LOCUS       NM_001017466            1616 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus charged multivesicular body protein 4C (Chmp4c),
            mRNA.
ACCESSION   NM_001017466 XM_342212
VERSION     NM_001017466.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1616)
  AUTHORS   Liu,A., Xie,H., Tian,F., Bai,P., Weng,H., Liu,Y., Liu,W., Tang,L.,
            You,H., Zhou,N. and Shu,X.
  TITLE     ESCRT-III Component CHMP4C Attenuates Cardiac Hypertrophy by
            Targeting the Endo-Lysosomal Degradation of EGFR
  JOURNAL   Hypertension 80 (12), 2674-2686 (2023)
   PUBMED   37846580
  REMARK    GeneRIF: ESCRT-III Component CHMP4C Attenuates Cardiac Hypertrophy
            by Targeting the Endo-Lysosomal Degradation of EGFR.
REFERENCE   2  (bases 1 to 1616)
  AUTHORS   Thoresen,S.B., Campsteijn,C., Vietri,M., Schink,K.O., Liestol,K.,
            Andersen,J.S., Raiborg,C. and Stenmark,H.
  TITLE     ANCHR mediates Aurora-B-dependent abscission checkpoint control
            through retention of VPS4
  JOURNAL   Nat Cell Biol 16 (6), 550-560 (2014)
   PUBMED   24814515
REFERENCE   3  (bases 1 to 1616)
  AUTHORS   Capalbo,L., Montembault,E., Takeda,T., Bassi,Z.I., Glover,D.M. and
            D'Avino,P.P.
  TITLE     The chromosomal passenger complex controls the function of
            endosomal sorting complex required for transport-III Snf7 proteins
            during cytokinesis
  JOURNAL   Open Biol 2 (5), 120070 (2012)
   PUBMED   22724069
REFERENCE   4  (bases 1 to 1616)
  AUTHORS   Dores,M.R., Chen,B., Lin,H., Soh,U.J., Paing,M.M., Montagne,W.A.,
            Meerloo,T. and Trejo,J.
  TITLE     ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates
            ubiquitin-independent ESCRT-III/MVB sorting
  JOURNAL   J Cell Biol 197 (3), 407-419 (2012)
   PUBMED   22547407
REFERENCE   5  (bases 1 to 1616)
  AUTHORS   Carlton,J.G., Caballe,A., Agromayor,M., Kloc,M. and
            Martin-Serrano,J.
  TITLE     ESCRT-III governs the Aurora B-mediated abscission checkpoint
            through CHMP4C
  JOURNAL   Science 336 (6078), 220-225 (2012)
   PUBMED   22422861
REFERENCE   6  (bases 1 to 1616)
  AUTHORS   Morita,E., Colf,L.A., Karren,M.A., Sandrin,V., Rodesch,C.K. and
            Sundquist,W.I.
  TITLE     Human ESCRT-III and VPS4 proteins are required for centrosome and
            spindle maintenance
  JOURNAL   Proc Natl Acad Sci U S A 107 (29), 12889-12894 (2010)
   PUBMED   20616062
REFERENCE   7  (bases 1 to 1616)
  AUTHORS   Martin-Serrano,J., Yarovoy,A., Perez-Caballero,D. and Bieniasz,P.D.
  TITLE     Divergent retroviral late-budding domains recruit vacuolar protein
            sorting factors by using alternative adaptor proteins
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12414-12419 (2003)
   PUBMED   14519844
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):152845.
            Yaravoy, A [corrected to Yarovoy, A]]
REFERENCE   8  (bases 1 to 1616)
  AUTHORS   von Schwedler,U.K., Stuchell,M., Muller,B., Ward,D.M., Chung,H.Y.,
            Morita,E., Wang,H.E., Davis,T., He,G.P., Cimbora,D.M., Scott,A.,
            Krausslich,H.G., Kaplan,J., Morham,S.G. and Sundquist,W.I.
  TITLE     The protein network of HIV budding
  JOURNAL   Cell 114 (6), 701-713 (2003)
   PUBMED   14505570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC092576.1 and CO383495.1.
            
            On Oct 10, 2007 this sequence version replaced NM_001017466.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092576.1, CK476021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BC092576.1         1-22
            23-205              CO383495.1         1-183
            206-1616            BC092576.1         206-1616
FEATURES             Location/Qualifiers
     source          1..1616
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..1616
                     /gene="Chmp4c"
                     /note="charged multivesicular body protein 4C"
                     /db_xref="GeneID:361916"
                     /db_xref="RGD:1564543"
     exon            1..300
                     /gene="Chmp4c"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..809
                     /gene="Chmp4c"
                     /note="chromatin-modifying protein 4c; Snf7 homologue
                     associated with Alix 3; chromatin modifying protein 4C"
                     /codon_start=1
                     /product="charged multivesicular body protein 4c"
                     /protein_id="NP_001017466.2"
                     /db_xref="GeneID:361916"
                     /db_xref="RGD:1564543"
                     /translation="MSKLGKFFKGSRSSRARAAPSAQEALARLRETEEMMAKKQEYLE
                     NRIQRELALAKKHGSQNKRAALQALKRKKRFEKQLTQIDGTLSTIEFQREALENSHTN
                     TEVLRNMGFAAKAMKAVHENMDLNKIDDLMQDITEQQDIAQEISEAFSQRVQFADGFD
                     EDELLAELEELEQEELNKKMTSMELPNVPSSSLPAQPSRKAGVPSSVHRSRAASSRRA
                     EEDDDFKQLAAWAT"
     exon            301..478
                     /gene="Chmp4c"
                     /inference="alignment:Splign:2.1.0"
     exon            479..593
                     /gene="Chmp4c"
                     /inference="alignment:Splign:2.1.0"
     exon            594..747
                     /gene="Chmp4c"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1596
                     /gene="Chmp4c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggtgtca cctgccgaaa caacttgttg attcccagga gctttgttgg ctctgagtgt
       61 ggctcacctg tctcgggagc gctgggacgc tcgcccacca ctgctcagcc atgagcaagt
      121 tgggcaagtt tttcaaaggg tctcgctctt ctcgggcccg cgcggctccc agcgctcagg
      181 aagccctggc tcgactccgg gagaccgagg agatgatggc caagaagcag gagtacctgg
      241 agaaccgaat ccagagggag cttgctctag ccaagaagca cggctcccag aacaagcgag
      301 ctgccttgca ggcactgaaa agaaagaaga gatttgagaa gcagctcaca cagattgacg
      361 gcaccctttc caccattgag ttccagcggg aggcgctaga gaactcacac accaacactg
      421 aggtcttacg gaacatgggc ttcgcagcca aggccatgaa agctgttcat gaaaacatgg
      481 atctcaacaa aatcgatgac ttgatgcaag acatcacaga gcagcaggac attgcccagg
      541 aaatctcaga agcgttttct caaagagttc agtttgctga tggcttcgat gaggatgagc
      601 ttctggcgga gctcgaggaa ctggagcagg aagaattaaa taagaagatg acaagcatgg
      661 agctcccaaa tgtgccttcc tcatccctcc cagcacagcc cagcaggaag gccggcgtgc
      721 cttcctctgt gcaccgctct cgagcagcat cttccaggag ggcagaggaa gatgatgact
      781 tcaagcagct ggcagcctgg gccacttaag ctacaacgga aaaaaaaatt gacacctaaa
      841 ttattgaact acacataaga cgtaaatgct ttgcgaagct tagaaattag cagagacatg
      901 ttttacatgg attgttgcct tttaaataac agttaaggta tagtcagggt tgcaaagggg
      961 cccagtatca ttggaggaga gctttccaga ctgctggact cacggagctg ctctatttac
     1021 tactgtgttt ctagtcctgg tatatagttg attttttttt tgtatgtatg tattgaaaac
     1081 aactcttctg acatttaata cacattccag tttataagcc ttcccgagga atacctagga
     1141 taactggggg tgcagggttg ggggatgtct atgcaaatac aaggcagctg tgtgcatcct
     1201 ggtcacccac agcaaaaata aatacgctgc tagaacagac ttgttctagt gagtctgtat
     1261 agtttcagtt gagtttcaca gctgaaaatc ttcagggagc tttactttaa ttgacgttta
     1321 gtacgctgat tgagctttga gtggggcaat ggagggatct ccccaaaaat ctgaaagcag
     1381 taacagctta gtgtgccggg caggcgtctc cgggctgtga agcacctgct gagtggacac
     1441 tcgcaggctg ttgccagcac cgttcattct ctgctgtttt gtgttctctt gcccttttaa
     1501 caagaacaaa acaaaacgag atccaaacat ttcacagcgt gcactttgta aatatattaa
     1561 aatactggca attaaaaaat gtatctcaag taaaaaaaaa aaaaaaaaaa aaaaaa
//
