LOCUS       NM_172331                831 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus charged multivesicular body protein 3 (Chmp3),
            mRNA.
ACCESSION   NM_172331
VERSION     NM_172331.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 831)
  AUTHORS   Cashikar,A.G., Shim,S., Roth,R., Maldazys,M.R., Heuser,J.E. and
            Hanson,P.I.
  TITLE     Structure of cellular ESCRT-III spirals and their relationship to
            HIV budding
  JOURNAL   Elife 3, e02184 (2014)
   PUBMED   24878737
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 831)
  AUTHORS   Effantin,G., Dordor,A., Sandrin,V., Martinelli,N., Sundquist,W.I.,
            Schoehn,G. and Weissenhorn,W.
  TITLE     ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro
            and act synergistically during HIV-1 budding
  JOURNAL   Cell Microbiol 15 (2), 213-226 (2013)
   PUBMED   23051622
REFERENCE   3  (bases 1 to 831)
  AUTHORS   Baietti,M.F., Zhang,Z., Mortier,E., Melchior,A., Degeest,G.,
            Geeraerts,A., Ivarsson,Y., Depoortere,F., Coomans,C., Vermeiren,E.,
            Zimmermann,P. and David,G.
  TITLE     Syndecan-syntenin-ALIX regulates the biogenesis of exosomes
  JOURNAL   Nat Cell Biol 14 (7), 677-685 (2012)
   PUBMED   22660413
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 831)
  AUTHORS   Morita,E., Colf,L.A., Karren,M.A., Sandrin,V., Rodesch,C.K. and
            Sundquist,W.I.
  TITLE     Human ESCRT-III and VPS4 proteins are required for centrosome and
            spindle maintenance
  JOURNAL   Proc Natl Acad Sci U S A 107 (29), 12889-12894 (2010)
   PUBMED   20616062
REFERENCE   5  (bases 1 to 831)
  AUTHORS   Rusten,T.E. and Stenmark,H.
  TITLE     How do ESCRT proteins control autophagy?
  JOURNAL   J Cell Sci 122 (Pt 13), 2179-2183 (2009)
   PUBMED   19535733
REFERENCE   6  (bases 1 to 831)
  AUTHORS   Muziol,T., Pineda-Molina,E., Ravelli,R.B., Zamborlini,A., Usami,Y.,
            Gottlinger,H. and Weissenhorn,W.
  TITLE     Structural basis for budding by the ESCRT-III factor CHMP3
  JOURNAL   Dev Cell 10 (6), 821-830 (2006)
   PUBMED   16740483
REFERENCE   7  (bases 1 to 831)
  AUTHORS   Bache,K.G., Stuffers,S., Malerod,L., Slagsvold,T., Raiborg,C.,
            Lechardeur,D., Walchli,S., Lukacs,G.L., Brech,A. and Stenmark,H.
  TITLE     The ESCRT-III subunit hVps24 is required for degradation but not
            silencing of the epidermal growth factor receptor
  JOURNAL   Mol Biol Cell 17 (6), 2513-2523 (2006)
   PUBMED   16554368
REFERENCE   8  (bases 1 to 831)
  AUTHORS   Hoffert,J.D., Pisitkun,T., Wang,G., Shen,R.F. and Knepper,M.A.
  TITLE     Quantitative phosphoproteomics of vasopressin-sensitive renal
            cells: regulation of aquaporin-2 phosphorylation at two sites
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 7159-7164 (2006)
   PUBMED   16641100
REFERENCE   9  (bases 1 to 831)
  AUTHORS   Whitley,P., Reaves,B.J., Hashimoto,M., Riley,A.M., Potter,B.V. and
            Holman,G.D.
  TITLE     Identification of mammalian Vps24p as an effector of
            phosphatidylinositol 3,5-bisphosphate-dependent endosome
            compartmentalization
  JOURNAL   J Biol Chem 278 (40), 38786-38795 (2003)
   PUBMED   12878588
  REMARK    GeneRIF: characterization of mVps24p; findings show it is selective
            in its binding to PtdIns(3,5)P2
REFERENCE   10 (bases 1 to 831)
  AUTHORS   von Schwedler,U.K., Stuchell,M., Muller,B., Ward,D.M., Chung,H.Y.,
            Morita,E., Wang,H.E., Davis,T., He,G.P., Cimbora,D.M., Scott,A.,
            Krausslich,H.G., Kaplan,J., Morham,S.G. and Sundquist,W.I.
  TITLE     The protein network of HIV budding
  JOURNAL   Cell 114 (6), 701-713 (2003)
   PUBMED   14505570
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY150169.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY150169.1, FQ215758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..831
                     /gene="Chmp3"
                     /gene_synonym="Vps24"
                     /note="charged multivesicular body protein 3"
                     /db_xref="GeneID:282834"
                     /db_xref="RGD:708556"
     exon            1..66
                     /gene="Chmp3"
                     /gene_synonym="Vps24"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..693
                     /gene="Chmp3"
                     /gene_synonym="Vps24"
                     /note="rVps24p; chromatin-modifying protein 3; vacuolar
                     protein sorting 24 homolog; vacuolar protein
                     sorting-associated protein 24; Vps24p protein"
                     /codon_start=1
                     /product="charged multivesicular body protein 3"
                     /protein_id="NP_758834.1"
                     /db_xref="GeneID:282834"
                     /db_xref="RGD:708556"
                     /translation="MGLFGKTQEKPPKELVNEWSLKIRKEMRVVDRQIRDIQREEEKV
                     KRSVKDAAKKGQKEVCVVLAKEMIRSRKAVSKLYASKAHMNSVLMGMKNQLAVLRVAG
                     SLQKSTEVMKAMQSLVKIPEIQATMRELSKEMMKAGIIEEMLEDTFESMDDQEEMEEA
                     AEMEIDRILFEITAGALGKAPSKVTDALPEPEPAGAMAASEGDEEDDEEDLEAMQSRL
                     ATLRS"
     exon            67..127
                     /gene="Chmp3"
                     /gene_synonym="Vps24"
                     /inference="alignment:Splign:2.1.0"
     exon            128..307
                     /gene="Chmp3"
                     /gene_synonym="Vps24"
                     /inference="alignment:Splign:2.1.0"
     exon            308..429
                     /gene="Chmp3"
                     /gene_synonym="Vps24"
                     /inference="alignment:Splign:2.1.0"
     exon            430..544
                     /gene="Chmp3"
                     /gene_synonym="Vps24"
                     /inference="alignment:Splign:2.1.0"
     exon            545..831
                     /gene="Chmp3"
                     /gene_synonym="Vps24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataagaggag ttcagttcat catggggctg tttggaaaaa cccaagagaa gcctcccaaa
       61 gagctggtta atgaatggtc actgaagatc agaaaggaaa tgagagttgt agacagacaa
      121 ataagagata tccaaagaga agaagagaaa gtaaaacggt ctgtgaaaga tgcagccaag
      181 aagggccaaa aagaagtctg tgtggttctg gccaaggaga tgatcaggtc aaggaaggct
      241 gtgagcaagc tctatgcatc caaagcacac atgaactctg tgctcatggg catgaagaac
      301 caacttgcgg tcctgagagt agcgggttcc ctgcagaaga gcacggaagt gatgaaggca
      361 atgcagagtc ttgtgaagat cccagaaatc caggccacca tgagggagct gtccaaagag
      421 atgatgaagg ctggaatcat agaagagatg ttagaggata cgtttgaaag catggatgat
      481 caagaggaaa tggaagaagc agcagaaatg gagattgaca ggatcctctt tgaaatcaca
      541 gcaggagcct tgggcaaagc acccagtaaa gtaaccgatg cccttcctga gcctgaaccc
      601 gcaggagcga tggctgcctc ggaaggagat gaggaagatg atgaagagga cctggaggct
      661 atgcagtccc ggctggccac actcagaagc tagggccccc cagttggggt ctcagttctc
      721 tggtgttctc ttctaggtgt gtatgcagcc tctgaggagt caccatttcc tatctcttgc
      781 actacacctc tattgtgaag cattgcattt ggagagggtt ctgtgctagt t
//
