LOCUS       NM_182738               1257 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus calcineurin-like EF hand protein 2 (Chp2), mRNA.
ACCESSION   NM_182738
VERSION     NM_182738.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1257)
  AUTHORS   Knaapen,M., Koch,A.H., Koch,C., Koch,K.T., Li,X., van Rooij,P.C.,
            Tijssen,J.G., Peters,R.J., van der Wal,A.C., Damman,P. and de
            Winter,R.J.
  TITLE     Prevalence of left and balanced coronary arterial dominance
            decreases with increasing age of patients at autopsy. A postmortem
            coronary angiograms study
  JOURNAL   Cardiovasc Pathol 22 (1), 49-53 (2013)
   PUBMED   22463919
REFERENCE   2  (bases 1 to 1257)
  AUTHORS   Li,Q.H., Wang,L.H., Lin,Y.N., Chang,G.Q., Li,H.W., Jin,W.N.,
            Hu,R.H. and Pang,T.X.
  TITLE     Nuclear accumulation of calcineurin B homologous protein 2 (CHP2)
            results in enhanced proliferation of tumor cells
  JOURNAL   Genes Cells 16 (4), 416-426 (2011)
   PUBMED   21392185
REFERENCE   3  (bases 1 to 1257)
  AUTHORS   Bales,J.W., Ma,X., Yan,H.Q., Jenkins,L.W. and Dixon,C.E.
  TITLE     Regional calcineurin subunit B isoform expression in rat
            hippocampus following a traumatic brain injury
  JOURNAL   Brain Res 1358, 211-220 (2010)
   PUBMED   20713027
  REMARK    GeneRIF: Calcineurin B isoforms showed increased expression
            throughout the CA1 and CA2 while there was a decrease in expression
            within the ipsilateral dentate gyrus.
REFERENCE   4  (bases 1 to 1257)
  AUTHORS   Li,G.D., Zhang,X., Li,R., Wang,Y.D., Wang,Y.L., Han,K.J.,
            Qian,X.P., Yang,C.G., Liu,P., Wei,Q., Chen,W.F., Zhang,J. and
            Zhang,Y.
  TITLE     CHP2 activates the calcineurin/nuclear factor of activated T cells
            signaling pathway and enhances the oncogenic potential of HEK293
            cells
  JOURNAL   J Biol Chem 283 (47), 32660-32668 (2008)
   PUBMED   18815128
REFERENCE   5  (bases 1 to 1257)
  AUTHORS   Inoue,H., Nakamura,Y., Nagita,M., Takai,T., Masuda,M., Nakamura,N.
            and Kanazawa,H.
  TITLE     Calcineurin homologous protein isoform 2 (CHP2), Na+/H+
            exchangers-binding protein, is expressed in intestinal epithelium
  JOURNAL   Biol Pharm Bull 26 (2), 148-155 (2003)
   PUBMED   12576672
  REMARK    GeneRIF: CHP2 is predominantly expressed in epithelial cells of the
            small and large intestine where it may regulate epithelial Na+/H+
            exchanger(NHE)isoforms NHE2-4.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB086189.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB086189.1, FM101005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1257
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1257
                     /gene="Chp2"
                     /gene_synonym="chp-2"
                     /note="calcineurin-like EF hand protein 2"
                     /db_xref="GeneID:308965"
                     /db_xref="RGD:727796"
     exon            1..105
                     /gene="Chp2"
                     /gene_synonym="chp-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..629
                     /gene="Chp2"
                     /gene_synonym="chp-2"
                     /codon_start=1
                     /product="calcineurin B homologous protein 2"
                     /protein_id="NP_877402.1"
                     /db_xref="GeneID:308965"
                     /db_xref="RGD:727796"
                     /translation="MGSRSSHVALIPDVDQIRRETGFSQASLLRLYHRFQALDREEKG
                     FLSRLDLQQIGALAVNPLGDRIIDSFFPNGSQRVYFAGFARVLAYFRPIDEDDATLRD
                     PKQPEPLNSRMNKLRFAFQLYDLDRDGKISRNEMLQVLRLMVGVQVTDEQLESITDRT
                     VQEADEDGDGAVSFLEFAKSLEKMNIEQKMSIRILK"
     exon            106..178
                     /gene="Chp2"
                     /gene_synonym="chp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            179..259
                     /gene="Chp2"
                     /gene_synonym="chp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            260..390
                     /gene="Chp2"
                     /gene_synonym="chp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            391..452
                     /gene="Chp2"
                     /gene_synonym="chp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            453..575
                     /gene="Chp2"
                     /gene_synonym="chp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..1230
                     /gene="Chp2"
                     /gene_synonym="chp-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttcctttg gctgttcgtc tccttctgtg gctttgccat gggctcacgg agctctcatg
       61 tcgcgctcat tcctgatgtg gaccaaattc gcagagagac gggcttctcc caagctagcc
      121 tgctccgtct ctaccacagg ttccaagccc tagacaggga ggaaaagggc ttcctgagcc
      181 gcctagacct ccagcagatt ggagccctgg ctgtgaaccc cctgggtgac cgcattatag
      241 acagcttctt ccccaatggg agtcagagag tgtatttcgc aggctttgcc agagtcctgg
      301 cttattttcg acctatagat gaagacgatg ccacactccg agaccccaag caacctgaac
      361 ccctaaacag cagaatgaat aaactgcgct ttgcatttca gctctatgat ctggatcggg
      421 atgggaagat ctccaggaat gaaatgctac aggttctccg cctcatggtt ggggtccagg
      481 tgacagacga gcagttggag agcatcacag accgcacagt gcaggaagcc gatgaagatg
      541 gggatggggc cgtgtccttc ctggagttcg ccaagtcctt agagaagatg aacatcgagc
      601 agaagatgag catccggatc ctgaagtgac ccctgtgtct ttgactcatg caaacatata
      661 tggactcggg atttatcctc aggcctctgg aagcaggagc ccacaagcca tattctattc
      721 tgaaactttg tttaaggtta ggaaagggaa ttggaggagc gtgtgctgaa gtctcatttg
      781 ctctcagatt tgtgaatcag ccagtgattt ggttgcaagt ggctgaaagg ccaacccaaa
      841 gtgacaagat aaaaaaggga aaaggatgac atgggcctgt gactagacag cccggaagta
      901 gttgccttta tgcacacctg gatccaagga cacgcatggt gtcatcggga ttgagttttg
      961 tcacctgggg ttctcaggtt ggctgccttc ttgcattggg atcattcctt tgggtacgaa
     1021 gagccgacag ctgtcgagac cacatcctct tagccctcta acccagagga cgggatgtca
     1081 tactccagaa atgccaacca agcagaacca ttgacccagc tgggggcttt tctctatctc
     1141 agggaagggg tgaggggaga tggaacattt aaataggcta tgcctgtgtc atataacaat
     1201 tccaaaccct gaataaatcc ggaagactta aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
