LOCUS       NM_199502               4106 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus chordin-like 1 (Chrdl1), mRNA.
ACCESSION   NM_199502 XM_343777
VERSION     NM_199502.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4106)
  AUTHORS   Huang,J., Wei,X., Ma,W. and Yuan,Z.
  TITLE     The miR-532-3p/Chrdl1 axis regulates the proliferation and
            migration of amniotic fluid-derived mesenchymal stromal cells
  JOURNAL   Biochem Biophys Res Commun 527 (1), 187-193 (2020)
   PUBMED   32446365
  REMARK    GeneRIF: The miR-532-3p/Chrdl1 axis regulates the proliferation and
            migration of amniotic fluid-derived mesenchymal stromal cells.
REFERENCE   2  (bases 1 to 4106)
  AUTHORS   Zhou,Y., Tanzie,C., Yan,Z., Chen,S., Duncan,M., Gaudenz,K., Li,H.,
            Seidel,C., Lewis,B., Moran,A., Libby,R.T., Kiernan,A.E. and Xie,T.
  TITLE     Notch2 regulates BMP signaling and epithelial morphogenesis in the
            ciliary body of the mouse eye
  JOURNAL   Proc Natl Acad Sci U S A 110 (22), 8966-8971 (2013)
   PUBMED   23676271
REFERENCE   3  (bases 1 to 4106)
  AUTHORS   Gao,W.L., Zhang,S.Q., Zhang,H., Wan,B. and Yin,Z.S.
  TITLE     Chordin-like protein 1 promotes neuronal differentiation by
            inhibiting bone morphogenetic protein-4 in neural stem cells
  JOURNAL   Mol Med Rep 7 (4), 1143-1148 (2013)
   PUBMED   23404565
  REMARK    GeneRIF: The current study indicates that CHRDL1 protein
            antagonizes BMP4 activity and induces spinal cordderived NSCs to
            differentiate into neurons.
REFERENCE   4  (bases 1 to 4106)
  AUTHORS   Webb,T.R., Matarin,M., Gardner,J.C., Kelberman,D., Hassan,H.,
            Ang,W., Michaelides,M., Ruddle,J.B., Pennell,C.E., Yazar,S.,
            Khor,C.C., Aung,T., Yogarajah,M., Robson,A.G., Holder,G.E.,
            Cheetham,M.E., Traboulsi,E.I., Moore,A.T., Sowden,J.C.,
            Sisodiya,S.M., Mackey,D.A., Tuft,S.J. and Hardcastle,A.J.
  TITLE     X-linked megalocornea caused by mutations in CHRDL1 identifies an
            essential role for ventroptin in anterior segment development
  JOURNAL   Am J Hum Genet 90 (2), 247-259 (2012)
   PUBMED   22284829
REFERENCE   5  (bases 1 to 4106)
  AUTHORS   Zheng,Z., Yin,Z., Gao,W., Zhang,H., Hu,Y. and Zhang,S.
  TITLE     [Effects of neurogenesin 1 gene on functional recovery of spinal
            cord injury in rats and its mechanism]
  JOURNAL   Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24 (4), 410-414 (2010)
   PUBMED   20459000
  REMARK    GeneRIF: Ng1 gene could promote the proliferation of endogenous
            neural stem cells and protect injured neurons following spinal cord
            injury.
REFERENCE   6  (bases 1 to 4106)
  AUTHORS   Ueki,T., Tanaka,M., Yamashita,K., Mikawa,S., Qiu,Z.,
            Maragakis,N.J., Hevner,R.F., Miura,N., Sugimura,H. and Sato,K.
  TITLE     A novel secretory factor, Neurogenesin-1, provides neurogenic
            environmental cues for neural stem cells in the adult hippocampus
  JOURNAL   J Neurosci 23 (37), 11732-11740 (2003)
   PUBMED   14684875
  REMARK    GeneRIF: Neurogenesin-1 contributes to neuronal differentiation of
            neural stem cells in the adult brain
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 27, 2020 this sequence version replaced NM_199502.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB080636.1, SRR26643291.44520.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               JAXUCZ010000021.1  111789267-111789661 c
            396-544             JAXUCZ010000021.1  111785402-111785550 c
            545-657             JAXUCZ010000021.1  111764275-111764387 c
            658-751             JAXUCZ010000021.1  111761926-111762019 c
            752-894             JAXUCZ010000021.1  111727427-111727569 c
            895-988             JAXUCZ010000021.1  111725471-111725564 c
            989-1056            JAXUCZ010000021.1  111711780-111711847 c
            1057-1225           JAXUCZ010000021.1  111703674-111703842 c
            1226-1420           JAXUCZ010000021.1  111700165-111700359 c
            1421-1588           JAXUCZ010000021.1  111694335-111694502 c
            1589-1678           JAXUCZ010000021.1  111691370-111691459 c
            1679-4106           JAXUCZ010000021.1  111685866-111688293 c
FEATURES             Location/Qualifiers
     source          1..4106
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq33"
     gene            1..4106
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /note="chordin-like 1"
                     /db_xref="GeneID:363455"
                     /db_xref="RGD:735215"
     exon            1..395
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1809
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /note="neurogenesin 1; neuralin-1; ventroptin; kohjirin"
                     /codon_start=1
                     /product="chordin-like protein 1"
                     /protein_id="NP_955796.2"
                     /db_xref="GeneID:363455"
                     /db_xref="RGD:735215"
                     /translation="MFFLPPTFESPLPLRAHSSSRHNLRAPDLGGAPQGAQSVCKRGR
                     RKRPVPSFSPPVLGVSELHFAVAQRRREWKMEGIKYIASLVFFFVFLEASKTEPVKHS
                     ETYCMFQDKKYRVGEKWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPTLHCLSPVHI
                     PHLCCPRCPDSLPPMNNKVTSKSCEYNGTTYQHGELFIAEGLFQNRQPNQCSQCSCSE
                     GNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGELSWEHSDADIFRQPANREARHSYL
                     RSPYDPPPSRQAGGLPRFAGSRSHRGAVIDSQQASGTIVQIVINNKHKHGQVCVSNGK
                     TYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKLDGKCCKVCP
                     EEPPSQNFDSKGSFCGEETMPVYEAVLVEDGETARKVALETEKPPQVEVHVWTIRKGI
                     LQHFHIEKISKEMFGGLHHFKLVTRTTMNQWKIFAEGEAQLSQMCSSRVCRTELEDLV
                     QVLYLERPEKDHC"
     exon            396..544
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..657
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..751
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..894
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..988
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1056
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1225
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1420
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1588
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1678
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..4106
                     /gene="Chrdl1"
                     /gene_synonym="Kjr; Neurogenesin-1; Ng1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccgttttg taactttcgg gtctgggatg taggaataaa gcccggtgct gggaccaaaa
       61 aggggtgcct atttgcagcg gctgggctgc ttgctggaga acttcccgcc agcgccagac
      121 agccaggcca agtggggagc ggacaggcgg gcgggcaggt ggccccgggc cgccgcgccc
      181 gcgccttggc tctgccccct ggagccaagc gagcctctgc tccctcgtgg tgcgagggcg
      241 gtgatgtttt tcctcccacc cacttttgag tcccccctcc cccttcgcgc gcactcaagt
      301 tctcgccaca acctgcgagc cccagacctc ggaggagcgc cccagggagc tcagagcgtg
      361 tgcaagcgtg gcagaaggaa gaggccagtg cccagcttta gcccaccagt cctaggagtc
      421 tctgagctgc attttgcagt agctcaaagg agaagagagt ggaaaatgga aggcataaaa
      481 tatatcgcct ccttggtttt cttctttgtt ttcctggaag caagcaaaac agagccagta
      541 aaacactcag agacatattg catgtttcaa gacaagaagt atagagttgg tgagaaatgg
      601 catccctacc tggaaccata tggactggtt tactgtgtga actgcatctg ctcagagaat
      661 gggaatgtgc tttgcagccg agtcagatgt ccaactcttc attgcctttc acccgtgcat
      721 attcctcatc tgtgttgccc ccgttgccca gactccttac caccgatgaa caataaggtg
      781 accagcaagt cctgcgaata caatgggacc acctaccaac acggagagct cttcatagct
      841 gaagggctct ttcagaaccg gcagcccaat cagtgcagtc agtgcagctg ctcggagggg
      901 aatgtgtatt gtggtctcaa gacttgcccc aaactgacct gtgcattccc agtctctgtt
      961 ccagattcct gctgccgagt atgcagaggg gatggagaat tatcatggga acattctgat
     1021 gctgatatct tccggcaacc tgccaacaga gaagcaagac attcttacct ccgttccccc
     1081 tacgatcctc caccaagcag acaagctgga ggtcttcccc gctttgctgg gagcagaagt
     1141 caccggggag ctgtcattga ttctcagcaa gcatcaggga ccatcgtgca gatcgtcatc
     1201 aataacaagc acaaacatgg acaagtgtgt gtttccaatg gaaagaccta ttctcacgga
     1261 gaatcctggc atccaaatct acgagctttt ggcattgtgg aatgtgttct atgcacttgt
     1321 aatgtcacca agcaagaatg taagaaaatc cactgcccca atcgataccc ctgcaagtat
     1381 cctcaaaaat tagatggaaa gtgctgcaag gtgtgcccag aagaacctcc aagtcaaaac
     1441 tttgacagca aaggttcctt ttgtggagaa gaaaccatgc ctgtatatga ggctgtgctc
     1501 gtggaggatg gagagacagc cagaaaagta gcactggaga ccgagaaacc acctcaagta
     1561 gaggttcacg tttggactat tcgaaagggc attctccagc acttccacat tgagaagatt
     1621 tccaaggaga tgtttggggg tctccatcat ttcaagctgg tgactcgaac caccatgaac
     1681 cagtggaaga tcttcgctga aggagaagct cagctcagcc agatgtgctc aagtcgggtg
     1741 tgcagaacag aactggaaga tttggtccag gttttgtacc tggagagacc tgaaaaggac
     1801 cactgttaga caaaacagtc aggattgaat agtatcaatc aaggaaaccc aagctgcagc
     1861 tggactgccg gcttacttta cttaagtcaa cagtgctcca aaaccccaaa gtcaacctca
     1921 gtcaaattat ccagtcacag cacaccttgt tcctctatgt gcagcggtgt gccagccctc
     1981 aaacatctcc tgtaaagaga atagaggagt ctttaatggt ttctgggggt ggggggagaa
     2041 gggataggac tttgtggtac agctctattt tctctgagaa tcacatttat ttgcaggtta
     2101 aagtagaaaa gaaaaccact ttttagggat tctatgtaga aagtcacaag agagagagag
     2161 agaaattgct gagtttgagt tggatcatgc caaacaaatt tgtgtgaaat actttttgaa
     2221 tgttcaagtg tcttccctac tttaaaaatg ttattcagtt ggtggttgaa cagtcaggtg
     2281 attatggagc acatacctat aatatgtgga gacctgggtt ctagtctcag aactgacaaa
     2341 aaaatttcta tcctcatatc tcacatgcac acacacacac acacacacac acacacacac
     2401 acacacagca cacgaaactg catttctttc tggctcctaa acacctttgt ggttgttcgt
     2461 atccagggaa acaaactaaa aatgtatgca aaaaactctg ccctcaagcc tttgaggcag
     2521 gttgtaagaa atcagccata gtcttagagt gaagaatgcc atttgtgggt cttgtttcct
     2581 tcgaagtact aaatacattt tgcctagtaa tatcacttct cttttcttat ctggcacccc
     2641 cattaggaag gtagaatttg gagaactcat cagaaactaa atttattcca aacaaaatga
     2701 caatagaaga atataactgg taaaaaataa aatagtccat tttttgtttt ggttttacag
     2761 ctataaatct aactgattaa taggctaatg atgctcacta attttcttga ggcaatagtc
     2821 acctaggcag acactttagg ttgacacttt tattctaaaa gcctttttaa gggtaatttc
     2881 ctactttgat tacaggagtt gaaatgtaac ttttcaaaaa ggctcaatcc ttacaagctt
     2941 ctcaacatca gttcttctgt taagtgctac tgttcattca cagagctgag aattctggca
     3001 aagatctttg tcccaaccct tcctaatatc cttgccttat tcttgagcat gggttgcagc
     3061 agggattgtg acagcactac ttctaaaatg ttcatttgca gcccagtgcc tcaacatcaa
     3121 ttttccttcc tgaggcttgg ctttagaaat caccttttgg aaaaactata actattccct
     3181 agcaaagatc ataggttcac tggatctgtc catctgccga gcatgaatga actcacatga
     3241 gtactaagaa atgtgaagat caagaaattc tatatttccc actctaagtg agaaaacatg
     3301 ataggaaaaa gtatgaagag tctggtcttt actagaacct gacagagaag ggaaggcttt
     3361 ggggccatgt tttcatgaga caaacttcct gccagccaat tacacattct cccaagaaga
     3421 gaagcatagg gcgtcctggg ctgcaaagac actgaacatt attgaagatg tgatggggca
     3481 atgccaaccc tctgctgctt ccctcttgga ggaaacacta tttccagagt gcggagatca
     3541 atcacaggtc ctgaaggaaa gtggtgattc ctgtgctaga cgattcaccc gcagggaagg
     3601 tggtgattcc cgtgctagat gattcactca caaaccttcc cgcccaggtg ttctctgaaa
     3661 gcttagcctc aagggaacac ctaaagagct cccctaccta cataaacccc tgcctccaag
     3721 tgtaggaact cacctttcta aagcgctgtg ggaagcagga actaggcatc tgtgctaagt
     3781 caatgtagaa tttctccagc gttttaatgc tgggtagaat atagagcata ggggaaaggg
     3841 gccaaactgc ctatagttag tagagaaaaa tgaatgtggt tcttttgtgc atttatgtgt
     3901 atcataaaca cttgggaaag caaaaaccat aagcaccatt ttgcagcttt atccattttc
     3961 cagttagctc atgtaaacga gcacgaataa caaaacagta ttactctttc gcacttctca
     4021 caggacatgt acccaaatac ggtacttatt tatgtagtca ctgtgtttca ggacttttac
     4081 gttaataaaa tttttattta aaattt
//
