LOCUS       NM_024485               1850 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus cholinergic receptor nicotinic alpha 1 subunit
            (Chrna1), mRNA.
ACCESSION   NM_024485
VERSION     NM_024485.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Witzemann,V., Chevessier,F., Pacifici,P.G. and Yampolsky,P.
  TITLE     The neuromuscular junction: selective remodeling of synaptic
            regulators at the nerve/muscle interface
  JOURNAL   Mech Dev 130 (6-8), 402-411 (2013)
   PUBMED   23032192
  REMARK    Review article
REFERENCE   2  (bases 1 to 1850)
  AUTHORS   Rasoulpour,R.J., Ellis-Hutchings,R.G., Terry,C., Millar,N.S.,
            Zablotny,C.L., Gibb,A., Marshall,V., Collins,T., Carney,E.W. and
            Billington,R.
  TITLE     A novel mode-of-action mediated by the fetal muscle nicotinic
            acetylcholine receptor resulting in developmental toxicity in rats
  JOURNAL   Toxicol Sci 127 (2), 522-534 (2012)
   PUBMED   22461452
REFERENCE   3  (bases 1 to 1850)
  AUTHORS   Alberola-Die,A., Martinez-Pinna,J., Gonzalez-Ros,J.M., Ivorra,I.
            and Morales,A.
  TITLE     Multiple inhibitory actions of lidocaine on Torpedo nicotinic
            acetylcholine receptors transplanted to Xenopus oocytes
  JOURNAL   J Neurochem 117 (6), 1009-1019 (2011)
   PUBMED   21480901
REFERENCE   4  (bases 1 to 1850)
  AUTHORS   Valkova,C., Albrizio,M., Roder,I.V., Schwake,M., Betto,R.,
            Rudolf,R. and Kaether,C.
  TITLE     Sorting receptor Rer1 controls surface expression of muscle
            acetylcholine receptors by ER retention of unassembled
            alpha-subunits
  JOURNAL   Proc Natl Acad Sci U S A 108 (2), 621-625 (2011)
   PUBMED   21187406
REFERENCE   5  (bases 1 to 1850)
  AUTHORS   Sigoillot,S.M., Bourgeois,F., Lambergeon,M., Strochlic,L. and
            Legay,C.
  TITLE     ColQ controls postsynaptic differentiation at the neuromuscular
            junction
  JOURNAL   J Neurosci 30 (1), 13-23 (2010)
   PUBMED   20053883
REFERENCE   6  (bases 1 to 1850)
  AUTHORS   Wang,Z.Z., Hardy,S.F. and Hall,Z.W.
  TITLE     Assembly of the nicotinic acetylcholine receptor. The first
            transmembrane domains of truncated alpha and delta subunits are
            required for heterodimer formation in vivo
  JOURNAL   J Biol Chem 271 (44), 27575-27584 (1996)
   PUBMED   8910344
REFERENCE   7  (bases 1 to 1850)
  AUTHORS   Engel,A.G., Ohno,K., Milone,M., Wang,H.L., Nakano,S., Bouzat,C.,
            Pruitt,J.N. 2nd, Hutchinson,D.O., Brengman,J.M., Bren,N., Sieb,J.P.
            and Sine,S.M.
  TITLE     New mutations in acetylcholine receptor subunit genes reveal
            heterogeneity in the slow-channel congenital myasthenic syndrome
  JOURNAL   Hum Mol Genet 5 (9), 1217-1227 (1996)
   PUBMED   8872460
REFERENCE   8  (bases 1 to 1850)
  AUTHORS   Witzemann,V., Stein,E., Barg,B., Konno,T., Koenen,M., Kues,W.,
            Criado,M., Hofmann,M. and Sakmann,B.
  TITLE     Primary structure and functional expression of the alpha-, beta-,
            gamma-, delta- and epsilon-subunits of the acetylcholine receptor
            from rat muscle
  JOURNAL   Eur J Biochem 194 (2), 437-448 (1990)
   PUBMED   1702709
REFERENCE   9  (bases 1 to 1850)
  AUTHORS   Gu,Y., Franco,A. Jr., Gardner,P.D., Lansman,J.B., Forsayeth,J.R.
            and Hall,Z.W.
  TITLE     Properties of embryonic and adult muscle acetylcholine receptors
            transiently expressed in COS cells
  JOURNAL   Neuron 5 (2), 147-157 (1990)
   PUBMED   2383398
REFERENCE   10 (bases 1 to 1850)
  AUTHORS   Porter,C.W., Barnard,E.A. and Chiu,T.H.
  TITLE     The ultrastructural localization and quantitation of cholinergic
            receptors at the mouse motor endplate
  JOURNAL   J Membr Biol 14 (4), 383-402 (1973)
   PUBMED   4781450
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_024485.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X74832.1, SRR26643290.11893.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000003.1  78877250-78877353   c
            105-250             JAXUCZ010000003.1  78871206-78871351   c
            251-295             JAXUCZ010000003.1  78871027-78871071   c
            296-405             JAXUCZ010000003.1  78869773-78869882   c
            406-601             JAXUCZ010000003.1  78867983-78868178   c
            602-839             JAXUCZ010000003.1  78867260-78867497   c
            840-1063            JAXUCZ010000003.1  78864810-78865033   c
            1064-1303           JAXUCZ010000003.1  78863435-78863674   c
            1304-1850           JAXUCZ010000003.1  78862286-78862832   c
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..1850
                     /gene="Chrna1"
                     /note="cholinergic receptor nicotinic alpha 1 subunit"
                     /db_xref="GeneID:79557"
                     /db_xref="RGD:69277"
     exon            1..104
                     /gene="Chrna1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1435
                     /gene="Chrna1"
                     /note="acetylcholine receptor subunit alpha; cholinergic
                     receptor, nicotinic, alpha polypeptide 1 (muscle);
                     cholinergic receptor nicotinic alpha polypeptide 1;
                     cholinergic receptor, nicotinic, alpha 1 (muscle)"
                     /codon_start=1
                     /product="acetylcholine receptor subunit alpha precursor"
                     /protein_id="NP_077811.1"
                     /db_xref="GeneID:79557"
                     /db_xref="RGD:69277"
                     /translation="MELTAVLLLLGLCSAGTVLGSEHETRLVAKLFKDYSSVVRPVGD
                     HREIVQVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPS
                     EKIWRPDVVLYNNADGDFAIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQ
                     NCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKEARGWKHWVFYSCCPNTPY
                     LDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLPTDSGEKMTLSISVLLSLTVF
                     LLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHIMPEWVRK
                     VFIDTIPNIMFFSTMKRPSRDKQEKRIFTEDIDISDISGKPGPPPMGFHSPLIKHPEV
                     KSAIEGVKYIAETMKSDQESNNASEEWKYVAMVMDHILLGVFMLVCLIGTLAVFAGRL
                     IELHQQG"
     exon            105..250
                     /gene="Chrna1"
                     /inference="alignment:Splign:2.1.0"
     exon            251..295
                     /gene="Chrna1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..405
                     /gene="Chrna1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..601
                     /gene="Chrna1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..839
                     /gene="Chrna1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1063
                     /gene="Chrna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1303
                     /gene="Chrna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1850
                     /gene="Chrna1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcagccaga gtgccaggga gtgggacagg ctgctggagg ccacaccagc gtccacagcc
       61 catggagctc accgctgtcc tcctgctgct gggcctctgc tccgctggca ctgttctggg
      121 ctccgaacat gagactcgtc tggtggcaaa gctctttaaa gactacagca gtgtggtccg
      181 gccagtaggg gaccaccgtg agattgtaca ggtcactgtg ggactgcaac tgatccagct
      241 tatcaacgtg gatgaagtaa atcagattgt gacaaccaac gttcgtctga aacagcaatg
      301 ggttgattac aacttgaaat ggaatccaga tgactatgga ggagtgaaaa aaattcacat
      361 cccctcggaa aagatctggc ggccggacgt tgttctctat aacaatgcag atggagactt
      421 tgccattgtc aaattcacca aggtgctcct ggactacacc ggtcacatca cctggacccc
      481 tccagccatc tttaaaagct actgtgagat cattgtcacc cactttccct tcgatgagca
      541 gaactgcagc atgaagctgg gcacttggac ctatgacggc tctgtggtgg ccatcaatcc
      601 ggaaagtgac cagcccgacc tgagtaactt catggagagc ggagagtggg tgatcaagga
      661 agcccggggc tggaagcact gggtgtttta ctcctgctgc cccaacaccc cttatctgga
      721 catcacctac cacttcgtca tgcagcgtct gcctctctac ttcattgtca acgtcatcat
      781 tccctgcctg ctcttctcct tcttaaccag tctggtgttc tacctgccca cagactcagg
      841 ggagaagatg acgctgagca tctctgtctt actgtccctg actgtgttcc ttctcgtcat
      901 tgtggagctg atcccttcca cctctagcgc tgtacccctg atcgggaagt acatgttgtt
      961 taccatggtc tttgtcattg cgtccataat aatcaccgtc attgtcatca acacacacca
     1021 ccgttcgccc agcacccaca tcatgcccga gtgggtgcgg aaggttttta tcgacactat
     1081 cccaaacatc atgtttttct ccacaatgaa aagaccatcc agagataaac aagaaaaaag
     1141 gattttcaca gaagacatag atatctctga catctctggg aagccggggc ctccacctat
     1201 gggctttcat tctccactga tcaagcaccc tgaggtgaaa agcgccattg agggtgtgaa
     1261 gtacattgca gagaccatga agtcagacca ggagtctaac aatgcgtctg aggagtggaa
     1321 gtatgtcgcc atggtgatgg accacatcct cctcggagtc tttatgctgg tgtgtctcat
     1381 cgggacgctg gctgtgtttg caggtcggct cattgagcta catcaacaag gatgagcaga
     1441 agctgaacta agcctccctc tgccccagct gcagccacca ccaggaaaga tagaagagag
     1501 gaaggcctgt ctacttgaat cctttcgcgc ttaccaagca cacagtgtgc tacatgtcct
     1561 gttaatgata gtggtctctg ctcacactgc tatgtcctta aagtatctcc cctttgcttc
     1621 tgcttttaac accatgggtc tccttaaaga gggaaccctt tgtagtaaat aaaagtgagt
     1681 cctcgggctg gagagatggc tcagcggtta agagcacccg actgctcttc cagaggtcat
     1741 gagttcaatt cccagcaacc acatggtggc tcacaaccat ctataaagag atctgatgcc
     1801 ctcttctggt gtatctgaag acagctacag tgtacttata tataataaaa
//
