LOCUS       NM_024139               2524 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus calcineurin-like EF-hand protein 1 (Chp1), mRNA.
ACCESSION   NM_024139
VERSION     NM_024139.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Mendoza-Ferreira,N., Coutelier,M., Janzen,E., Hosseinibarkooie,S.,
            Lohr,H., Schneider,S., Milbradt,J., Karakaya,M., Riessland,M.,
            Pichlo,C., Torres-Benito,L., Singleton,A., Zuchner,S., Brice,A.,
            Durr,A., Hammerschmidt,M., Stevanin,G. and Wirth,B.
  TITLE     Biallelic CHP1 mutation causes human autosomal recessive ataxia by
            impairing NHE1 function
  JOURNAL   Neurol Genet 4 (1), e209 (2018)
   PUBMED   29379881
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Liu,Y., Zaun,H.C., Orlowski,J. and Ackerman,S.L.
  TITLE     CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje
            cell axon homeostasis
  JOURNAL   J Neurosci 33 (31), 12656-12669 (2013)
   PUBMED   23904602
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Knaapen,M., Koch,A.H., Koch,C., Koch,K.T., Li,X., van Rooij,P.C.,
            Tijssen,J.G., Peters,R.J., van der Wal,A.C., Damman,P. and de
            Winter,R.J.
  TITLE     Prevalence of left and balanced coronary arterial dominance
            decreases with increasing age of patients at autopsy. A postmortem
            coronary angiograms study
  JOURNAL   Cardiovasc Pathol 22 (1), 49-53 (2013)
   PUBMED   22463919
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Zhang-James,Y., DasBanerjee,T., Sagvolden,T., Middleton,F.A. and
            Faraone,S.V.
  TITLE     SLC9A9 mutations, gene expression, and protein-protein interactions
            in rat models of attention-deficit/hyperactivity disorder
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 156B (7), 835-843 (2011)
   PUBMED   21858920
REFERENCE   5  (bases 1 to 2524)
  AUTHORS   Matsushita,M., Tanaka,H., Mitsui,K. and Kanazawa,H.
  TITLE     Dual functional significance of calcineurin homologous protein 1
            binding to Na(+)/H(+) exchanger isoform 1
  JOURNAL   Am J Physiol Cell Physiol 301 (2), C280-C288 (2011)
   PUBMED   21543739
REFERENCE   6  (bases 1 to 2524)
  AUTHORS   Pang,T., Su,X., Wakabayashi,S. and Shigekawa,M.
  TITLE     Calcineurin homologous protein as an essential cofactor for Na+/H+
            exchangers
  JOURNAL   J Biol Chem 276 (20), 17367-17372 (2001)
   PUBMED   11350981
REFERENCE   7  (bases 1 to 2524)
  AUTHORS   Lin,X., Sikkink,R.A., Rusnak,F. and Barber,D.L.
  TITLE     Inhibition of calcineurin phosphatase activity by a calcineurin B
            homologous protein
  JOURNAL   J Biol Chem 274 (51), 36125-36131 (1999)
   PUBMED   10593895
REFERENCE   8  (bases 1 to 2524)
  AUTHORS   Timm,S., Titus,B., Bernd,K. and Barroso,M.
  TITLE     The EF-hand Ca(2+)-binding protein p22 associates with microtubules
            in an N-myristoylation-dependent manner
  JOURNAL   Mol Biol Cell 10 (10), 3473-3488 (1999)
   PUBMED   10512881
REFERENCE   9  (bases 1 to 2524)
  AUTHORS   Lin,X. and Barber,D.L.
  TITLE     A calcineurin homologous protein inhibits GTPase-stimulated Na-H
            exchange
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12631-12636 (1996)
   PUBMED   8901634
REFERENCE   10 (bases 1 to 2524)
  AUTHORS   Barroso,M.R., Bernd,K.K., DeWitt,N.D., Chang,A., Mills,K. and
            Sztul,E.S.
  TITLE     A novel Ca2+-binding protein, p22, is required for constitutive
            membrane traffic
  JOURNAL   J Biol Chem 271 (17), 10183-10187 (1996)
   PUBMED   8626580
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062029.1.
            
            On Dec 20, 2003 this sequence version replaced NM_024139.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062029.1, U39875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..2524
                     /gene="Chp1"
                     /gene_synonym="Chp; Wrch2"
                     /note="calcineurin-like EF-hand protein 1"
                     /db_xref="GeneID:64152"
                     /db_xref="RGD:620447"
     exon            1..202
                     /gene="Chp1"
                     /gene_synonym="Chp; Wrch2"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..723
                     /gene="Chp1"
                     /gene_synonym="Chp; Wrch2"
                     /note="calcium-binding protein p22; calcium-binding
                     protein CHP; calcineurin homologous protein; EF-hand
                     Ca2+-binding protein p22; calcineurin B-like protein;
                     EF-hand calcium-binding domain-containing protein p22"
                     /codon_start=1
                     /product="calcineurin B homologous protein 1"
                     /protein_id="NP_077053.1"
                     /db_xref="GeneID:64152"
                     /db_xref="RGD:620447"
                     /translation="MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENG
                     TLSREDFQRIPELAINPLGDRIINAFFSEGEDQVNFRGFMRTLAHFRPIEDNEKSKDV
                     NGPEPLNSRSNKLHFAFRLYDLDKDDKISRDELLQVLRMMVGVNISDEQLGSIADRTI
                     QEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFLH"
     exon            203..275
                     /gene="Chp1"
                     /gene_synonym="Chp; Wrch2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..356
                     /gene="Chp1"
                     /gene_synonym="Chp; Wrch2"
                     /inference="alignment:Splign:2.1.0"
     exon            357..484
                     /gene="Chp1"
                     /gene_synonym="Chp; Wrch2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..546
                     /gene="Chp1"
                     /gene_synonym="Chp; Wrch2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..669
                     /gene="Chp1"
                     /gene_synonym="Chp; Wrch2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..2513
                     /gene="Chp1"
                     /gene_synonym="Chp; Wrch2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctagtttc cctccccggg ccgcaggaga aacagtgccc tctcccttct tgacccctgg
       61 cccttccctc ccttattccc tcttgccgcc gctgcttctg gcgctgccgc tcccggagga
      121 gctcccgtca cggtgatggg gtctcgggcc tccacgttac tgcgggacga agagctcgag
      181 gagatcaaga aggagactgg cttttcccac agtcagatca cacgcctgta cagccgcttc
      241 accagcctgg acaaagggga gaacggaact ctcagccggg aagatttcca gaggattcca
      301 gaacttgcca tcaacccact gggggaccgg atcatcaatg ccttcttctc agagggagag
      361 gatcaggtaa acttccgagg attcatgaga actttggctc atttccgacc cattgaggat
      421 aacgaaaaga gcaaagatgt gaatggaccg gaacccctca acagccggag caacaaactg
      481 cactttgctt tcagacttta tgacttggat aaagatgaca agatctcccg cgatgagctg
      541 ttacaggtac tgcgaatgat ggtcggagtg aatatctcag atgagcagct gggcagtatt
      601 gcagacagga ccatccagga ggctgaccaa gatggagaca gtgccatatc ttttacagaa
      661 tttgttaagg ttttggagaa ggtggatgta gaacagaaga tgagcatccg atttcttcac
      721 taaagggcag agaccaaatt attcttgctt tctagtattt aagaactgaa acttccttct
      781 gtcctccagc cccaccccat cctgtcatcc ccctttccca gaatactaca gctcctgcat
      841 gacaacctga agtctctcct gtccatacaa acttgccttt ggtgtataaa cagggcgtta
      901 cagaatggta ccctgtctat ttctgttcgg tatccaccca tcagtcttta ttgtaagtac
      961 caacttcccc tgttctactg ctcagtgcca cgcatccgtc ctgtctgagg aaagaaacag
     1021 ggactcatgt caagaaccag ccagcaaagc tcccactaga tgggaccata tccatgctgc
     1081 cttcccttca tcagccctcc atcatggtcc tgtgtgctgt gtcctgtgtc ctgtgtctgt
     1141 ttcttcctac ctctctgtca tccagccttc tctccattca gtctttcagc tgtcctcctg
     1201 tcgttgagat tccctgcatt ctacttgact ctgggctctg ctggtaagcc tgtttctgat
     1261 gtggcaggat agttagtggt ctggtgatct gtatctacct tctgatgtgg gatattgcct
     1321 atccaggagc tattgctctg tcgtcacagg gcttatgagc agacatgttc ttaaaaggta
     1381 gtcatggtga ggcttgtaga gccatgtctc ctaggtggct tcccaggtct ctctacctct
     1441 gactttttat tttcaaatat atttatgtgg cttttctggg tacagtgttg acattcagaa
     1501 aatagtctaa tgcctgccag tttgcttctc tttgggacat tgtcaccacc caagcggctg
     1561 ttctgacaat atggtagagg gccttcttgt gttttctgac aaggatgggc accctggaga
     1621 gctgcccaca tttgctccac agcatgggtt atgcctcagt gttctgtaca cttgaagatt
     1681 cttcacattt ccaaacagaa agactagtgt tacagaagtg cctgacttac ctcagtccta
     1741 aagaattaga ttgtcctcag tgtcttaaag ttttgcacaa aactctgaat gaattttata
     1801 cttggcaaat tttaatgctg gaagatgtat agtcagttca taatcctggt ccaggcactg
     1861 tatgcatcga atgtattgtc tcatgagctt cctaatgaca cgaccttcct agctccttgt
     1921 gaatactata ctatgcagat ccctcagaag catgggacct gggactggtg gcaccaactg
     1981 aggtgacatt ctctgccaat gtcagcttga tttagatgtc actgaatcaa gctgcttccg
     2041 ccctgtgttc ctgtgaatct gctcttggct ggctttctct ggtgttgcct gcttgcttgc
     2101 ttgctttgtt gctttggaag gctatccaag atatgtaagc aattctttag gaaataaatt
     2161 gctgttaacc caaacaaaca aaaacactgc agacgagatg ggtaaaggcg agcagtgggg
     2221 gcgtggctag gacagatggc tagggtctac atgaactggg gaattcttta tgaaatatgt
     2281 cagactttgt gatcaaatga tgtgatataa gaattgtata aagggaataa ttgtctgata
     2341 cttatctgtt tgagaagtac ttcagaagca tcttgattta attatttaaa gtttctaaga
     2401 ttatgccccc cttggctgta tagcaaactg tttttatcca cagttgtgcc ttattgtccc
     2461 attaaaattg tattcctcaa tccaccaata aattaattgt cgttaaaaca aaaaaaaaaa
     2521 aaaa
//
