LOCUS       NM_017067               3482 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus CHM Rab escort protein (Chm), mRNA.
ACCESSION   NM_017067
VERSION     NM_017067.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3482)
  AUTHORS   Guo,Z., Wu,Y.W., Das,D., Delon,C., Cramer,J., Yu,S., Thuns,S.,
            Lupilova,N., Waldmann,H., Brunsveld,L., Goody,R.S., Alexandrov,K.
            and Blankenfeldt,W.
  TITLE     Structures of RabGGTase-substrate/product complexes provide
            insights into the evolution of protein prenylation
  JOURNAL   EMBO J 27 (18), 2444-2456 (2008)
   PUBMED   18756270
  REMARK    GeneRIF: RabGGTase has evolved from a GGTase-I-like molecule that
            'learned' to interact with a recycling factor (GDI) that, in turn,
            eventually gave rise to REP1.
REFERENCE   2  (bases 1 to 3482)
  AUTHORS   Shi,W., van den Hurk,J.A., Alamo-Bethencourt,V., Mayer,W.,
            Winkens,H.J., Ropers,H.H., Cremers,F.P. and Fundele,R.
  TITLE     Choroideremia gene product affects trophoblast development and
            vascularization in mouse extra-embryonic tissues
  JOURNAL   Dev Biol 272 (1), 53-65 (2004)
   PUBMED   15242790
REFERENCE   3  (bases 1 to 3482)
  AUTHORS   Rak,A., Pylypenko,O., Niculae,A., Pyatkov,K., Goody,R.S. and
            Alexandrov,K.
  TITLE     Structure of the Rab7:REP-1 complex: insights into the mechanism of
            Rab prenylation and choroideremia disease
  JOURNAL   Cell 117 (6), 749-760 (2004)
   PUBMED   15186776
REFERENCE   4  (bases 1 to 3482)
  AUTHORS   Pylypenko,O., Rak,A., Reents,R., Niculae,A., Sidorovitch,V.,
            Cioaca,M.D., Bessolitsyna,E., Thoma,N.H., Waldmann,H.,
            Schlichting,I., Goody,R.S. and Alexandrov,K.
  TITLE     Structure of Rab escort protein-1 in complex with Rab
            geranylgeranyltransferase
  JOURNAL   Mol Cell 11 (2), 483-494 (2003)
   PUBMED   12620235
REFERENCE   5  (bases 1 to 3482)
  AUTHORS   Tolmachova,T., Ramalho,J.S., Anant,J.S., Schultz,R.A., Huxley,C.M.
            and Seabra,M.C.
  TITLE     Cloning, mapping and characterization of the human RAB27A gene
  JOURNAL   Gene 239 (1), 109-116 (1999)
   PUBMED   10571040
REFERENCE   6  (bases 1 to 3482)
  AUTHORS   Alexandrov,K., Horiuchi,H., Steele-Mortimer,O., Seabra,M.C. and
            Zerial,M.
  TITLE     Rab escort protein-1 is a multifunctional protein that accompanies
            newly prenylated rab proteins to their target membranes
  JOURNAL   EMBO J 13 (22), 5262-5273 (1994)
   PUBMED   7957092
REFERENCE   7  (bases 1 to 3482)
  AUTHORS   Andres,D.A., Seabra,M.C., Brown,M.S., Armstrong,S.A., Smeland,T.E.,
            Cremers,F.P. and Goldstein,J.L.
  TITLE     cDNA cloning of component A of Rab geranylgeranyl transferase and
            demonstration of its role as a Rab escort protein
  JOURNAL   Cell 73 (6), 1091-1099 (1993)
   PUBMED   8513495
REFERENCE   8  (bases 1 to 3482)
  AUTHORS   Seabra,M.C., Brown,M.S., Slaughter,C.A., Sudhof,T.C. and
            Goldstein,J.L.
  TITLE     Purification of component A of Rab geranylgeranyl transferase:
            possible identity with the choroideremia gene product
  JOURNAL   Cell 70 (6), 1049-1057 (1992)
   PUBMED   1525821
REFERENCE   9  (bases 1 to 3482)
  AUTHORS   Zderkiewicz,E.
  TITLE     [Autoregulation of cerebral blood flow]
  JOURNAL   Pol Tyg Lek 33 (29), 1157-1159 (1978)
   PUBMED   704419
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L13722.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by NM_017067.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L13722.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3482
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq31"
     gene            1..3482
                     /gene="Chm"
                     /note="CHM Rab escort protein"
                     /db_xref="GeneID:24942"
                     /db_xref="RGD:2340"
     exon            1..54
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1958
                     /gene="Chm"
                     /function="escort protein"
                     /note="REP-1; rab escort protein 1; choroideraemia protein
                     homolog; choroidermia; choroideremia (Rab escort protein
                     1); choroideremia protein homolog; CHM, Rab escort protein
                     1"
                     /codon_start=1
                     /product="rab proteins geranylgeranyltransferase component
                     A 1"
                     /protein_id="NP_058763.1"
                     /db_xref="GeneID:24942"
                     /db_xref="RGD:2340"
                     /translation="MADNLPSDFDVIVIGTGLPESIIAAACSRSGQRVLHVDSRSYYG
                     GNWASFSFSGLLSWLKEYQENNDVVTENSMWQEQILENEEAIPLSSKDKTIQHVEVFC
                     YASQDLHKDVEEAGALQKNHASVTSAQSAEAAEAAETSCLPTAVEPLSMGSCEIPAEQ
                     SQCPGPESSPEVNDAEATGKKENSDAKSSTEEPSENVPKVQDNTETPKKNRITYSQII
                     KEGRRFNIDLVSQLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGTVEQVPCSRA
                     DVFNSKQLTMVEKRMLMKFLTFCVEYEEHPDEYRAYEGTTFSEYLKTQKLTPNLQYFV
                     LHSIAMTSETTSCTVDGLKATKKFLQCLGRYGNTPFLFPLYGQGELPQCFCRMCAVFG
                     GIYCLRHSVQCLVVDKESRKCKAVIDQFGQRIISKHFIIEDSYLSENTCSRVQYRQIS
                     RAVLITDGSVLKTDADQQVSILAVPAEEPGSFGVRVIELCSSTMTCMKGTYLVHLTCM
                     SSKTAREDLERVVQKLFTPYTEIEAENEQVEKPRLLWALYFNMRDSSDISRDCYNDLP
                     SNVYVCSGPDSGLGNDNAVKQAETLFQQICPNEDFCPAPPNPEDIVLDGDSSQQEVPE
                     SSVTPETNSETPKESTVLGNPEEPSE"
     exon            55..121
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            122..194
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            195..319
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            320..698
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            699..815
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            816..936
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1162
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1240
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1345
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1409
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1506
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1605
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1766
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..3482
                     /gene="Chm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcaagatggc ggataatctc ccttcggact ttgatgtgat cgtaataggg acgggtttgc
       61 ctgaatccat cattgcagct gcatgttcaa ggagtggcca gagggttctg catgttgatt
      121 caagaagcta ctatggagga aactgggcca gtttcagctt ttcaggactg ttgtcctggc
      181 taaaggaata ccaggaaaat aatgatgttg tgactgaaaa ttcaatgtgg caagaacaga
      241 tacttgaaaa cgaagaagct attcctctta gtagcaagga caaaacaatt caacatgtag
      301 aagtattttg ttatgccagt caggatttgc acaaagatgt tgaagaagct ggtgcactgc
      361 agaaaaatca tgcttctgtg acatctgcac agtccgcaga ggctgccgag gctgcagaaa
      421 cttcttgcct tcctactgca gtggagccat taagcatggg gagctgtgaa atacctgcag
      481 aacaaagcca gtgccctggt ccagagagtt caccagaagt caatgatgct gaagccacag
      541 gaaagaaaga aaatagtgat gctaaaagtt caacagaaga accaagtgaa aatgtgccta
      601 aagtccaaga caacacagag acaccaaaga aaaacagaat cacttactca cagattatta
      661 aagaaggcag aagatttaac attgatttag tttcacaact tctgtattct cggggattac
      721 taattgatct tctaatcaaa tcaaatgtta gtcgatatgc agagtttaaa aatattacga
      781 ggattcttgc atttcgagaa ggaactgtgg aacaggttcc atgttccaga gcagatgtct
      841 tcaatagcaa acaacttact atggtagaaa agcgaatgct tatgaaattt cttacgtttt
      901 gtgtagaata tgaagaacat cctgacgagt acagagcata tgagggaact acattttctg
      961 aatatttaaa aactcaaaaa ttaaccccta acctacaata ttttgtcctg cactcaattg
     1021 caatgacatc agagacaaca agctgtactg tagatggtct caaagctact aaaaagtttc
     1081 ttcagtgtct tgggcgatat ggcaacactc catttctgtt tcctttatat ggccaaggag
     1141 aacttccaca gtgtttttgc agaatgtgtg ctgtatttgg tggaatctat tgtcttcgcc
     1201 attctgtaca gtgccttgta gtggacaaag aatccagaaa atgtaaagca gtgatagatc
     1261 agtttggtca aaggataatc tctaaacatt tcattattga agacagttac ctttctgaga
     1321 atacatgttc ccgtgtgcaa tacaggcaaa tatccagggc agtactgatt acagatggat
     1381 ctgtactaaa aacggatgca gaccaacagg tctccatttt ggcggtgcca gcagaagagc
     1441 caggaagttt tggtgtacga gttattgagt tatgctcttc aacaatgaca tgcatgaaag
     1501 gcacatattt ggtgcatttg acttgcatgt cttctaaaac agcaagagaa gatttagaac
     1561 gggtagtcca gaaattgttt actccgtata cagaaataga agcagaaaat gaacaggttg
     1621 aaaagccaag acttctatgg gcactctact tcaatatgag agactcttca gatatcagca
     1681 gagattgtta taatgattta ccatccaatg tctatgtgtg ctctggccct gactccggtc
     1741 taggaaatga taatgcagtc aaacaggcgg aaacactttt ccagcaaatc tgcccaaatg
     1801 aagacttctg tccagccccg ccaaatcctg aagatattgt tcttgatgga gacagctccc
     1861 aacaagaagt tccagaatcc agtgtcacac ccgaaaccaa ctcagagact cccaaggaaa
     1921 gtacagtcct gggaaaccca gaagagcctt ctgaatagtg gatatgcatc agacttaaca
     1981 acctactttg gaaattcctc ttgccttcac agtgttctca atagaaggaa tatttgagat
     2041 ctttaaaata caacaaccaa tttattaggt aaaattagaa gaaatgagtc ccagaaatcc
     2101 aaaaaggcat tttcttcaaa gaggtcattt ccagaaacat aaaacactta taaagcacat
     2161 taacttgcct attttaacat accaaacctg taagattagc aggcgacaaa tataaatgga
     2221 ctgattccta gaaatgtagt tatgatgtaa aagggatcct gttcttcatt aataattatg
     2281 ttctgtccac ataaatttgt ttgccacttg ggatcttttt tgttgaaagc cacatataga
     2341 gagtcagctc acatacttat tttggttatt tgaattatat tttaatctgg gtatgatata
     2401 acatataaaa tcatatgtaa atatggtaga gtaaagctaa actatcatca tctggccagg
     2461 agcctatatt tggagtaaaa gttgatttta ttttctatgt taaaaactga ataggttaat
     2521 actaaggtat ttagacattt tgctaatttt aatgtcttag taattagtga tttggatgta
     2581 tatcatacac acattggcta aaattcaaag atgaagaaat agaagactac aagcaaacat
     2641 ttggatagga tgagtctaag tcaactcaag cactaacatc ttatccacag aactaatttc
     2701 atcataggta tgttactgaa tatctgagcc caaattgttt agcttcttat cttcagtttt
     2761 caggtatcaa gtgaaacatt atacctatga ttacagagca gttatgaaga ccaatgcctt
     2821 acagtggttc ttctggaata tactgtttta gaacttacct gttaattgat ctgtggataa
     2881 atatcaaacc acctcatgat tatagcgtta tagttattgc agtaaagttt taatgcaagt
     2941 ctgtttccta tactcattaa taacaggtgg aatggtggtt cgtgaagtct tatgaatact
     3001 tgataaattc atatttctct tctggcaact aaaccagaac agagtgttaa cagttaataa
     3061 cctgtaatat acactttaca tgaaaaaatg agggctatcc attgccagaa aacctatttg
     3121 caatgcctac atttaaatgt ctctaagctc tgatgatcta ctttctttga gcaatagttt
     3181 ggaccaggaa ctacctgtaa ataaatacac aataaataaa cccaatgctt cctgtcaggg
     3241 agccatggct ccaacgaaaa gcacagaatt ctttctccat gtgcagctgg ttcctgacct
     3301 gggcaggttg cagaaaagat tttaaaggtc ctagcacaga ttcttaagaa atgggaaaat
     3361 ccaaggaatg tgctgacccc tgcagattga gatggactga gaaaatggga aaaacttccc
     3421 agactcccag gctgctcctc tcaggctacc tgcacctcct gctgtccagc cctctccttc
     3481 tc
//
