LOCUS       NM_052805               1966 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus cholinergic receptor nicotinic alpha 3 subunit
            (Chrna3), mRNA.
ACCESSION   NM_052805 XM_001072823
VERSION     NM_052805.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Elayouby,K.S., Ishikawa,M., Dukes,A.J., Smith,A.C.W., Lu,Q.,
            Fowler,C.D. and Kenny,P.J.
  TITLE     alpha3* Nicotinic Acetylcholine Receptors in the
            Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake
  JOURNAL   J Neurosci 41 (8), 1779-1787 (2021)
   PUBMED   33380469
  REMARK    GeneRIF: alpha3* Nicotinic Acetylcholine Receptors in the
            Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake.
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Perez-Morales,R., Gonzalez-Zamora,A., Gonzalez-Delgado,M.F.,
            Calleros Rincon,E.Y., Olivas Calderon,E.H., Martinez-Ramirez,O.C.
            and Rubio,J.
  TITLE     CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms are associated
            with heavy smoking, lung cancer, and chronic obstructive pulmonary
            disease in a mexican population
  JOURNAL   Ann Hum Genet 82 (6), 415-424 (2018)
   PUBMED   29993116
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Sun,Y., Li,J., Zheng,C. and Zhou,B.
  TITLE     Study on polymorphisms in CHRNA5/CHRNA3/CHRNB4 gene cluster and the
            associated with the risk of non-small cell lung cancer
  JOURNAL   Oncotarget 9 (2), 2435-2444 (2017)
   PUBMED   29416783
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1966)
  AUTHORS   Han,S., Yang,S.H., Kim,J.Y., Mo,S., Yang,E., Song,K.M., Ham,B.J.,
            Mechawar,N., Turecki,G., Lee,H.W. and Kim,H.
  TITLE     Down-regulation of cholinergic signaling in the habenula induces
            anhedonia-like behavior
  JOURNAL   Sci Rep 7 (1), 900 (2017)
   PUBMED   28420875
  REMARK    Erratum:[Sci Rep. 2017 Dec 1;7(1):17090. doi:
            10.1038/s41598-017-16991-1.. PMID: 29196669]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1966)
  AUTHORS   Richmond-Rakerd,L.S., Otto,J.M., Slutske,W.S., Ehlers,C.L.,
            Wilhelmsen,K.C. and Gizer,I.R.
  TITLE     A Novel Tobacco Use Phenotype Suggests the 15q25 and 19q13 Loci May
            be Differentially Associated With Cigarettes per Day and
            Tobacco-Related Problems
  JOURNAL   Nicotine Tob Res 19 (4), 426-434 (2017)
   PUBMED   27663783
REFERENCE   6  (bases 1 to 1966)
  AUTHORS   Elliott,K.J., Ellis,S.B., Berckhan,K.J., Urrutia,A.,
            Chavez-Noriega,L.E., Johnson,E.C., Velicelebi,G. and Harpold,M.M.
  TITLE     Comparative structure of human neuronal alpha 2-alpha 7 and beta
            2-beta 4 nicotinic acetylcholine receptor subunits and functional
            expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and
            beta 4 subunits
  JOURNAL   J Mol Neurosci 7 (3), 217-228 (1996)
   PUBMED   8906617
REFERENCE   7  (bases 1 to 1966)
  AUTHORS   Yang,X., McDonough,J., Fyodorov,D., Morris,M., Wang,F. and
            Deneris,E.S.
  TITLE     Characterization of an acetylcholine receptor alpha 3 gene promoter
            and its activation by the POU domain factor SCIP/Tst-1
  JOURNAL   J Biol Chem 269 (14), 10252-10264 (1994)
   PUBMED   8144606
REFERENCE   8  (bases 1 to 1966)
  AUTHORS   Loring,R.H., Sah,D.W., Landis,S.C. and Zigmond,R.E.
  TITLE     The ultrastructural distribution of putative nicotinic receptors on
            cultured neurons from the rat superior cervical ganglion
  JOURNAL   Neuroscience 24 (3), 1071-1080 (1988)
   PUBMED   3380297
REFERENCE   9  (bases 1 to 1966)
  AUTHORS   Boulter,J., Connolly,J., Deneris,E., Goldman,D., Heinemann,S. and
            Patrick,J.
  TITLE     Functional expression of two neuronal nicotinic acetylcholine
            receptors from cDNA clones identifies a gene family
  JOURNAL   Proc Natl Acad Sci U S A 84 (21), 7763-7767 (1987)
   PUBMED   2444984
REFERENCE   10 (bases 1 to 1966)
  AUTHORS   Boulter,J., Evans,K., Goldman,D., Martin,G., Treco,D., Heinemann,S.
            and Patrick,J.
  TITLE     Isolation of a cDNA clone coding for a possible neural nicotinic
            acetylcholine receptor alpha-subunit
  JOURNAL   Nature 319 (6052), 368-374 (1986)
   PUBMED   3753746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Sep 22, 2022 this sequence version replaced NM_052805.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X03440.1, L31621.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               JAXUCZ010000008.1  64311035-64311251   c
            218-357             JAXUCZ010000008.1  64308996-64309135   c
            358-402             JAXUCZ010000008.1  64308846-64308890   c
            403-512             JAXUCZ010000008.1  64306828-64306937   c
            513-1524            JAXUCZ010000008.1  64300425-64301436   c
            1525-1966           JAXUCZ010000008.1  64297755-64298196   c
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1966
                     /gene="Chrna3"
                     /note="cholinergic receptor nicotinic alpha 3 subunit"
                     /db_xref="GeneID:25101"
                     /db_xref="RGD:2345"
     exon            1..217
                     /gene="Chrna3"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1653
                     /gene="Chrna3"
                     /note="neuronal acetylcholine receptor subunit alpha-3;
                     cholinergic receptor, nicotinic, alpha polypeptide 3;
                     Acetylcholine receptor alpha 3 (neuronal nicotine);
                     cetylcholine receptor alpha 3 (neuronal nicotine);
                     acetylcholine receptor alpha3; cholinergic receptor
                     nicotinic alpha polypeptide 4; cholinergic receptor,
                     nicotinic, alpha 3 (neuronal)"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit alpha-3
                     precursor"
                     /protein_id="NP_434692.2"
                     /db_xref="GeneID:25101"
                     /db_xref="RGD:2345"
                     /translation="MGVVLLPPPLSMLMLVLMLLPAASASEAEHRLFQYLFEDYNEII
                     RPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEF
                     MRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYF
                     PFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCC
                     EEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLS
                     LTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPT
                     WVKAVFLNLLPRVMFMTRPTSGEGDTPKTRTFYGAELSNLNCFSRADSKSCKEGYPCQ
                     DGTCGYCHHRRVKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMK
                     AQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLMARDDT"
     exon            218..357
                     /gene="Chrna3"
                     /inference="alignment:Splign:2.1.0"
     exon            358..402
                     /gene="Chrna3"
                     /inference="alignment:Splign:2.1.0"
     exon            403..512
                     /gene="Chrna3"
                     /inference="alignment:Splign:2.1.0"
     exon            513..1524
                     /gene="Chrna3"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1966
                     /gene="Chrna3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttggctgcct ggggttcgtg cactcgggcg cgcaggtgcg ccggagctcg gctgcgcgaa
       61 gccgggagga actccgcggt gccagcactt gagtagctgt gcttcggtgg tcagcaccag
      121 agtggctccc tccctgtcta tcgggtctta gacatgggtg ttgtgctgct cccgccgccg
      181 ctgtccatgc tgatgctggt gctgatgctg ctgccagcgg ccagtgcctc agaagctgag
      241 caccgcctgt tccagtacct gttcgaagat tacaacgaga tcatccggcc agtggctaat
      301 gtgtcccatc cagtcatcat ccagtttgag gtgtccatgt ctcagctggt gaaggtggat
      361 gaagtaaacc agatcatgga aaccaacctg tggctgaagc aaatctggaa tgactacaag
      421 ctgaaatgga aaccctctga ctaccaaggg gtggagttca tgcgtgttcc tgcagagaag
      481 atctggaaac cagacatcgt actgtacaac aacgctgatg gggatttcca ggtggatgac
      541 aagaccaaag ctctactcaa gtacacagga gaagtgactt ggatcccgcc ggccatcttt
      601 aagagctcat gcaaaatcga cgtgacctac ttcccattcg actaccaaaa ctgcaccatg
      661 aagttcggct cctggtccta cgacaaggca aagatcgacc tggtcctcat cggctcctcc
      721 atgaacctca aggactactg ggagagtggc gagtgggcta tcattaaagc cccgggctac
      781 aaacatgaaa tcaagtacaa ctgctgtgag gagatctacc aagacatcac gtactcgctg
      841 tacatccgtc gcctgccgct gttctacacc atcaacctca tcatcccctg cctgctcatc
      901 tccttcctca ctgtgcttgt cttctacctg ccctccgact gtggggagaa ggtgacactc
      961 tgcatctctg tgctcctctc cctgactgtc tttctcctgg tgatcaccga gaccattcct
     1021 tccacctcgc tggtcatccc cctgattggg gagtacctcc tcttcactat gatttttgtc
     1081 accttgtcca ttgtcatcac agtctttgtg ctcaatgtgc actatagaac tccaaccaca
     1141 cacaccatgc ccacttgggt caaggccgtg ttcttgaacc tgctccccag ggtcatgttt
     1201 atgactaggc cgaccagtgg tgagggggac actcctaaga cgaggacctt ctacggcgct
     1261 gagctctcaa acctgaactg cttcagccgt gcagactcca aaagctgcaa ggaaggctac
     1321 ccctgccaag atgggacctg tggctactgc caccaccgta gggtaaaaat ctcaaatttc
     1381 agtgccaacc tcacaagaag ctccagttct gagtctgtcg acgctgtgtt gtccctctct
     1441 gccctgtcac cagaaatcaa agaagccatc caaagtgtga agtacattgc cgaaaacatg
     1501 aaagcacaga atgtagccaa agagattcaa gatgattgga agtacgttgc catggtgatt
     1561 gatcgcatct ttctctgggt tttcatcctg gtgtgcattt taggaacggc gggattattt
     1621 ctgcaaccct tgatggccag agatgacaca tagactgtgc actgttcatc gaggctcacc
     1681 tgtgctgacg caagggcact tcctcaatag cactatactt tatctgatca ctggcttgga
     1741 gtttgctatt tcaagggtta ttttcaactc atcttgattt ttcgtaaaaa agaaatgtgg
     1801 gagacaaatg tctagttatt tatcatgggt aaatgaacat ttcactaccc ctgtgattga
     1861 aactttaggt agaaaaattt tctgttcata aatattaact ccattagtgc aggatctcca
     1921 tagaactcat ttgctcagcc cataaacttc ttgaaatcgt agtgta
//
