LOCUS       NM_001108906             920 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus charged multivesicular body protein 2A (Chmp2a),
            transcript variant 1, mRNA.
ACCESSION   NM_001108906 XM_001055138 XM_344860
VERSION     NM_001108906.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 920)
  AUTHORS   Gu,M., LaJoie,D., Chen,O.S., von Appen,A., Ladinsky,M.S.,
            Redd,M.J., Nikolova,L., Bjorkman,P.J., Sundquist,W.I., Ullman,K.S.
            and Frost,A.
  TITLE     LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in
            fission yeast and human cells
  JOURNAL   Proc Natl Acad Sci U S A 114 (11), E2166-E2175 (2017)
   PUBMED   28242692
REFERENCE   2  (bases 1 to 920)
  AUTHORS   Vietri,M., Schink,K.O., Campsteijn,C., Wegner,C.S., Schultz,S.W.,
            Christ,L., Thoresen,S.B., Brech,A., Raiborg,C. and Stenmark,H.
  TITLE     Spastin and ESCRT-III coordinate mitotic spindle disassembly and
            nuclear envelope sealing
  JOURNAL   Nature 522 (7555), 231-235 (2015)
   PUBMED   26040712
REFERENCE   3  (bases 1 to 920)
  AUTHORS   Cashikar,A.G., Shim,S., Roth,R., Maldazys,M.R., Heuser,J.E. and
            Hanson,P.I.
  TITLE     Structure of cellular ESCRT-III spirals and their relationship to
            HIV budding
  JOURNAL   Elife 3, e02184 (2014)
   PUBMED   24878737
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 920)
  AUTHORS   Sandrin,V. and Sundquist,W.I.
  TITLE     ESCRT requirements for EIAV budding
  JOURNAL   Retrovirology 10, 104 (2013)
   PUBMED   24107264
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 920)
  AUTHORS   Effantin,G., Dordor,A., Sandrin,V., Martinelli,N., Sundquist,W.I.,
            Schoehn,G. and Weissenhorn,W.
  TITLE     ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro
            and act synergistically during HIV-1 budding
  JOURNAL   Cell Microbiol 15 (2), 213-226 (2013)
   PUBMED   23051622
REFERENCE   6  (bases 1 to 920)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 920)
  AUTHORS   Lata,S., Schoehn,G., Jain,A., Pires,R., Piehler,J., Gottlinger,H.G.
            and Weissenhorn,W.
  TITLE     Helical structures of ESCRT-III are disassembled by VPS4
  JOURNAL   Science 321 (5894), 1354-1357 (2008)
   PUBMED   18687924
REFERENCE   8  (bases 1 to 920)
  AUTHORS   Stuchell-Brereton,M.D., Skalicky,J.J., Kieffer,C., Karren,M.A.,
            Ghaffarian,S. and Sundquist,W.I.
  TITLE     ESCRT-III recognition by VPS4 ATPases
  JOURNAL   Nature 449 (7163), 740-744 (2007)
   PUBMED   17928862
REFERENCE   9  (bases 1 to 920)
  AUTHORS   Fujita,H., Umezuki,Y., Imamura,K., Ishikawa,D., Uchimura,S.,
            Nara,A., Yoshimori,T., Hayashizaki,Y., Kawai,J., Ishidoh,K.,
            Tanaka,Y. and Himeno,M.
  TITLE     Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact
            with and regulate the function of an AAA-ATPase SKD1/Vps4B
  JOURNAL   J Cell Sci 117 (Pt 14), 2997-3009 (2004)
   PUBMED   15173323
REFERENCE   10 (bases 1 to 920)
  AUTHORS   von Schwedler,U.K., Stuchell,M., Muller,B., Ward,D.M., Chung,H.Y.,
            Morita,E., Wang,H.E., Davis,T., He,G.P., Cimbora,D.M., Scott,A.,
            Krausslich,H.G., Kaplan,J., Morham,S.G. and Sundquist,W.I.
  TITLE     The protein network of HIV budding
  JOURNAL   Cell 114 (6), 701-713 (2003)
   PUBMED   14505570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 6, 2023 this sequence version replaced NM_001108906.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231086.1, FQ232385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000001.1  82734489-82734618   c
            131-344             JAXUCZ010000001.1  82733828-82734041   c
            345-524             JAXUCZ010000001.1  82732858-82733037   c
            525-655             JAXUCZ010000001.1  82732652-82732782   c
            656-717             JAXUCZ010000001.1  82732507-82732568   c
            718-920             JAXUCZ010000001.1  82732230-82732432   c
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..920
                     /gene="Chmp2a"
                     /gene_synonym="RGD1305050"
                     /note="charged multivesicular body protein 2A"
                     /db_xref="GeneID:365191"
                     /db_xref="RGD:1305050"
     exon            1..130
                     /gene="Chmp2a"
                     /gene_synonym="RGD1305050"
                     /inference="alignment:Splign:2.1.0"
     exon            131..344
                     /gene="Chmp2a"
                     /gene_synonym="RGD1305050"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..845
                     /gene="Chmp2a"
                     /gene_synonym="RGD1305050"
                     /note="chromatin modifying protein 2A"
                     /codon_start=1
                     /product="charged multivesicular body protein 2a"
                     /protein_id="NP_001102376.1"
                     /db_xref="GeneID:365191"
                     /db_xref="RGD:1305050"
                     /translation="MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKII
                     ADIKKMAKQGQMDAVRIMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQA
                     MKGVTKAMGTMNRQLKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEES
                     DAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGGKKAEATASALADADADLEERLKN
                     LRRD"
     exon            345..524
                     /gene="Chmp2a"
                     /gene_synonym="RGD1305050"
                     /inference="alignment:Splign:2.1.0"
     exon            525..655
                     /gene="Chmp2a"
                     /gene_synonym="RGD1305050"
                     /inference="alignment:Splign:2.1.0"
     exon            656..717
                     /gene="Chmp2a"
                     /gene_synonym="RGD1305050"
                     /inference="alignment:Splign:2.1.0"
     exon            718..920
                     /gene="Chmp2a"
                     /gene_synonym="RGD1305050"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtggtctc tgctgagccg caggtcccgt ttgggcggca gcgtaggagg gcttttaggc
       61 tggagcatcg gatgccgtgc ggtccgcctg tccctgccca catcgaggtc ttcacctctg
      121 cctgctctcg ctaggtctga cggctgtctt agacctgctg gtggagtcct accaccatgg
      181 acctgttgtt tgggcgccgg aagacgccag aggaactact tcggcaaaac cagagggccc
      241 tgaaccgagc catgagagaa ctggacaggg aacgacaaaa actagaaacc caggaaaaga
      301 aaatcattgc agacatcaaa aagatggcaa agcaaggcca gatggatgct gttcgaatca
      361 tggcaaaaga cctggtgcgt acccggcgat atgtgcgcaa gtttgtgttg atgcgggcca
      421 atatccaggc tgtgtccctc aagatacaaa ctctaaaatc caacaactca atggcacaag
      481 ccatgaaggg tgttactaag gccatgggca ccatgaacag acagctgaaa ttaccccaga
      541 tccagaagat catgatggag tttgaacggc aggcagagat catggacatg aaggaagaaa
      601 tgatgaatga tgccattgat gatgcaatgg gtgatgagga agatgaagag gagagtgatg
      661 ctgttgtgtc ccaggtactg gatgagctgg gactgagcct cacagatgag ctgtcaaacc
      721 tcccctccac tggaggctca ctcagtgtgg ctgctggcgg aaagaaagca gaggccacag
      781 cctcagctct ggctgatgct gatgcagacc tggaagagag gctcaagaac cttcgcaggg
      841 actgaacact ccacctggac tcaatgccta ggatcttcat cctgtccccc ctgtaataaa
      901 gaaatttgga cactaactta
//
