LOCUS       NM_001399657            1609 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus charged multivesicular body protein 4B (Chmp4b),
            mRNA.
ACCESSION   NM_001399657 XM_039106697
VERSION     NM_001399657.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1609)
  AUTHORS   Vietri,M., Schink,K.O., Campsteijn,C., Wegner,C.S., Schultz,S.W.,
            Christ,L., Thoresen,S.B., Brech,A., Raiborg,C. and Stenmark,H.
  TITLE     Spastin and ESCRT-III coordinate mitotic spindle disassembly and
            nuclear envelope sealing
  JOURNAL   Nature 522 (7555), 231-235 (2015)
   PUBMED   26040712
REFERENCE   2  (bases 1 to 1609)
  AUTHORS   Shen,J., Liu,Y., Song,Y., Li,L., Duan,C., Zhou,Y. and Ke,K.
  TITLE     CHMP4B, ESCRT-III associating protein, associated with neuronal
            apoptosis following intracerebral hemorrhage
  JOURNAL   Brain Res 1597, 1-13 (2015)
   PUBMED   25478783
  REMARK    GeneRIF: Study suggests that CHMP4B may play a role in promoting
            the brain damage following intracerebral hemorrhage by exerting a
            pro-apoptotic function on neuronal apoptosis
REFERENCE   3  (bases 1 to 1609)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1609)
  AUTHORS   Cashikar,A.G., Shim,S., Roth,R., Maldazys,M.R., Heuser,J.E. and
            Hanson,P.I.
  TITLE     Structure of cellular ESCRT-III spirals and their relationship to
            HIV budding
  JOURNAL   Elife 3, e02184 (2014)
   PUBMED   24878737
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1609)
  AUTHORS   Sandrin,V. and Sundquist,W.I.
  TITLE     ESCRT requirements for EIAV budding
  JOURNAL   Retrovirology 10, 104 (2013)
   PUBMED   24107264
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1609)
  AUTHORS   Lee,J.A., Beigneux,A., Ahmad,S.T., Young,S.G. and Gao,F.B.
  TITLE     ESCRT-III dysfunction causes autophagosome accumulation and
            neurodegeneration
  JOURNAL   Curr Biol 17 (18), 1561-1567 (2007)
   PUBMED   17683935
  REMARK    Erratum:[Curr Biol. 2007 Sep 18;17(18):1622]
REFERENCE   7  (bases 1 to 1609)
  AUTHORS   Shiels,A., Bennett,T.M., Knopf,H.L., Yamada,K., Yoshiura,K.,
            Niikawa,N., Shim,S. and Hanson,P.I.
  TITLE     CHMP4B, a novel gene for autosomal dominant cataracts linked to
            chromosome 20q
  JOURNAL   Am J Hum Genet 81 (3), 596-606 (2007)
   PUBMED   17701905
REFERENCE   8  (bases 1 to 1609)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
REFERENCE   9  (bases 1 to 1609)
  AUTHORS   Martin-Serrano,J., Yarovoy,A., Perez-Caballero,D. and Bieniasz,P.D.
  TITLE     Divergent retroviral late-budding domains recruit vacuolar protein
            sorting factors by using alternative adaptor proteins
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12414-12419 (2003)
   PUBMED   14519844
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):152845.
            Yaravoy, A [corrected to Yarovoy, A]]
REFERENCE   10 (bases 1 to 1609)
  AUTHORS   von Schwedler,U.K., Stuchell,M., Muller,B., Ward,D.M., Chung,H.Y.,
            Morita,E., Wang,H.E., Davis,T., He,G.P., Cimbora,D.M., Scott,A.,
            Krausslich,H.G., Kaplan,J., Morham,S.G. and Sundquist,W.I.
  TITLE     The protein network of HIV budding
  JOURNAL   Cell 114 (6), 701-713 (2003)
   PUBMED   14505570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 12, 2022 this sequence version replaced XM_039106697.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399484.636233.1,
                                           SRR22582419.280928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               JAXUCZ010000003.1  163631054-163631386
            334-511             JAXUCZ010000003.1  163664375-163664552
            512-626             JAXUCZ010000003.1  163667069-163667183
            627-753             JAXUCZ010000003.1  163668218-163668344
            754-1609            JAXUCZ010000003.1  163670714-163671569
FEATURES             Location/Qualifiers
     source          1..1609
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1609
                     /gene="Chmp4b"
                     /gene_synonym="RGD1309846; RGD1565889"
                     /note="charged multivesicular body protein 4B"
                     /db_xref="GeneID:100359642"
                     /db_xref="RGD:1309846"
     exon            1..333
                     /gene="Chmp4b"
                     /gene_synonym="RGD1309846; RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..818
                     /gene="Chmp4b"
                     /gene_synonym="RGD1309846; RGD1565889"
                     /note="chromatin modifying protein 4B"
                     /codon_start=1
                     /product="charged multivesicular body protein 4b"
                     /protein_id="NP_001386586.1"
                     /db_xref="GeneID:100359642"
                     /db_xref="RGD:1309846"
                     /translation="MSVFGKLFGAGGGKAGKGGPTPQEAIQRLRDTEEMLSKKQEFLE
                     KKIEQELTAAKKHGTKNKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTN
                     TEVLKNMGYAAKAMKAAHDNMDIDKVDELMQDIADQQELAEEISTAISKPVGFGEEFD
                     EDELMAELEELEQEELDKNLLEISGPETVPLPNVPSVALPSKPAKKKEEEDDDMKELE
                     NWAGSM"
     exon            334..511
                     /gene="Chmp4b"
                     /gene_synonym="RGD1309846; RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            512..626
                     /gene="Chmp4b"
                     /gene_synonym="RGD1309846; RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            627..753
                     /gene="Chmp4b"
                     /gene_synonym="RGD1309846; RGD1565889"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1609
                     /gene="Chmp4b"
                     /gene_synonym="RGD1309846; RGD1565889"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggcgcgg ccgggcccag ctgcggggcg gaggtggagg cgaggcctgc ggctgcgggg
       61 agcggcaggc cgggagtggg cgcgggagcc gagccgagcc gagccggagt gggcgccgga
      121 ggccggcgcg gcgagcagca accatgtcgg tgttcgggaa gctgttcggg gctggagggg
      181 gtaaggcggg caagggcggc ccgacccccc aggaggccat acagcgactt cgggacacgg
      241 aggaaatgct aagcaagaaa caagagtttc tggagaagaa gatcgagcag gagctgacgg
      301 ctgccaagaa gcacggcacc aaaaataagc gcgcggcctt gcaggctctg aagcgcaaga
      361 agaggtatga gaagcagctg gcacagattg atggcaccct gtcaaccatc gagttccagc
      421 gggaggccct agagaatgcc aacaccaaca cggaggtgct caagaacatg ggctatgccg
      481 ccaaggccat gaaggctgcc cacgacaaca tggacattga taaagtggat gagttaatgc
      541 aggacattgc tgaccagcaa gaacttgcag aagagatttc cacagctatc tccaaacctg
      601 tgggctttgg agaagagttt gacgaggatg agctcatggc agagctggag gaactcgaac
      661 aagaggagct agacaagaat ttgttggaga tcagtgggcc cgaaacagtc cctctaccaa
      721 atgtcccctc tgtagcccta ccatccaaac ccgccaagaa gaaggaggag gaagacgacg
      781 acatgaagga gttggagaac tgggcgggat ccatgtaact gtcccagcag aggctgggcc
      841 cagacggact ctggtggcct gtgcatcggg caggtgtgtg cgtgcgcagg gcaggcagga
      901 cgaggtgcag gctcctccat cgctcagctc tcacccaaag cagtaggccg catccctgct
      961 cactctcaca tagcacggcc tgtgcccagg ggcgggtggg gggaggggtg ggcgggtggg
     1021 aggtgcctgc tgtttataat gttgaatttc tgtaaaataa actgtatttg caaatccaac
     1081 actgagcttc tggactacgc taaccccact gctgaggcct ctgtggagag ggtcggccat
     1141 ttgcagttga aacaacctgg agaatatagc ccgtgtcctt taaatcagct gacttgtctc
     1201 acatttctct gtaggacgtg tacggtactg gcaggagagt catttttaaa gccatagata
     1261 ggcttttcct cgttcttagc tgtaataaca tacctggttt gattcctcaa gagctgtgtt
     1321 tctgtctgtc acctgtgtac tggccccatg tgtacctccc tgcccttgtc actcctgccc
     1381 cccagtcttt tggagtctgt gacacggatc tgaagtggat gtgctctctt gcgagcagat
     1441 gagattgtta gaattaagct ccagctatcc agttttctaa catagctcta aggtcctcat
     1501 tgctgtttgt gataattggt acataactca ttggaaacat gtgcatacat ttatattcag
     1561 atgaaattat ggtttgcact gtctattaaa tatcttgatt taattttca
//
