LOCUS       NM_001105856            1558 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus charged multivesicular body protein 6 (Chmp6),
            mRNA.
ACCESSION   NM_001105856 XM_001081792 XM_237816
VERSION     NM_001105856.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1558)
  AUTHORS   Cashikar AG, Shim S, Roth R, Maldazys MR, Heuser JE and Hanson PI.
  TITLE     Structure of cellular ESCRT-III spirals and their relationship to
            HIV budding
  JOURNAL   Elife 3, e02184 (2014)
   PUBMED   24878737
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1558)
  AUTHORS   Baietti MF, Zhang Z, Mortier E, Melchior A, Degeest G, Geeraerts A,
            Ivarsson Y, Depoortere F, Coomans C, Vermeiren E, Zimmermann P and
            David G.
  TITLE     Syndecan-syntenin-ALIX regulates the biogenesis of exosomes
  JOURNAL   Nat Cell Biol 14 (7), 677-685 (2012)
   PUBMED   22660413
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1558)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1558)
  AUTHORS   Morita E, Colf LA, Karren MA, Sandrin V, Rodesch CK and Sundquist
            WI.
  TITLE     Human ESCRT-III and VPS4 proteins are required for centrosome and
            spindle maintenance
  JOURNAL   Proc Natl Acad Sci U S A 107 (29), 12889-12894 (2010)
   PUBMED   20616062
REFERENCE   5  (bases 1 to 1558)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 1558)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1558)
  AUTHORS   Kieffer C, Skalicky JJ, Morita E, De Domenico I, Ward DM, Kaplan J
            and Sundquist WI.
  TITLE     Two distinct modes of ESCRT-III recognition are required for VPS4
            functions in lysosomal protein targeting and HIV-1 budding
  JOURNAL   Dev Cell 15 (1), 62-73 (2008)
   PUBMED   18606141
REFERENCE   8  (bases 1 to 1558)
  AUTHORS   Langelier C, von Schwedler UK, Fisher RD, De Domenico I, White PL,
            Hill CP, Kaplan J, Ward D and Sundquist WI.
  TITLE     Human ESCRT-II complex and its role in human immunodeficiency virus
            type 1 release
  JOURNAL   J Virol 80 (19), 9465-9480 (2006)
   PUBMED   16973552
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_237816.4, XM_001081792.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EV769650.1, DN936007.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1558
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1558
                     /gene="Chmp6"
                     /gene_synonym="RGD1565325"
                     /note="charged multivesicular body protein 6"
                     /db_xref="GeneID:287873"
                     /db_xref="RGD:1565325"
     exon            1..105
                     /gene="Chmp6"
                     /gene_synonym="RGD1565325"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..645
                     /gene="Chmp6"
                     /gene_synonym="RGD1565325"
                     /note="chromatin modifying protein 6"
                     /codon_start=1
                     /product="charged multivesicular body protein 6"
                     /protein_id="NP_001099326.1"
                     /db_xref="GeneID:287873"
                     /db_xref="RGD:1565325"
                     /translation="MGNLFGRKKQSRVTEQDRAILQLKQQRDKLRQYQKRVTQQLERE
                     RALARQLLRDGRKERAKLLLKKKRYREQLLDRTENQISSLEAMVQSIEFTQIEMKVME
                     GLQVGNECLNKMHQVMSIEEVERILDETQEAVEYQRQIDELLAGSFTQEDEDAILEEL
                     NAITQEQIELPEVPSEPLPDTSPEAPAKARSRQAELVAAS"
     exon            106..215
                     /gene="Chmp6"
                     /gene_synonym="RGD1565325"
                     /inference="alignment:Splign:2.1.0"
     exon            216..303
                     /gene="Chmp6"
                     /gene_synonym="RGD1565325"
                     /inference="alignment:Splign:2.1.0"
     exon            304..390
                     /gene="Chmp6"
                     /gene_synonym="RGD1565325"
                     /inference="alignment:Splign:2.1.0"
     exon            391..456
                     /gene="Chmp6"
                     /gene_synonym="RGD1565325"
                     /inference="alignment:Splign:2.1.0"
     exon            457..537
                     /gene="Chmp6"
                     /gene_synonym="RGD1565325"
                     /inference="alignment:Splign:2.1.0"
     exon            538..592
                     /gene="Chmp6"
                     /gene_synonym="RGD1565325"
                     /inference="alignment:Splign:2.1.0"
     exon            593..1558
                     /gene="Chmp6"
                     /gene_synonym="RGD1565325"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcggcgg cgacgggctc ggccggccgg cgcggggccg ccatgggcaa cctgttcggt
       61 cgcaagaagc agagccgggt cactgaacag gacagggcca tcctgcaact gaagcagcag
      121 agagacaagc tgaggcagta ccagaagagg gtcacgcagc agctggagag ggaacgggct
      181 ttggccaggc agctgcttcg ggatggcagg aaagaacggg ccaagctgct actcaagaag
      241 aagaggtacc gggagcaact gctcgatagg acagaaaacc agatcagcag cctggaagcc
      301 atggttcaga gcattgagtt cacgcagatc gagatgaagg tgatggaggg gcttcaggtg
      361 gggaacgaat gtctgaataa gatgcaccag gtgatgtcca tagaggaggt ggagaggatc
      421 ctggacgaga cccaggaggc cgtggagtac cagcggcaaa ttgatgagct gctggcagga
      481 agtttcaccc aggaggacga ggatgccatc ctggaagagc tgaatgcaat cactcaggaa
      541 caaatcgagt taccagaggt tccttcggag cccctgcctg acacaagccc agaagcccct
      601 gccaaggcca gatccaggca ggcagagctg gtggccgctt cgtaacctcc agggactcat
      661 agggattctc cgaggactgt cccacagagc ctttggctgc gagtcaaccc tgagggctcc
      721 caggaggcct gaagggctgg acgggccagt gcaggtgccg atggctggag cagcagctta
      781 cacgggagct gatgtcaggg cgccacgttg tgcaatttag tctggatgca ccttcatctc
      841 tgctcctgga ctaagtggac actcggccag ccaggcgcag cttcaggccg ctgtggaccc
      901 cacgttggcc gcagcccact actcctggtg ctgttctcat gctgacccag cccgtgtgac
      961 ctgcactctt ctgtgaggaa gcacctcaga cctcggggtc cctgtgctcc cttctcttgt
     1021 atctcctgct cacatgagct ggtgggggct tcagttgagg agttcttacc ttgcctggca
     1081 tcctgatatc cctgtttccc tgcaggctag tgacagaaac cctaggatac tggtgttctc
     1141 caaatctctt ggagcatctt tggcacctca gacttgattg agcctcttat gttgggggag
     1201 gtggaccagg ggccatcctg ctgaatggac aaatctagga gcctgacttg ggagtctgtt
     1261 cacagaagaa aggcatgttg aagttggtga caagaccctg ttttaatgga catgtacccg
     1321 atggtgtcct ggacacacta agccaccaac gcccaggagg cacagaactg ggaggacctc
     1381 cagagcccta cacttgtttg ataatggaca atctctggtc ctctagtctt tgaggaacaa
     1441 agggtcttac atacccttag ggcctaccag gaaaggaggg cacctcttcc ttaacccaaa
     1501 acaggtcaac ctcagtatta aagttgaccc ctgcatggtc tttggcctct tgcacttg
//
