LOCUS       NP_077053                195 aa            linear   ROD 03-APR-2024
DEFINITION  calcineurin B homologous protein 1 [Rattus norvegicus].
ACCESSION   NP_077053
VERSION     NP_077053.1
DBSOURCE    REFSEQ: accession NM_024139.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 195)
  AUTHORS   Mendoza-Ferreira,N., Coutelier,M., Janzen,E., Hosseinibarkooie,S.,
            Lohr,H., Schneider,S., Milbradt,J., Karakaya,M., Riessland,M.,
            Pichlo,C., Torres-Benito,L., Singleton,A., Zuchner,S., Brice,A.,
            Durr,A., Hammerschmidt,M., Stevanin,G. and Wirth,B.
  TITLE     Biallelic CHP1 mutation causes human autosomal recessive ataxia by
            impairing NHE1 function
  JOURNAL   Neurol Genet 4 (1), e209 (2018)
   PUBMED   29379881
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 195)
  AUTHORS   Liu,Y., Zaun,H.C., Orlowski,J. and Ackerman,S.L.
  TITLE     CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje
            cell axon homeostasis
  JOURNAL   J Neurosci 33 (31), 12656-12669 (2013)
   PUBMED   23904602
REFERENCE   3  (residues 1 to 195)
  AUTHORS   Knaapen,M., Koch,A.H., Koch,C., Koch,K.T., Li,X., van Rooij,P.C.,
            Tijssen,J.G., Peters,R.J., van der Wal,A.C., Damman,P. and de
            Winter,R.J.
  TITLE     Prevalence of left and balanced coronary arterial dominance
            decreases with increasing age of patients at autopsy. A postmortem
            coronary angiograms study
  JOURNAL   Cardiovasc Pathol 22 (1), 49-53 (2013)
   PUBMED   22463919
REFERENCE   4  (residues 1 to 195)
  AUTHORS   Zhang-James,Y., DasBanerjee,T., Sagvolden,T., Middleton,F.A. and
            Faraone,S.V.
  TITLE     SLC9A9 mutations, gene expression, and protein-protein interactions
            in rat models of attention-deficit/hyperactivity disorder
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 156B (7), 835-843 (2011)
   PUBMED   21858920
REFERENCE   5  (residues 1 to 195)
  AUTHORS   Matsushita,M., Tanaka,H., Mitsui,K. and Kanazawa,H.
  TITLE     Dual functional significance of calcineurin homologous protein 1
            binding to Na(+)/H(+) exchanger isoform 1
  JOURNAL   Am J Physiol Cell Physiol 301 (2), C280-C288 (2011)
   PUBMED   21543739
REFERENCE   6  (residues 1 to 195)
  AUTHORS   Pang,T., Su,X., Wakabayashi,S. and Shigekawa,M.
  TITLE     Calcineurin homologous protein as an essential cofactor for Na+/H+
            exchangers
  JOURNAL   J Biol Chem 276 (20), 17367-17372 (2001)
   PUBMED   11350981
REFERENCE   7  (residues 1 to 195)
  AUTHORS   Lin,X., Sikkink,R.A., Rusnak,F. and Barber,D.L.
  TITLE     Inhibition of calcineurin phosphatase activity by a calcineurin B
            homologous protein
  JOURNAL   J Biol Chem 274 (51), 36125-36131 (1999)
   PUBMED   10593895
REFERENCE   8  (residues 1 to 195)
  AUTHORS   Timm,S., Titus,B., Bernd,K. and Barroso,M.
  TITLE     The EF-hand Ca(2+)-binding protein p22 associates with microtubules
            in an N-myristoylation-dependent manner
  JOURNAL   Mol Biol Cell 10 (10), 3473-3488 (1999)
   PUBMED   10512881
REFERENCE   9  (residues 1 to 195)
  AUTHORS   Lin,X. and Barber,D.L.
  TITLE     A calcineurin homologous protein inhibits GTPase-stimulated Na-H
            exchange
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12631-12636 (1996)
   PUBMED   8901634
REFERENCE   10 (residues 1 to 195)
  AUTHORS   Barroso,M.R., Bernd,K.K., DeWitt,N.D., Chang,A., Mills,K. and
            Sztul,E.S.
  TITLE     A novel Ca2+-binding protein, p22, is required for constitutive
            membrane traffic
  JOURNAL   J Biol Chem 271 (17), 10183-10187 (1996)
   PUBMED   8626580
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062029.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062029.1, U39875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..195
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     Protein         1..195
                     /product="calcineurin B homologous protein 1"
                     /note="calcium-binding protein p22; calcium-binding
                     protein CHP; calcineurin homologous protein; EF-hand
                     Ca2+-binding protein p22; calcineurin B-like protein;
                     EF-hand calcium-binding domain-containing protein p22"
                     /calculated_mol_wt=22301
     Region          2..6
                     /region_name="Necessary for association with microtubule
                     and interaction with GAPDH"
                     /note="propagated from UniProtKB/Swiss-Prot (P61023.2)"
     Region          27..182
                     /region_name="FRQ1"
                     /note="Ca2+-binding protein, EF-hand superfamily [Signal
                     transduction mechanisms]; COG5126"
                     /db_xref="CDD:444056"
     Region          138..147
                     /region_name="Nuclear export signal 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P61023.2)"
     Region          176..185
                     /region_name="Nuclear export signal 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P61023.2)"
     CDS             1..195
                     /gene="Chp1"
                     /gene_synonym="Chp; Wrch2"
                     /coded_by="NM_024139.2:136..723"
                     /db_xref="GeneID:64152"
                     /db_xref="RGD:620447"
ORIGIN      
        1 mgsrastllr deeleeikke tgfshsqitr lysrftsldk gengtlsred fqripelain
       61 plgdriinaf fsegedqvnf rgfmrtlahf rpiedneksk dvngpeplns rsnklhfafr
      121 lydldkddki srdellqvlr mmvgvnisde qlgsiadrti qeadqdgdsa isftefvkvl
      181 ekvdveqkms irflh
//
