LOCUS       NM_001398813            2376 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus charged multivesicular body protein 2B (Chmp2b),
            mRNA.
ACCESSION   NM_001398813 XM_343995
VERSION     NM_001398813.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2376)
  AUTHORS   Bai,Y., Shi,J.H., Liu,Q., Yang,D.J., Yan,Z.P., Zhang,J.K.,
            Tang,H.W., Guo,W.Z., Jin,Y. and Zhang,S.J.
  TITLE     Charged multivesicular body protein 2B ameliorates biliary injury
            in the liver from donation after cardiac death rats via autophagy
            with air-oxygenated normothermic machine perfusion
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (5), 166686 (2023)
   PUBMED   36907288
  REMARK    GeneRIF: Charged multivesicular body protein 2B ameliorates biliary
            injury in the liver from donation after cardiac death rats via
            autophagy with air-oxygenated normothermic machine perfusion.
REFERENCE   2  (bases 1 to 2376)
  AUTHORS   Chassefeyre,R., Martinez-Hernandez,J., Bertaso,F., Bouquier,N.,
            Blot,B., Laporte,M., Fraboulet,S., Coute,Y., Devoy,A., Isaacs,A.M.,
            Pernet-Gallay,K., Sadoul,R., Fagni,L. and Goldberg,Y.
  TITLE     Regulation of postsynaptic function by the dementia-related
            ESCRT-III subunit CHMP2B
  JOURNAL   J Neurosci 35 (7), 3155-3173 (2015)
   PUBMED   25698751
  REMARK    Erratum:[J Neurosci. 2015 May 20;35(20):8035-7]
REFERENCE   3  (bases 1 to 2376)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2376)
  AUTHORS   Cashikar,A.G., Shim,S., Roth,R., Maldazys,M.R., Heuser,J.E. and
            Hanson,P.I.
  TITLE     Structure of cellular ESCRT-III spirals and their relationship to
            HIV budding
  JOURNAL   Elife 3, e02184 (2014)
   PUBMED   24878737
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2376)
  AUTHORS   Sandrin,V. and Sundquist,W.I.
  TITLE     ESCRT requirements for EIAV budding
  JOURNAL   Retrovirology 10, 104 (2013)
   PUBMED   24107264
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2376)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 2376)
  AUTHORS   Schumacher,A., Friedrich,P., Diehl-Schmid,J., Ibach,B., Eisele,T.,
            Laws,S.M., Forstl,H., Kurz,A. and Riemenschneider,M.
  TITLE     No association of chromatin-modifying protein 2B with sporadic
            frontotemporal dementia
  JOURNAL   Neurobiol Aging 28 (11), 1789-1790 (2007)
   PUBMED   16979267
REFERENCE   8  (bases 1 to 2376)
  AUTHORS   Stuchell-Brereton,M.D., Skalicky,J.J., Kieffer,C., Karren,M.A.,
            Ghaffarian,S. and Sundquist,W.I.
  TITLE     ESCRT-III recognition by VPS4 ATPases
  JOURNAL   Nature 449 (7163), 740-744 (2007)
   PUBMED   17928862
REFERENCE   9  (bases 1 to 2376)
  AUTHORS   Parkinson,N., Ince,P.G., Smith,M.O., Highley,R., Skibinski,G.,
            Andersen,P.M., Morrison,K.E., Pall,H.S., Hardiman,O., Collinge,J.,
            Shaw,P.J. and Fisher,E.M.
  CONSRTM   MRC Proteomics in ALS Study; FReJA Consortium
  TITLE     ALS phenotypes with mutations in CHMP2B (charged multivesicular
            body protein 2B)
  JOURNAL   Neurology 67 (6), 1074-1077 (2006)
   PUBMED   16807408
REFERENCE   10 (bases 1 to 2376)
  AUTHORS   Skibinski,G., Parkinson,N.J., Brown,J.M., Chakrabarti,L.,
            Lloyd,S.L., Hummerich,H., Nielsen,J.E., Hodges,J.R.,
            Spillantini,M.G., Thusgaard,T., Brandner,S., Brun,A., Rossor,M.N.,
            Gade,A., Johannsen,P., Sorensen,S.A., Gydesen,S., Fisher,E.M. and
            Collinge,J.
  TITLE     Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in
            frontotemporal dementia
  JOURNAL   Nat Genet 37 (8), 806-808 (2005)
   PUBMED   16041373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Dec 23, 2021 this sequence version replaced XM_343995.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3059400.1, FQ212834.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000011.1  16810257-16810500   c
            245-336             JAXUCZ010000011.1  16796471-16796562   c
            337-531             JAXUCZ010000011.1  16792338-16792532   c
            532-634             JAXUCZ010000011.1  16790847-16790949   c
            635-741             JAXUCZ010000011.1  16785781-16785887   c
            742-2376            JAXUCZ010000011.1  16783971-16785605   c
FEATURES             Location/Qualifiers
     source          1..2376
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11p12"
     gene            1..2376
                     /gene="Chmp2b"
                     /gene_synonym="RGD1306781"
                     /note="charged multivesicular body protein 2B"
                     /db_xref="GeneID:363720"
                     /db_xref="RGD:1306781"
     exon            1..244
                     /gene="Chmp2b"
                     /gene_synonym="RGD1306781"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..852
                     /gene="Chmp2b"
                     /gene_synonym="RGD1306781"
                     /note="chromatin modifying protein 2B"
                     /codon_start=1
                     /product="charged multivesicular body protein 2b"
                     /protein_id="NP_001385742.1"
                     /db_xref="GeneID:363720"
                     /db_xref="RGD:1306781"
                     /translation="MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLEL
                     EIKKMAKIGNKEACRVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAM
                     STTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQ
                     DIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD"
     exon            245..336
                     /gene="Chmp2b"
                     /gene_synonym="RGD1306781"
                     /inference="alignment:Splign:2.1.0"
     exon            337..531
                     /gene="Chmp2b"
                     /gene_synonym="RGD1306781"
                     /inference="alignment:Splign:2.1.0"
     exon            532..634
                     /gene="Chmp2b"
                     /gene_synonym="RGD1306781"
                     /inference="alignment:Splign:2.1.0"
     exon            635..741
                     /gene="Chmp2b"
                     /gene_synonym="RGD1306781"
                     /inference="alignment:Splign:2.1.0"
     exon            742..2376
                     /gene="Chmp2b"
                     /gene_synonym="RGD1306781"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtcttagtt cccggtcacc tgagcaccga ggacgcgttc acgggagcct cgcagagcca
       61 cgcccgccac aggtcgtgct tggagaccct gtctttctcc tcctgccgct gcgtgcctcc
      121 cccgggatct gtccttctac ccgacctagc cccagaaccg ggccggaccg aaccgggccg
      181 agctgggccg cccggacgcg gccgctgacc atggcgtccc tcttcaagaa gaagaccgtg
      241 gacgatgtca taaaggagca gaatcgagag ctgcggggca cacagagggc cataatcagg
      301 gaccgagcag ccttagagaa acaggagaaa cagctggagt tagaaattaa gaagatggcc
      361 aagattggga ataaagaagc ttgcagggtt ttagctaagc agcttgtcca tctacggaaa
      421 cagaagacaa gaacatttgc tgtaagctca aaagtcacat ctatgtccac acaaacgaaa
      481 gtgatgaatt cccagatgaa gatggccggt gccatgtcta ccactgcaaa gacgatgcaa
      541 gcagtgaaca agaaaatgga tccacagaag acactacaaa caatgcagaa tttccagaag
      601 gaaaacatga aaatggaaat gactgaagaa atgatcaacg acaccctgga tgacatcttt
      661 gatggctctg atgatgaaga ggaaagccag gacatcgtga atcaagttct tgatgaaatc
      721 ggaattgaaa tctctggaaa gatggccaaa gccccatcgg ctgccagaag tttgccatct
      781 gcttctactt caaaggctac aatttctgat gaagagattg aacggcagct caaagctttg
      841 ggggtagatt agaacaaaaa gccatacgta ctgttctcac tttggcctaa agtgagtccg
      901 gtgtagattc tttttacaaa atacattcat tttacaaaaa tgaagaccat gagtgaacag
      961 ctattttctg acccatggct attctgaatc ctttgccaaa gaatgccagt gatgcaaaac
     1021 acagggacac tttgggcttt aaccagagtc actgcagcct gagacctgtg caagctgagt
     1081 tcttttctgc atggcatagg gagatggtgt cactacttag tgttgggttg tgttctaaat
     1141 tgttttacac tgaaatcaga attcatgtta aatgccatta ggcatcaact taaagagact
     1201 tgtaaaaata ttaaaggtat accgttaatt ctgtatctgt cgcttgtcct ttgtagacac
     1261 ttatgttagg gccacaggca gtgcagctgc caaattattt ttaaaccatc taaaagaaga
     1321 gtgctattta aacatctgtc ttaaagactg tcatgagctt ttacttttct tccatttttc
     1381 cgcctttggg agaacattct agttggtaag tttattacct ttcaaaatgt gcttggcacc
     1441 tgccttaaac atattgtgca catctttaaa ttaatttacc tggcaaaaac aattacattt
     1501 taaaataaaa ttgagagtta cccaaacagt tacccaatct gtcttacaaa gcttataaaa
     1561 gtgaattgga tataattagc caaatgaaga aagaagacac tgaattaata acactttaca
     1621 gtgatgaaaa tatacttggt ctttcttcca agaactgaga ttttctctgt atgaattata
     1681 agtctgtgct ggaattttgg attgcattaa tatacacatt aaactctgta aatgaagcca
     1741 ttcttgtaaa ggaaacactg ctaccatgac agtactggat ctagatttct aaagaaaatg
     1801 tttctgtttt gtcgtggttt gggtaataaa ctgcaacttt gtcagaagtt accgcctcac
     1861 gttcagcact gtgtgagcag catttgaagg tgagagagct gtgccctgga gagaggagga
     1921 aaggaggagg ccatagagtt agaagtggaa agtgaggtag gttcattctg aaggaccgtg
     1981 tcccagcaga agctatagaa atcctgatca gtggaaactg gctaacctgg agttggacct
     2041 ctggactccg ttagcaaacg cagatgtgca ctacgacgtt aaaggagaca ccaataggtg
     2101 cgaagagcag aggctcggcc gtagactcca taacggttct gtgttcagtg ctgacatcta
     2161 cagtgtccag ttctcattgc tcctgagtgg gaatgggtcc aaacactgta ctgtatcatg
     2221 gggtattaca cccaaacatg gtttgggcgt acattataac gttgtctaac ctaagtcact
     2281 gttttgttta cttgtgacag ttgagtttta atattatttt gtcttttttt aaaaaaactc
     2341 aataaagatt attgctctta tccttttttc cttaaa
//
