LOCUS       NM_080773               2930 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cholinergic receptor, muscarinic 1 (Chrm1), mRNA.
ACCESSION   NM_080773 XM_006230974
VERSION     NM_080773.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2930)
  AUTHORS   Brugnoli,A., Pisano,C.A. and Morari,M.
  TITLE     Striatal and nigral muscarinic type 1 and type 4 receptors modulate
            levodopa-induced dyskinesia and striato-nigral pathway activation
            in 6-hydroxydopamine hemilesioned rats
  JOURNAL   Neurobiol Dis 144, 105044 (2020)
   PUBMED   32798726
  REMARK    GeneRIF: Striatal and nigral muscarinic type 1 and type 4 receptors
            modulate levodopa-induced dyskinesia and striato-nigral pathway
            activation in 6-hydroxydopamine hemilesioned rats.
REFERENCE   2  (bases 1 to 2930)
  AUTHORS   Chen,M.W., Zhu,H., Xiong,C.H., Li,J.B., Zhao,L.X., Chen,H.Z. and
            Qiu,Y.
  TITLE     PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated
            Modulation of AMPA Receptor GluA1 Subunit
  JOURNAL   Cell Mol Neurobiol 40 (4), 547-554 (2020)
   PUBMED   31721013
  REMARK    GeneRIF: PKC and Ras are Involved in M1 Muscarinic
            Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit.
REFERENCE   3  (bases 1 to 2930)
  AUTHORS   Braga,L.E.G., Miranda,R.L., Granja,M.G., Giestal-de-Araujo,E. and
            Dos Santos,A.A.
  TITLE     PKC delta activation increases neonatal rat retinal cells survival
            in vitro: Involvement of neurotrophins and M1 muscarinic receptors
  JOURNAL   Biochem Biophys Res Commun 500 (4), 917-923 (2018)
   PUBMED   29705702
  REMARK    GeneRIF: PKC delta activation modulates neurotrophins levels by a
            signaling pathway that involves M1R activation and ultimately
            leading to an increase in retinal ganglion cells survival in vitro.
REFERENCE   4  (bases 1 to 2930)
  AUTHORS   Stiver,M.L., Cloke,J.M., Nightingale,N., Rizos,J., Messer,W.S. Jr.
            and Winters,B.D.
  TITLE     Linking muscarinic receptor activation to UPS-mediated object
            memory destabilization: Implications for long-term memory
            modification and storage
  JOURNAL   Neurobiol Learn Mem 145, 151-164 (2017)
   PUBMED   29030298
  REMARK    GeneRIF: Results establish an intracellular pathway linking M1
            receptors, inositol triphosphate receptors, and ubiquitin
            proteasome system activity to object memory destabilization and
            suggest a previously unacknowledged role for cholinergic signaling
            in long-term memory modification and storage.
REFERENCE   5  (bases 1 to 2930)
  AUTHORS   Aitken,P., Benoit,A., Zheng,Y., Philoxene,B., Le Gall,A.,
            Denise,P., Besnard,S. and Smith,P.F.
  TITLE     Hippocampal and striatal M1 -muscarinic acetylcholine receptors are
            down-regulated following bilateral vestibular loss in rats
  JOURNAL   Hippocampus 26 (12), 1509-1514 (2016)
   PUBMED   27569857
  REMARK    GeneRIF: Study examined the expression of M1 muscarinic ACh
            receptors in the hippocampus at 7 and 30 days following
            experimental bilateral vestibular lesions (BVL) in rats using
            autoradiography. Analysis of the brain tissue revealed a
            significant reduction in the number of M1 receptors throughout the
            hippocampus and striatum at 30 days but not at 7 days following
            BVL.
REFERENCE   6  (bases 1 to 2930)
  AUTHORS   Hersch,S.M., Gutekunst,C.A., Rees,H.D., Heilman,C.J. and Levey,A.I.
  TITLE     Distribution of m1-m4 muscarinic receptor proteins in the rat
            striatum: light and electron microscopic immunocytochemistry using
            subtype-specific antibodies
  JOURNAL   J Neurosci 14 (5 Pt 2), 3351-3363 (1994)
   PUBMED   8182478
REFERENCE   7  (bases 1 to 2930)
  AUTHORS   Savarese,T.M., Wang,C.D. and Fraser,C.M.
  TITLE     Site-directed mutagenesis of the rat m1 muscarinic acetylcholine
            receptor. Role of conserved cysteines in receptor function
  JOURNAL   J Biol Chem 267 (16), 11439-11448 (1992)
   PUBMED   1317867
REFERENCE   8  (bases 1 to 2930)
  AUTHORS   Lai,J., Smith,T.L., Mei,L., Ikeda,M., Fujiwara,Y., Gomez,J.,
            Halonen,M., Roeske,W.R. and Yamamura,H.I.
  TITLE     The molecular properties of the M1 muscarinic receptor and its
            regulation of cytosolic calcium in a eukaryotic gene expression
            system
  JOURNAL   Adv Exp Med Biol 287, 313-330 (1991)
   PUBMED   1759615
REFERENCE   9  (bases 1 to 2930)
  AUTHORS   Kurtenbach,E., Curtis,C.A., Pedder,E.K., Aitken,A., Harris,A.C. and
            Hulme,E.C.
  TITLE     Muscarinic acetylcholine receptors. Peptide sequencing identifies
            residues involved in antagonist binding and disulfide bond
            formation
  JOURNAL   J Biol Chem 265 (23), 13702-13708 (1990)
   PUBMED   2380182
REFERENCE   10 (bases 1 to 2930)
  AUTHORS   Bonner,T.I., Buckley,N.J., Young,A.C. and Brann,M.R.
  TITLE     Identification of a family of muscarinic acetylcholine receptor
            genes
  JOURNAL   Science 237 (4814), 527-532 (1987)
   PUBMED   3037705
  REMARK    Erratum:[Science 1987 Sep 25;237(4822):237]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 13, 2022 this sequence version replaced
            XM_006230974.4, NM_080773.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.617359.1,
                                           SRR26360194.913323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-386               JAXUCZ010000001.1  214996359-214996744
            387-2930            JAXUCZ010000001.1  215009593-215012136
FEATURES             Location/Qualifiers
     source          1..2930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2930
                     /gene="Chrm1"
                     /note="cholinergic receptor, muscarinic 1"
                     /db_xref="GeneID:25229"
                     /db_xref="RGD:2342"
     exon            1..386
                     /gene="Chrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..2930
                     /gene="Chrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..1839
                     /gene="Chrm1"
                     /note="m1 muscarinic acetylcholine receptor protein;
                     Cholinergic receptor, muscarin 1"
                     /codon_start=1
                     /product="muscarinic acetylcholine receptor M1"
                     /protein_id="NP_542951.1"
                     /db_xref="GeneID:25229"
                     /db_xref="RGD:2342"
                     /translation="MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNL
                     LVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWL
                     ALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPA
                     ILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENR
                     ARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKE
                     EEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGR
                     DRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCK
                     DCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPG
                     SVHRTPSRQC"
ORIGIN      
        1 ctctcctctt ggacttttag ctttcctggg ctccctttcc tcatgtcctg cctcctccct
       61 ctcaaggctc aaagtgggtg cccttgtgga caaggggggc acactccagg acttagtcca
      121 accccagatg ctgcctgagg cttccctcct gctccccctc cctttctttc ctctctttcc
      181 tccctccctc tctttccctt cctccctccc ccccaaggct ggcgtgccag ggggtgggac
      241 atgccaatca ctggctgtgc ctctccggct gccagcacag ggcgcagctc cccccgggag
      301 ccaggtgttt gggtcccagg agacactgca ggcccctgga gaagcagtga agctgaggac
      361 cctacagacc cctctctgat cccatggtga tgccctttct ctgaggaaaa cctgtgactg
      421 gaggaagggg ctgcgccttc atcccacccg gctgccatga acacctcagt gccccctgct
      481 gtcagtccca acatcactgt cttggcacca ggaaagggtc cctggcaggt ggccttcatc
      541 gggatcacca caggcctcct gtctctagct acagtgacag gcaacctact ggtactcatc
      601 tccttcaagg tcaacaccga gctcaagaca gtcaacaact acttcctgct gagcctggcc
      661 tgtgctgacc tcatcattgg caccttctcc atgaacctct ataccacgta cctgctcatg
      721 ggccactggg ctctgggcac actggcctgt gacctctggc tggccctgga ctatgtggcc
      781 agcaacgcct ctgtcatgaa tcttctgctc atcagctttg accgttactt ctcggtgacc
      841 cgacccctga gctaccgagc caagcgcact ccccgaaggg cagctctgat gattggccta
      901 gcatggctgg tttccttcgt tctctgggcc ccagccatcc tcttctggca atacctagtt
      961 ggggagcgga cagtgctggc tgggcagtgc tacatccagt tcctctccca acccatcatc
     1021 acttttggca cagccatggc cgccttctac ctccctgtca cggtcatgtg tacactgtac
     1081 tggcgcatct accgggagac agaaaaccga gcccgggagc tggccgccct gcagggctct
     1141 gagacaccag gcaaaggtgg tggcagcagc agcagctcag agaggtcaca gccaggggct
     1201 gaaggctcac ccgagtcgcc tccaggccgc tgctgccgct gttgccgggc acccaggctc
     1261 ctgcaggcct acagctggaa ggaagaagaa gaggaggatg aaggctccat ggagtccctc
     1321 acatcctccg aaggtgagga gcctggctca gaagtggtga tcaagatgcc catggtagat
     1381 tctgaagcac aggcacccac caagcagcct cccaaaagct ccccaaatac agtcaagagg
     1441 cccaccaaga aaggccgaga ccgaggcggc aagggccaaa aaccccgagg gaaggaacag
     1501 ctggccaaga gaaagacctt ctcactggtc aaggagaaga aggcagctcg gaccctgagt
     1561 gccatcctgc tggccttcat cctcacctgg acaccatata acatcatggt gctggtatct
     1621 accttctgca aggactgtgt tcctgaaacc ctgtgggagc tgggctactg gctatgctac
     1681 gtcaacagca ctgtcaaccc catgtgctat gcactgtgca acaaagcctt ccgggacacg
     1741 ttccgcctgc tgctgctctg ccgctgggac aagaggcgct ggcgcaagat ccccaagcgc
     1801 cctggctctg tgcaccgcac cccctcccgc caatgctaac ggcccccttc tcctgcatcc
     1861 ttccacccca gctccaggga gaggccggtg gaaagtgtcc cggaaaaacg ggctgcatct
     1921 tcagccccag agccctgctc aggactcccc tggcttccca ggcccctggg tcaccttcct
     1981 ggacagccca gagagactct actagctttc caaactttgc tattcccaga cggggaatga
     2041 aacccgggga actggttttc tgatccccgc tgtgtgggaa tgggcccagc aggaggatcc
     2101 gggctttgga ctgtttgcgt ttaggcagga agtcaggagc cagcggggtg ggccggccgg
     2161 ccagtagttt aaaggtgcag tctttcttgg cccagcaggg ggcctggatt gcagtggtca
     2221 tagaacccac tgcatctaca tttgggagat gacaccaagc acagagagaa aggtttggaa
     2281 cggggagggg ggagggggtg gggtgttgga gggagggagg ttgtgacccc tggctggaaa
     2341 ttccctcctt tcctaggcag agctcatcca ggtaggccct aggcacactc tccaggatcg
     2401 ttcaacctcc ttacaaatga ccccaggtca tccctatgtg gatcatctcc aagacaaata
     2461 tccaagcgtg agcaggacaa tgacactagg ggagagcagc ttggctaaac acaccaagtc
     2521 ccaaagcagc atcaggacca gatgtcaggt gtcctaaccg gcccattcta tgccattttc
     2581 ctgggggtgg gggtggggta aggtgcctgc tccagtccca caccctttct cctctctccc
     2641 tgccccgaag tgacctaggc ccctcccttc tggctcacag ccattacctg ggtggatctg
     2701 ctctgggcag atctagccag acctcctgca tgctgcctgc ctcctccagc ctggccccac
     2761 acaggtctgg cccagccagc agattctctt ctgtaaactc ctgaatccaa tccatgcatg
     2821 gcctccctgc caccctgatc tccaggccct gcctggcccc tgttctttct ttccatcctc
     2881 agcatatgct gagtctgtga ataaagccac gtaactagtg ggaactacaa
//
