LOCUS       NM_057184               1755 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus cholinergic receptor nicotinic alpha 6 subunit
            (Chrna6), mRNA.
ACCESSION   NM_057184 XM_346490
VERSION     NM_057184.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1755)
  AUTHORS   Siciliano,C.A., McIntosh,J.M., Jones,S.R. and Ferris,M.J.
  TITLE     alpha6beta2 subunit containing nicotinic acetylcholine receptors
            exert opposing actions on rapid dopamine signaling in the nucleus
            accumbens of rats with high-versus low-response to novelty
  JOURNAL   Neuropharmacology 126, 281-291 (2017)
   PUBMED   28666811
  REMARK    GeneRIF: Study shows that alpha6beta2 subunit containing nicotinic
            acetylcholine receptors exert opposing actions on rapid dopamine
            signaling in the nucleus accumbens of rats with high-versus
            low-response to novelty.
REFERENCE   2  (bases 1 to 1755)
  AUTHORS   Wen,L., Han,H., Liu,Q., Su,K., Yang,Z., Cui,W., Yuan,W., Ma,Y.,
            Fan,R., Chen,J., Jiang,K., Jiang,X., Payne,T.J., Wang,J. and
            Li,M.D.
  TITLE     Significant association of the CHRNB3-CHRNA6 gene cluster with
            nicotine dependence in the Chinese Han population
  JOURNAL   Sci Rep 7 (1), 9745 (2017)
   PUBMED   28851948
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1755)
  AUTHORS   Garcao,P., Oliveira,C.R., Cunha,R.A. and Agostinho,P.
  TITLE     Subsynaptic localization of nicotinic acetylcholine receptor
            subunits: a comparative study in the mouse and rat striatum
  JOURNAL   Neurosci Lett 566, 106-110 (2014)
   PUBMED   24607281
REFERENCE   4  (bases 1 to 1755)
  AUTHORS   Luo,S., Zhangsun,D., Schroeder,C.I., Zhu,X., Hu,Y., Wu,Y.,
            Weltzin,M.M., Eberhard,S., Kaas,Q., Craik,D.J., McIntosh,J.M. and
            Whiteaker,P.
  TITLE     A novel alpha4/7-conotoxin LvIA from Conus lividus that selectively
            blocks alpha3beta2 vs. alpha6/alpha3beta2beta3 nicotinic
            acetylcholine receptors
  JOURNAL   FASEB J 28 (4), 1842-1853 (2014)
   PUBMED   24398291
  REMARK    GeneRIF: Data indicate that the affinity of alpha-CTxLvIA
            selectively blocks alpha3beta2 vs. alpha6/alpha3beta2beta3
            nicotinic acetylcholine receptors.
REFERENCE   5  (bases 1 to 1755)
  AUTHORS   Sadler,B., Haller,G., Agrawal,A., Culverhouse,R., Bucholz,K.,
            Brooks,A., Tischfield,J., Johnson,E.O., Edenberg,H., Schuckit,M.,
            Saccone,N., Bierut,L. and Goate,A.
  TITLE     Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use
            disorder: evidence for pleiotropy
  JOURNAL   Sci Rep 4, 4497 (2014)
   PUBMED   24675634
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1755)
  AUTHORS   Cox,B.C., Marritt,A.M., Perry,D.C. and Kellar,K.J.
  TITLE     Transport of multiple nicotinic acetylcholine receptors in the rat
            optic nerve: high densities of receptors containing alpha6 and
            beta3 subunits
  JOURNAL   J Neurochem 105 (5), 1924-1938 (2008)
   PUBMED   18266937
  REMARK    GeneRIF: The concentration of alpha6- and beta3-containing neuronal
            nicotinic acetylcholine receptors (nAChRs) is higher in the optic
            nerve than in any other area of the rat brain.
REFERENCE   7  (bases 1 to 1755)
  AUTHORS   Marritt,A.M., Cox,B.C., Yasuda,R.P., McIntosh,J.M., Xiao,Y.,
            Wolfe,B.B. and Kellar,K.J.
  TITLE     Nicotinic cholinergic receptors in the rat retina: simple and mixed
            heteromeric subtypes
  JOURNAL   Mol Pharmacol 68 (6), 1656-1668 (2005)
   PUBMED   16129735
REFERENCE   8  (bases 1 to 1755)
  AUTHORS   Champtiaux,N., Gotti,C., Cordero-Erausquin,M., David,D.J.,
            Przybylski,C., Lena,C., Clementi,F., Moretti,M., Rossi,F.M., Le
            Novere,N., McIntosh,J.M., Gardier,A.M. and Changeux,J.P.
  TITLE     Subunit composition of functional nicotinic receptors in
            dopaminergic neurons investigated with knock-out mice
  JOURNAL   J Neurosci 23 (21), 7820-7829 (2003)
   PUBMED   12944511
REFERENCE   9  (bases 1 to 1755)
  AUTHORS   Ebihara,M., Ohba,H., Ohno,S.I. and Yoshikawa,T.
  TITLE     Genomic organization and promoter analysis of the human nicotinic
            acetylcholine receptor alpha6 subunit (CHNRA6) gene: Alu and other
            elements direct transcriptional repression
  JOURNAL   Gene 298 (1), 101-108 (2002)
   PUBMED   12406580
REFERENCE   10 (bases 1 to 1755)
  AUTHORS   Champtiaux,N., Han,Z.Y., Bessis,A., Rossi,F.M., Zoli,M.,
            Marubio,L., McIntosh,J.M. and Changeux,J.P.
  TITLE     Distribution and pharmacology of alpha 6-containing nicotinic
            acetylcholine receptors analyzed with mutant mice
  JOURNAL   J Neurosci 22 (4), 1208-1217 (2002)
   PUBMED   11850448
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 26, 2020 this sequence version replaced NM_057184.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L08227.1, SRR26360176.1506630.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN14984033
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000016.1  71400615-71400871
            258-397             JAXUCZ010000016.1  71402624-71402763
            398-442             JAXUCZ010000016.1  71403820-71403864
            443-552             JAXUCZ010000016.1  71404769-71404878
            553-1528            JAXUCZ010000016.1  71404991-71405966
            1529-1755           JAXUCZ010000016.1  71407089-71407315
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.3"
     gene            1..1755
                     /gene="Chrna6"
                     /note="cholinergic receptor nicotinic alpha 6 subunit"
                     /db_xref="GeneID:81721"
                     /db_xref="RGD:69281"
     exon            1..257
                     /gene="Chrna6"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1660
                     /gene="Chrna6"
                     /note="cholinergic receptor, nicotinic, alpha polypeptide
                     6; cholinergic receptor, nicotinic, alpha 6 (neuronal);
                     neuronal acetylcholine receptor subunit alpha-6"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit alpha-6
                     precursor"
                     /protein_id="NP_476532.2"
                     /db_xref="GeneID:81721"
                     /db_xref="RGD:69281"
                     /translation="MLNCWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAH
                     YNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEY
                     DGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPM
                     DITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDI
                     KYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCI
                     SVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPAT
                     HTMPKWVKTMFLQVFPSILMMRRPLDKTKEADGVKDPKTHTKRPAKVKFTHRKEPKLL
                     KECRHCHKSSEIAPGKRLSQQPAQWVAENSEHPPDVEDVIDSVQFITENMKSHNETKE
                     VEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQPLLGNTGAS"
     exon            258..397
                     /gene="Chrna6"
                     /inference="alignment:Splign:2.1.0"
     exon            398..442
                     /gene="Chrna6"
                     /inference="alignment:Splign:2.1.0"
     exon            443..552
                     /gene="Chrna6"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1528
                     /gene="Chrna6"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1755
                     /gene="Chrna6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcttcagc ccaggacgca gggagcaacc gtgtggtagc ccgtgttttc acttcacaga
       61 agatccgtgt ggacttcagg agcttcccga ggctttcgtg gtctgattct tgcagctgac
      121 tgacagcttc ggtttccaca gccctctgtg tcgggatcag aattcatgtg cttttatcat
      181 gctgaactgc tggggtcggg gagaccttcg ctccggtttg tgtctgtgga tatgtggatt
      241 cttggctttc tttaaaggca gtagaggctg tgtgtctgag gaacagctct tccacacact
      301 cttcgcccac tacaaccgct tcatccggcc agtggaaaac gtttctgatc ccgtcacggt
      361 gcactttgag ttggccatca cgcagctggc caatgtggat gaagtcaacc agattatgga
      421 gaccaatctg tggctgcgtc acgtctggaa ggactacaga ttgtgttggg atccaacgga
      481 gtacgatggc atcgagacgc ttcgtgttcc agcagataac atctggaagc ctgacatcgt
      541 tctgtataat aatgccgtcg gcgacttcca ggtcgaaggc aagaccaaag ctcttcttaa
      601 gtacgatggg gtgataacct ggaccccgcc agccatcttt aagagttcct gtccaatgga
      661 catcaccttc ttcccatttg atcatcaaaa ctgctccctg aaatttgggt cctggactta
      721 cgacaaggct gaaatcgacc ttctcatcat tggctctaaa gtggacatga acgacttttg
      781 ggaaaacagt gagtgggaaa ttgtcgatgc ctctggctac aagcatgaca tcaagtacaa
      841 ctgctgtgaa gagatttaca cagatatcac ctactcgttc tacatcagga gactgcccat
      901 gttttatacc atcaatctca tcatcccctg cctcttcatt tcctttctca ccgtgctggt
      961 cttttacctt ccttccgact gtggcgagaa agtgactctt tgcatctcgg ttctgctttc
     1021 tctaactgtc tttttgctgg tgattacaga gaccatccca tccacgtctc tcgtgatccc
     1081 actagtgggt gagtatctac tgttcaccat gatctttgtc acgctgtcca ttgtggtgac
     1141 cgtgtttgtg ttgaacatac actacaggac cccagcaacg cataccatgc ccaagtgggt
     1201 gaagaccatg ttccttcagg tcttcccctc gattctgatg atgaggagac ctctggacaa
     1261 gacaaaggaa gcagatggtg ttaaggaccc caaaacccac accaagaggc cggccaaggt
     1321 caagtttact catcgaaaag aacccaagct tctaaaggaa tgccgccact gccataagtc
     1381 aagtgagata gcgcctggca agaggttaag ccagcagcct gcacagtggg tggcagagaa
     1441 ttcagagcac ccacctgatg ttgaagacgt gatcgatagt gttcaattca taacagaaaa
     1501 catgaaaagc cacaatgaaa caaaggaggt agaagatgac tggaaataca tggccatggt
     1561 ggtggacaga gtcttcctct gggtgtttat aatcgtctgt gtgtttggaa ctgtggggct
     1621 ctttctacag ccactgcttg ggaacacagg agcgtcttaa tcgggatttt ccttttgcct
     1681 tctaaatctt ttaaatgttt tttcctccac tacttaccac aagaaaaagt caagtttgca
     1741 gtctcctaaa ccaag
//
