LOCUS       NM_057134               3267 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus chordin (Chrd), mRNA.
ACCESSION   NM_057134 XM_001059575 XM_221307
VERSION     NM_057134.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3267)
  AUTHORS   Hayashi,Y., Mikawa,S., Masumoto,K., Katou,F. and Sato,K.
  TITLE     Chordin and noggin expression in the adult rat trigeminal nuclei
  JOURNAL   J Chem Neuroanat 78, 36-41 (2016)
   PUBMED   27546891
  REMARK    GeneRIF: Chordin and noggin were intensely expressed throughout the
            trigeminal nuclei. chordin prefers dendritic expression than
            noggin, suggesting that chordin is involved in the regulation of
            dendritic morphology and synaptic homeostasis. Furthermore, chordin
            and noggin were differentially expressed in the neuropil of the
            trigeminal nuclei.
REFERENCE   2  (bases 1 to 3267)
  AUTHORS   Mikawa,S. and Sato,K.
  TITLE     Chordin expression in the adult rat brain
  JOURNAL   Neuroscience 258, 16-33 (2014)
   PUBMED   24231736
  REMARK    GeneRIF: Data indicate that chordin is more widely expressed
            throughout the adult CNS than previously reported, and its
            continued abundant expression in the adult brain strongly supports
            the idea that chordin plays pivotal roles also in the adult brain
REFERENCE   3  (bases 1 to 3267)
  AUTHORS   Misra,K. and Matise,M.P.
  TITLE     A critical role for sFRP proteins in maintaining caudal neural tube
            closure in mice via inhibition of BMP signaling
  JOURNAL   Dev Biol 337 (1), 74-83 (2010)
   PUBMED   19850029
REFERENCE   4  (bases 1 to 3267)
  AUTHORS   Kwong,F.N., Richardson,S.M. and Evans,C.H.
  TITLE     Chordin knockdown enhances the osteogenic differentiation of human
            mesenchymal stem cells
  JOURNAL   Arthritis Res Ther 10 (3), R65 (2008)
   PUBMED   18533030
REFERENCE   5  (bases 1 to 3267)
  AUTHORS   Moll,F., Millet,C., Noel,D., Orsetti,B., Bardin,A., Katsaros,D.,
            Jorgensen,C., Garcia,M., Theillet,C., Pujol,P. and Francois,V.
  TITLE     Chordin is underexpressed in ovarian tumors and reduces tumor cell
            motility
  JOURNAL   FASEB J 20 (2), 240-250 (2006)
   PUBMED   16449796
REFERENCE   6  (bases 1 to 3267)
  AUTHORS   Bachiller,D., Klingensmith,J., Shneyder,N., Tran,U., Anderson,R.,
            Rossant,J. and De Robertis,E.M.
  TITLE     The role of chordin/Bmp signals in mammalian pharyngeal development
            and DiGeorge syndrome
  JOURNAL   Development 130 (15), 3567-3578 (2003)
   PUBMED   12810603
REFERENCE   7  (bases 1 to 3267)
  AUTHORS   Anderson,R.M., Lawrence,A.R., Stottmann,R.W., Bachiller,D. and
            Klingensmith,J.
  TITLE     Chordin and noggin promote organizing centers of forebrain
            development in the mouse
  JOURNAL   Development 129 (21), 4975-4987 (2002)
   PUBMED   12397106
REFERENCE   8  (bases 1 to 3267)
  AUTHORS   Stottmann,R.W., Anderson,R.M. and Klingensmith,J.
  TITLE     The BMP antagonists Chordin and Noggin have essential but redundant
            roles in mouse mandibular outgrowth
  JOURNAL   Dev Biol 240 (2), 457-473 (2001)
   PUBMED   11784076
REFERENCE   9  (bases 1 to 3267)
  AUTHORS   Millet,C., Lemaire,P., Orsetti,B., Guglielmi,P. and Francois,V.
  TITLE     The human chordin gene encodes several differentially expressed
            spliced variants with distinct BMP opposing activities
  JOURNAL   Mech Dev 106 (1-2), 85-96 (2001)
   PUBMED   11472837
REFERENCE   10 (bases 1 to 3267)
  AUTHORS   Bachiller,D., Klingensmith,J., Kemp,C., Belo,J.A., Anderson,R.M.,
            May,S.R., McMahon,J.A., McMahon,A.P., Harland,R.M., Rossant,J. and
            De Robertis,E.M.
  TITLE     The organizer factors Chordin and Noggin are required for mouse
            forebrain development
  JOURNAL   Nature 403 (6770), 658-661 (2000)
   PUBMED   10688202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Dec 17, 2009 this sequence version replaced
            XM_221307.3, XM_001059575.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.39905.1,
                                           SRR26643294.45000.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               JAXUCZ010000011.1  93684932-93685100   c
            170-273             JAXUCZ010000011.1  93684592-93684695   c
            274-403             JAXUCZ010000011.1  93684076-93684205   c
            404-532             JAXUCZ010000011.1  93683810-93683938   c
            533-632             JAXUCZ010000011.1  93683626-93683725   c
            633-720             JAXUCZ010000011.1  93683439-93683526   c
            721-862             JAXUCZ010000011.1  93682956-93683097   c
            863-991             JAXUCZ010000011.1  93682712-93682840   c
            992-1074            JAXUCZ010000011.1  93682543-93682625   c
            1075-1222           JAXUCZ010000011.1  93682318-93682465   c
            1223-1329           JAXUCZ010000011.1  93682067-93682173   c
            1330-1449           JAXUCZ010000011.1  93681827-93681946   c
            1450-1606           JAXUCZ010000011.1  93681152-93681308   c
            1607-1827           JAXUCZ010000011.1  93680645-93680865   c
            1828-1941           JAXUCZ010000011.1  93679733-93679846   c
            1942-2205           JAXUCZ010000011.1  93679232-93679495   c
            2206-2299           JAXUCZ010000011.1  93679051-93679144   c
            2300-2353           JAXUCZ010000011.1  93678885-93678938   c
            2354-2457           JAXUCZ010000011.1  93678563-93678666   c
            2458-2560           JAXUCZ010000011.1  93678039-93678141   c
            2561-2715           JAXUCZ010000011.1  93677439-93677593   c
            2716-2815           JAXUCZ010000011.1  93677188-93677287   c
            2816-3267           JAXUCZ010000011.1  93676400-93676851   c
FEATURES             Location/Qualifiers
     source          1..3267
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..3267
                     /gene="Chrd"
                     /note="chordin"
                     /db_xref="GeneID:117275"
                     /db_xref="RGD:620181"
     exon            1..169
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..2868
                     /gene="Chrd"
                     /codon_start=1
                     /product="chordin precursor"
                     /protein_id="NP_476475.1"
                     /db_xref="GeneID:117275"
                     /db_xref="RGD:620181"
                     /translation="MPSLPAPPAPRLLLGLLLLGSRPAGGTGPEAPALPIRSEKEPLP
                     VRGAAGCSFGGKVYALDETWHPDLGEPFGVMRCVLCACEAPQWARRGRGPGRVSCKNI
                     KPQCPTLACRQPRQLPGHCCQTCPQERSNLDPQPAGLVFEYPRDPEHRSYSDRGEPGT
                     GERTRGDGHTDFVALLTGPRTQAVARARVSLLRSSLRFSISYQRLDRPSRVRFTDPTG
                     NILFEHPAAPTQDGLVCGVWRAVPRLSVRLLRAEQLRVALVTPTHPSEEVWGPLIWQG
                     ALTAETFSAILTLEDPLQRGVGGIALLTLSDTEDALHFLLLFRGLLGGLAHVPLKLQI
                     LHQGQLLRELQANASAQEPGFAEVLPSLTDQEMDWLVLGELQMVLEKMGGPELRISGY
                     ITTRQSCDVLQSVLCGADALIPVQTGAAGSASFILLGNGSLIYQVQVIGTGSEVVAMT
                     LETKPQRKNQRTVLCHMAGLQLGGHMAVGVCSGLGARGAHMLLQNELFLNIGTKDFPD
                     GELRGHVTALCYSGHSAHYDRLPVPLAGALVLPPVRSQAAGHAWLSLDTHCHLHYEVL
                     LAGLGGSEQGTVTAHLLGPPGMPGPQRLLKGFYGSEAQGVVKDLEPVLLRHLTQGTAS
                     LLITTKSNPRGELRGQVHIASQCEVGGLRLASEGVRMSLAPNGEAATSPMLPAGPGPE
                     APVPAKHGSSGRPRDPNTCFFEGQQRPHGARWAPNYDPLCSLCTCQRRTVICDPVVCP
                     PPSCPHPVQALDQCCPVCPEKQRSRDLPSLPNLEPGEGCYFDGDRSWRAAGTRWHPVV
                     PPFGLIKCAVCTCKGATGEVHCEKVQCPRLACAQPVRANPTDCCKQCPVGSGTHAKLG
                     DPMQADGPRGCRFAGQWFPENQSWHPSVPPFGEMSCITCRCGAGVPHCERDDCSPPLS
                     CGSGKESRCCSHCTAQRSSETRTLPELEKEAQRS"
     exon            170..273
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            274..403
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            404..532
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            533..632
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            633..720
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            721..862
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            863..991
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1074
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1222
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1329
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1449
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1606
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1827
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1941
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2205
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2299
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2353
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2457
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2560
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2715
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2815
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..3267
                     /gene="Chrd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagctgtc tgctccgcgt catgccgagc ctcccggccc cgccggcccc tcggctgctc
       61 ctcgggctgc tgctgctcgg ctcgcggccg gccggtggca ctggccctga ggcccccgca
      121 ctgcccatcc gttccgagaa ggagccactg cctgtccggg gagcggcagg ctgctccttc
      181 ggcgggaagg tctatgcctt ggacgagacg tggcacccgg acctggggga gccttttggg
      241 gtgatgcgct gtgtgctgtg cgcctgcgaa gcgcctcagt gggctcgccg tgggaggggc
      301 cctggcaggg tcagctgcaa gaacatcaaa cctcagtgcc ccaccctggc ctgcaggcag
      361 ccgcgccagc tgccaggaca ctgctgccag acctgcccgc aggagcgcag caatctagat
      421 ccacagccgg ctggcctggt cttcgagtat ccaagggacc cagagcatcg cagttatagc
      481 gatcgagggg aacccggcac tggggagcgg acacgtggtg atggccacac ggactttgtg
      541 gcgttgctga ctggaccgag gacgcaggcg gtagctcgtg ctcgagtctc tttgctgcgc
      601 tcaagtttac gcttctctat ctcctaccag cggctggacc gtcccagcag ggttcggttc
      661 acagacccca caggcaacat cctgtttgaa caccctgctg cccccaccca agatggcctg
      721 gtctgtgggg tgtggcgggc agtgcctcgg ctgtctgtga ggctcctgag ggcagagcag
      781 ctgcgtgttg cccttgtgac acccactcac ccttcagaag aagtctgggg gcctctcatt
      841 tggcagggtg ctctcactgc agagaccttc agtgccatcc tgaccctgga ggacccactg
      901 cagcggggtg tcgggggcat agccctgctc actctcagtg acacagaaga tgccttacat
      961 tttttgctgc tcttccgggg tctgctggga ggactagctc acgtcccctt gaagcttcag
     1021 attctccacc agggacagct acttcgagag ctccaggcca atgcctcagc tcaggagcca
     1081 ggttttgctg aggtgctgcc cagccttaca gaccaagaga tggactggtt ggtgctgggg
     1141 gagctgcaga tggtcctaga gaagatgggt gggccagagc tacgcatcag cgggtatatc
     1201 acgaccaggc agagctgtga tgtccttcaa agcgtcctct gtggggctga tgccttgatc
     1261 ccagtccaga cgggtgctgc tggctcagcc agcttcatac tgctaggaaa tggctccctt
     1321 atctatcagg tacaagtgat aggtacaggt agcgaggtgg tggccatgac gctggagacc
     1381 aagcctcagc ggaagaacca gcgcactgtc ctgtgccaca tggctggact ccagctggga
     1441 ggacacatgg ctgtgggtgt ctgctctggg ctgggtgccc gaggggctca catgctgcta
     1501 cagaatgagt tgttcctgaa tattggtacc aaggacttcc cagacggaga gcttcggggg
     1561 cacgtgactg ccctatgcta cagcgggcac agtgcccact acgacagatt gcctgtgcct
     1621 ctggcagggg cactagtact gccccctgtg cggagtcagg cagcaggaca tgcctggctg
     1681 tccttggata cacattgcca cttacactat gaggttctat tggctgggct tggtggctca
     1741 gagcaaggaa ctgtcactgc tcatctcctc gggcctcctg ggatgccagg gccccagcga
     1801 ctgctgaagg gattctatgg ctcagaggct cagggtgtgg taaaagatct agagcccgtg
     1861 ctgctgcggc acctgacaca gggcaccgcc tccctgctta tcaccaccaa gagtaaccct
     1921 agaggagagc tacgcgggca ggtgcacatt gccagtcagt gtgaggtggg aggcctgcgc
     1981 ctggcctcag aaggagtgcg gatgtccttg gctccaaatg gagaggcagc tacatcaccc
     2041 atgctgcctg ctgggcccgg ccctgaagcc cccgtaccag ccaaacacgg cagctctggg
     2101 agaccccgag atcctaacac atgtttcttc gaggggcagc agcgtcccca cggggctcgc
     2161 tgggcaccca actatgaccc actctgctcc ctctgcacct gccagagacg gacagtgatc
     2221 tgtgatcctg tagtatgccc accaccaagc tgtccccacc cggtgcaggc actggaccag
     2281 tgctgtcccg tgtgtccaga gaaacaacgc agtagagacc ttcccagcct accaaatctg
     2341 gagccaggag agggctgcta ttttgatggt gaccggagct ggagggcagc gggtacccga
     2401 tggcaccccg ttgtgccccc ctttggccta attaagtgtg ctgtctgcac ctgcaagggg
     2461 gccaccggag aggtgcactg tgagaaggtg cagtgtcctc gcctcgcctg tgctcagcct
     2521 gtccgtgcca accccaccga ctgctgcaaa cagtgcccag tagggtcagg gactcatgcc
     2581 aagctgggag accccatgca ggctgatggg cctcggggtt gtcgctttgc tgggcagtgg
     2641 ttcccagaga atcagagctg gcacccatca gtgcccccct ttggggagat gagctgtatt
     2701 acctgcagat gtggggcagg ggtaccccac tgtgagcggg acgattgctc gccgccacta
     2761 tcctgcggct cagggaagga gagtcgatgc tgttcccact gtacagccca aaggtcctct
     2821 gagactagaa cccttcccga gctggagaaa gaagctcaac gctcctagga agcatccaga
     2881 agcacatgac caagaggatg ggcctgaact gggagaagga gtggtgctga ggaccctgat
     2941 tctcctgcgg gaacccagtg ccttccgtgc ctctgttctg cttcttctcc tcccccacta
     3001 cctctgggaa ccacgattct acaaggggaa agactgctgg gtcagaccaa ggccatatcc
     3061 acgcgaactc ctgccctgtt ttcttttggc ctctgtccca gaagcttaac tcttttcttc
     3121 tgtacaaaac accaccggct tattgggatt ctttaattta tcctcactca gcactaaggg
     3181 ttccctcaca ccattcctgc tgcccctgag ctgagcagag tcattattag agatttttgt
     3241 atttattaaa acatcttttt tttttca
//
