LOCUS       NM_001399177            3275 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus chimerin 1 (Chn1), transcript variant 1, mRNA.
ACCESSION   NM_001399177 XM_039105972
VERSION     NM_001399177.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3275)
  AUTHORS   Garces,M.F., Sanchez,E., Acosta,B.J., Angel,E., Ruiz,A.I.,
            Rubio-Romero,J.A., Dieguez,C., Nogueiras,R. and Caminos,J.E.
  TITLE     Expression and regulation of chemerin during rat pregnancy
  JOURNAL   Placenta 33 (5), 373-378 (2012)
   PUBMED   22369992
  REMARK    GeneRIF: serum levels decreased significantly as gestation
            progressed
REFERENCE   2  (bases 1 to 3275)
  AUTHORS   Marland,J.R., Pan,D. and Buttery,P.C.
  TITLE     Rac GTPase-activating protein (Rac GAP) alpha1-Chimaerin undergoes
            proteasomal degradation and is stabilized by diacylglycerol
            signaling in neurons
  JOURNAL   J Biol Chem 286 (1), 199-207 (2011)
   PUBMED   21056981
  REMARK    GeneRIF: signaling via diacylglycerol may regulate the abundance of
            alpha1-chimaerin under physiological conditions
REFERENCE   3  (bases 1 to 3275)
  AUTHORS   Shi,L., Fu,W.Y., Hung,K.W., Porchetta,C., Hall,C., Fu,A.K. and
            Ip,N.Y.
  TITLE     Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent
            growth cone collapse
  JOURNAL   Proc Natl Acad Sci U S A 104 (41), 16347-16352 (2007)
   PUBMED   17911252
  REMARK    GeneRIF: identified a new alpha2-chimaerin-dependent signaling
            mechanism through which EphA4 transduces its signals to the actin
            cytoskeleton and modulates growth cone morphology
REFERENCE   4  (bases 1 to 3275)
  AUTHORS   Beg,A.A., Sommer,J.E., Martin,J.H. and Scheiffele,P.
  TITLE     alpha2-Chimaerin is an essential EphA4 effector in the assembly of
            neuronal locomotor circuits
  JOURNAL   Neuron 55 (5), 768-778 (2007)
   PUBMED   17785183
REFERENCE   5  (bases 1 to 3275)
  AUTHORS   Iwasato,T., Katoh,H., Nishimaru,H., Ishikawa,Y., Inoue,H.,
            Saito,Y.M., Ando,R., Iwama,M., Takahashi,R., Negishi,M. and
            Itohara,S.
  TITLE     Rac-GAP alpha-chimerin regulates motor-circuit formation as a key
            mediator of EphrinB3/EphA4 forward signaling
  JOURNAL   Cell 130 (4), 742-753 (2007)
   PUBMED   17719550
REFERENCE   6  (bases 1 to 3275)
  AUTHORS   Brown,M., Jacobs,T., Eickholt,B., Ferrari,G., Teo,M., Monfries,C.,
            Qi,R.Z., Leung,T., Lim,L. and Hall,C.
  TITLE     Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target
            collapsin response mediator protein-2 are essential components in
            semaphorin 3A-induced growth-cone collapse
  JOURNAL   J Neurosci 24 (41), 8994-9004 (2004)
   PUBMED   15483118
  REMARK    GeneRIF: These results indicate that active alpha2-chimaerin Rac
            GAP, Cdk5/p35, and its substrate CRMP-2, are implicated in the
            dynamics of growth cone guidance initiated through Sema 3A
            signaling.
REFERENCE   7  (bases 1 to 3275)
  AUTHORS   Lim,H.H., Michael,G.J., Smith,P., Lim,L. and Hall,C.
  TITLE     Developmental regulation and neuronal expression of the mRNA of rat
            n-chimaerin, a p21rac GAP:cDNA sequence
  JOURNAL   Biochem J 287 (Pt 2) (Pt 2), 415-422 (1992)
   PUBMED   1445199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 4, 2022 this sequence version replaced XM_039105972.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2176259.1,
                                           SRR26643293.17157.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               JAXUCZ010000003.1  79083617-79083950   c
            335-373             JAXUCZ010000003.1  79031434-79031472   c
            374-429             JAXUCZ010000003.1  79026885-79026940   c
            430-461             JAXUCZ010000003.1  79021566-79021597   c
            462-575             JAXUCZ010000003.1  79018194-79018307   c
            576-864             JAXUCZ010000003.1  78987270-78987558   c
            865-942             JAXUCZ010000003.1  78960008-78960085   c
            943-1027            JAXUCZ010000003.1  78940663-78940747   c
            1028-1201           JAXUCZ010000003.1  78931054-78931227   c
            1202-1279           JAXUCZ010000003.1  78930289-78930366   c
            1280-1417           JAXUCZ010000003.1  78923511-78923648   c
            1418-1523           JAXUCZ010000003.1  78920298-78920403   c
            1524-3275           JAXUCZ010000003.1  78917329-78919080   c
FEATURES             Location/Qualifiers
     source          1..3275
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..3275
                     /gene="Chn1"
                     /note="chimerin 1"
                     /db_xref="GeneID:84030"
                     /db_xref="RGD:620139"
     exon            1..334
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..1695
                     /gene="Chn1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N-chimaerin; NC; N-chimerin; A-chimaerin; alpha-chimerin;
                     rho GTPase-activating protein 2; chimerin (chimaerin) 1"
                     /codon_start=1
                     /product="N-chimaerin isoform 1"
                     /protein_id="NP_001386106.1"
                     /db_xref="GeneID:84030"
                     /db_xref="RGD:620139"
                     /translation="MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRVTCTCEVENRPK
                     YYGREFHGMISREETDQLLSVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGK
                     HFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHIGYTTLNREPAYKQH
                     MAVLKETHDEKEATGQDGVSEKRLTSLVRRATLKENEQIPKYEKVHNFKVHTFRGPHW
                     CEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKA
                     HITKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYE
                     DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIVDPDEQLETLHEALRSLPPAHCE
                     TLRYLMAHLKRVTLHEKENLMSAENLGIVFGPTLMRSPELDPMAALNDIRYQRLVVEL
                     LIKNEDILF"
     exon            335..373
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..429
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..461
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..575
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..864
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..942
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1027
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1201
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1279
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1417
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1523
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..3275
                     /gene="Chn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctctggcaa gatggcgtcc gcgaggtcgc ggggtgcgcg gtgagcgccg gccgccgtcg
       61 ctccgcccgg ccggtcgcgc ttcaggtcgg cccgcccgcg cgcgccccgc gggcccatgg
      121 cggcgacagg tgcgggcgcg cggcggcttg ccgggctgcc gcgggccggg cgcgcccctc
      181 gctaacgcgc gcgtaacttt tcctcgccgc ggccccccgc ggcctccgcg ccacgccccc
      241 cgggccgccg ccccgccgag gtgccgtctg ccggccgccg cgggagctag gagcgccggg
      301 aggcgcggct ccaccatggc cctgaccctg ttcgatacag atgaatatag acctcctgtt
      361 tggaaatctt acttatacca gctgcagcag gaagcccctc accctcgaag ggtcacctgc
      421 acttgcgagg tagaaaacag accaaagtat tatggaagag agtttcatgg catgatctct
      481 agagaagaga ctgaccagct cctgagtgtg gctgagggga gctacctcat ccgtgagagc
      541 cagcggcagc ccggaacata cactttggct ttaagatttg gaagtcagac cagaaacttc
      601 aggctgtact acgatggaaa gcactttgtt ggggagaaac gctttgagtc catccacgat
      661 ctggtgactg atggcttgat tactctctat attgaaacca aggcagcaga atacattgcc
      721 aagatgacga taaacccaat ttatgagcac ataggataca caaccttaaa cagagagcca
      781 gcatacaaac agcacatggc agtcctgaaa gagacacatg atgagaaaga ggctacaggc
      841 caggatgggg tgtcagagaa aaggttgaca tcacttgtta gaagagcaac tctgaaagaa
      901 aatgaacaaa ttccaaaata tgagaaggtt cacaatttca aggtgcatac gttccgaggg
      961 ccacactggt gtgaatactg tgccaacttc atgtggggcc tcattgctca gggagtgaaa
     1021 tgtgcagatt gtgggttgaa tgttcataag cagtgttcca agatggtccc caatgactgt
     1081 aagccagacc tgaagcacgt gaagaaggtg tatagctgtg acctgacaac actcgtgaaa
     1141 gctcacatca ccaagaggcc catggtggta gacatgtgca tcagggagat cgagtccaga
     1201 ggtctgaatt ctgaaggact ctaccgagtg tcgggattta gtgacctaat tgaagacgtc
     1261 aagatggctt ttgatagaga cggtgaaaag gcggatattt ctgtgaacat gtatgaggac
     1321 atcaacatta tcactggagc gcttaaactg tacttcaggg atctgccaat tcctctcatc
     1381 acctacgatg cctaccccaa gttcatagag tctgccaaaa ttgtggaccc tgatgagcaa
     1441 ctggagaccc ttcatgaagc actgaggtct ctgccgcccg cccactgcga gacgctccgg
     1501 tacctcatgg cacacctcaa gagagtgacc cttcacgaga aggagaatct gatgagtgca
     1561 gagaaccttg ggatcgtgtt tggtccaacc ctcatgagat caccagagct agaccccatg
     1621 gccgccctga acgacatacg ctatcagaga ctggtggtgg agctgcttat caaaaatgaa
     1681 gacattttat tttagagttt tgacttgagg agaaaagaaa tggtttacag atgaaggaat
     1741 gttttctagt aatttaatta gcttcattag ctgaattgtt tcttggttag aggtttggcc
     1801 aaatacccag attaaaatga aggaacttcc tgtcatttct ctagcaccgc tcagccgtcc
     1861 ttgtaaaacc gtgaacacac gctttctggt cctggtaatc ctgggtgttt atcatgttaa
     1921 gagaaactca agctactgca tgattacccc tttttggtga ggaaacccca tattgaagaa
     1981 tcacagactt gttcctgcac catctctctg tcctgggttg tctgtggttg tcacccagca
     2041 tgcttcccag agtaaactgt catgacattg cttttggggt ccataccatt ggtttctgac
     2101 gcttgcacat gcgcacacgt gcacacgtac tcacacacac acacatgcac atacacatac
     2161 acacacatac acaccacaca cacaccacaa acacacacac accacaaaca cgcacacaca
     2221 caccacaaac acactcacac cacaaacacg cacacacaca ccacaaacac actcacacac
     2281 acacagacac acacgtataa gcagcaccct ggctgttgca ctctcatccc tgtaccatac
     2341 gccagctcca cagcagttcc ttcccagctt cctcctctca gacatagtgc tttgtcttca
     2401 gcagaagcga gacgtgtttt cagatgttac ttcagtaagc ttccaataaa aatgcaccac
     2461 acagcatttc ctgttaaatt attggttttc aactgtaaat ttatattttt acctggcatg
     2521 cagttattaa tttattaaat ttggccttta gaaatcaaaa acacttatag cttttttctt
     2581 gctgtgggaa gaataggaaa tcatgtttgg cattcattta acatcgatta cttccctatc
     2641 cctgcctgtc actaaaatac tgtggtaatc tcctaaaata acttaaactg cctagaatcg
     2701 acattcattc attgggttta ttttttctcc tattattctg ggagaaatct gtaacatttt
     2761 ctccactttg gggtcagttt tccatccaag gagggctaag gaaaagggct ctgaacacct
     2821 gcccggcttg tctggaacag ccagggtcct gtgtgtgatg tcataacgtg ctctgtgaca
     2881 aggcagcttg ttgggcagag agcaggtctg cactggatga ggggagcctg agatctgtgt
     2941 ttgatcagcc atcttgttat gcgtctcaga ccgttagagg agcatccacc taaactgaag
     3001 ctccatcctg ctttaaacag tgaacagaac ctgtgtggtt ttgggttcca gtaataacag
     3061 tgctgtactc ccagcacttg ggaggacaga tcaggaggat cgagttcagg gccagcccag
     3121 gatacacgag accctgtatc ctccgtggaa cggctgagca cagtggtgta ctgtggtcct
     3181 aactactaaa ggaaagaggt gcacttgaat ccaagggttc aagaccaact caggcaaact
     3241 gagaaaagtg actcaaaata aaaggtgaag aagta
//
