcaaa tgcaagaggc
      601 agatatcagc agctatatcc ccaacggaga atgggatctc atgggaatcc ctggcaaaag
      661 gaatgagaag ttctatgagt gctgcaaaga gccataccca gatgtcacct acacagtaac
      721 catgcgccgt aggacactct actatggcct caatctgctc atcccttgtg tactcatttc
      781 agccctggct ctgctggtat tcttgctgcc tgcagactct ggagagaaaa tctctcttgg
      841 aataactgtc ttactttctc tgactgtctt catgctgctt gtggctgaga tcatgccagc
      901 aacatctgat tctgtgccct tgatagcaca atacttcgcc agcaccatga tcatcgtggg
      961 cctctctgta gtggtgacag tgattgtgct gagatatcac caccatgacc ctgatggtgg
     1021 caaaatgcct aagtggacca gaatcattct cctgaactgg tgtgcatggt ttctgcgcat
     1081 gaagaggccc ggagaggaca aggtgcggcc agcttgtcag cacaagcctc ggcgctgcag
     1141 cctggccagt gtggagctga gtgcaggtgc tgggccaccc accagcaatg gcaacctgct
     1201 ctacattggc ttccgaggcc tggagggcat gcactgtgcc ccaactccag actctggggt
     1261 cgtatgtggc cgtttggcct gctccccaac acatgatgag cacctcatgc acggtgcaca
     1321 cccctctgat ggggaccccg acctggccaa gatcctggag gaggtccgct acatcgccaa
     1381 ccgcttccgc tgccaggacg agagtgaggt gatctgcagt gaatggaagt ttgcagcctg
     1441 cgtggtggac cgcttgtgcc tcatggcctt ttcggtcttt accatcatct gtaccatcgg
     1501 catcctcatg tcagctccaa actttgtgga ggctgtgtcc aaagactttg cttaatgtta
     1561 tcaagtagga aatgcgcaga taagaagaga atctggaggg tgagaattgg ggtcctaact
     1621 ccacagtgtg ataaatggaa gaactctgag gtatccctgt agctgtcaat cttgagactt
     1681 agttttctgg ttactttaac tgaaaagatc tcagcagcct tctgtttatt cttctctccc
     1741 ttatcactgg catagccttg tactcagcag gggcactacg tggtcgtttg tctgctctgg
     1801 acagccctat aggatagatc ttagtggctc ttgcagccca gtaaaagcct gtcctgttgg
     1861 tggtgcatgg aaacatgccc cagtcctggg ctcacaagaa ttcgctgtct gcctttgcta
     1921 tgcgcagacc caggctgaaa ccaatgcaga gcagtcccca ctggatccac cgcagcaact
     1981 gccatgaaaa aggaaggcaa atacaaattc aaactgcaaa cttctctgct agtttctctg
     2041 ctagttttcc tgtgattcaa cttacatttc tgtctgttta tctgtctgtc tgtctgtctg
     2101 tctatctatc tatctatcta tctatctatc tatctatcta tctatctatc tatctatcta
     2161 tctatctatc tatctatcat ctatcatctt tgtcttttct aatgacaact ctataccagg
     2221 gagaaagttg gccttctaaa tgatgtttta agcaagctaa ttcctgtaga tttgtcctga
     2281 caattaaatt agcacacagg ttgcatcagt tcaaaactag gactcaccct agccaaaagg
     2341 gttttgaggc tttggcccct gtagatctca gatgaccccc aagcttcatg ttgacatgtt
     2401 ccgtgtccta aggagtttaa tgaatttgtt tgtataaaac ctgaagggaa aatagagttc
     2461 tgagtgttaa ctaaggacta gctgaaactt acctaaactc tgtgtgtgtg tgtgtgtgtg
     2521 tgtgtgtgtg tatgtgtgtg tgttaaaaat aaaagcatgt tagttgctgt gcatgtcaga
     2581 cttcacaagt cttagaaggt tttgcatcag taccgctgct catcaagtgc acataccctc
     2641 tggctttttc cccatgtgag gctagaaaga atcagtttag tcccccctgg gctcctgtgt
     2701 gacaggaact gtggagcgat gctgtggagc actcatccag atacaaagct agtaccgtca
     2761 gaattaggct tctgaggatc tgctttccta tggcttcaga tgcaaagctc actctgtccg
     2821 tgcctggagt cactggagat gggtgtgaag tgttgttgtt tatgtttttt ccttcttctg
     2881 agctaaggtc cctctggctg tatagctcat accagcctgt ttgcacttca catctttatt
     2941 tgttaatgag atgagaggct tttttttttt accaagaaaa actgctggat agtgttgttg
     3001 aacttcttga ggattaaaac tatatcaagc ttctgaaact cccagaaact ttaaacttct
     3061 gactccagaa atggaatcat gagagaagat tagatttctc agaataacaa aagccaaata
     3121 ctcacatttt cccaaccatt aatttttaat tttactgtag aaagatgaag gcttggtggt
     3181 actctgtgtg tacatgggca tgtgcatgta tgcactgtgt gtgtgtgtat gtgtgtgtgt
     3241 ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt ttggctgaag agaggagata
     3301 gtgcaagtga catggataaa tttggagact gttgatttca gcacccccca tccggagcag
     3361 gatcattccc agcatgcatc tgttacatac agtatcatta agtggtataa agtattttgc
     3421 tggtattatg ctttttgatt aaagtaacta gaaacaaata gatatgtttt gatacccaaa
     3481 gaccaggctt tgtgtcttac tggtaaaaat tgaaccctag ccattgcttt gactatctga
     3541 gtaattatta tcgttataaa ctaatgataa agaatagctg tgctcatagt taggtgtgtg
     3601 cagttcaaaa cagtctctcc ttgctcccat ttccttctag ggacagtgtt agagagaaag
     3661 aacggaaagg tgggaacaga gagagggagg agaacacgga gagacttggt tgttgctttc
     3721 ctagaacttg tgtttgaaaa gtgctaggca cctagtcttt tgtcctagaa agctttccat
     3781 aatggtctaa aggtctacct cattcctctt aatagctgct tagagttcct ctccattggt
     3841 ggcttataat ttattggatc agtcttttag ggatgaacac atagctgcaa catttccaag
     3901 ttttattttt atacacaagt ctatagttag cattttggtg cgtactttgc caaaattttt
     3961 gtgtataaat tccagtttag aaatggaact actggatcta agactatgtg agactctaga
     4021 taaatatatc cagatggtcc tccctgagct ggtcagtgga tacccctatc taagttaaaa
     4081 ggccagattc tcagcttact gctgttaaat attttcagat ttaatttttc cctttctgat
     4141 cttatgggta aaaatgatga ggcaaaaaca ttctgatttt ggttcatttt actatgagca
     4201 aggttgaagt tttcatatat atatatatat atatatatat atatatatgt atgtattggt
     4261 aatttcagtt ttataatatt tataacttta atacaaattt caggtttttt attcttttag
     4321 cttttattta tcatttgttt tttatggtgt tcattgattg tgtgtttata ttagaaagtt
     4381 taaaactctg tgttgttagt ttatttatgt tttactttgt agaacacgat tgccacctag
     4441 gtttgaagag gccttcctgt gttaaaatta caaataaatt agtcatattt tatttctaaa
     4501 atttaacatt tctacttgtt tgcctttata acttttcatt ctttaagact cattatagga
     4561 aatgtagata aaggtgtagt tgcttatgac ctagggtggt cactggtaca cagacatata
     4621 attaagcgtt tctaaaatgc agtgagactc cacactattc agattgtcac cttctgtgga
     4681 aactatgttt ctccaagtgc ttttctgttc cactgattaa tctgtctcaa tgctgttgat
     4741 ttacaaagtt ttcttggtat taccagtatt ttcaagtaga tactattttc caacccctcc
     4801 ctcttattct ttgtgttatg aactggggtc gaaatggatt cacacagcag gtcttcctgt
     4861 tagggagcac cacaagttca gcttgtactc aaatgtagta ttatggcagt cagtagggct
     4921 gctcagaaaa actgaacagt tcttgctgtt tatttctggc tctcctatca gttggttacc
     4981 attttcagtt tacgtttctt ttggttttct agccaagtat atataggaca gtggttgtgt
     5041 tttgtatgtt aatgttaaat aatttgtcac cacaattgtg tctgatttcc ctttgactca
     5101 ttcttcctaa tatctttact tccttttcta tcgaattgca cttgagaaca gtaattggct
     5161 tgtttgcata cgtgtcttgt tcttaatgtt gatggatgtt ttaatgatgc acaactttac
     5221 ttgtatgaag acatgtattt tcttcatcgt aataaaaatt atacatgtat cctttcaacc
     5281 at
//
